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As of January 2016, the journal only publishes open access content, and legacy subscription content published in Nature Communications prior to 2016 has been made freely accessible. For more information visit our website.
Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | The evolution of sex-specific virulence in infectious diseases OPEN | | | Francisco Úbeda and Vincent A. A. Jansen | | | Many infectious diseases are more likely to progress to serious illness or death in men than in women, which has been attributed to a stronger immune response in women. Here, the authors propose that pathogen transmission from mother to child favours the evolution of lower virulence in women, and argue that the higher risk of HTLV-1 infection progressing to leukaemia in Japanese men is due to prolonged breastfeeding in Japan. | | | 13 December 2016 | doi: 10.1038/ncomms13849 | | |
| Neuroanatomy accounts for age-related changes in risk preferences OPEN | | | Michael A. Grubb, Agnieszka Tymula, Sharon Gilaie-Dotan, Paul W. Glimcher and Ifat Levy | | | Tolerance for risk decreases with age, but it is not known whether this shift can be accounted for by a neurobiological marker. Here, authors show that the age-related decrease in risk tolerance is better accounted for by grey matter decreases in right posterior parietal cortex than by age per se. | | | 13 December 2016 | doi: 10.1038/ncomms13822 | | |
| Radiative cooling to deep sub-freezing temperatures through a 24-h day–night cycle OPEN | | | Zhen Chen, Linxiao Zhu, Aaswath Raman and Shanhui Fan | | | Radiative cooling relies on the atmosphere’s transparency window. Here the authors achieve up to 42 °C drops in temperature for low thermal loads under diffuse sunlight by improving the selectivity of the emissivity and the thermal management of their devices. | | | 13 December 2016 | doi: 10.1038/ncomms13729 | | |
| Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer OPEN | | | Yundong He, Shihong Peng, Jinhua Wang, Huang Chen, Xiaonan Cong, Ang Chen, Meichun Hu, Min Qin, Haigang Wu, Shuman Gao, Liguo Wang, Xin Wang, Zhengfang Yi and Mingyao Liu | | | Prostate cancers often become castration resistant due to alternative expression of androgen receptor (AR) splice variants. Here, the authors screened a library of natural compounds and identified Ailanthone as a potent inhibitor of AR through its binding to the co-chaperone protein p23 that, by preventing AR interaction with HSP90, results in ubiquitin/proteasome-mediated degradation of the receptor. | | | 13 December 2016 | doi: 10.1038/ncomms13122 | | |
| Extreme warming challenges sentinel status of kelp forests as indicators of climate change OPEN | | | Daniel Reed, Libe Washburn, Andrew Rassweiler, Robert Miller, Tom Bell and Shannon Harrer | | | Giant kelp is sometimes considered the ‘canary in the coal mine’ of coastal ecosystems. However, Reed et al. demonstrate that kelp did not decline during recent ocean warming in California, questioning whether this species is an appropriate indicator for ecosystem responses to future climate change. | | | 13 December 2016 | doi: 10.1038/ncomms13757 | | |
| Carbon storage in US wetlands OPEN | | | A. M. Nahlik and M. S. Fennessy | | | Wetlands store large quantities of carbon, the distribution and quantity of which is little known. Here, Nahlik and Fennessy use data collected as part of the 2011 National Wetland Condition Assessment to estimate wetland carbon stocks across the United States, illustrating total storage of 11.52 PgC. | | | 13 December 2016 | doi: 10.1038/ncomms13835 | | |
| Imaging high-speed friction at the nanometer scale OPEN | | | Per-Anders Thorén, Astrid S. de Wijn, Riccardo Borgani, Daniel Forchheimer and David B. Haviland | | | It has been a challenge to characterize microscopic origins of friction at high velocities. Here authors extend atomic force microscopy to develop a dynamic technique combining force sensitivity and spatial resolution and able to probe, at each image pixel, frictional forces at velocities up to several cm per second. | | | 13 December 2016 | doi: 10.1038/ncomms13836 | | |
| A metal-free electrocatalyst for carbon dioxide reduction to multi-carbon hydrocarbons and oxygenates OPEN | | | Jingjie Wu, Sichao Ma, Jing Sun, Jake I. Gold, ChandraSekhar Tiwary, Byoungsu Kim, Lingyang Zhu, Nitin Chopra, Ihab N. Odeh, Robert Vajtai, Aaron Z. Yu, Raymond Luo, Jun Lou, Guqiao Ding, Paul J. A. Kenis and Pulickel M. Ajayan | | | Electroreduction of CO2 into C2 hydrocarbons and liquid fuels is a promising but challenging energy conversion technology, with copper exhibiting fair selectivity for these products. Here, the authors report that N-doped graphene quantum dots can also catalyze the electrochemical reduction of CO2 into multi-carbon hydrocarbons and oxygenates. | | | 13 December 2016 | doi: 10.1038/ncomms13869 | | |
| ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A OPEN | | | Chris T. Williamson, Rowan Miller, Helen N. Pemberton, Samuel E. Jones, James Campbell, Asha Konde, Nicholas Badham, Rumana Rafiq, Rachel Brough, Aditi Gulati, Colm J. Ryan, Jeff Francis, Peter B. Vermulen, Andrew R. Reynolds, Philip M. Reaper, John R. Pollard, Alan Ashworth and Christopher J. Lord | | | Mutations in the BAF SWI/SNF complex subunits are frequent in cancers but selective therapeutic approaches are not available yet. Here, the authors demonstrate that defects of ARID1A and other subunits sensitizes cancer cells to the DNA checkpoint kinase inhibitor ATR in a synthetic lethal manner. | | | 13 December 2016 | doi: 10.1038/ncomms13837 | | |
