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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | | | | | Latest Articles | View all Articles | | | | | Memory consolidation reconfigures neural pathways involved in the suppression of emotional memories OPEN | | | Yunzhe Liu, Wanjun Lin, Chao Liu, Yuejia Luo, Jianhui Wu, Peter J. Bayley and Shaozheng Qin | | | As memories consolidate over time, they become resistant to change, though how this impacts the volitional suppression of memories is not known. Liu and colleagues show that, after overnight consolidation, aversive memories exhibit distributed prefrontal representations and are harder to suppress. | | | 29 November 2016 | doi: 10.1038/ncomms13375 | | |
| Increased DNA methylation variability in type 1 diabetes across three immune effector cell types OPEN | | | Dirk S. Paul, Andrew E. Teschendorff, Mary A.N. Dang, Robert Lowe, Mohammed I. Hawa, Simone Ecker, Huriya Beyan, Stephanie Cunningham, Alexandra R. Fouts, Anita Ramelius, Frances Burden, Samantha Farrow, Sophia Rowlston, Karola Rehnstrom, Mattia Frontini, Kate Downes, Stephan Busche, Warren A. Cheung, Bing Ge, Marie-Michelle Simon et al. | | | The incidence of type 1 diabetes is increasing, potentially implicating non-genetic factors. Here the authors conduct an epigenome-wide association study in disease-discordant twins and find increased DNA methylation variability at genes associated with immune cell metabolism and the cell cycle. | | | 29 November 2016 | doi: 10.1038/ncomms13555 | | |
| PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia OPEN | | | Roxana Ola, Alexandre Dubrac, Jinah Han, Feng Zhang, Jennifer S. Fang, Bruno Larrivée, Monica Lee, Ana A. Urarte, Jan R. Kraehling, Gael Genet, Karen K. Hirschi, William C. Sessa, Francesc V. Canals, Mariona Graupera, Minhong Yan, Lawrence H. Young, Paul S. Oh and Anne Eichmann | | | Arteriovenous malformations (AVM) is a hallmark of hereditary haemorrhagic telangiectasia type 2, a disease caused by mutations in BMP receptor ALK1. Ola et al. show that AVM can be caused by blocking BMP9 and BMP10 in mice, leading to increased VEGF and PI3K activity, and that pharmacologic inhibition of PI3K prevents AVM development. | | | 29 November 2016 | doi: 10.1038/ncomms13650 | | |
| Quantum enhanced feedback cooling of a mechanical oscillator using nonclassical light OPEN | | | Clemens Schäfermeier, Hugo Kerdoncuff, Ulrich B. Hoff, Hao Fu, Alexander Huck, Jan Bilek, Glen I. Harris, Warwick P. Bowen, Tobias Gehring and Ulrik L. Andersen | | | Real-time quantum feedback control can be used to cool quantum systems to their motional ground states, but this has been so far achieved via classical probe fields. Here the authors report feedback cooling of a mechanical oscillator using a squeezed field, reporting higher cooling rate over classical light. | | | 29 November 2016 | doi: 10.1038/ncomms13628 | | |
| Quantifying electronic band interactions in van der Waals materials using angle-resolved reflected-electron spectroscopy OPEN | | | Johannes Jobst, Alexander J. H. van der Torren, Eugene E. Krasovskii, Jesse Balgley, Cory R. Dean, Rudolf M. Tromp and Sense Jan van der Molen | | | Heterostructures of graphene and hexagonal boron nitride have great potential for high-mobility electronics, yet little is known about the electronic interaction between these two atomically thin materials. Here, the authors perform angle-resolved reflected-electron spectroscopy to unveil their interplay. | | | 29 November 2016 | doi: 10.1038/ncomms13621 | | |
