Scientific Reports Biology Table of Contents e-alert: 22 November 2016

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22 November 2016      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports       Biological Sciences               Corrigendum: Proteome mapping of Plasmodium: identification of the P. yoelii remodellome ▶     Anthony Siau, Ximei Huang, Mei Weng et al.                 Erratum: Control of ADAM17 activity by regulation of its cellular localisation ▶     Inken Lorenzen, Juliane Lokau, Yvonne Korpys et al.                 Sub-optimality in motor planning is retained throughout 9 days practice of 2250 trials ▶     Keiji Ota, Masahiro Shinya, Kazutoshi Kudo     Optimality in motor planning, as well as accuracy in motor execution, is required to maximize expected gain under risk. In this study, we tested whether humans are able to update …             Structural and immunomodulatory differences among lactobacilli exopolysaccharides isolated from intestines of mice with experimentally induced inflammatory bowel disease ▶     Sabina Górska, Corine Sandstrőm, Justyna Wojas-Turek et al.     Characteristic changes in the microbiota biostructure and a decreased tolerance to intestinal bacteria have been associated with inflammatory bowel disease (IBD). However, few …             Using the virtual reality device Oculus Rift for neuropsychological assessment of visual processing capabilities ▶     Rebecca M. Foerster, Christian H. Poth, Christian Behler et al.     Neuropsychological assessment of human visual processing capabilities strongly depends on visual testing conditions including room lighting, stimuli, and viewing-distance. This …             Silver Nanoparticles Impact Biofilm Communities and Mussel Settlement ▶     Jin-Long Yang, Yi-Feng Li, Xiao Liang et al.     Silver nanoparticles (AgNPs) demonstrating good antimicrobial activity are widely used in many fields. However, the impact of AgNPs on the community structures of marine biofilms …             Corrigendum: Efficient delivery of C/EBP beta gene into human mesenchymal stem cells via polyethylenimine-coated gold nanoparticles enhances adipogenic differentiation ▶     Joydeep Das, Yun-Jung Choi, Hideyo Yasuda et al.                 Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells ▶     Yuanyuan Kong, Gege Chen, Zhijian Xu et al.     Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Pterostilbene, a natural dimethylated analog of resveratrol, has been shown to …             No effect of natural transformation on the evolution of resistance to bacteriophages in the Acinetobacter baylyi model system ▶     Amy McLeman, Pawel Sierocinski, Elze Hesse et al.     The adaptive benefits of natural transformation, the active uptake of free DNA molecules from the environment followed by incorporation of this DNA into the genome, may be the …             Direct comparison of gluco-oligosaccharide oxidase variants and glucose oxidase: substrate range and H2O2 stability ▶     Thu V. Vuong, Maryam Foumani, Benjamin MacCormick et al.     Glucose oxidase (GO) activity is generally restricted to glucose and is susceptible to inactivation by H2O2. By comparison, the Y300A variant of gluco-oligosaccharide oxidase …             Repressor logic modules assembled by rolling circle amplification platform to construct a set of logic gates ▶     Hua Wei, Bo Hu, Suming Tang et al.     Small molecule metabolites and their allosterically regulated repressors play an important role in many gene expression and metabolic disorder processes. These natural sensors, …             Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans ▶     Liwei Liu, Tingting Hao, Zhoujie Xie et al.     Streptococcus mutans is a major pathogen causing human dental caries. As a Gram-positive bacterium with a small genome (about 2 Mb) it is considered a poor source of natural …             Insight into the metabolic mechanism of scoparone on biomarkers for inhibiting Yanghuang syndrome ▶     Heng Fang, Aihua Zhang, Jingbo Yu et al.     Scoparone (6,7-dimethoxycoumarin) is the representative ingredient of Yinchenhao (Artemisia capillaris Thunb.) which is a famous Chinese medicinal herb and shows favorable …             Classification of Tandem Mass Spectra for Identification of N- and O-linked Glycopeptides ▶     Shadi Toghi Eshghi, Weiming Yang, Yingwei Hu et al.     Analysis of intact glycopeptides by mass spectrometry is essential to determining the microheterogeneity of protein glycosylation. Higher-energy collisional dissociation (HCD) …             Autoimmune susceptibility imposed by public TCRβ chains ▶     Yunqian Zhao, Phuong Nguyen, Peter Vogel et al.     Although the TCR repertoire is highly diverse, a small fraction of TCR chains, referred to as public, preferentially form and are shared by most individuals. Prior studies …             Skin-on-a-chip model simulating inflammation, edema and drug-based treatment ▶     Maierdanjiang Wufuer, GeonHui Lee, Woojune Hur et al.     Recent advances in microfluidic cell cultures enable the construction of in vitro human skin models that can be used for drug toxicity testing, disease study. However, current in …             The ERF transcription factor family in cassava: genome-wide characterization and expression analyses against drought stress ▶     Wei Fan, Meirong Hai, Yunling Guo et al.     Cassava (Manihot esculenta) shows strong tolerance to drought stress; however, the mechanisms underlying this tolerance are poorly understood. Ethylene response factor (ERF) …             Corrigendum: NPNT is Expressed by Osteoblasts and Mediates Angiogenesis via the Activation of Extracellular Signal-regulated Kinase ▶     Vincent Kuek, Zhifan Yang, Shek Man Chim et al.                 A new species of Trichoderma hypoxylon harbours abundant secondary metabolites ▶     Jingzu Sun, Yunfei Pei, Erwei Li et al.     Some species of Trichoderma are fungicolous on fungi and have been extensively studied and commercialized as biocontrol agents. Multigene analyses coupled with morphology, …             Selection of reliable reference genes for normalization of quantitative RT-PCR from different developmental stages and tissues in amphioxus ▶     Qi-Lin Zhang, Qian-Hua Zhu, Xin Liao et al.     Amphioxus is a closest living proxy to the ancestor of cephalochordates with vertebrates, and key animal for novel understanding in the evolutionary origin of vertebrate body …             Embodied neurofeedback with an anthropomorphic robotic hand ▶     Niclas Braun, Reiner Emkes, Jeremy D. Thorne et al.     Neurofeedback-guided motor imagery training (NF-MIT) has been suggested as a promising therapy for stroke-induced motor impairment. Whereas much NF-MIT research has aimed at …             Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin ▶     Andrea Henze, Thomas Homann, Isabelle Rohn et al.     The visceral protein transthyretin (TTR) is frequently affected by oxidative post-translational protein modifications (PTPMs) in various diseases. Thus, better insight into …             Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos ▶     Wei Cui, Xiangpeng Dai, Chelsea Marcho et al.     With readily available transcriptome-wide data, understanding the role of each expressed gene is an essential next step. Although RNAi technologies allow for genome-wide screens …             Erratum: Lipid membrane-mediated attraction between curvature inducing objects ▶     Casper van der Wel, Afshin Vahid, Anđela Šarić et al.                 Corrigendum: SparRec: An effective matrix completion framework of missing data imputation for GWAS ▶     Bo Jiang, Shiqian Ma, Jason Causey et al.                 Regulation of Anticancer Styrylpyrone Biosynthesis in the Medicinal Mushroom Inonotus obliquus Requires Thioredoxin Mediated Transnitrosylation of S-nitrosoglutathione Reductase ▶     Yanxia Zhao, Meihong He, Jianing Ding et al.     The medicinal macrofungus Inonotus obliquus widely utilized as folk medicine in Russia and Baltic countries is a source of phenylpropanoid-derived styrylpyrone polyphenols that …             The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens ▶     Mariya I. Petrova, Elke Lievens, Tine L. A. Verhoeven et al.     The probiotic Lactobacillus rhamnosus GR-1 has been documented to survive implantation onto the vaginal epithelium and interfere with urogenital pathogens. However, the molecular …             An ortholog of LEAFY in Jatropha curcas regulates flowering time and floral organ development ▶     Mingyong Tang, Yan-Bin Tao, Qiantang Fu et al.     Jatropha curcas seeds are an excellent biofuel feedstock, but seed yields of Jatropha are limited by its poor flowering and fruiting ability. Thus, identifying genes controlling …             The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation ▶     Hwijin Kim     Nonalcoholic fatty liver disease (NAFLD) is a rapidly emerging global health-problem. NAFLD encompasses a range of conditions associated with hepatic steatosis, aberrant …             Suppression of Rac1 Signaling by Influenza A Virus NS1 Facilitates Viral Replication ▶     Wei Jiang, Chunjie Sheng, Xiuling Gu et al.     Influenza A virus (IAV) is a major human pathogen with the potential to become pandemic. IAV contains only eight RNA segments; thus, the virus must fully exploit the host …             Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis ▶     Diptiman Chanda, Ashish Kurundkar, Sunad Rangarajan et al.     Cellular plasticity and de-differentiation are hallmarks of tissue/organ regenerative capacity in diverse species. Despite a more restricted capacity for regeneration, humans …             Functional states of rat cortical circuits during the unpredictable availability of a reward-related cue ▶     Iván Fernández-Lamo, Raudel Sánchez-Campusano, Agnès Gruart et al.     Proper performance of acquired abilities can be disturbed by the unexpected occurrence of external changes. Rats trained with an operant conditioning task (to press a lever in …             The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ ▶     Russell J. Eason, Kara S. Bell, Fraser A. Marshall et al.     We have previously shown that ES-62, a phosphorylcholine (PC)-containing glycoprotein secreted by the parasitic filarial nematode Acanthocheilonema viteae targets dendritic cell …             Endotoxin free hyaluronan and hyaluronan fragments do not stimulate TNF-α, interleukin-12 or upregulate co-stimulatory molecules in dendritic cells or macrophages ▶     Yifei Dong, Arif Arif , Mia Olsson et al.     The extracellular matrix glycosaminoglycan, hyaluronan, has been described as a regulator of tissue inflammation, with hyaluronan fragments reported to stimulate innate immune …             Crosstalk between sugarcane and a plant-growth promoting Burkholderia species ▶     Chanyarat Paungfoo-Lonhienne, Thierry G. A. Lonhienne, Yun Kit Yeoh et al.     Bacterial species in the plant-beneficial-environmental clade of Burkholderia represent a substantial component of rhizosphere microbes in many plant species. To better …             Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice ▶     Lee Wei Lim, Smeeta Shrestha, Yu Zuan Or et al.     Tetratricopeptide repeat domain 9A (TTC9A) expression is abundantly expressed in the brain. Previous studies in TTC9A knockout (TTC9A−/−) mice have indicated that TTC9A …             Cardioprotection by combination of three compounds from ShengMai preparations in mice with myocardial ischemia/reperfusion injury through AMPK activation-mediated mitochondrial fission ▶     Fang Li, Xiaoxue Fan, Yu Zhang et al.     GRS is a drug combination of three active components including ginsenoside Rb1, ruscogenin and schisandrin. It derived from the well-known TCM formula ShengMai preparations, a …             Noisy galvanic vestibular stimulation induces a sustained improvement in body balance in elderly adults ▶     Chisato Fujimoto, Yoshiharu Yamamoto, Teru Kamogashira et al.     