| Trapping gases in metal-organic frameworks with a selective surface molecular barrier layer OPEN | | | Kui Tan, Sebastian Zuluaga, Erika Fuentes, Eric C. Mattson, Jean-François Veyan, Hao Wang, Jing Li, Timo Thonhauser and Yves J. Chabal | | | Metal-organic frameworks are extensively studied for gas storage applications, but one potential limitation is their relatively weak adsorption of gases. Here, the authors report that the exposure of metal-organic frameworks to ethylenediamine forms a monolayer thick cap which improves gas molecule retention. | | | 13 December 2016 | doi: 10.1038/ncomms13871 | | |
| Robust spin-orbit torque and spin-galvanic effect at the Fe/GaAs (001) interface at room temperature OPEN | | | L. Chen, M. Decker, M. Kronseder, R. Islinger, M. Gmitra, D. Schuh, D. Bougeard, J. Fabian, D. Weiss and C. H. Back | | | Interfacial spin-orbit torque allows electrical manipulation of magnetization, but this has been shown mostly in polycrystalline metal bilayers. Here the authors show robust spin-orbit torque in single crystalline Fe/GaAs interface at room temperature, observing conversion between spin and charge current. | | | 13 December 2016 | doi: 10.1038/ncomms13802 | | |
| Observation of a reversal of rotation in a sunspot during a solar flare OPEN | | | Yi Bi, Yunchun Jiang, Jiayan Yang, Junchao Hong, Haidong Li, Bo Yang and Zhe Xu | | | Back reaction of coronal magnetic fields on the solar surface may help to understand the coronal reconfiguration during a solar flare. Here the authors report observation of reversal of the rotation of a sunspot during a X1.6 flare with data from HMI. | | | 13 December 2016 | doi: 10.1038/ncomms13798 | | |
| Making brain–machine interfaces robust to future neural variability OPEN | | | David Sussillo, Sergey D. Stavisky, Jonathan C. Kao, Stephen I. Ryu and Krishna V. Shenoy | | | Brain-machine interfaces (BMI) depend on algorithms to decode neural signals, but these decoders cope poorly with signal variability. Here, authors report a BMI decoder which circumvents these problems by using a large and perturbed training dataset to improve performance with variable neural signals. | | | 13 December 2016 | doi: 10.1038/ncomms13749 | | |
| Stability of peatland carbon to rising temperatures OPEN | | | R. M. Wilson, A. M. Hopple, M. M. Tfaily, S. D. Sebestyen, C. W. Schadt, L. Pfeifer-Meister, C. Medvedeff, K. J. McFarlane, J. E. Kostka, M. Kolton, R.K. Kolka, L. A. Kluber, J. K. Keller, T. P. Guilderson, N. A. Griffiths, J. P. Chanton, S. D. Bridgham and P. J. Hanson | | | Peatlands store large quantities of carbon, yet their response to deep warming remains unexplored. Here, Wilson et al. perform large scale ecosystem manipulation to reveal deep peat heating exponentially increases CH4 emissions due to surface processes, but that deep carbon remains relatively stable. | | | 13 December 2016 | doi: 10.1038/ncomms13723 | | |
| In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway OPEN | | | Jiying Ning, Gonca Erdemci-Tandogan, Ernest L. Yufenyuy, Jef Wagner, Benjamin A. Himes, Gongpu Zhao, Christopher Aiken, Roya Zandi and Peijun Zhang | | | Two competing models—disassembly/reassembly and displacive—have been proposed for how immature spherical HIV virions transform into mature particles with conical cores. Here the authors provide evidence that both disassembly/reassembly and displacive processes occur sequentially during the maturation process. | | | 13 December 2016 | doi: 10.1038/ncomms13689 | | |
| Nanoscopy of bacterial cells immobilized by holographic optical tweezers OPEN | | | Robin Diekmann, Deanna L. Wolfson, Christoph Spahn, Mike Heilemann, Mark Schüttpelz and Thomas Huser | | | Nanoscopy of non-adherent cells is currently not possible, due to their movement in solution. Here the authors immobilize and manipulate fixed E. coli by multiple optical traps; their holographic optical tweezers enable dSTORM imaging of orthogonal planes via 3D realignment of the sample. | | | 13 December 2016 | doi: 10.1038/ncomms13711 | | |
| Phase-referenced nonlinear spectroscopy of the α-quartz/water interface OPEN | | | Paul E. Ohno, Sarah A. Saslow, Hong-fei Wang, Franz M. Geiger and Kenneth B. Eisenthal | | | Probing the polarization of water molecules at charged interfaces reveals insights into surface behaviour, but current methods are limited to isotropic materials. Here the authors exploit the nonlinear optical properties of the α-quartz/water interface to expand the scope of such methods to non-isotropic materials. | | | 13 December 2016 | doi: 10.1038/ncomms13587 | | |
| A programmable DNA origami nanospring that reveals force-induced adjacent binding of myosin VI heads OPEN | | | M. Iwaki, S. F. Wickham, K. Ikezaki, T. Yanagida and W. M. Shih | | | Characterizing the mechanical response of molecular motors involves the use of methods such as optical trapping to apply force. Here the authors develop a DNA origami nanospring to apply progressive force to human myosin VI, and discover that it adopts different stepping modes when subjected to low load or high load. | | | 12 December 2016 | doi: 10.1038/ncomms13715 | | |
| Universal structural parameter to quantitatively predict metallic glass properties OPEN | | | Jun Ding, Yong-Qiang Cheng, Howard Sheng, Mark Asta, Robert O. Ritchie and Evan Ma | | | Various known structural descriptors of metallic glasses have limitations in quantitatively predicting properties. Here authors define a physically-motivated measure and show it to correlate strongly with elastic properties, local structure and relaxation kinetics over a wide range of simulated compositions. | | | 12 December 2016 | doi: 10.1038/ncomms13733 | | |