| Direct visualization of a Fe(IV)–OH intermediate in a heme enzyme OPEN | | | Hanna Kwon, Jaswir Basran, Cecilia M. Casadei, Alistair J. Fielding, Tobias E. Schrader, Andreas Ostermann, Juliette M. Devos, Pierre Aller, Matthew P. Blakeley, Peter C. E. Moody and Emma L. Raven | | | The nature of the ferryl intermediate generated in reactions catalysed by heme-containing enzymes is uncertain, due to the ambiguity of X-ray crystallography data. Here, the authors apply neutron diffraction, kinetics and other spectroscopy to directly observe a protonated ferryl intermediate in a heme peroxidase. | | | 29 November 2016 | doi: 10.1038/ncomms13445 | | |
| Nonreciprocity and magnetic-free isolation based on optomechanical interactions OPEN | | | Freek Ruesink, Mohammad-Ali Miri, Andrea Alù and Ewold Verhagen | | | Nonreciprocal components are widely used in optical circuits but the magneto-optic effects they are based on pose difficulties for on-chip integration. Here, Ruesink et al. propose an optomechanical scheme to break reciprocity without the need for magnetic fields. | | | 29 November 2016 | doi: 10.1038/ncomms13662 | | |
| Functional exploration of colorectal cancer genomes using Drosophila OPEN | | | Erdem Bangi, Claudio Murgia, Alexander G.S. Teague, Owen J. Sansom and Ross L. Cagan | | | Colorectal cancers carry multiple mutations. Here, the authors use Drosophila as a model organism and assess multiple combinations of mutations and their response to various drugs, providing further insight into drug resistance mechanisms. | | | 29 November 2016 | doi: 10.1038/ncomms13615 | | |
| Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer OPEN | | | Christine Henzler, Yingming Li, Rendong Yang, Terri McBride, Yeung Ho, Cynthia Sprenger, Gang Liu, Ilsa Coleman, Bryce Lakely, Rui Li, Shihong Ma, Sean R. Landman, Vipin Kumar, Tae Hyun Hwang, Ganesh V. Raj, Celestia S. Higano, Colm Morrissey, Peter S. Nelson, Stephen R. Plymate and Scott M. Dehm et al. | | | Castration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity. | | | 29 November 2016 | doi: 10.1038/ncomms13668 | | |
| Time-resolved scattering of a single photon by a single atom OPEN | | | Victor Leong, Mathias Alexander Seidler, Matthias Steiner, Alessandro Cerè and Christian Kurtsiefer | | | The efficient excitation of atoms using photons is a fundamental step in the control of photon-atom interaction and quantum information protocols. Here the authors show that photons with an exponentially rising envelope excite a single atom efficiently compared to a decaying temporal shape. | | | 29 November 2016 | doi: 10.1038/ncomms13716 | | |
| TruePrime is a novel method for whole-genome amplification from single cells based on TthPrimPol OPEN | | | Ángel J. Picher, Bettina Budeus, Oliver Wafzig, Carola Krüger, Sara García-Gómez, María I. Martínez-Jiménez, Alberto Díaz-Talavera, Daniela Weber, Luis Blanco and Armin Schneider | | | Single cell genomic analysis needs DNA amplification with high fidelity and accuracy. Here, the authors devise a novel multiple displacement amplification method called TruePrime that is based in Thermus thermophilus PrimPol and Phi29 DNA polymerase, and demonstrate its utility and accuracy. | | | 29 November 2016 | doi: 10.1038/ncomms13296 | | |
| A design principle of polymers processable into 2D homeotropic order OPEN | | | Zhen Chen, Yi-Tsu Chan, Daigo Miyajima, Takashi Kajitani, Atsuko Kosaka, Takanori Fukushima, Jose M. Lobez and Takuzo Aida | | | Vertical alignment of polymers on surfaces is challenging due to their flexibility and tendency to arrange on horizontal planes. Here, the authors report a design principle allowing polymers to be arranged into 2D homeotropic orientations by using long-range dipole-dipole interactions and hot-pressing on Teflon sheets. | | | 29 November 2016 | doi: 10.1038/ncomms13640 | | |
| EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy OPEN | | | Julian C. Lui, Presley Garrison, Quang Nguyen, Michal Ad, Chithra Keembiyehetty, Weiping Chen, Youn Hee Jee, Ellie Landman, Ola Nilsson, Kevin M. Barnes and Jeffrey Baron | | | EZH1 and EZH2 are associated with epigenetic bone and cartilage developmental defects. Here the authors show that cartilage-specific double knockout mice have reduced skeletal growth and how these histone methyltransferases regulate chondrogenesis and endochondral bone development. | | | 29 November 2016 | doi: 10.1038/ncomms13685 | | |
| Accelerated pseudogenization on the neo-X chromosome in Drosophila miranda OPEN | | | Masafumi Nozawa, Kanako Onizuka, Mai Fujimi, Kazuho Ikeo and Takashi Gojobori | | | Over time, Y chromosomes tend to degenerate as their genes become non-functional and transposable elements accumulate. Here, Nozawa and colleagues investigate the novel sex chromosomes of Drosophila miranda and show that the X chromosome also degenerates rapidly compared to autosomes. | | | 29 November 2016 | doi: 10.1038/ncomms13659 | | |
| Massive remobilization of permafrost carbon during post-glacial warming OPEN | | | T. Tesi, F. Muschitiello, R. H. Smittenberg, M. Jakobsson, J. E. Vonk, P. Hill, A. Andersson, N. Kirchner, R. Noormets, O. Dudarev, I. Semiletov and Ö Gustafsson | | | Atmospheric CO2 increases during the last deglaciation have been linked to the destabilisation of permafrost carbon reservoirs. Here, using a sediment core from the Laptev Sea, Tesi et al. indicate a massive supply of permafrost carbon was released from Siberia following active layer deepening. | | | 29 November 2016 | doi: 10.1038/ncomms13653 | | |
| Atomistic characterization of the active-site solvation dynamics of a model photocatalyst OPEN | | | Tim B. van Driel, Kasper S. Kjær, Robert W. Hartsock, Asmus O. Dohn, Tobias Harlang, Matthieu Chollet, Morten Christensen, Wojciech Gawelda, Niels E. Henriksen, Jong Goo Kim, Kristoffer Haldrup, Kyung Hwan Kim, Hyotcherl Ihee, Jeongho Kim, Henrik Lemke, Zheng Sun, Villy Sundström, Wenkai Zhang, Diling Zhu, Klaus B. Møller et al. | | | Interactions between reactive excited states of molecular photocatalysts and surrounding solvent can dictate reaction pathways, but are not readily accessible to conventional spectroscopic methods. Here the authors use diffuse X-ray scattering and theory to study the atomistic solvation dynamics of a photoexcited di-iridium complex in acetonitrile. | | | 28 November 2016 | doi: 10.1038/ncomms13678 | | |
| Amplification of USP13 drives ovarian cancer metabolism OPEN | | | Cecil Han, Lifeng Yang, Hyun Ho Choi, Joelle Baddour, Abhinav Achreja, Yunhua Liu, Yujing Li, Jiada Li, Guohui Wan, Cheng Huang, Guang Ji, Xinna Zhang, Deepak Nagrath and Xiongbin Lu | | | Cancer cells need to reprogramme their metabolism to allow rapid cell proliferation. Here, the authors show that USP13 is amplified in ovarian cancer and its protein product, a deubiquitinase, drives tumour progression by rewiring the metabolism of cancer cells by stabilising two critical metabolic enzymes. | | | 28 November 2016 | doi: 10.1038/ncomms13525 | | |