Vestibular dysfunction causes postural instability, which is prevalent in the elderly. We previously showed that an imperceptible level of noisy galvanic vestibular stimulation …             Importance of the C-terminal histidine residues of Helicobacter pylori GroES for Toll-like receptor 4 binding and interleukin-8 cytokine production ▶     Haur Lee, Yu-Lin Su, Bo-Shih Huang et al.     Helicobacter pylori infection is associated with the development of gastric and duodenal ulcers as well as gastric cancer. GroES of H. pylori (HpGroES) was previously identified …             Interplay between VEGF and Nrf2 regulates angiogenesis due to intracranial venous hypertension ▶     Liwen Li, Hao Pan, Handong Wang et al.     Venous hypertension(VH) plays an important role in the pathogenesis of cerebral arteriovenous malformations (AVMs) and is closely associated with the HIF-1α/VEGF signaling …             Quantitative secretomic analysis of pancreatic cancer cells in serum-containing conditioned medium ▶     Peng Liu, Yejing Weng, Zhigang Sui et al.     Pancreatic cancer is a highly metastatic and chemo-resistant disease. Secreted proteins involved in cell-cell interactions play an important role in changing the tumor …             An antibacterial and absorbable silk-based fixation material with impressive mechanical properties and biocompatibility ▶     Chenglong Shi, Xiaobing Pu, Guan Zheng et al.     Implant-associated infections and non-absorbing materials are two important reasons for a second surgical procedure to remove internal fixation devices after an orthopedic …             Assessing SABU (Serum Anti Bisa Ular), the sole Indonesian antivenom: A proteomic analysis and neutralization efficacy study ▶     Choo Hock Tan, Jia Lee Liew, Kae Yi Tan et al.     Serum Anti Ular Bisa (SABU) is the only snake antivenom produced locally in Indonesia; however, its effectiveness has not been rigorously evaluated. This study aimed to assess …             Species-Specific Standard Redox Potential of Thiol-Disulfide Systems: A Key Parameter to Develop Agents against Oxidative Stress ▶     Arash Mirzahosseini, Béla Noszál     Microscopic standard redox potential, a new physico-chemical parameter was introduced and determined to quantify thiol-disulfide equilibria of biological significance. The highly …             The effects of non-self-sustained oscillators on the en-trainment ability of the suprachiasmatic nucleus ▶     Changgui Gu, Ming Tang, Jos H. T. Rohling et al.     In mammals, the circadian rhythms of behavioral and physiological activities are regulated by an endogenous clock located in the suprachiasmatic nucleus (SCN). The SCN is …             N-linked glycosylation at Asn152 on CD147 affects protein folding and stability: promoting tumour metastasis in hepatocellular carcinoma ▶     Jiang-Hua Li, Wan Huang, Peng Lin et al.     Cluster of differentiation 147 (CD147), also known as extracellular matrix metalloproteinase inducer, is a transmembrane glycoprotein that mediates oncogenic processes partly …             Motor noise is rich signal in autism research and pharmacological treatments ▶     E. B. Torres, K. Denisova     The human body is in constant motion, from every breath that we take, to every visibly purposeful action that we perform. Remaining completely still on command is a major …             mRNA changes in nucleus accumbens related to methamphetamine addiction in mice ▶     Li Zhu, Jiaqi Li, Nan Dong et al.     Methamphetamine (METH) is a highly addictive psychostimulant that elicits aberrant changes in the expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the …             Observation selection bias in contact prediction and its implications for structural bioinformatics ▶     G. Orlando, D. Raimondi, W. F. Vranken     Next Generation Sequencing is dramatically increasing the number of known protein sequences, with related experimentally determined protein structures lagging behind. Structural …             Bright blue-shifted fluorescent proteins with Cys in the GAF domain engineered from bacterial phytochromes: fluorescence mechanisms and excited-state dynamics ▶     Yusaku Hontani, Daria M. Shcherbakova, Mikhail Baloban et al.     Near-infrared fluorescent proteins (NIR FPs) engineered from bacterial phytochromes (BphPs) are of great interest for in vivo imaging. They utilize biliverdin (BV) as a …             Heat shock transcription factors in banana: genome-wide characterization and expression profile analysis during development and stress response ▶     Yunxie Wei, Wei Hu, Feiyu Xia et al.     Banana (Musa acuminata) is one of the most popular fresh fruits. However, the rapid spread of fungal pathogen Fusarium oxysporum f. sp. cubense (Foc) in tropical areas severely …             miRNAsong: a web-based tool for generation and testing of miRNA sponge constructs in silico ▶     Tomas Barta, Lucie Peskova, Ales Hampl     MicroRNA (miRNA) sponges are RNA transcripts containing multiple high-affinity binding sites that associate with and sequester specific miRNAs to prevent them from interacting …             Assessment of Circulating LncRNAs Under Physiologic and Pathologic Conditions in Humans Reveals Potential Limitations as Biomarkers ▶     Kenny Schlosser, Jennifer Hanson, Patrick J. Villeneuve et al.     Long non-coding RNAs (lncRNA) are a new class of regulatory molecules with diverse cellular functions. Recent reports have suggested that extracellular lncRNAs are detectable in …             Glycation potentiates neurodegeneration in models of Huntington’s disease ▶     Hugo Vicente Miranda, Marcos António Gomes, Joana Branco-Santos et al.     Protein glycation is an age-dependent posttranslational modification associated with several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. By …             Low-voltage scanning electron microscopy study of lampbrush chromosomes and nuclear bodies in avian and amphibian oocytes ▶     Tatiana Kulikova, Tatiana Khodyuchenko, Yuri Petrov et al.     Nucleus is a highly compartmentalized part of the cell where the key processes of genome functionality are realized through the formation of non-membranous nuclear domains. …             Cloning and characterization of TaVIP2 gene from Triticum aestivum and functional analysis in Nicotiana tabacum ▶     Pei Zhao, Ke Wang, Zhishan Lin et al.     Wheat is recalcitrant to genetic transformation. A potential solution is to manipulate the expression of some host proteins involved in T-DNA integration process. VirE2 …             The Modification of Tet1 in Male Germline Stem Cells and Interact with PCNA, HDAC1 to promote their Self-renewal and Proliferation ▶     Liming Zheng, Yuanxin Zhai, Na Li et al.     Epigenetic modification plays key roles in spermatogenesis, especially DNA methylation dynamic is important in sustaining normal spermatogenesis. Ten-eleven translocation 1 …             Principles of proteome allocation are revealed using proteomic data and genome-scale models ▶     Laurence Yang, James T. Yurkovich, Colton J. Lloyd et al.     Integrating omics data to refine or make context-specific models is an active field of constraint-based modeling. Proteomics now cover over 95% of the Escherichia coli proteome …             Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis ▶     Li-Yuan Chang, Yonghai Li, David E. Kaplan     Peripheral CD27+ memory B-cells become quantitatively reduced and dysfunctional in patients with cirrhosis through poorly characterized mechanisms. We hypothesized that the …             Strong interactions between learned helplessness and risky decision-making in a rat gambling model ▶     José N. Nobrega, Parisa S. Hedayatmofidi, Daniela S. Lobo     Risky decision-making is characteristic of depression and of addictive disorders, including pathological gambling. However it is not clear whether a propensity to risky choices …             Synthesis of (3R)-acetoin and 2,3-butanediol isomers by metabolically engineered Lactococcus lactis ▶     Vijayalakshmi Kandasamy, Jianming Liu, Shruti Harnal Dantoft et al.     The potential that lies in harnessing the chemical synthesis capabilities inherent in living organisms is immense. Here we demonstrate how the biosynthetic machinery of …             Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease ▶     Xianli Wang, Chuanming Dong, Lixin Sun et al.     Aging is characterized by a progressive decline in the function of adult tissues which can lead to neurodegenerative disorders. However, little is known about the correlation …             Dopamine regulates renal osmoregulation during hyposaline stress via DRD1 in the spotted scat (Scatophagus argus) ▶     Maoliang Su, Xingjiang Mu, Lang Gui et al.     Dopamine is an important regulator of renal natriuresis and is critical for the adaptation of many animals to changing environmental salinity. However, the molecular mechanisms …             Using community analysis to explore bacterial indicators for disease suppression of tobacco bacterial wilt ▶     Xiaojiao Liu, Shuting Zhang, Qipeng Jiang et al.     Although bacterial communities play important roles in the suppression of pathogenic diseases and crop production, little is known about the bacterial communities associated with …             Significant Phylogenetic Signal and Climate-Related Trends in Leaf Caloric Value from Tropical to Cold-Temperate Forests ▶     Guangyan Song, Ying Li, Jiahui Zhang et al.     Leaf caloric value (LCV) is a useful index to represent the conversion efficiency of leaves for solar energy. We investigated the spatial pattern of LCV and explored the factors …             Deregulation of the miR-16-KRAS axis promotes colorectal cancer ▶     Chaoying You, Hongwei Liang, Wu Sun et al.     KRAS plays a significant role in the etiology and progression of colorectal cancer (CRC), but the mechanism underlying this process has not been fully elucidated. In this study, …             Inhibiting MDSC differentiation from bone marrow with phytochemical polyacetylenes drastically impairs tumor metastasis ▶     Wen-Chi Wei, Sheng-Yen Lin, Chun-Wen Lan et al.     Myeloid-derived suppressor cells (MDSCs) are implicated in the promotion of tumor metastasis by protecting metastatic cancerous cells from immune surveillance and have thus been …             Elevated Mitochondrial DNA Copy Number in Peripheral Blood and Tissue Predict the Opposite Outcome of Cancer: A Meta-Analysis ▶     Nan Chen, Shu Wen, Xiaoru Sun et al.     Previous studies have suggested that mitochondrial DNA (mtDNA) copy number was associated with cancer risk. However, no solid conclusion revealed the potential predictive value …             Evaluation of promoters and ribosome binding sites for biotechnological applications in the unicellular cyanobacterium Synechocystis sp. PCC 6803 ▶     Elias Englund, Feiyan Liang, Pia Lindberg     For effective metabolic engineering, a toolbox of genetic components that enables predictable control of gene expression is needed. Here we present a systematic study of …             Neural correlates underlying impaired memory facilitation and suppression of negative material in depression ▶     Dandan Zhang, Hui Xie, Yunzhe Liu et al.     Previous behavioral studies demonstrated that depressed individuals have difficulties in forgetting unwanted, especially negative, event. However, inconsistent results still exit …             A Nonparametric Regression Approach to Control for Population Stratification in Rare Variant Association Studies ▶     Qiuying Sha, Kui Zhang, Shuanglin Zhang     Recently, there is increasing interest to detect associations between rare variants and complex traits. Rare variant association studies usually need large sample sizes due to …             Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy ▶     Taku Nakayama, Shimpei Otsuka, Tatsuya Kobayashi et al.     Photodynamic therapy (PDT) and diagnosis (PDD) using 5-aminolevulinic acid (ALA) to drive the production of an intracellular photosensitizer, protoporphyrin IX (PpIX), are in …             Postnatal auditory preferences in piglets differ according to maternal emotional experience with the same sounds during gestation ▶     Céline Tallet, Marine Rakotomahandry, Carole Guérin et al.     Prenatal sensory experience, notably auditory experience, is a source of fetal memories in many species. The contiguity between sensory stimuli and maternal emotional reactions …             Aspirin upregulates αB-Crystallin to protect the myocardium against heat stress in broiler chickens ▶     Shu Tang, Bin Yin, Erbao Song et al.     We established in vivo and in vitro models to investigate the role of αB-Crystallin (CryAB) and assess the ability of aspirin (ASA) to protect the myocardium during prolonged …             GR-independent down-modulation on GM-CSF bone marrow-derived dendritic cells by the selective glucocorticoid receptor modulator Compound A ▶     Andres E. Barcala Tabarrozzi, Luz Andreone, Julie Deckers et al.     Dendritic cells (DC) initiate the adaptive immune response. Glucocorticoids (GCs) down-modulate the function of DC. Compound A (CpdA, …             Fluorescence- and magnetic-activated cell sorting strategies to separate spermatozoa involving plural contributors from biological mixtures for human identification ▶     Yan Xu, Jianhui Xie, Ronghua Chen et al.     No effective method has been developed to distinguish sperm cells originating from different men in multi-suspect sexual assault cases. Here we combined MACS and FACS to isolate …             NapB in excess inhibits growth of Shewanella oneidensis by dissipating electrons of the quinol pool ▶     Miao Jin, Qianyun Zhang, Yijuan Sun et al.     Shewanella, a group of ubiquitous bacteria renowned for respiratory versatility, thrive in environments where various electron acceptors (EAs) of different chemical and …             Rapid and efficient CRISPR/Cas9 gene inactivation in human neurons during human pluripotent stem cell differentiation and direct reprogramming ▶     Alicia Rubio, Mirko Luoni, Serena G. Giannelli et al.     The CRISPR/Cas9 system is a rapid and customizable tool for gene editing in mammalian cells. In particular, this approach has widely opened new opportunities for genetic studies …             Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD ▶     Kathryn E. Price, Christopher M. Armstrong, Leah S. Imlay et al.     The methylerythritol phosphate (MEP) pathway is an essential metabolic pathway found in malaria parasites, but absent in mammals, making it a highly attractive target for the …             Taurine Treatment Modulates Circadian Rhythms in Mice Fed A High Fat Diet ▶     Ana Lucia C. Figueroa, Hugo Figueiredo, Sandra A. Rebuffat et al.     Close ties have been made among certain nutrients, obesity, type 2 diabetes and circadian clocks. Among nutrients, taurine has been documented as being effective against obesity …             miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer ▶     Yeting Hong, Hongwei Liang, Uzair-ur-Rehman et al.     microRNAs (miRNAs) have emerged as major regulators of the initiation and progression of human cancers, including breast cancer. The aim of this study is to determine the …             LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activity ▶     Yuan Li, Masahiko Ito, Suofeng Sun et al.     The core promoter of hepatitis B virus (HBV) genome is a critical region for transcriptional initiation of 3.5 kb, pregenome and precore RNAs and for the viral replication. …             STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit ▶     Meng Tian, Jian Xu, Gang Lei et al.     N-methyl-D-aspartate receptors (NMDARs) are necessary for the induction of synaptic plasticity and for the consolidation of learning and memory. NMDAR function is tightly …             Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs ▶     Anindya Siddharta, Stephanie Pfaender, Angelina Malassa et al.     Hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) transmissions among people who inject drugs (PWID) continue to pose a challenging global health problem. Here, we …             Evaluating renewable natural resources flow and net primary productivity with a GIS-Emergy approach: A case study of Hokkaido, Japan ▶     Chengdong Wang, Shenyan Zhang, Wanglin Yan et al.     Renewable natural resources, such as solar radiation, rainfall, wind, and geothermal heat, together with ecosystem services, provide the elementary supports for the sustainable …             Tet1-dependent epigenetic modification of BDNF expression in dorsal horn neurons mediates neuropathic pain in rats ▶     Ming-Chun Hsieh, Cheng-Yuan Lai, Yu-Cheng Ho et al.     Ten-eleven translocation methylcytosine dioxygenase 1 (Tet1) mediates the conversion of 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5 hmC), hence promoting DNA …             Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn’s disease ▶     Chunhui Bao, Peng Liu, Huirong Liu et al.     This study aimed to investigate changes in resting state brain activity in remissive Crohn’s Disease (CD) patients after electro-acupuncture or moxibustion treatment. Fifty-two …             Tree species, tree genotypes and tree genotypic diversity levels affect microbe-mediated soil ecosystem functions in a subtropical forest ▶     Witoon Purahong, Walter Durka, Markus Fischer et al.     Tree species identity and tree genotypes contribute to the shaping of soil microbial communities. However, knowledge about how these two factors influence soil ecosystem …             Simulated ischemia/reperfusion-induced p65-Beclin 1-dependent autophagic cell death in human umbilical vein endothelial cells ▶     Min Zeng, Xin Wei, Zhiyong Wu et al.     Myocardial ischemia/reperfusion (I/R) injury detrimentally alters the prognosis of patients undergoing revascularization after acute myocardial infarction. Our previous study …             YY1 binding association with sex-biased transcription revealed through X-linked transcript levels and allelic binding analyses ▶     Chih-yu Chen, Wenqiang Shi, Bradley P. Balaton et al.     Sex differences in susceptibility and progression have been reported in numerous diseases. Female cells have two copies of the X chromosome with X-chromosome inactivation …             Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates ▶     P. M. Tsimbouri, L. Fisher, N. Holloway et al.     Nanotopographical cues on Ti have been shown to elicit different cell responses such as cell differentiation and selective growth. Bone remodelling is a constant process …             Inter-isoform Hetero-dimerization of Human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A9, and 2B7 and Impacts on Glucuronidation Activity ▶     Ling-Min Yuan, Zhang-Zhao Gao, Hong-Ying Sun et al.     Human UDP-glucuronosyltransferases (UGTs) play a pivotal role in phase II metabolism by catalyzing the glucuronidation of endobiotics and xenobiotics. The catalytic activities of …             Mobile phone signal exposure triggers a hormesis-like effect in Atm+/+ and Atm−/− mouse embryonic fibroblasts ▶     Chuan Sun, Xiaoxia Wei, Yue Fei et al.     Radiofrequency electromagnetic fields (RF-EMFs) have been classified by the International Agency for Research on Cancer as possible carcinogens to humans; however, this …             FPA-FTIR Microspectroscopy for Monitoring Chemotherapy Efficacy in Triple-Negative Breast Cancer ▶     Izabela Zawlik, Ewa Kaznowska, Jozef Cebulski et al.     Triple-negative breast cancer is the most aggressive breast cancer subtype with limited treatment options and a poor prognosis. Approximately 70% of triple-negative breast cancer …             A van der Waals-like Transition Between Normal and Cancerous Phases in Cell Populations Dynamics of Colorectal Cancer ▶     Kang Qiu, Li-fang Wang, Jian Shen et al.     Based on a deterministic continuous model of cell populations dynamics in the colonic crypt and in colorectal cancer, we propose four combinations of feedback mechanisms in the …             Red blood cell phase separation in symmetric and asymmetric microchannel networks: effect of capillary dilation and inflow velocity ▶     Francesco Clavica, Alexandra Homsy, Laure Jeandupeux et al.     The non-uniform partitioning or phase separation of red blood cells (RBCs) at a diverging bifurcation of a microvascular network is responsible for RBC heterogeneity within the …             Erratum: REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model ▶     Luca Lorenzini, Alessandro Giuliani, Sandra Sivilia et al.                 How a High-Gradient Magnetic Field Could Affect Cell Life ▶     Vitalii Zablotskii, Tatyana Polyakova, Oleg Lunov et al.     The biological effects of high-gradient magnetic fields (HGMFs) have steadily gained the increased attention of researchers from different disciplines, such as cell biology, cell …             Lineage mapper: A versatile cell and particle tracker ▶     Joe Chalfoun, Michael Majurski, Alden Dima et al.     The ability to accurately track cells and particles from images is critical to many biomedical problems. To address this, we developed Lineage Mapper, an open-source tracker for …             Genetic determination of the enhanced drought resistance of rice maintainer HuHan2B by pedigree breeding ▶     Haibin Wei, Fangjun Feng, Qiaojun Lou et al.     The ongoing deficit of fresh water resource in rice growing regions has made the selection of water-saving and drought-resistance rice (WDR) a crucial factor in developing …             Declines in benthic macroinvertebrate community metrics and microphytobenthic biomass in an estuarine lake following enrichment by hippo dung ▶     Jessica Dawson, Deena Pillay, Peter Jean Roberts et al.     Hippos transfer massive quantities of trophic resources from terrestrial to aquatic ecosystems through defecation. The ramifications of the latter for the functioning of benthic …             Disulfide mapping the voltage-sensing mechanism of a voltage-dependent potassium channel ▶     Tomohiro Nozaki, Shin-ichiro Ozawa, Hitomi Harada et al.     Voltage-dependent potassium (Kv) channels allow for the selective permeability of potassium ions in a membrane potential dependent manner, playing crucial roles in …             Loss of NMDA receptors in dopamine neurons leads to the development of affective disorder-like symptoms in mice ▶     Kamila Jastrzębska, Magdalena Walczak, Przemysław Eligiusz Cieślak et al.     The role of changes in dopamine neuronal activity during the development of symptoms in affective disorders remains controversial. Here, we show that inactivation of NMDA …             Solid-state NMR reveals differential carbohydrate utilization in diapausing Culex pipiens ▶     James Chang, Jugeshwar Singh, Sungshil Kim et al.     Culex pipiens is the mosquito that vectors West Nile Virus and other human-pathogenic flavivruses in North America. In response to shortened day length and lower temperatures, …             Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids ▶     Yeonhwa Song, Se-hyuk Kim, Kang Mo Kim et al.     Most Hepatocellular carcinoma (HCC) are resistant to conventional chemotherapeutic agents and remain an unmet medical need. Recently, multiple studies on the crosstalk between …             Non-coding RNAs match the deleted genomic regions in humans ▶     Boseon Byeon, Igor Kovalchuk     RNA is transcribed from DNA, and therefore, there should be no RNA transcript from the deleted DNA region. Our study attempted to analyse whether any RNA cache that maps the …             Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases ▶     Rasmus Rydbirk, Jonas Folke, Kristian Winge et al.     Evaluation of gene expression levels by reverse transcription quantitative real-time PCR (RT-qPCR) has for many years been the favourite approach for discovering …             High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300 ▶     Shweta Malik, Mariya I. Petrova, Nicole C. E. Imholz et al.     To characterize the interaction potential of the human vaginal isolate Lactobacillus plantarum CMPG5300, its genome was mined for genes encoding lectin-like proteins. …             Axin2-expressing cells execute regeneration after skeletal injury ▶     R. C. Ransom, D. J. Hunter, S. Hyman et al.     The mammalian skeleton performs a diverse range of vital functions, requiring mechanisms of regeneration that restore functional skeletal cell populations after injury. We …             The archaeal “7 kDa DNA-binding” proteins: extended characterization of an old gifted family ▶     Valentina Kalichuk, Ghislaine Béhar, Axelle Renodon-Cornière et al.     The “7 kDa DNA-binding” family, also known as the Sul7d family, is composed of chromatin proteins from the Sulfolobales archaeal order. Among them, Sac7d and Sso7d have been the …             Mucosal vaccination with a live recombinant rhinovirus followed by intradermal DNA administration elicits potent and protective HIV-specific immune responses ▶     Khamis Tomusange, Danushka Wijesundara, Jason Gummow et al.     Mucosal immunity is deemed crucial to control sexual transmission of human immunodeficiency virus (HIV). Herein we report the efficacy of a mucosal HIV vaccine strategy …             Comparison of high-titer lactic acid fermentation from NaOH- and NH3-H2O2-pretreated corncob by Bacillus coagulans using simultaneous saccharification and fermentation ▶     Zhenting Zhang, Yuejiao Xie, Xiaolan He et al.     Lignocellulose is one of the most abundant renewable feedstocks that has attracted considerable attention as a substrate for biofuel and biochemical production. One such …             Mechanism of Consistent Gyrus Formation: an Experimental and Computational Study ▶     Tuo Zhang, Mir Jalil Razavi, Xiao Li et al.     As a significant type of cerebral cortical convolution pattern, the gyrus is widely preserved across species. Although many hypotheses have been proposed to study the underlying …             Thermal gradient induced tweezers for the manipulation of particles and cells ▶     Jiajie Chen, Hengji Cong, Fong-Chuen Loo et al.     Optical tweezers are a well-established tool for manipulating small objects. However, their integration with microfluidic devices often requires an objective lens. More …             Temporal dynamics, population characterization and mycotoxins accumulation of Fusarium graminearum in Eastern China ▶     Jian-bo Qiu, Jing-Tao Sun, Ming-Zheng Yu et al.     Trichothecene genotype composition, mycotoxin production, genetic diversity, and population structure were analyzed, using 185 Fusarium strains collected from wheat (Triticum …             Timing predictability enhances regularity encoding in the human subcortical auditory pathway ▶     Natàlia Gorina-Careta, Katarzyna Zarnowiec, Jordi Costa-Faidella et al.     The encoding of temporal regularities is a critical property of the auditory system, as short-term neural representations of environmental statistics serve to auditory object …             Selective sweep on human amylase genes postdates the split with Neanderthals ▶     Charlotte E. Inchley, Cynthia D. A. Larbey, Nzar A. A. Shwan et al.     Humans have more copies of amylase genes than other primates. It is still poorly understood, however, when the copy number expansion occurred and whether its spread was enhanced …             Antagonizing STAT5B dimerization with an osmium complex ▶     Li-Juan Liu, Wanhe Wang, Tian-Shu Kang et al.     Targeting STAT5 is an appealing therapeutic strategy for the treatment of hematologic malignancies and inflammation. Here, we present the novel osmium(II) complex 1 as the first …             Generation of metastatic melanoma specific antibodies by affinity purification ▶     Birgit Schütz, Anita Koppensteiner, David Schörghofer et al.     Melanoma is the most aggressive type of skin cancer and one of the most frequent tumours in young adults. Identification of primary tumours prone to develop metastasis is of …             Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells? ▶     Eugenia Becker, Susan Bengs, Sirisha Aluri et al.     Inflammatory bowel disease (IBD) may develop due to an inflammatory response to commensal gut microbiota triggered by environmental factors in a genetically susceptible host. …             Molecular analysis of the factorless internal ribosome entry site in Cricket Paralysis virus infection ▶     Craig H. Kerr, Zi Wang Ma, Christopher J. Jang et al.     The dicistrovirus Cricket Paralysis virus contains a unique dicistronic RNA genome arrangement, encoding two main open reading frames that are driven by distinct internal …             Emergence of the ability to perceive dynamic events from still pictures in human infants ▶     Nobu Shirai, Tomoko Imura     The ability to understand a visual scene depicted in a still image is among the abilities shared by all human beings. The aim of the present study was to examine when human …             Multi-species collapses at the warm edge of a warming sea ▶     Gil Rilov     Even during the current biodiversity crisis, reports on population collapses of highly abundant, non-harvested marine species were rare until very recently. This is starting to …             A comparison of biological characteristics of three strains of Chinese sacbrood virus in Apis cerana ▶     Ying Hu, Dongliang Fei, Lili Jiang et al.     We selected and sequenced the entire genomes of three strains of Chinese sacbrood virus (CSBV): LNQY-2008 (isolated in Qingyuan, Liaoning Province), SXYL-2015 (isolated in Yulin, …             Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target ▶     Hamish T. J. Gilbert, Nathan Hodson, Pauline Baird et al.     The aetiology of intervertebral disc (IVD) degeneration remains poorly understood. Painful IVD degeneration is associated with an acidic intradiscal pH but the response of NP …             Labeling and analysis of chicken taste buds using molecular markers in oral epithelial sheets ▶     Prasangi Rajapaksha, Zhonghou Wang, Nandakumar Venkatesan et al.     In chickens, the sensory organs for taste are the taste buds in the oral cavity, of which there are ~240–360 in total number as estimated by scanning electron microscopy (SEM). …             Enhancing Virion Tethering by BST2 Sensitizes Productively and Latently HIV-infected T cells to ADCC Mediated by Broadly Neutralizing Antibodies ▶     Tram N. Q. Pham, Sabelo Lukhele, Frédéric Dallaire et al.     Binding of anti-HIV antibodies (Abs) to envelope (Env) glycoproteins on infected cells can mark them for elimination via antibody-dependent cell-mediated cytotoxicity (ADCC). …             Structured plant metabolomics for the simultaneous exploration of multiple factors ▶     Nikolay Vasilev, Julien Boccard, Gerhard Lang et al.     Multiple factors act simultaneously on plants to establish complex interaction networks involving nutrients, elicitors and metabolites. Metabolomics offers a better understanding …             Phosphorylation induces distinct alpha-synuclein strain formation ▶     Meng-Rong Ma, Zhi-Wen Hu, Yu-Fen Zhao et al.     Synucleinopathies are a group of neurodegenerative diseases associated with alpha-synuclein (α-Syn) aggregation. Recently, increasing evidence has demonstrated the existence of …             Lent-On-Plus Lentiviral vectors for conditional expression in human stem cells ▶     Karim Benabdellah, Pilar Muñoz, Marién Cobo et al.     Conditional transgene expression in human stem cells has been difficult to achieve due to the low efficiency of existing delivery methods, the strong silencing of the transgenes …             Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching ▶     Michael X. Le, Dania Haddad, Alexanda K. Ling et al.     Class switch recombination (CSR) in B cells requires the timely repair of DNA double-stranded breaks (DSBs) that result from lesions produced by activation-induced cytidine …             Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation ▶     Mei-Mei Xiao, Yu-Qi Zhang, Wen-Ting Wang et al.     Tissue injury is known to produce inflammation and pain. Synaptic potentiation between peripheral nociceptors and spinal lamina I neurons has been proposed to serve as a trigger …             Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of the Drosophila brain ▶     Naoto Shimada, Show Inami, Shoma Sato et al.     Apterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. …             Unraveling the association between genetic integrity and metabolic activity in pre-implantation stage embryos ▶     Fiona D’Souza, Shivanand M. Pudakalakatti, Shubhashree Uppangala et al.     Early development of certain mammalian embryos is protected by complex checkpoint systems to maintain the genomic integrity. Several metabolic pathways are modulated in response …             Genome wide transcriptome profiling of Fusarium oxysporum f sp. ciceris conidial germination reveals new insights into infection-related genes ▶     Mamta Sharma, Anindita Sengupta, Raju Ghosh et al.     Vascular wilt caused by Fusarium oxysporum f. sp. ciceris (Foc) is a serious disease of chickpea (Cicer arietinum L.) accounting for approximately 10–15% annual crop loss. The …             Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy ▶     Chin Siang Kue, Anyanee Kamkaew, Siew Hui Voon et al.     Tropomyosin receptor kinase C (TrkC) targeted ligand-photosensitizer construct, IYIY-diiodo-boron-dipyrromethene (IYIY-I2-BODIPY) and its scrambled counterpart YIYI-I2-BODIPY …             Rapid identification of nine species of diphyllobothriidean tapeworms by pyrosequencing ▶     Tongjit Thanchomnang, Chairat Tantrawatpan, Pewpan M. Intapan et al.     The identification of diphyllobothriidean tapeworms (Cestoda: Diphyllobothriidea) that infect humans and intermediate/paratenic hosts is extremely difficult due to their …             Novel Genomic and Evolutionary Insight of WRKY Transcription Factors in Plant Lineage ▶     Tapan Kumar Mohanta, Yong-Hwan Park, Hanhong Bae     The evolutionarily conserved WRKY transcription factor (TF) regulates different aspects of gene expression in plants, and modulates growth, development, as well as biotic and …             Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction ▶     Kalina Duszka, Alexandre Picard, Sandrine Ellero-Simatos et al.     Nuclear receptor PPARγ has been proven to affect metabolism in multiple tissues, and has received considerable attention for its involvement in colon cancer and inflammatory …             OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis ▶     Yung-Liang Liu, Sung-Sen Yang, Shyi-Jou Chen et al.     We investigated the role of oxidative stress-responsive kinase-1 (OSR1) and STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase (SPAK), upstream regulators of the Na+-K+…             Imprinting of cerebral cytochrome P450s in offsprings prenatally exposed to cypermethrin augments toxicity on rechallenge ▶     Anshuman Singh, Anita Agrahari, RadhaDutt Singh et al.     Epigenetic studies were carried in the rat offsprings, born to dams treated with cypermethrin (orally; 5.0 mg/kg) from gestation day (GD) 5 to 21 and rechallenged with …             Genetic Epidemiology of Glucose-6-Dehydrogenase Deficiency in the Arab World ▶     C. George Priya Doss, Dima R. Alasmar, Reem I. Bux et al.     A systematic search was implemented using four literature databases (PubMed, Embase, Science Direct and Web of Science) to capture all the causative mutations of …             A multiscale computational model predicts distribution of anti-angiogenic isoform VEGF165b in peripheral arterial disease in human and mouse ▶     Liang-Hui Chu, Vijay Chaitanya Ganta, Min H. Choi et al.     Angiogenesis is the growth of new blood vessels from pre-existing microvessels. Peripheral arterial disease (PAD) is caused by atherosclerosis that results in ischemia mostly in …             Supplementation with D-serine prevents the onset of cognitive deficits in adult offspring after maternal immune activation ▶     Yuko Fujita, Tamaki Ishima, Kenji Hashimoto     Prenatal maternal infection contributes to the etiology of schizophrenia, with D-serine, an endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, playing a role in …             Human CD133+ Renal Progenitor Cells Induce Erythropoietin Production and Limit Fibrosis After Acute Tubular Injury ▶     Shikhar Aggarwal, Cristina Grange, Corinne Iampietro et al.     Persistent alterations of the renal tissue due to maladaptive repair characterize the outcome of acute kidney injury (AKI), despite a clinical recovery. Acute damage may also …             Six2creFrs2α knockout mice are a novel model of renal cystogenesis ▶     Pawan Puri, Daniel Bushnell, Caitlin M. Schaefer et al.     Six2cre-mediated deletion of Frs2α (Six2creFrs2αKO), a major fibroblast growth factor receptor (Fgfr) docking protein in mouse nephron progenitors results in perinatal renal …             Pyroptosis of Salmonella Typhimurium-infected macrophages was suppressed and elimination of intracellular bacteria from macrophages was promoted by blocking QseC ▶     Zhi Li, Qing Zheng, Xiaoyan Xue et al.     QseC is a membrane-bound histidine sensor kinase found in Gram-negative pathogens and is involved in the regulation of bacterial virulence. LED209, a QseC-specific inhibitor, …             Digital Detection of Exosomes by Interferometric Imaging ▶     George G. Daaboul, Paola Gagni, Luisa Benussi et al.     Exosomes, which are membranous nanovesicles, are actively released by cells and have been attributed to roles in cell-cell communication, cancer metastasis, and early disease …             Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1 ▶     Yannis Gerakis, Julie Dunys, Charlotte Bauer et al.     The aspartyl protease β-site APP cleaving enzyme, BACE1, is the rate-limiting enzyme involved in the production of amyloid-β peptide, which accumulates in both sporadic and …             The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression ▶     Xiang Cui, Min Cui, Rie Asada et al.     Androgen-Induced bZIP (AIbZIP) is structurally a bZIP transmembrane transcription factor belonging to the CREB/ATF family. This molecule is highly expressed in androgen-sensitive …             The Lnc RNA SPRY4-IT1 Modulates Trophoblast Cell Invasion and Migration by Affecting the Epithelial-Mesenchymal Transition ▶     Qing Zuo, Shiyun Huang, Yanfen Zou et al.     Preeclampsia is a common, pregnancy-specific disease and a major contributor to maternal and foetal morbidity and mortality. Some placental abnormalities, including deficient …             Intronless WNT10B-short variant underlies new recurrent allele-specific rearrangement in acute myeloid leukaemia ▶     Francesca Lazzaroni, Luca Del Giacco, Daniele Biasci et al.     Defects in the control of Wnt signaling have emerged as a recurrent mechanism involved in cancer pathogenesis and acute myeloid leukaemia (AML), including the hematopoietic …             Spatial Hearing with Incongruent Visual or Auditory Room Cues ▶     Juan C. Gil-Carvajal, Jens Cubick, Sébastien Santurette et al.     In day-to-day life, humans usually perceive the location of sound sources as outside their heads. This externalized auditory spatial perception can be reproduced through …             Piezoelectric extraction of ECG signal ▶     Mahmoud Al Ahmad     The monitoring and early detection of abnormalities or variations in the cardiac cycle functionality are very critical practices and have significant impact on the prevention of …             Activation of FXR protects against renal fibrosis via suppressing Smad3 expression ▶     Kai Zhao, Jialin He, Yan Zhang et al.     Renal fibrosis is the common pathway of most chronic kidney disease progression to end-stage renal failure. The nuclear receptor FXR (farnesoid X receptor), a multiple functional …             Resting-state high-frequency heart rate variability is related to respiratory frequency in individuals with severe mental illness but not healthy controls ▶     Daniel S. Quintana, Maja Elstad, Tobias Kaufmann et al.     Heart rate variability (HRV) has become central to biobehavioral models of self-regulation and interpersonal interaction. While research on healthy populations suggests changes …             Foetal programming by methyl donor deficiency produces steato-hepatitis in rats exposed to high fat diet ▶     Anaïs Bison, Aude Marchal-Bressenot, Zhen Li et al.     Non-alcoholic steatohepatitis (NASH) is a manifestation of metabolic syndrome, which emerges as a major public health problem. Deficiency in methyl donors (folate and vitamin …             Characterizing Focused-Ultrasound Mediated Drug Delivery to the Heterogeneous Primate Brain In Vivo with Acoustic Monitoring ▶     Shih-Ying Wu, Carlos Sierra Sanchez, Gesthimani Samiotaki et al.     Focused ultrasound with microbubbles has been used to noninvasively and selectively deliver pharmacological agents across the blood-brain barrier (BBB) for treating brain …             Comparative Transcriptome Analysis of Chinary, Assamica and Cambod tea (Camellia sinensis) Types during Development and Seasonal Variation using RNA-seq Technology ▶     Ajay Kumar, Vandna Chawla, Eshita Sharma et al.     Tea quality and yield is influenced by various factors including developmental tissue, seasonal variation and cultivar type. Here, the molecular basis of these factors was …             Controlled Mycobacterium tuberculosis infection in mice under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNFα neutralization ▶     Noria Segueni, Elaine Tritto, Marie-Laure Bourigault et al.     Antibodies targeting IL-17A or its receptor IL-17RA show unprecedented efficacy in the treatment of autoimmune diseases such as psoriasis. These therapies, by neutralizing …             Integrative mutation, haplotype and G × G interaction evidence connects ABGL4, LRP8 and PCSK9 genes to cardiometabolic risk ▶     Tao Guo, Rui-Xing Yin, Li-Mei Yao et al.     This study is expected to investigate the association of ATP/GTP binding protein-like 4 (AGBL4), LDL receptor related protein 8 (LRP8) and proprotein convertase subtilisin/kexin …             Performance error-related activity in monkey striatum during social interactions ▶     Raymundo Báez-Mendoza, Wolfram Schultz     Monitoring our performance is fundamental to motor control while monitoring other’s performance is fundamental to social coordination. The striatum is hypothesized to play a role …             Investigating the effect of AS03 adjuvant on the plasma cell repertoire following pH1N1 influenza vaccination ▶     J. D. Galson, J. Trück, D. F. Kelly et al.     Influenza pandemics require rapid deployment of effective vaccines for control. Adjuvants such as AS03 improve vaccine immunogenicity, but this mechanism is poorly understood. We …             An automated approach to prepare tissue-derived spatially barcoded RNA-sequencing libraries ▶     Anders Jemt, Fredrik Salmén, Anna Lundmark et al.     Sequencing the nucleic acid content of individual cells or specific biological samples is becoming increasingly common. This drives the need for robust, scalable and automated …             Observations of severe and lethal coalitionary attacks in wild mountain gorillas ▶     Stacy Rosenbaum, Veronica Vecellio, Tara Stoinski     In humans and chimpanzees, most intraspecific killing occurs during coalitionary intergroup conflict. In the closely related genus Gorilla, such behavior has not been described. …             The caste- and sex-specific DNA methylome of the termite Zootermopsis nevadensis ▶     Karl M. Glastad, Kaustubh Gokhale, Jürgen Liebig et al.     Epigenetic inheritance plays an important role in mediating alternative phenotype in highly social species. In order to gain a greater understanding of epigenetic effects in …             Listeria monocytogenes sequence type 1 is predominant in ruminant rhombencephalitis ▶     Margaux Dreyer, Lisandra Aguilar-Bultet, Sebastian Rupp et al.     Listeria (L.) monocytogenes is an opportunistic pathogen causing life-threatening infections in diverse mammalian species including humans and ruminants. As little is known on …             Influence of leaf vein density and thickness on hydraulic conductance and photosynthesis in rice (Oryza sativa L.) during water stress ▶     Muhammad Adnan Tabassum, Guanglong Zhu, Abdul Hafeez et al.     The leaf venation architecture is an ideal, highly structured and efficient irrigation system in plant leaves. Leaf vein density (LVD) and vein thickness are the two major …             Alterations in the airborne bacterial community during Asian dust events occurring between February and March 2015 in South Korea ▶     Seho Cha, Dongwook Lee, Jun Hyeong Jang et al.     During Asian dust events, a relatively high concentration of particulate matter is transported by wind from arid and semi-arid regions, such as the Gobi and Taklamakan deserts, …             Evolutionarily conserved odorant receptor function questions ecological context of octenol role in mosquitoes ▶     Amir Dekel, Ronald J. Pitts, Esther Yakir et al.     Olfaction is a key insect adaptation to a wide range of habitats. In the last thirty years, the detection of octenol by blood-feeding insects has been primarily understood in the …             Regulation of Ebola virus VP40 matrix protein by SUMO ▶     Maite Baz-Martínez, Ahmed El Motiam, Paula Ruibal et al.     The matrix protein of Ebola virus (EBOV) VP40 regulates viral budding, nucleocapsid recruitment, virus structure and stability, viral genome replication and transcription, and …             Forms and Lability of Phosphorus in Algae and Aquatic Macrophytes Characterized by Solution 31P NMR Coupled with Enzymatic Hydrolysis ▶     Weiying Feng, Yuanrong Zhu, Fengchang Wu et al.     Solution Phosphorus-31 nuclear magnetic resonance (31P NMR) spectroscopy coupled with enzymatic hydrolysis (EH) with commercially available phosphatases was used to characterize …             Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury ▶     Shuai Liu, Xiaoli Su, Pinhua Pan et al.     Neutrophil extracellular traps (NETs) facilitate the extracellular killing of pathogens. However, excessive NETs formation and poor degradation are associated with exacerbated …             The correlation between expression profiles measured in single cells and in traditional bulk samples ▶     David Dzamba, Lukas Valihrach, Mikael Kubista et al.     Reverse transcription quantitative PCR (RT-qPCR) is already an established tool for mRNA detection and quantification. Since recently, this technique has been successfully …             The high-affinity metal Transporters NRAMP1 and IRT1 Team up to Take up Iron under Sufficient Metal Provision ▶     Loren Castaings, Antoine Caquot, Stéphanie Loubet et al.     Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in …             Cell senescence is an antiviral defense mechanism ▶     Maite Baz-Martínez, Sabela Da Silva-Álvarez, Estefanía Rodríguez et al.     Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated …             Tea-induced calmness: Sugar-sweetened tea calms consumers exposed to acute stressor ▶     Shilpa. S. Samant, Katherine Wilkes, Zephania Odek et al.     The food and beverage industry has been increasingly replacing sugar with non-nutritive sweeteners in their sweetened products to control or reduce total calories. Research …             Unconscious processing of facial attractiveness: invisible attractive faces orient visual attention ▶     Shao-Min Hung, Chih-Hsuan Nieh, Po-Jang Hsieh     Past research has proven human’s extraordinary ability to extract information from a face in the blink of an eye, including its emotion, gaze direction, and attractiveness. …             Run-and-pause dynamics of cytoskeletal motor proteins ▶     Anne E. Hafner, Ludger Santen, Heiko Rieger et al.     