| Emergent Weyl excitations in systems of polar particles OPEN | | | Sergey V. Syzranov, Michael L. Wall, Bihui Zhu, Victor Gurarie and Ana Maria Rey | | | Systems with Weyl excitations can display very interesting physical phenomena. Here the authors demonstrate that Weyl excitations exist generically in 3D systems of dipolar particles following angular momentum transfer, and discuss how to observe them in cold alkaline-earth-atom systems. | | | 12 December 2016 | doi: 10.1038/ncomms13543 | | |
| Hall effect in charged conducting ferroelectric domain walls OPEN | | | M. P. Campbell, J.P.V. McConville, R.G.P. McQuaid, D. Prabhakaran, A. Kumar and J. M. Gregg | | | Conduction in ferroelectric domain walls is now an established phenomenon, yet fundamental aspects of transport physics remain elusive. Here, Campbell et al. report the type, density and mobility of carriers in conducting domain walls in ytterbium manganite using nanoscale Hall effect measurements. | | | 12 December 2016 | doi: 10.1038/ncomms13764 | | |
| Atomic-scale observation of structural and electronic orders in the layered compound α-RuCl3 OPEN | | | M. Ziatdinov, A. Banerjee, A. Maksov, T. Berlijn, W. Zhou, H. B. Cao, J.-Q. Yan, C. A. Bridges, D. G. Mandrus, S. E. Nagler, A. P. Baddorf and S. V. Kalinin | | | The two-dimensional Kitaev model is a quantum spin liquid state that theory predicts should appear in some materials with a honeycomb lattice. Here, the authors use atom-resolution scanning transmission electron and scanning tunnelling microscopies to characterize one such candidate material, α-RuCl3. | | | 12 December 2016 | doi: 10.1038/ncomms13774 | | |
| Inferring time derivatives including cell growth rates using Gaussian processes OPEN | | | Peter S. Swain, Keiran Stevenson, Allen Leary, Luis F. Montano-Gutierrez, Ivan B.N. Clark, Jackie Vogel and Teuta Pilizota | | | High-throughput time-series data is increasingly available, yet estimating time-derivatives from such data can remain a challenge. Here, the authors provide a non-parametric method for inferring the first and second time-derivatives from multiple replicates of time-series data and for estimating errors in this inference and in any summary statistics. | | | 12 December 2016 | doi: 10.1038/ncomms13766 | | |
| Additional energy scale in SmB6 at low-temperature OPEN | | | L. Jiao, S. Rößler, D. J. Kim, L. H. Tjeng, Z. Fisk, F. Steglich and S. Wirth | | | Many discrepancies exist to question the nature of the candidate topological Kondo insulator, SmB6. Here, Jiao et al. observe in-gap states on well characterized (001) surfaces of SmB6, indicating a suppression of the Kondo effect at surface, which reconciles current discrepancies on this compound. | | | 12 December 2016 | doi: 10.1038/ncomms13762 | | |
| Dual matter-wave inertial sensors in weightlessness OPEN | | | Brynle Barrett, Laura Antoni-Micollier, Laure Chichet, Baptiste Battelier, Thomas Lévèque, Arnaud Landragin and Philippe Bouyer | | | Atom interferometers in microgravity environments can reach precisions unattainable on Earth. Here the authors report the operation of a dual species interferometer onboard a zero-G aircraft, testing universality of free fall in microgravity and providing a test bed for future moving inertial sensors. | | | 12 December 2016 | doi: 10.1038/ncomms13786 | | |
| Conditional repair by locally switching the thermal healing capability of dynamic covalent polymers with light OPEN | | | Anne Fuhrmann, Robert Göstl, Robert Wendt, Julia Kötteritzsch, Martin D. Hager, Ulrich S. Schubert, Kerstin Brademann-Jock, Andreas F. Thünemann, Ulrich Nöchel, Marc Behl and Stefan Hecht | | | Healable materials are typically repaired by heat, which can affect the properties of the substance. Here the authors report a dynamic covalent polymer network in which light can switch the healing abilities on or off, allowing healing at defined locations without affecting the polymer as a whole. | | | 12 December 2016 | doi: 10.1038/ncomms13623 | | |
| Suppressing photochemical reactions with quantized light fields OPEN | | | Javier Galego, Francisco J. Garcia-Vidal and Johannes Feist | | | Photochemical reactions can limit the efficiency of organic solar cells. Here the authors show that strong coupling of organic molecules to a confined light mode can effectively suppress such reactions and convert normally unstable molecules into photostable forms. | | | 12 December 2016 | doi: 10.1038/ncomms13841 | | |
| Superconductivity in the antiperovskite Dirac-metal oxide Sr3−xSnO OPEN | | | Mohamed Oudah, Atsutoshi Ikeda, Jan Niklas Hausmann, Shingo Yonezawa, Toshiyuki Fukumoto, Shingo Kobayashi, Masatoshi Sato and Yoshiteru Maeno | | | Superconductivity has not been observed in any antiperovskite oxide up to now. Here Oudah et al. report superconducting transition around 5 K in antiperovskite oxide Sr3−x SnO, making it a new class of oxide superconductors. | | | 12 December 2016 | doi: 10.1038/ncomms13617 | | |
| Spin doping using transition metal phthalocyanine molecules OPEN | | | A. Atxabal, M. Ribeiro, S. Parui, L. Urreta, E. Sagasta, X. Sun, R. Llopis, F. Casanova and L. E. Hueso | | | Molecular magnets are molecules with an inherent non-zero spin that can exhibit magnetic ordering. Here, the authors show that such molecules can change the many-body ground state of nonmagnetic metals at a functional scale with magnetic phthalocyanines. | | | 12 December 2016 | doi: 10.1038/ncomms13751 | | |
| Co-axial heterostructures integrating palladium/titanium dioxide with carbon nanotubes for efficient electrocatalytic hydrogen evolution OPEN | | | Giovanni Valenti, Alessandro Boni, Michele Melchionna, Matteo Cargnello, Lucia Nasi, Giovanni Bertoni, Raymond J. Gorte, Massimo Marcaccio, Stefania Rapino, Marcella Bonchio, Paolo Fornasiero, Maurizio Prato and Francesco Paolucci | | | Hydrogen evolution by water electrolysis is a promising route to 'green energy', but efficiency is still an issue. Here, the authors make mixed organic/inorganic hierarchical nanostructures with high hydrogen evolution activity, identifying synergic effects in the material contributing to enhanced efficiency. | | | 12 December 2016 | doi: 10.1038/ncomms13549 | | |
| Role of syn-eruptive plagioclase disequilibrium crystallization in basaltic magma ascent dynamics OPEN | | | G. La Spina, M. Burton, M. de’ Michieli Vitturi and F. Arzilli | | | The quantification of timing for crystallization and exsolution processes are fundamental to our understanding of basaltic magma ascent dynamics. Here, the authors constrain timings to show that plagioclase reaches equilibrium in 1-2 hours, whereas ascent times were <1 hour. | | | 12 December 2016 | doi: 10.1038/ncomms13402 | | |
| Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence OPEN | | | Ajinkya Revandkar, Maria Luna Perciato, Alberto Toso, Abdullah Alajati, Jingjing Chen, Hermeto Gerber, Mitko Dimitrov, Andrea Rinaldi, Nicolas Delaleu, Emiliano Pasquini, Rocco D’Antuono, Sandra Pinton, Marco Losa, Letizia Gnetti, Alberto Arribas, Patrick Fraering, Francesco Bertoni, Alain Nepveu and Andrea Alimonti | | | Notch signalling is involved in prostate cancer progression and therapeutic resistance. Here, the authors show that loss of PTEN in prostate cancer models results in increased Notch1 cleavage and activation through CUX1-mediated transactivation of ADAM17. | | | 12 December 2016 | doi: 10.1038/ncomms13719 | | |
| Achieving ZT=2.2 with Bi-doped n-type SnSe single crystals OPEN | | | Anh Tuan Duong, Van Quang Nguyen, Ganbat Duvjir, Van Thiet Duong, Suyong Kwon, Jae Yong Song, Jae Ki Lee, Ji Eun Lee, SuDong Park, Taewon Min, Jaekwang Lee, Jungdae Kim and Sunglae Cho | | | The good thermoelectric figures of merit of p-type tin selenide single crystals are actively studied. Here, the authors show that n-type SnSe can also reach a figure of merit of around 2, at high temperatures, when doped with bismuth. | | | 12 December 2016 | doi: 10.1038/ncomms13713 | | |
| Thermal imaging of spin Peltier effect OPEN | | | Shunsuke Daimon, Ryo Iguchi, Tomosato Hioki, Eiji Saitoh and Ken-ichi Uchida | | | The spin Peltier effect produces a temperature difference along the direction of a spin current. Here, the authors use an active thermography technique to visualize the temperature modulation induced by a spin current injected into a magnetic insulator from an adjacent metal. | | | 12 December 2016 | doi: 10.1038/ncomms13754 | | |
| In-plane topological p-n junction in the three-dimensional topological insulator Bi2−xSbxTe3−ySey OPEN | | | Ngoc Han Tu, Yoichi Tanabe, Yosuke Satake, Khuong Kim Huynh and Katsumi Tanigaki | | | Dirac cone surface states rectify an ultralow dissipative spin and charge current, but it is yet to be confirmed in devices. Here, Tu et al. observe p-type electrical transport on one half surface and n-type on the other in Bi2−x Sb x Te3−y Se y thin films, realizing a topological p-n junction. | | | 09 December 2016 | doi: 10.1038/ncomms13763 | | |
| Carbon monoxide in an extremely metal-poor galaxy OPEN | | | Yong Shi, Junzhi Wang, Zhi-Yu Zhang, Yu Gao, Cai-Na Hao, Xiao-Yang Xia and Qiusheng Gu | | | Extremely metal-poor galaxies in the local universe are the best analogues to investigating the interstellar medium at a quasi-primitive environment in the early universe. Here, the authors detect CO emission in a galaxy at 7% solar metallicity, offering direct evidence for the presence of molecular gas. | | | 09 December 2016 | doi: 10.1038/ncomms13789 | | |
| TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments OPEN | | | Mohamed Fareh, Kyu-Hyeon Yeom, Anna C. Haagsma, Sweeny Chauhan, Inha Heo and Chirlmin Joo | | | The RNA binding protein TRBP is a component of the Dicer complex but its role in microRNA biogenesis remains poorly understood. Here the authors use a crowded RNA environment and single-molecule imaging to show that TRBP acts as a gatekeeper to prevent Dicer engagement with pre miRNA-like substrates. | | | 09 December 2016 | doi: 10.1038/ncomms13694 | | |
| Scanning superlens microscopy for non-invasive large field-of-view visible light nanoscale imaging OPEN | | | Feifei Wang, Lianqing Liu, Haibo Yu, Yangdong Wen, Peng Yu, Zhu Liu, Yuechao Wang and Wen Jung Li | | | Rare subcellular events can be tracked by correlating structural-information gathered by imaging with specific-molecule fluorescent identification. Here, the authors achieve this correlation in a quick and non-invasive way using microsphere-based scanning superlens microscopy. | | | 09 December 2016 | doi: 10.1038/ncomms13748 | | |
| K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression OPEN | | | Han-Tsang Wu, Yi-Chih Kuo, Jung-Jyh Hung, Chi-Hung Huang, Wei-Yi Chen, Teh-Ying Chou, Yeh Chen, Yi-Ju Chen, Yu-Ju Chen, Wei-Chung Cheng, Shu-Chun Teng and Kou-Juey Wu | | | Hypoxia-induced transcriptional responses mediated by HIF-1a are regulated through the ubiquitin-dependent pathway to control HIF-1a stability. Here the authors show that the deubiquitinase HAUSP modulates the stability of HIF-1a and K63-polyubiquitinated HAUSP serves as an anchor for HIF-1a-induced gene transcription. | | | 09 December 2016 | doi: 10.1038/ncomms13644 | | |
| Multiple signal classification algorithm for super-resolution fluorescence microscopy OPEN | | | Krishna Agarwal and Radek Macháň | | | Single-molecule localization microscopy offers super-resolution imaging, but needs a long acquisition time and a toxic photochemical environment. Here, the authors demonstrate a multiple signal classification algorithm that achieves a resolution of 50 nm with as few as 50 frames in a biologically conducive environment. | | | 09 December 2016 | doi: 10.1038/ncomms13752 | | |
| Bond selectivity in electron-induced reaction due to directed recoil on an anisotropic substrate OPEN | | | Kelvin Anggara, Kai Huang, Lydie Leung, Avisek Chatterjee, Fang Cheng and John C. Polanyi | | | The ability to selectively break a chemical bond in a molecule is indispensable to chemical synthesis. Here, the authors show that a hundred-fold bond selectivity can be obtained in electron-induced surface reaction due simply to different bond alignments at the surface. | | | 09 December 2016 | doi: 10.1038/ncomms13690 | | |
| Nanoscale assembly of superconducting vortices with scanning tunnelling microscope tip OPEN | | | Jun-Yi Ge, Vladimir N. Gladilin, Jacques Tempere, Cun Xue, Jozef T. Devreese, Joris Van de Vondel, Youhe Zhou and Victor V. Moshchalkov | | | Scanning tunneling microscope (STM) is a powerful tool but local control of superconductivity with the STM tip is still lacking. Here, Ge et al. show the use of an STM tip to control the local pinning in a superconductor through the heating effect, allowing to manipulate single superconducting vortex at nanoscale. | | | 09 December 2016 | doi: 10.1038/ncomms13880 | | |
| Raman signatures of inversion symmetry breaking and structural phase transition in type-II Weyl semimetal MoTe2 OPEN | | | Kenan Zhang, Changhua Bao, Qiangqiang Gu, Xiao Ren, Haoxiong Zhang, Ke Deng, Yang Wu, Yuan Li, Ji Feng and Shuyun Zhou | | | To experimentally confirm the predicted type-II Weyl fermions in transition metal dichalcogenide, the evidence of inversion symmetry breaking is required. Here, Zhang et al. report Raman spectroscopic evidence for the inversion symmetry breaking in MoTe2. | | | 09 December 2016 | doi: 10.1038/ncomms13552 | | |
| Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells OPEN | | | Henning Kempf, Ruth Olmer, Alexandra Haase, Annika Franke, Emiliano Bolesani, Kristin Schwanke, Diana Robles-Diaz, Michelle Coffee, Gudrun Göhring, Gerald Dräger, Oliver Pötz, Thomas Joos, Erik Martinez-Hackert, Axel Haverich, Falk F. R. Buettner, Ulrich Martin and Robert Zweigerdt | | | Differentiation of human pluripotent stem cells (hPSC) mimics aspects of embryonic development in vitro but is poorly understood. Here, the authors identify bulk cell density as a key parameter directing transition from pluripotency to primitive streak-like priming in hPSCs via secreted LEFTY/CERBERUS. | | | 09 December 2016 | doi: 10.1038/ncomms13602 | | |
| CCT complex restricts neuropathogenic protein aggregation via autophagy OPEN | | | Mariana Pavel, Sara Imarisio, Fiona M. Menzies, Maria Jimenez-Sanchez, Farah H. Siddiqi, Xiaoting Wu, Maurizio Renna, Cahir J. O’Kane, Damian C. Crowther and David C. Rubinsztein | | | The CCT complex, a key player in the chaperone machinery, has been implicated in Huntington’s disease. Pavel et al. show that CCT2/5/7 also play an essential role in autophagosome degradation, and that the aggregation of proteins upon CCT2/5/7 depletion is primarily a consequence of impaired autophagy. | | | 08 December 2016 | doi: 10.1038/ncomms13821 | | |
| A diverse intrinsic antibiotic resistome from a cave bacterium OPEN | | | Andrew C. Pawlowski, Wenliang Wang, Kalinka Koteva, Hazel A. Barton, Andrew G. McArthur and Gerard D. Wright | | | Antibiotic resistance is common in environmental bacteria, including those living in isolated caves. Here, Pawlowski et al. study one of these bacterial strains, showing that it is resistant to most clinically used antibiotics through a remarkable variety of mechanisms, some of which are new to science. | | | 08 December 2016 | doi: 10.1038/ncomms13803 | | |
| Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish OPEN | | | Chenglu Xiao, Lu Gao, Yu Hou, Congfei Xu, Nannan Chang, Fang Wang, Keping Hu, Aibin He, Ying Luo, Jun Wang, Jinrong Peng, Fuchou Tang, Xiaojun Zhu and Jing-Wei Xiong | | | The adult zebrafish heart is capable of regeneration but the molecular mechanisms are poorly understood. Here the authors show that chromatin remodeling factor Brg1 represses cyclin-dependent kinase inhibitors to promote myocardial regeneration. | | | 08 December 2016 | doi: 10.1038/ncomms13787 | | |
| Tracking the coherent generation of polaron pairs in conjugated polymers OPEN | | | Antonietta De Sio, Filippo Troiani, Margherita Maiuri, Julien Réhault, Ephraim Sommer, James Lim, Susana F. Huelga, Martin B. Plenio, Carlo Andrea Rozzi, Giulio Cerullo, Elisa Molinari and Christoph Lienau | | | Understanding of charge transfer dynamics is essential to the design of high-performance organic semiconductors for optoelectronic applications. Here, the authors show that excitons, polaron pairs and a long-lived vibrational mode are strongly coupled to each other up to 1 picosecond in polythiophene. | | | 08 December 2016 | doi: 10.1038/ncomms13742 | | |
| Export of piRNA precursors by EJC triggers assembly of cytoplasmic Yb-body in Drosophila OPEN | | | Cynthia Dennis, Emilie Brasset, Arpita Sarkar and Chantal Vaury | | | In Drosophila ovarian follicle cells, piRNAs generated from RNA precursors are processed in cytoplasmic Yb-bodies. The authors identify the exportin and the exon junction complexes as required to transfer precursors to cytoplasm. They also show that Yb-body formation requires piRNA precursor export. | | | 08 December 2016 | doi: 10.1038/ncomms13739 | | |
| A large carnivorous mammal from the Late Cretaceous and the North American origin of marsupials OPEN | | | Gregory P. Wilson, Eric G. Ekdale, John W. Hoganson, Jonathan J. Calede and Abby Vander Linden | | | The early fossil record of metatherian mammals, the group including marsupials, is limited. Here, Wilson and colleagues describe a fossil skull of the Late Cretaceous metatherian Didelphodon vorax, providing insight into the ecology of this species as well as the North American origin of marsupials. | | | 08 December 2016 | doi: 10.1038/ncomms13734 | | |
| The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3 OPEN | | | Hui Song, Bingyu Liu, Wanwan Huai, Zhongxia Yu, Wenwen Wang, Jing Zhao, Lihui Han, Guosheng Jiang, Lining Zhang, Chengjiang Gao and Wei Zhao | | | The NLRP3 inflammasome controls the response of the host to pathogens; precise regulation is required to limit autoimmune diseases. Here, the authors identify the E3 ligase TRIM31 that aids the ubiquitin-mediated proteasomal degradation of NLRP3, which may be a therapeutic target for alleviating disease. | | | 08 December 2016 | doi: 10.1038/ncomms13727 | | |
| The STIM1-binding site nexus remotely controls Orai1 channel gating OPEN | | | Yandong Zhou, Xiangyu Cai, Natalia A. Loktionova, Xianming Wang, Robert M. Nwokonko, Xizhuo Wang, Youjun Wang, Brad S. Rothberg, Mohamed Trebak and Donald L. Gill | | | How plasma membrane Orai Ca2+ channels are activated by STIM proteins to activate Ca2+ signals is still not fully known. Here the authors show that a nexus region located at the Orai1 C-terminus allows channel gating without a direct interaction of STIM1 with the channel pore. | | | 08 December 2016 | doi: 10.1038/ncomms13725 | | |
| Current crowding mediated large contact noise in graphene field-effect transistors OPEN | | | Paritosh Karnatak, T. Phanindra Sai, Srijit Goswami, Subhamoy Ghatak, Sanjeev Kaushal and Arindam Ghosh | | | The performance of graphene field effect transistors is adversely affected by fluctuations in the electrical resistance at the graphene/metal interface. Here, the authors unveil the microscopic origin of such contact noise, highlighting the role of current crowding. | | | 08 December 2016 | doi: 10.1038/ncomms13703 | | |
| Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity OPEN | | | Haiyoung Jung, Dong Oh Kim, Jae-Eun Byun, Won Sam Kim, Mi Jeong Kim, Hae Young Song, Young Kwan Kim, Du-Kyeong Kang, Young-Jun Park, Tae-Don Kim, Suk Ran Yoon, Hee Gu Lee, Eun-Ji Choi, Sang-Hyun Min and Inpyo Choi | | | The processes regulating the ageing of stem cells are not clearly defined. Here, the authors report that in haematopoietic stem cells (HSC) thioredoxin-interacting protein, known to regulate the cell cycle, binds to p38 mitogen-activated protein kinase and regulates HSC ageing and rejuvenation. | | | 08 December 2016 | doi: 10.1038/ncomms13674 | | |
| Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer OPEN | | | Beth O. Van Emburgh, Sabrina Arena, Giulia Siravegna, Luca Lazzari, Giovanni Crisafulli, Giorgio Corti, Benedetta Mussolin, Federica Baldi, Michela Buscarino, Alice Bartolini, Emanuele Valtorta, Joana Vidal, Beatriz Bellosillo, Giovanni Germano, Filippo Pietrantonio, Agostino Ponzetti, Joan Albanell, Salvatore Siena, Andrea Sartore-Bianchi, Federica Di Nicolantonio et al. | | | Some colorectal cancer patients respond well to treatment with anti-EGFR antibodies, however response is almost invariably followed by acquired resistance. Here, the authors show that patients with shorter responses acquire RAS mutations, while those relapsing later preferentially develop mutations in the extracellular domain of EGFR. | | | 08 December 2016 | doi: 10.1038/ncomms13665 | | |
| Evidence for social parasitism of early insect societies by Cretaceous rove beetles OPEN | | | Shûhei Yamamoto, Munetoshi Maruyama and Joseph Parker | | | Social insects are commonly parasitized by beetles that live inside colonies and consume nest resources or even the brood. Here, Yamamoto et al. present fossil evidence that social parasitism by beetles dates back at least 99 million years—contemporaneous with the earliest fossil indications of ant and termite eusociality. | | | 08 December 2016 | doi: 10.1038/ncomms13658 | | |
| Engineering the magnetic coupling and anisotropy at the molecule–magnetic surface interface in molecular spintronic devices OPEN | | | Victoria E. Campbell, Monica Tonelli, Irene Cimatti, Jean-Baptiste Moussy, Ludovic Tortech, Yannick J. Dappe, Eric Rivière, Régis Guillot, Sophie Delprat, Richard Mattana, Pierre Seneor, Philippe Ohresser, Fadi Choueikani, Edwige Otero, Florian Koprowiak, Vijay Gopal Chilkuri, Nicolas Suaud, Nathalie Guihéry, Anouk Galtayries, Frederic Miserque et al. | | | Controlling the magnetic response of a molecular device is important for spintronic applications. Here the authors report the self-assembly, magnetic coupling, and anisotropy of two transition metal complexes bound to a ferrimagnetic surface, and probe the role of the nature of the transition metal ion. | | | 08 December 2016 | doi: 10.1038/ncomms13646 | | |
| An oxygen-sensitive toxin–antitoxin system OPEN | | | Oriol Marimon, João M. C. Teixeira, Tiago N. Cordeiro, Valerie W. C. Soo, Thammajun L. Wood, Maxim Mayzel, Irene Amata, Jesús García, Ainara Morera, Marina Gay, Marta Vilaseca, Vladislav Yu Orekhov, Thomas K. Wood and Miquel Pons | | | Classical toxin–antitoxin systems in bacteria are based on silencing of a toxin by an antitoxin that, when inactivated, releases the toxin, resulting in a change in metabolism. Here, the authors characterize an oxygen-sensitive toxin–antitoxin system and discuss the implications for the role of the Hha antitoxin. | | | 08 December 2016 | doi: 10.1038/ncomms13634 | | |
| Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus OPEN | | | Polona Jager, Zhiwen Ye, Xiao Yu, Laskaro Zagoraiou, Hong-Ting Prekop, Juha Partanen, Thomas M. Jessell, William Wisden, Stephen G. Brickley and Alessio Delogu | | | The development and function of thalamic interneurons is only partially understood. Here the authors describe the unexpected mesencephalic origin of the GABAergic interneurons of the visual thalamus that provide both phasic and tonic modulation of thalamic relay neuron excitability. | | | 08 December 2016 | doi: 10.1038/ncomms13579 | | |
| Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins OPEN | | | Karthik Sathiyamoorthy, Yao Xiong Hu, Britta S. Möhl, Jia Chen, Richard Longnecker and Theodore S. Jardetzky | | | The entry of herpesviruses (such as Epstein-Barr virus) into host cells is mediated by a multitude of glycoproteins. Here, the authors show the structure of a viral glycoprotein complex, gHgL/gp42, bound to an anti-gHgL antibody, clarifying determinants of EBV host cell tropism. | | | 08 December 2016 | doi: 10.1038/ncomms13557 | | |
| Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping OPEN | | | Marie N. Bongiovanni, Julien Godet, Mathew H. Horrocks, Laura Tosatto, Alexander R. Carr, David C. Wirthensohn, Rohan T. Ranasinghe, Ji-Eun Lee, Aleks Ponjavic, Joelle V. Fritz, Christopher M. Dobson, David Klenerman and Steven F. Lee | | | Many super-resolution imaging techniques use fluorescence emission intensity to obtain precise positional information, but other spectral information is ignored. Here, the authors develop a method that records the spectrum and position of single dye molecules to map the hydrophobicity of a surface. | | | 08 December 2016 | doi: 10.1038/ncomms13544 | | |
| A room-temperature magnetic semiconductor from a ferromagnetic metallic glass OPEN | | | Wenjian Liu, Hongxia Zhang, Jin-an Shi, Zhongchang Wang, Cheng Song, Xiangrong Wang, Siyuan Lu, Xiangjun Zhou, Lin Gu, Dmitri V. Louzguine-Luzgin, Mingwei Chen, Kefu Yao and Na Chen | | | Magnetic semiconductors provide control of spin states in addition to charge states realized in conventional semiconductors, yet currently limited to weak magnetism at low temperature. Liu et al. introduce oxygen into a ferromagnetic metallic glass, resulting in a Curie temperature above 600 K. | | | 08 December 2016 | doi: 10.1038/ncomms13497 | | |
| Interrogation of bimetallic particle oxidation in three dimensions at the nanoscale OPEN | | | Lili Han, Qingping Meng, Deli Wang, Yimei Zhu, Jie Wang, Xiwen Du, Eric A. Stach and Huolin L. Xin | | | Understanding bimetallic alloy oxidation is key to design of hollow-structured binary oxides and their optimization for applications, e.g., as catalysts. Here the authors combine real-time imaging and chemically-sensitive electron tomography to uncover unexpected complexity in possible morphological outcomes of bimetallic oxidation. | | | 08 December 2016 | doi: 10.1038/ncomms13335 | | |
| Taotie neurons regulate appetite in Drosophila OPEN | | | Yin Peng Zhan, Li Liu and Yan Zhu | | | Feeding control requires the integration and coordination of motivational, sensory and motor circuits in the brain. Here, the authors discover a set of neurons that regulate feeding in Drosophila by promoting insulin release, and whose activity reflects physiological hunger and satiety states of flies. | | | 07 December 2016 | doi: 10.1038/ncomms13633 | | |
| Constraints and spandrels of interareal connectomes OPEN | | | Mikail Rubinov | | | Whole-brain networks of long-range neuronal pathways are characterized by interdependencies between structural features. Here the author shows that module hierarchy and rich club features in these networks are structural byproducts (spandrels) of module and hub constraints, but not of wiring-cost constraints. | | | 07 December 2016 | doi: 10.1038/ncomms13812 | | |
| Species-specific control of external superoxide levels by the coral holobiont during a natural bleaching event OPEN | | | Julia M. Diaz, Colleen M. Hansel, Amy Apprill, Caterina Brighi, Tong Zhang, Laura Weber, Sean McNally and Liping Xun | | | Corals may vary in their ability to regulate reactive oxygen species (ROS) that can influence coral health. Diaz and colleagues conduct in vivo measurements of the ROS superoxide at the surface of corals and find substantial species-level variation in superoxide regulation that is independent of bleaching status. | | | 07 December 2016 | doi: 10.1038/ncomms13801 | | |
| A general strategy for the ultrafast surface modification of metals OPEN | | | Mingli Shen, Shenglong Zhu and Fuhui Wang | | | Surface modification techniques can allow metals to be used in aggressive environments for emerging applications. Here authors demonstrate an ultrafast process for aluminizing austenitic stainless steels and propose an electromigration-assisted mechanism suggesting generalizability of the method. | | | 07 December 2016 | doi: 10.1038/ncomms13797 | | |
| Transcriptional bursting is intrinsically caused by interplay between RNA polymerases on DNA OPEN | | | Keisuke Fujita, Mitsuhiro Iwaki and Toshio Yanagida | | | Transcriptional bursting is a potential source of cell-to-cell variability but the molecular mechanisms are unclear. Here the authors use single molecule imaging to analyse the kinetics of bursting on DNA and observe that bursting is an intrinsic property of RNA polymerases on DNA. | | | 07 December 2016 | doi: 10.1038/ncomms13788 | | |
| ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion OPEN | | | Wei-Guang Li, Ming-Gang Liu, Shining Deng, Yan-Mei Liu, Lin Shang, Jing Ding, Tsan-Ting Hsu, Qin Jiang, Ying Li, Fei Li, Michael Xi Zhu and Tian-Le Xu | | | The acid-sensing ion channel, ASIC1a, is known to play a role in synaptic transmission and plasticity. Here, the authors demonstrate a role for ASIC1a in regulating plasticity in the insular cortex and find that extinction of conditioned taste aversion memory is disrupted in the ASIC1a knockout mice. | | | 07 December 2016 | doi: 10.1038/ncomms13770 | | |
| Pressure-induced nano-crystallization of silicate garnets from glass OPEN | | | T. Irifune, K. Kawakami, T. Arimoto, H. Ohfuji, T. Kunimoto and T. Shinmei | | | It is suggested that the optical and mechanical properties of transparent ceramics become very favourable if they can be synthesized as nanocrystals. Here, the authors report direct conversion of bulk glass starting material to pore-free nano-polycrystalline silicate garnet at high pressure and temperature. | | | 07 December 2016 | doi: 10.1038/ncomms13753 | | |
| Water striders adjust leg movement speed to optimize takeoff velocity for their morphology OPEN | | | Eunjin Yang, Jae Hak Son, Sang-im Lee, Piotr G. Jablonski and Ho-Young Kim | | | How water striders escape from danger by jumping vertically from the water surface without sinking is an open question in biomechanics. Yang et al. show that water strider species with varying leg lengths and body masses tune their leg movements to maximize jump speeds without breaking the surface of the water. | | | 07 December 2016 | doi: 10.1038/ncomms13698 | | |
| Interstitial oxygen as a source of p-type conductivity in hexagonal manganites OPEN | | | Sandra H. Skjærvø, Espen T. Wefring, Silje K. Nesdal, Nikolai H. Gaukås, Gerhard H. Olsen, Julia Glaum, Thomas Tybell and Sverre M. Selbach | | | Hexagonal manganites are multiferroic materials that can exhibit magnetoelectric coupling and electrically conducting domain walls. Here, the authors produce yttrium manganite with p-type conductivity, useful for devices, by using excess oxygen to introduce point defects in the crystal lattice. | | | 07 December 2016 | doi: 10.1038/ncomms13745 | | |
| An ultra-tunable platform for molecular engineering of high-performance crystalline porous materials OPEN | | | Quan-Guo Zhai, Xianhui Bu, Chengyu Mao, Xiang Zhao, Luke Daemen, Yongqiang Cheng, Anibal J. Ramirez-Cuesta and Pingyun Feng | | | Synthetic design of crystalline porous materials is important for applications such as catalysis and adsorption. Here, the authors demonstrate a platform for the development of crystalline porous materials with a variety of organic ligands and metallic clusters, and control of their gas sorption properties. | | | 07 December 2016 | doi: 10.1038/ncomms13645 | | |
| Tuning the role of charge-transfer states in intramolecular singlet exciton fission through side-group engineering OPEN | | | Steven Lukman, Kai Chen, Justin M. Hodgkiss, David H. P. Turban, Nicholas D. M. Hine, Shaoqiang Dong, Jishan Wu, Neil C. Greenham and Andrew J. Musser | | | The understanding of how a singlet exciton separates into triplet states in organic semiconductors is crucial to the design of efficient organic solar cells. Here, Lukman et al. identify the role played by charge-transfer states during triplet formation through side-group engineering of pentacenes. | | | 07 December 2016 | doi: 10.1038/ncomms13622 | | |
| Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge OPEN | | | Pascal Blanc, Ludovic Moro-Sibilot, Lucas Barthly, Ferdinand Jagot, Sébastien This, Simon de Bernard, Laurent Buffat, Sébastien Dussurgey, Renaud Colisson, Elias Hobeika, Thierry Fest, Morgan Taillardet, Olivier Thaunat, Antoine Sicard, Paul Mondière, Laurent Genestier, Stephen L. Nutt and Thierry Defrance | | | Plasma cells produce secreted antibodies and are thought to lack expression of the membrane-bound immunoglobulins that constitute B-cell receptors. Here the authors show that IgM-expressing plasma cells maintain B-cell receptor expression and initiate cytokine production following antigen stimulation. | | | 07 December 2016 | doi: 10.1038/ncomms13600 | | |
| Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma OPEN | | | Xiao-Yan Ming, Li Fu, Li-Yi Zhang, Yan-Ru Qin, Ting-Ting Cao, Kwok Wah Chan, Stephanie Ma, Dan Xie and Xin-Yuan Guan | | | There is still no consensus on tumour type-specific cancer stem cell markers. Here, the authors demonstrate that ITGA7 is a potential functional marker of oesophageal cancer stem cells involved in the resistance to chemotherapy and metastasis through activation of FAK-mediated signalling. | | | 07 December 2016 | doi: 10.1038/ncomms13568 | | | | | | | | | | | | | Latest Corrigendum | | | | | | Corrigendum: Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues OPEN | | | Erica L. Scheller, Casey R. Doucette, Brian S. Learman, William P. Cawthorn, Shaima Khandaker, Benjamin Schell, Brent Wu, Shi-Ying Ding, Miriam A. Bredella, Pouneh K. Fazeli, Basma Khoury, Karl J. Jepsen, Paul F. Pilch, Anne Klibanski, Clifford J. Rosen and Ormond A. MacDougald | | | 08 December 2016 | doi: 10.1038/ncomms13775 | | | Biological Sciences Medical research | | | | | |
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