| Miniature optical planar camera based on a wide-angle metasurface doublet corrected for monochromatic aberrations OPEN | | | Amir Arbabi, Ehsan Arbabi, Seyedeh Mahsa Kamali, Yu Horie, Seunghoon Han and Andrei Faraon | | | Metasurfaces have the potential to be used in imaging systems since they can modify optical wavefronts at subwavelength spatial resolution. Here, Arbabi et al. demonstrate a metasurface lens doublet corrected for monochromatic aberrations, and integrate it with an image sensor to realize a miniature planar camera. | | | 28 November 2016 | doi: 10.1038/ncomms13682 | | |
| IL-12 protects from psoriasiform skin inflammation OPEN | | | Paulina Kulig, Stephanie Musiol, Sandra Nicole Freiberger, Bettina Schreiner, Gabor Gyülveszi, Giancarlo Russo, Stanislav Pantelyushin, Kenji Kishihara, Francesca Alessandrini, Thomas Kündig, Federica Sallusto, Günther F.L. Hofbauer, Stefan Haak and Burkhard Becher | | | IL-12 and IL-23 share the common p40 subunit yet have distinct immunological functions with IL-12 typically contributing to Th1 responses and IL-23 to Th17 responses. Here the authors show that current p40 based therapies for psoriasis are counterproductive owing to an IFN-γ-independent tissue protective function of IL-12 in skin. | | | 28 November 2016 | doi: 10.1038/ncomms13466 | | |
| Modulation of mRNA and lncRNA expression dynamics by the Set2–Rpd3S pathway OPEN | | | Ji Hyun Kim, Bo Bae Lee, Young Mi Oh, Chenchen Zhu, Lars M. Steinmetz, Yookyeong Lee, Wan Kyu Kim, Sung Bae Lee, Stephen Buratowski and TaeSoo Kim | | | H3K36 methylation by Set2 targets Rpd3S histone deacetylase to transcribed mRNA genes, repressing internal cryptic promoters and modulating elongation. Here, the authors provide evidence that the Set2-Rpd3S pathway also regulates dynamic expression of mRNAs and lncRNAs. | | | 28 November 2016 | doi: 10.1038/ncomms13534 | | |
| Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan OPEN | | | Alireza Noormohammadi, Amirabbas Khodakarami, Ricardo Gutierrez-Garcia, Hyun Ju Lee, Seda Koyuncu, Tim König, Christina Schindler, Isabel Saez, Azra Fatima, Christoph Dieterich and David Vilchez | | | Pluripotent stem cells are thought to require a highly active proteostatic machinery. Here, the authors show that CCT8, a subunit of the proteostatic chaperonin complex, is increased in pluripotent stem cells, and that overexpression of CCT8 in worms increases cellular proteostasis and organismal longevity. | | | 28 November 2016 | doi: 10.1038/ncomms13649 | | |
| Selective suppression of antisense transcription by Set2-mediated H3K36 methylation OPEN | | | Swaminathan Venkatesh, Hua Li, Madelaine M. Gogol and Jerry L. Workman | | | Maintenance of chromatin structure in coding regions is partially dependent on transcription, with histone methyltransferase Set2 playing a role in this process. Here, the authors provide evidence that Set2 regulates repression of a specific set of antisense RNAs embedded within the coding genes. | | | 28 November 2016 | doi: 10.1038/ncomms13610 | | |
| Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway OPEN | | | Fumiaki Ando, Eisei Sohara, Tetsuji Morimoto, Naofumi Yui, Naohiro Nomura, Eriko Kikuchi, Daiei Takahashi, Takayasu Mori, Alain Vandewalle, Tatemitsu Rai, Sei Sasaki, Yoshiaki Kondo and Shinichi Uchida | | | The water channel AQP2 mediates the concentration of urine in the kidney. Here Ando et al. show that Wnt5 promotes collecting duct permeability by regulating AQP2 expression and localization through activation of the calmodulin/calcineurin signalling pathway. | | | 28 November 2016 | doi: 10.1038/ncomms13636 | | |
| Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2 OPEN | | | Sarah Cooper, Anne Grijzenhout, Elizabeth Underwood, Katia Ancelin, Tianyi Zhang, Tatyana B. Nesterova, Burcu Anil-Kirmizitas, