Nature Reviews Immunology Contents December 2016 Volume 16 Number 12 pp 715-774

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TABLE OF CONTENTS
December 2016 Volume 16 Number 12		Advertisement
2015 2-year Impact Factor 39.416 Journal Metrics 2-year Median 31	In this issue Comment Research Highlights Reviews Perspectives Also this month  Featured article: Emerging roles of p53 and other tumour-suppressor genes in immune regulation César Muñoz-Fontela, Anna Mandinova, Stuart A. Aaronson & Sam W. Lee	Are you working on a novel drug target? Our drug discovery labs are looking for collaborations with researchers who have identified new drug targets or mechanisms involved in disease. We have expertise in developing small molecules and therapeutic antibodies, and have helped to develop four antibody drugs currently in the clinic. For more information click here.
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Comment: Prime-boost strategies to embrace diversity and inclusion in immunology Cherie L. Butts, Irelene P. Ricks & Avery August p715 | doi:10.1038/nri.2016.122 Immunologists appreciate the need for creative approaches to tackle complex scientific questions, which can involve not only the use of novel technologies but also the experience of scientists from diverse backgrounds. Here, we highlight measures to prime for the inclusion of women and underrepresented individuals in science to boost immunology research. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top T cells: A tissue checkpoint for TH2s p717 | doi:10.1038/nri.2016.130 A cell-intrinsic checkpoint restricts type 2 cytokine production by ILC2s and TH2 cells at sites of tissue damage. PDF Infection: Zika virus: end of transmission? p718 | doi:10.1038/nri.2016.131 Broadly neutralizing human antibodies for Zika virus protect adult mice and prevent maternal-fetal transmission. PDF Macrophages: Granuloma macrophage differentiation p718 | doi:10.1038/nri.2016.132 Multinuclear granuloma macrophages arise through a distinct differentiation pathway mediated by chronic TLR2 signalling, rather than by cell fusion. PDF Macrophages: Shaping good eating habits p719 | doi:10.1038/nri.2016.127 Macrophages regulate phagocytic and inflammatory responses by non-professional phagocytes. PDF Infection: Interferons suppress antibody responses p720 | doi:10.1038/nri.2016.128 Type I interferons induced by chronic viral infections suppress the induction of early neutralizing antibody responses. PDF Macrophages: Macrophage muscle man p720 | doi:10.1038/nri.2016.133 Macrophages expressing PPARγ support skeletal muscle regeneration by inducing secretion of the myoblast growth factor GDF3. PDF JOURNAL CLUB A Third signal from Conditioned DCs dictates microbial effector choice p721 | doi:10.1038/nri.2016.126 Alan Sher describes a 2002 paper by Martien Kapsenberg and Pawel Kalinski that provided evidence for the conditioning of DCs by microbial compounds to promote TH1 or TH2 cell responses. PDF Immunology JOBS of the week Roche Postdoctoral Fellow in Immunology of chronic HBV infection F. Hoffmann-La Roche PhD Student / Postdoc Position in Neuroinflammation and Mucosal Immunology Max Planck Institute of Biochemistry Postdoc In Vascular Biology Uppsala University MRC WIMM Prize PhD Studentships the Weatherall Institute of Molecular Medicine (WIMM), University of Oxford Animal health – Immunology Research assistant / Team leadership Institute of Virology and Immunology, University of Bern More Science jobs from Immunology EVENT Systems Biology of Adaptive Immunity 14.05.17 Ascona, Switzerland More science events from
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REVIEWS		Top
Immunoregulation by members of the TGFβ superfamily WanJun Chen & Peter ten Dijke p723 | doi:10.1038/nri.2016.112 In this Review, the authors discuss the emerging roles for members of the transforming growth factor-β (TGFβ) superfamily in regulating immune responses. In particular, they focus on how activin A and bone morphogenetic proteins (BMPs) regulate innate and adaptive immune cells in inflammatory diseases and cancer. Abstract | Full Text | PDF
Emerging roles of p53 and other tumour-suppressor genes in immune regulation César Muñoz-Fontela, Anna Mandinova, Stuart A. Aaronson & Sam W. Lee p741 | doi:10.1038/nri.2016.99 The tumour suppressor p53 has well-known functions in cell repair and cell death that have led to its title as the 'guardian of the genome'. Here, the authors discuss the less-well appreciated roles of p53 and other tumour suppressor genes in shaping immune responses; they propose that these genes could also be considered to be 'guardians of immune integrity'. Abstract | Full Text | PDF
Food allergy: immune mechanisms, diagnosis and immunotherapy Wong Yu, Deborah M. Hussey Freeland & Kari C. Nadeau p751 | doi:10.1038/nri.2016.111 Research into the immune mechanisms associated with healthy tolerance to common foods, the inflammatory response underlying food allergies, and immunotherapy-induced desensitization promises new approaches to the diagnosis, prevention and treatment of food allergy. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION Do antibodies select a healthy microbiota? Jason L. Kubinak & June L. Round p767 | doi:10.1038/nri.2016.114 A hypothesis is presented proposing that antibodies raised against commensal microorganisms shape the composition of the microbiota — through a process the authors call antibody-mediated immunoselection — and influence the overall health of the host. Abstract | Full Text | PDF
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