Cytoskeletal motor proteins are involved in major intracellular transport processes which are vital for maintaining appropriate cellular function. When attached to cytoskeletal …             A biodiversity hotspot losing its top predator: The challenge of jaguar conservation in the Atlantic Forest of South America ▶     Agustin Paviolo, Carlos De Angelo, Katia M. P. M. B. Ferraz et al.     The jaguar is the top predator of the Atlantic Forest (AF), which is a highly threatened biodiversity hotspot that occurs in Brazil, Paraguay and Argentina. By combining data …             Insulin-IGF signaling affects cell transformation in the BALB/c 3T3 cell model ▶     Doerte Poburski, Christiane Leovsky, Josefine Barbara Boerner et al.     The increased cancer mortality of diabetes type 2 patients is most likely an evidence of the tight connection between tumor development and energy metabolism. A major focus of …             Nitrogen-induced metabolic changes and molecular determinants of carbon allocation in Dunaliella tertiolecta ▶     Kenneth Wei Min Tan, Huixin Lin, Hui Shen et al.     Certain species of microalgae are natural accumulators of lipids, while others are more inclined to store starch. However, what governs the preference to store lipids or starch …             Employing Escherichia coli-derived outer membrane vesicles as an antigen delivery platform elicits protective immunity against Acinetobacter baumannii infection ▶     Weiwei Huang, Shijie Wang, Yufeng Yao et al.     Outer membrane vesicles (OMVs) have proven to be highly immunogenic and induced an immune response against bacterial infection in human clinics and animal models. We sought to …             Progesterone Receptor Membrane Component 1 Mediates Progesterone-Induced Suppression of Oocyte Meiotic Prophase I and Primordial Folliculogenesis ▶     Meng Guo, Cheng Zhang, Yan Wang et al.     Well-timed progression of primordial folliculogenesis is essential for mammalian female fertility. Progesterone (P4) inhibits primordial follicle formation under physiological …             Irigenin, a novel lead from Western Himalayan chemiome inhibits Fibronectin-Extra Domain A induced metastasis in Lung cancer cells ▶     Asif Amin, Naveed Anjum Chikan, Taseem A. Mokhdomi et al.     Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity of tumor cells by engaging cell surface α9β1 integrins. This interaction …             Non-neutralizing antibodies induced by seasonal influenza vaccine prevent, not exacerbate A(H1N1)pdm09 disease ▶     Jin Hyang Kim, Adrian J. Reber, Amrita Kumar et al.     The association of seasonal trivalent influenza vaccine (TIV) with increased infection by 2009 pandemic H1N1 (A(H1N1)pdm09) virus, initially observed in Canada, has elicited …             Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response ▶     Victoria L. Fell, Elizabeth A. Walden, Sarah M. Hoffer et al.     The Ku heterodimer (Ku70/Ku80) is the central DNA binding component of the classical non-homologous end joining (NHEJ) pathway that repairs DNA double-stranded breaks (DSBs), …             Modulation of NMDA channel gating by Ca2+ and Cd2+ binding to the external pore mouth ▶     Ya-Chi Tu, Ya-Chin Yang, Chung-Chin Kuo     NMDA receptor channels are characterized by high Ca2+ permeability. It remains unclear whether extracellular Ca2+ could directly modulate channel gating and control Ca2+ …             Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation ▶     Verena Dexheimer, Jessica Gabler, Katharina Bomans et al.     Proteins of the transforming-growth-factor-β (TGF-β)-superfamily have a remarkable ability to induce cartilage and bone and the crosstalk of TGF-β - and BMP-signalling pathways …             Reactivation of flagellar motility in demembranated Leishmania reveals role of cAMP in flagellar wave reversal to ciliary waveform ▶     Aakash Gautam Mukhopadhyay, Chinmoy Sankar Dey     The flagellum of parasitic trypanosomes is a multifunctional appendage essential for its viability and infectivity. However, the biological mechanisms that make the flagellum so …             Enterovirus 71 infection of motor neuron-like NSC-34 cells undergoes a non-lytic exit pathway ▶     Issac Horng Khit Too, Huimin Yeo, October Michael Sessions et al.     Enterovirus 71 (EV71) causing Hand, Foot and Mouth Disease, is regarded as the most important neurotropic virus worldwide. EV71 is believed to replicate in muscles and infect …             A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice ▶     Hong Ming Huang, Denis C. Bauer, Patrick M. Lelliott et al.     Genetic defects in various red blood cell (RBC) cytoskeletal proteins have been long associated with changes in susceptibility towards malaria infection. In particular, while …             An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria ▶     Daniel R. Swale, Darren W. Engers, Sean R. Bollinger et al.     Insecticide resistance is a growing threat to mosquito control programs around the world, thus creating the need to discover novel target sites and target-specific compounds for …             Two PTP receptors mediate CSPG inhibition by convergent and divergent signaling pathways in neurons ▶     Yosuke Ohtake, Daniella Wong, P. M. Abdul-Muneer et al.     Receptor protein tyrosine phosphatase σ (PTPσ) and its subfamily member LAR act as transmembrane receptors that mediate growth inhibition of chondroitin sulfate proteoglycans …             Reconstructing Druze population history ▶     Scarlett Marshall, Ranajit Das, Mehdi Pirooznia et al.     The Druze are an aggregate of communities in the Levant and Near East living almost exclusively in the mountains of Syria, Lebanon and Israel whose ~1000 year old religion …             Deletion of Neurotrophin Signaling through the Glucocorticoid Receptor Pathway Causes Tau Neuropathology ▶     Margarita Arango-Lievano, Camille Peguet, Matthias Catteau et al.     Glucocorticoid resistance is a risk factor for Alzheimer’s disease (AD). Molecular and cellular mechanisms of glucocorticoid resistance in the brain have remained unknown and are …             Mitigation of radiation-induced hematopoietic injury by the polyphenolic acetate 7, 8-diacetoxy-4-methylthiocoumarin in mice ▶     Kavya Venkateswaran, Anju Shrivastava, Paban K. Agrawala et al.     Protection of the hematopoietic system from radiation damage, and/or mitigation of hematopoietic injury are the two major strategies for developing medical countermeasure agents …             Intrinsic cellular signaling mechanisms determine the sensitivity of cancer cells to virus-induced apoptosis ▶     Yunfei Wang, Dawei Li, Jian Luo et al.     Cancer cells of epithelial and mesenchymal phenotypes exhibit different sensitivities to apoptosis stimuli, but the mechanisms underlying this phenomenon remain partly …             Large-scale identification of human protein function using topological features of interaction network ▶     Zhanchao Li, Zhiqing Liu, Wenqian Zhong et al.     The annotation of protein function is a vital step to elucidate the essence of life at a molecular level, and it is also meritorious in biomedical and pharmaceutical industry. …             The Adhesive System and Anisotropic Shear Force of Guizhou Gastromyzontidae ▶     Jun Zou, Jinrong Wang, Chen Ji     The Guizhou gastromyzontidae (Beaufortia kweichowensis) can adhere to slippery and fouled surfaces in torrential streams. A unique adhesive system utilized by the fish was …             The disruption of GDP-fucose de novo biosynthesis suggests the presence of a novel fucose-containing glycoconjugate in Plasmodium asexual blood stages ▶     Sílvia Sanz, Borja López-Gutiérrez, Giulia Bandini et al.     Glycosylation is an important posttranslational protein modification in all eukaryotes. Besides glycosylphosphatidylinositol (GPI) anchors and N-glycosylation, O-fucosylation has …             Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells ▶     C. Mayer, M. Adam, L. Glashauser et al.     Changes in the wall of seminiferous tubules in men with impaired spermatogenesis imply sterile inflammation of the testis. We tested the hypothesis that the cells forming the …             Evidences for Cooperative Resonance-Assisted Hydrogen Bonds in Protein Secondary Structure Analogs ▶     Yu Zhou, Geng Deng, Yan-Zhen Zheng et al.     Cooperative behaviors of the hydrogen bonding networks in proteins have been discovered for a long time. The structural origin of this cooperativity, however, is still under …             Analysis of Microarray Data on Gene Expression and Methylation to Identify Long Non-coding RNAs in Non-small Cell Lung Cancer ▶     Nannan Feng, Travers Ching, Yu Wang et al.     To identify what long non-coding RNAs (lncRNAs) are involved in non-small cell lung cancer (NSCLC), we analyzed microarray data on gene expression and methylation. Gene …             A novel approach of utilization of the fungal conidia biomass to remove heavy metals from the aqueous solution through immobilization ▶     Chun-Xiang Cai, Jian Xu, Nian-Fang Deng et al.     The biomass of filamentous fungi is an important cost-effective biomass for heavy metal biosorption. However, use of free fungal cells can cause difficulties in the separation of …             PiHOG1, a stress regulator MAP kinase from the root endophyte fungus Piriformospora indica, confers salinity stress tolerance in rice plants ▶     Abhimanyu Jogawat, Jyothilakshmi Vadassery, Nidhi Verma et al.     In this study, yeast HOG1 homologue from the root endophyte Piriformospora indica (PiHOG1) was isolated and functionally characterized. Functional expression of PiHOG1 in S. …             The host genetic background defines diverse immune-reactivity and susceptibility to chronic Pseudomonas aeruginosa respiratory infection ▶     Lorenza Spagnuolo, Maura De Simone, Nicola Ivan Lorè et al.     Patients with P. aeruginosa airways infection show markedly variable clinical phenotypes likely influenced by genetic backgrounds. Here, we investigated the cellular events …             Dynamics of adsorbed polymers on attractive homogeneous surfaces ▶     Qing-Hui Yang, Meng-Bo Luo     Dynamic behaviors of polymer chains adsorbed on an attractive, homogeneous surface are studied by using dynamic Monte Carlo simulations. The translational diffusion coefficient D…             The fluctuating ribosome: thermal molecular dynamics characterized by neutron scattering ▶     Giuseppe Zaccai, Francesca Natali, Judith Peters et al.     Conformational changes associated with ribosome function have been identified by X-ray crystallography and cryo-electron microscopy. These methods, however, inform poorly on …             Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells ▶     Joanna Stelmaszewska, Marcin Chrusciel, Milena Doroszko et al.     Expression of follicle-stimulation hormone receptor (FSHR) is confined to gonads and at low levels to some extragonadal tissues like human umbilical vein endothelial cells (HUV…             Stage-dependent stoichiometric homeostasis and responses of nutrient resorption in Amaranthus mangostanus to nitrogen and phosphorus addition ▶     Huiyuan Peng, Yahan Chen, Zhengbing Yan et al.     Stoichiometric homeostasis is the ability of plants remaining their element composition relatively stable regardless of changes in nutrient availability, via various …             The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells ▶     Md. Mostafizur Rahman, Laura Prünte, Leonard F. Lebender et al.     Protein phosphatase 2A (PP2A) activity can be enhanced pharmacologically by PP2A-activating drugs (PADs). The sphingosine analog FTY720 is the best known PAD and we have shown …             Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate ▶     Zhiwu Yu, Zhiwei Zeng, Jing Zhang et al.     