Nature Biotechnology Contents: Volume 34 pp 1209 - 1300

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Advertisement White Paper: Best Practices for Integrating Biomarkers Across The Drug Development Continuum  Are you employing these 8 critical steps for an optimal biomarker Development program?  Download our complimentary white paper that features an immuno-oncology case study to learn how to optimize your Biomarker lifecycle all the way through companion diagnostics. TABLE OF CONTENTS December 2016 Volume 34, Issue 12 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Research Careers and Recruitment Advertisement Tomorrow's medicines are on a different path to market than blockbuster drugs of the past, as pioneering scientists reimagine nearly every aspect of drug discovery R&D. They're refocusing their efforts on areas of strength, applying new skill sets, and establishing creatively-structured collaborations.  How can you apply these principles to the benefit of your own research? Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Ready to see a glimpse of tomorrow? Visit KAUST Discovery today  KAUST Discovery highlights the cutting-edge research, technologies and innovations emerging from the King Abdullah University of Science and Technology. From biotechnology, to solar, to materials and marine science: KAUST is working on it.   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Nature Outlook: Science-led Economies This Nature Outlook will explore the elements that make up a strong science-led economy, the role research funding policy has to play, and how the diverse needs of research economies around the globe may be met. Access the Outlook free online for six months>     Advertisement In January 2017 Cell Press will take over publishing the Molecular Therapy family of journals. To keep receiving e-alerts for these titles, please visit http://www.cell.com/molecular-therapy-family/home   Editorial Top Evolving fixes for drug pricing   p1209 doi:10.1038/nbt.3748 Despite an increasingly strident outcry against drug prices in the United States, manufacturers likely face an evolution in the reimbursement landscape, rather than a revolution. News Top Trump election sends aftershocks through biotech sector   pp1211 - 1212 Chris Morrison doi:10.1038/nbt1216-1211 UK forms a £1-billion life sciences powerhouse   p1212 doi:10.1038/nbt1216-1212 Alnylam terminates revusiran program, stock plunges   pp1213 - 1214 Ken Garber doi:10.1038/nbt1216-1213 Pfizer drops phase 3 lipid-lowering antibody   p1214 doi:10.1038/nbt1216-1214 Despite slow progress, bispecifics generate buzz   pp1215 - 1217 Cormac Sheridan doi:10.1038/nbt1216-1215 New anti-IL-23 drugs raise hopes for psoriasis plaque clearance   pp1218 - 1219 Elie Dolgin doi:10.1038/nbt1216-1218 Medtronic automated insulin delivery device gets FDA nod   p1220 Eric Smalley doi:10.1038/nbt1216-1220 Around the world in a month   p1221 doi:10.1038/nbt1216-1221 Advertisement Nature Index 2016 Australia & New Zealand Nature Index 2016 Australia and New Zealand highlights the quality natural science research within these countries. This supplement examines the cities and institutions that largely contribute to the research as well as the factors that drive their success.  Access the free supplement for six months!   Bioentrepreneur Top Building a business Closing the deal   pp1222 - 1225 Sadhana Chitale, Colm Lawler and Scott Macfarlane doi:10.1038/nbt.3687 Podcast First Rounders Podcast: Anu Acharya   p1225 doi:10.1038/nbt.3736 Opinion and Comment Top Correspondence US National Academies report misses the mark   pp1226 - 1228 L Val Giddings and Henry Miller doi:10.1038/nbt.3746 Getting stem cell patients 'on the grid'   pp1228 - 1230 Paul Wicks and Jamie Heywood doi:10.1038/nbt.3740 Features Top America's drug problem   pp1231 - 1241 Brady Huggett doi:10.1038/nbt.3734 Chasing treatments and gouging patients in a bloated, capitalist healthcare system. Patents An update on obtaining and enforcing therapeutic antibody patent claims   pp1242 - 1244 Theresa Gresl, Ulrich Storz and Colin Sandercock doi:10.1038/nbt.3735 Therapeutic antibody patent owners face continuing challenges trying to obtain broad patents and enforce them in the United States and Europe. Recent patents in antibody engineering   p1245 doi:10.1038/nbt.3752 Advertisement An open access, online-only, multidisciplinary research journal dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms. Explore the benefits of submitting your next research article. News and Views Top Let there be light—at the right place   pp1246 - 1247 Lars Hufnagel and Rainer Pepperkok