Human adenoviruses (HAdVs) are highly contagious pathogens causing acute respiratory disease (ARD), such as community-acquired pneumonia. HAdV-7d, a re-emergent genomic variant, …             ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions ▶     Krishna Rakesh Sharma, Karl Heckler, Sandra J. Stoll et al.     Engulfment and cell motility 1 (ELMO1) functions as a guanine exchange factor for Rac1 and was recently found to protect endothelial cells from apoptosis. Genome wide association …             Vibrational resonance, allostery, and activation in rhodopsin-like G protein-coupled receptors ▶     Kristina N. Woods, Jürgen Pfeffer, Arpana Dutta et al.     G protein-coupled receptors are a large family of membrane proteins activated by a variety of structurally diverse ligands making them highly adaptable signaling molecules. …             Continuous exposure to non-lethal doses of sodium iodate induces retinal pigment epithelial cell dysfunction ▶     Xiao-Yu Zhang, Tsz Kin Ng, Mårten Erik Brelén et al.     Age-related macular degeneration (AMD), characterized by progressive degeneration of retinal pigment epithelium (RPE), is the major cause of irreversible blindness and visual …             A submerged dielectric barrier discharge plasma inactivation mechanism of biofilms produced by Escherichia coli O157:H7, Cronobacter sakazakii, and Staphylococcus aureus ▶     Muhammad Saiful Islam Khan, Eun-Jung Lee, Yun-Ji Kim     A submerged dielectric barrier discharge plasma reactor (underwater DBD) has been used to inactivate biofilm produced by three different food-borne pathogens, namely Escherichia …             Harnessing Nature’s Diversity: Discovering organophosphate bioscavenger characteristics among low molecular weight proteins ▶     Reed B. Jacob, Kenan C. Michaels, Cathy J. Anderson et al.     Organophosphate poisoning can occur from exposure to agricultural pesticides or chemical weapons. This exposure inhibits acetylcholinesterase resulting in increased acetylcholine …             Integrins outside focal adhesions transmit tensions during stable cell adhesion ▶     Yongliang Wang, Xuefeng Wang     Integrins coupled with other proteins form protein complexes named focal adhesions (FA) which are considered as the primary sites for cellular forces transduction during cell …             Odour-induced analgesia mediated by hypothalamic orexin neurons in mice ▶     Shogo Tashiro, Ran Yamaguchi, Sodemi Ishikawa et al.     Various folk remedies employ certain odorous compounds with analgesic effects. In fact, linalool, a monoterpene alcohol found in lavender extracts, has been found to attenuate …             Enhancement of protein production via the strong DIT1 terminator and two RNA-binding proteins in Saccharomyces cerevisiae ▶     Yoichiro Ito, Takao Kitagawa, Mamoru Yamanishi et al.     Post-transcriptional upregulation is an effective way to increase the expression of transgenes and thus maximize the yields of target chemicals from metabolically engineered …             Avoidance, escape and microstructural adaptations of the tea green leafhopper to water droplets ▶     Meizhen Lin, Liette Vasseur, Guang Yang et al.     Rain and dew droplets can dislodge or drown small insects and may be important factors that drive adaptations for avoidance and escape. Studying the microstructure of small …             Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways ▶     Yumei Yan, Ke Jiang, Peng Liu et al.     Hepatocellular carcinoma (HCC) is refractory to chemotherapies, necessitating novel effective agents. The lysosome inhibitor Bafilomycin A1 (BafA1) at high concentrations …             Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions ▶     Sezen Vatansever, Zeynep H. Gümüş, Burak Erman     K-Ras is the most frequently mutated oncogene in human cancers, but there are still no drugs that directly target it in the clinic. Recent studies utilizing dynamics information …             Effects of seasonal meteorological variables on E. coli persistence in livestock faeces and implications for environmental and human health ▶     David M. Oliver, Trevor Page     Agriculture contributes significant volumes of livestock faeces to land. Understanding how faecal microbes respond to shifts in meteorological patterns of contrasting seasons is …             Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue ▶     Kai Rausalu, Age Utt, Tania Quirin et al.     Chikungunya virus (CHIKV), genus Alphavirus, family Togaviridae, has a positive-stand RNA genome approximately 12 kb in length. In infected cells, the genome is translated into …             Adenoviral vectors encoding CRISPR/Cas9 multiplexes rescue dystrophin synthesis in unselected populations of DMD muscle cells ▶     Ignazio Maggio, Jin Liu, Josephine M. Janssen et al.     Mutations disrupting the reading frame of the ~2.4 Mb dystrophin-encoding DMD gene cause a fatal X-linked muscle-wasting disorder called Duchenne muscular dystrophy (DMD). Genome …             Identification and molecular characterization of an IDA-like gene from litchi, LcIDL1, whose ectopic expression promotes floral organ abscission in Arabidopsis ▶     Peiyuan Ying, Caiqin Li, Xuncheng Liu et al.     Unexpected abscission of flowers or fruits is a major limiting factor for crop productivity. Key genes controlling abscission in plants, especially in popular fruit trees, are …             Systems-level chromosomal parameters represent a suprachromosomal basis for the non-random chromosomal arrangement in human interphase nuclei ▶     Sarosh N. Fatakia, Ishita S. Mehta, Basuthkar J. Rao     Forty-six chromosome territories (CTs) are positioned uniquely in human interphase nuclei, wherein each of their positions can range from the centre of the nucleus to its …             Aberrant SSEA-4 upregulation mediates myofibroblast activity to promote pre-cancerous oral submucous fibrosis ▶     Cheng-Chia Yu, Chuan-Hang Yu, Yu-Chao Chang     Oral submucous fibrosis (OSF), regarded as a precancerous condition, is characterized by juxta-epithelial inflammatory reaction followed by fibro-elastic change in the lamina …             Structure and Function of Cyanobacterial DHDPS and DHDPR ▶     Janni B. Christensen, T. P. Soares da Costa, Pierre Faou et al.     Lysine biosynthesis in bacteria and plants commences with a condensation reaction catalysed by dihydrodipicolinate synthase (DHDPS) followed by a reduction reaction catalysed by …             Biomechanics of subcellular structures by non-invasive Brillouin microscopy ▶     Giuseppe Antonacci, Sietse Braakman     Cellular biomechanics play a pivotal role in the pathophysiology of several diseases. Unfortunately, current methods to measure biomechanical properties are invasive and mostly …             SNP discovery and genotyping using Genotyping-by-Sequencing in Pekin ducks ▶     Feng Zhu, Qian-Qian Cui, Zhuo-Cheng Hou     Genomic selection and genome-wide association studies need thousands to millions of SNPs. However, many non-model species do not have reference chips for detecting variation. Our …             Ecotypic differentiation matters for latitudinal variation in energy metabolism and flight performance in a butterfly under climate change ▶     Hans Van Dyck, Marie-Jeanne Holveck     Life histories of organisms may vary with latitude as they experience different thermal constraints and challenges. This geographic, intraspecific variation could be of …             Glycine increases preimplantation development of mouse oocytes following vitrification at the germinal vesicle stage ▶     Xin-Yan Cao, Jack Rose, Shi-Yong Wang et al.     Ice-free cryopreservation, referred to as vitrification, is receiving increased attention in the human and animal assisted reproduction. However, it introduces the detrimental …             Two-stage (photoautotrophy and heterotrophy) cultivation enables efficient production of bioplastic poly-3-hydroxybutyrate in auto-sedimenting cyanobacterium ▶     Tanakarn Monshupanee, Palida Nimdach, Aran Incharoensakdi     Sustainable production of bioplastics by heterotrophic microbes has been restricted by the limited resources of organic substrates and the energy required for biomass harvest. …             Discriminating cancer-related and cancer-unrelated chemoradiation-response genes for locally advanced rectal cancers ▶     You Guo, Jun Cheng, Lu Ao et al.     For patients with locally advanced rectal cancer (LARC) treated with preoperation chemoradiation (pCRT), identifying differentially expressed (DE) genes between non-responders …             Effect of bio-engineering on size, shape, composition and rigidity of bacterial microcompartments ▶     Matthias J. Mayer, Rokas Juodeikis, Ian R. Brown et al.     Bacterial microcompartments (BMCs) are proteinaceous organelles that are found in a broad range of bacteria and are composed of an outer shell that encases an enzyme cargo …             Chromatin associated SETD3 negatively regulates VEGF expression ▶     Ofir Cohn, Michal Feldman, Lital Weil et al.     SETD3 is a member of the protein lysine methyltransferase (PKMT) family, which catalyzes the addition of methyl group to lysine residues. Accumulating data suggest that PKMTs are …             A dual inhibition mechanism of herpesviral ICP47 arresting a conformationally thermostable TAP complex ▶     Valentina Herbring, Anja Bäucker, Simon Trowitzsch et al.     As a centerpiece of antigen processing, the ATP-binding cassette transporter associated with antigen processing (TAP) became a main target for viral immune evasion. The …             Novel synthetic (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol inhibits arthritis by targeting signal transducer and activator of transcription 3 ▶     Dong Ju Son, Dae Hwan Kim, Seong-Su Nah et al.     Rheumatoid arthritis (RA) is a severely debilitating chronic autoimmune disease that leads to long-term joint damage. Signal transducer and activator of transcription 3 …             Investigation of TbfA in Riemerella anatipestifer using plasmid-based methods for gene over-expression and knockdown ▶     MaFeng Liu, MengYi Wang, DeKang Zhu et al.     Riemerella anatipestifer is a duck pathogen that has caused serious economic losses to the duck industry worldwide. Despite this, there are few reported studies of the …             Profiling ribonucleotide and deoxyribonucleotide pools perturbed by gemcitabine in human non-small cell lung cancer cells ▶     Jian-Ru Guo, Qian-Qian Chen, Christopher Wai Kei Lam et al.     In this study, we investigated the dosage effect of gemcitabine, an inhibitor of ribonucleotide reductase (RR), on cellular levels of ribonucleotides and deoxyribonucleotides …             Serotonergic Modulation Differentially Targets Distinct Network Elements within the Antennal Lobe of Drosophila melanogaster ▶     Tyler R. Sizemore, Andrew M. Dacks     Neuromodulation confers flexibility to anatomically-restricted neural networks so that animals are able to properly respond to complex internal and external demands. However, …             Production of selenium nanoparticles in Pseudomonas putida KT2440 ▶     Roberto Avendaño, Nefertiti Chaves, Paola Fuentes et al.     Selenium (Se) is an essential element for the cell that has multiple applications in medicine and technology; microorganisms play an important role in Se transformations in the …             Quantifying side-chain conformational variations in protein structure ▶     Zhichao Miao, Yang Cao     Protein side-chain conformation is closely related to their biological functions. The side-chain prediction is a key step in protein design, protein docking and structure …             A genomic island in Vibrio cholerae with VPI-1 site-specific recombination characteristics contains CRISPR-Cas and type VI secretion modules ▶     Maurizio Labbate, Fabini D. Orata, Nicola K. Petty et al.     Cholera is a devastating diarrhoeal disease caused by certain strains of serogroup O1/O139 Vibrio cholerae. Mobile genetic elements such as genomic islands (GIs) have been …             Gesture recognition by instantaneous surface EMG images ▶     Weidong Geng, Yu Du, Wenguang Jin et al.     Gesture recognition in non-intrusive muscle-computer interfaces is usually based on windowed descriptive and discriminatory surface electromyography (sEMG) features because the …             Cancer derived peptide of vacuolar ATPase ‘a2’ isoform promotes neutrophil migration by autocrine secretion of IL-8 ▶     Safaa A. Ibrahim, Arpita Kulshrestha, Gajendra K. Katara et al.     Neutrophils play significant regulatory roles within the tumor microenvironment by directly promoting tumor progression that leads to poor clinical outcomes. Identifying the …             Computational Drug Target Screening through Protein Interaction Profiles ▶     Santiago Vilar, Elías Quezada, Eugenio Uriarte et al.     The development of computational methods to discover novel drug-target interactions on a large scale is of great interest. We propose a new method for virtual screening based on …             Decoding intentions from movement kinematics ▶     Andrea Cavallo, Atesh Koul, Caterina Ansuini et al.     How do we understand the intentions of other people? There has been a longstanding controversy over whether it is possible to understand others’ intentions by simply observing …             The RNA-binding protein CsrA plays a central role in positively regulating virulence factors in Erwinia amylovora ▶     Veronica Ancona, Jae Hoon Lee, Youfu Zhao     The GacS/GacA two-component system (also called GrrS/GrrA) is a global regulatory system which is highly conserved among gamma-proteobacteria. This system positively regulates …             An iron detection system determines bacterial swarming initiation and biofilm formation ▶     Chuan-Sheng Lin, Yu-Huan Tsai, Chih-Jung Chang et al.     Iron availability affects swarming and biofilm formation in various bacterial species. However, how bacteria sense iron and coordinate swarming and biofilm formation remains …             Ligand-mediated changes in conformational dynamics of NpmA: implications for ribosomal interactions ▶     Nilofer Husain, Nikhil Kumar Tulsian, Wang Loo Chien et al.     Aminoglycosides are broad-spectrum antibiotics that bind to the 30S ribosomal subunit (30S) of bacteria and disrupt protein translation. NpmA, a structurally well-characterized …             Default Mode Network alterations in alexithymia: an EEG power spectra and connectivity study ▶     Claudio Imperatori, Giacomo Della Marca, Riccardo Brunetti et al.     Recent neuroimaging studies have shown that alexithymia is characterized by functional alterations in different brain areas [e.g., posterior cingulate cortex (PCC)], during …             MiR-101 Targets the EZH2/Wnt/β-Catenin the Pathway to Promote the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells ▶     Hongrui Wang, Yake Meng, Quanjun Cui et al.     Mounting evidence indicates that microRNAs (miRNAs) are involved in multiple processes of osteogenic differentiation. MicroRNA-101 (miR-101), identified as a tumor suppressor, …             rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk ▶     Jingjing Liu, Ivona Lončar, J. Margriet Collée et al.     NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3′-untranslated …             Potential costs of heterospecific sexual interactions in golden orbweb spiders (Nephila spp.) ▶     Shakira G. Quiñones-Lebrón, Simona Kralj-Fišer, Matjaž Gregorič et al.     Though not uncommon in other animals, heterospecific mating is rarely reported in arachnids. We investigated sexual interactions among four closely related and syntopical African …             Hypometabolism during Daily Torpor in Mice is Dominated by Reduction in the Sensitivity of the Thermoregulatory System ▶     Genshiro A. Sunagawa, Masayo Takahashi     Some mammals enter a hypometabolic state either daily torpor (minutes to hours in length) or hibernation (days to weeks), when reducing metabolism would benefit survival. …             Neuroprotection Mediated through GluN2C-Containing N-methyl-D-aspartate (NMDA) Receptors Following Ischemia ▶     Connie Chung, John D. Marson, Quan-Guang Zhang et al.     Post-ischemic activation of NMDA receptors (NMDARs) has been linked to NMDAR subunit-specific signaling that mediates pro-survival or pro-death activity. Although extensive …             Transcriptome analysis of Arabidopsis mutants suggests a crosstalk between ABA, ethylene and GSH against combined cold and osmotic stress ▶     Deepak Kumar, Saptarshi Hazra, Riddhi Datta et al.     The involvement of ethylene and abscisic acid in providing stress tolerance and defence response to plants is widely recognized. However, little is known about the cross-talk …             Sex-Specific Effects of Testosterone on the Sexually Dimorphic Transcriptome and Epigenome of Embryonic Neural Stem/Progenitor Cells ▶     Matthew S. Bramble, Lara Roach, Allen Lipson et al.     The mechanisms by which sex differences in the mammalian brain arise are poorly understood, but are influenced by a combination of underlying genetic differences and gonadal …             Human endometrial mesenchymal stem cells exhibit intrinsic anti-tumor properties on human epithelial ovarian cancer cells ▶     Shixia Bu, Qian Wang, Qiuwan Zhang et al.     Epithelial ovarian cancer (EOC) is the most lethal tumor of all gynecologic tumors. There is no curative therapy for EOC thus far. The tumor-homing ability of adult mesenchymal …             First steps to define murine amniotic fluid stem cell microenvironment ▶     E. Bertin, M. Piccoli, C. Franzin et al.     Stem cell niche refers to the microenvironment where stem cells reside in living organisms. Several elements define the niche and regulate stem cell characteristics, such as …             Fasting and Feeding Signals Control the Oscillatory Expression of Angptl8 to Modulate Lipid Metabolism ▶     Fabin Dang, Rong Wu, Pengfei Wang et al.     Emerging evidence implies a key role of angiopoietin-like protein 8 (Angptl8) in the metabolic transition between fasting and feeding, whereas much less is known about the …             Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration ▶     Jian-Nan Zhang, Uwe Michel, Christof Lenz et al.     Axonal degeneration is a key initiating event in many neurological diseases. Focal lesions to axons result in a rapid disintegration of the perilesional axon by acute axonal …             Microbiome analysis reveals the abundance of bacterial pathogens in Rousettus leschenaultii guano ▶     Sunil Banskar, Shrikant S. Bhute, Mangesh V. Suryavanshi et al.     Bats are crucial for proper functioning of an ecosystem. They provide various important services to ecosystem and environment. While, bats are well-known carrier of pathogenic …             Pathophysiological mechanisms underlying phenotypic differences in pulmonary radioresponse ▶     Isabel L. Jackson, Yuji Zhang, Søren M. Bentzen et al.     Differences in the pathogenesis of radiation-induced lung injury among murine strains offer a unique opportunity to elucidate the molecular mechanisms driving the divergence in …             Non-invasive Quantitative Analysis of Specific Fat Accumulation in Subcutaneous Adipose Tissues using Raman Spectroscopy ▶     Phiranuphon Meksiarun, Bibin B. Andriana, Hiroko Matsuyoshi et al.     Subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and fat beneath the dermis layer were investigated using a ball lens top hollow optical fiber Raman probe …             Imaging Cytometry of Human Leukocytes with Third Harmonic Generation Microscopy ▶     Cheng-Ham Wu, Tzung-Dau Wang, Chia-Hung Hsieh et al.     Based on third-harmonic-generation (THG) microscopy and a k-means clustering algorithm, we developed a label-free imaging cytometry method to differentiate and determine the …             TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin ▶     Cao Xiaobo, Mourad Majidi, Meng Feng et al.     Expression of the TUSC2/FUS1 tumor suppressor gene in TUSC2 deficient EGFR wildtype lung cancer cells increased sensitivity to erlotinib. Microarray mRNA expression analysis of T…             Mutation tendency of mutator Plasmodium berghei with proofreading-deficient DNA polymerase δ ▶     Hajime Honma, Mamoru Niikura, Fumie Kobayashi et al.     In this study, we investigated the mutation tendency of a mutator rodent malaria parasite, Plasmodium berghei, with proofreading-deficient DNA polymerase δ. Wild-type and mutator …             A comparative analysis and guidance for individualized chemotherapy of stage II and III colorectal cancer patients based on pathological markers ▶     Yang Han, Su Lu, Fudong Yu et al.     Adjuvant chemotherapy is considered the standard of care for patients with colorectal cancer after curative resection. Although current guidelines provide clear instructions for …             Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome ▶     Kazuya Sakata, Kimi Araki, Hiroyasu Nakano et al.     The loss-of-function mutations of serine protease inhibitor, Kazal type 1 (SPINK1) gene are associated with human chronic pancreatitis, but the underlying mechanisms remain …             Serum metabolomics analysis of patients with chikungunya and dengue mono/co-infections reveals distinct metabolite signatures in the three disease conditions ▶     Jatin Shrinet, Jayanthi S. Shastri, Rajni Gaind et al.     Chikungunya and dengue are arboviral infections with overlapping clinical symptoms. A subset of chikungunya infection occurs also as co-infections with dengue, resulting in …             Terahertz molecular resonance of cancer DNA ▶     Hwayeong Cheon, Hee-jin Yang, Sang-Hun Lee et al.     Carcinogenesis involves the chemical and structural alteration of biomolecules in cells. Aberrant methylation of DNA is a well-known carcinogenic mechanism and a common chemical …             Non-linear Equation using Plasma Brain Natriuretic Peptide Levels to Predict Cardiovascular Outcomes in Patients with Heart Failure ▶     Hiroki Fukuda, Hideaki Suwa, Atsushi Nakano et al.     Brain natriuretic peptide (BNP) is the most effective predictor of outcomes in chronic heart failure (CHF). This study sought to determine the qualitative relationship between …             Protein Inhibitor of Activated STAT3 Suppresses Oxidized LDL-induced Cell Responses during Atherosclerosis in Apolipoprotein E-deficient Mice ▶     Rong Wang, Yanjin Zhang, Liran Xu et al.     Atherosclerosis is a serious public health concern. Excessive inflammatory responses of vascular cells are considered a pivotal pathogenesis mechanism underlying atherosclerosis …             Analysis of Serum Metabolites to Diagnose Bicuspid Aortic Valve ▶     Wenshuo Wang, Aikebaier Maimaiti, Yun Zhao et al.     Bicuspid aortic valve (BAV) is the most common congenital heart disease. The current study aims to construct a diagnostic model based on metabolic profiling as a non-invasive …             Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism ▶     Ilanit Gordon, Allison Jack, Charlotte M. Pretzsch et al.     Oxytocin (OT) has become a focus in investigations of autism spectrum disorder (ASD). The social deficits that characterize ASD may relate to reduced connectivity between brain …             Effects of behavioral patterns and network topology structures on Parrondo’s paradox ▶     Ye Ye, Kang Hao Cheong, Yu-wan Cen et al.     A multi-agent Parrondo’s model based on complex networks is used in the current study. For Parrondo’s game A, the individual interaction can be categorized into five types of …                       npj Regenerative Medicine is an online-only, open access journal publishing high-quality research on ways to help the human body repair, replace and regenerate damaged tissues and organs. 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