doi:10.1038/nbt.3738 A light-sheet microscope that automatically corrects optical aberrations enables quantitative imaging of deep tissue. See also: Research by Royer et al. Are human oocytes from stem cells next?   pp1247 - 1248 Johan E J Smitz and Robert B Gilchrist doi:10.1038/nbt.3742 The generation of oocytes in a dish from mouse pluripotent cells may be difficult to replicate with human cells. Research Highlights   p1249 doi:10.1038/nbt.3741 Hacking rules for E. coli    p1249 Irene Jarchum doi:10.1038/nbt.3744 Biotechnology JOBS of the week Postdoc position in Enzyme Engineering and Biocatalysis (870936) Aarhus University 8 Doctoral Fellowships within NanoMedPhD Programme (COFUND) Andalusian Center for Nanomedicine and Biotechnology (BIONAND) - Progress and Health Foundation Chief Science Officer Infectious Disease Research Institute (IDRI) Senior Scientist in Biological Manufacturing SuperMeat Advertisement for the Post of Dean Translational Health Science and Technology Institute (THSTI) More Science jobs from Biotechnology EVENT Plant Organ Growth Symposium 2017 March 15, 2017 Elche, Spain More science events from Research Top Perspective Imagining the future of bioimage analysis   pp1250 - 1255 Erik Meijering, Anne E Carpenter, Hanchuan Peng, Fred A Hamprecht and Jean-Christophe Olivo-Marin doi:10.1038/nbt.3722 Modern biological research increasingly relies on image data as a primary source of information in unraveling the cellular and molecular mechanisms of life. The quantity and complexity of the data generated by state-of-the-art microscopes preclude visual or manual analysis and require advanced computational methods to fully explore the wealth of information. In addition to making bioimage analysis more efficient, objective, and reproducible, the use of computers improves the accuracy and sensitivity of the analyses and helps to reveal subtleties that may be unnoticeable to the human eye. Many methods and software tools have already been developed to this end, but there is still a long way to go before biologists can blindly trust automated measurements. Here, we summarize the current state of the art in bioimage analysis and provide a perspective on likely future developments. Analysis Measurement of bacterial replication rates in microbial communities   pp1256 - 1263 Christopher T Brown, Matthew R Olm, Brian C Thomas and Jillian F Banfield doi:10.1038/nbt.3704 Replication rates of bacteria in both human and environmental microbiomes are measured without reference genome sequences. Brief Communications Single-cell sequencing of the small-RNA transcriptome   pp1264 - 1266 Omid R Faridani, Ilgar Abdullayev, Michael Hagemann-Jensen, John P Schell, Fredrik Lanner et al. doi:10.1038/nbt.3701 The small RNA transcriptome is sequenced in single cells, facilitating study of microRNAs and other small RNAs. Articles Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms   pp1267 - 1278 Loic A Royer, William C Lemon, Raghav K Chhetri, Yinan Wan, Michael Coleman et al. doi:10.1038/nbt.3708 Adaptive light-sheet microscopy improves imaging of live organisms by correcting for optical aberrations in real time. See also: News and Views by Hufnagel & Pepperkok Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR-Cas9 library   pp1279 - 1286 Shiyou Zhu, Wei Li, Jingze Liu, Chen-Hao Chen, Qi Liao et al. doi:10.1038/nbt.3715 Long non-coding RNAs are identified using a high-throughput paired-guide RNA genomic deletion screen. Letter Modeling of RNA-seq fragment sequence bias reduces systematic errors in transcript abundance estimation   pp1287 - 1291 Michael I Love, John B Hogenesch and Rafael A Irizarry doi:10.1038/nbt.3682 Estimates of transcript abundance in RNA-seq data are improved by accounting for sample-specific biases. Errata Erratum: Top 20 translational researchers of 2015   p1292 Brady Huggett and Kathryn Paisner doi:10.1038/nbt1216-1292a Erratum: A spark at the periphery   p1292 Emily Waltz doi:10.1038/nbt1216-1292b Erratum: Rekindling cancer vaccines   p1292 Malorye Allison Branca doi:10.1038/nbt1216-1292c Careers and Recruitment Top Interactive and scalable biology cloud experimentation for scientific inquiry and education   pp1293 - 1298 Zahid Hossain, Engin W Bumbacher, Alice M Chung, Honesty Kim, Casey Litton et al. doi:10.1038/nbt.3747 A real-time interactive, fully automated, low-cost and scalable biology cloud experimentation platform could provide access to scientific experimentation for learners and researchers alike. People People   p1300 doi:10.1038/nbt.3751 Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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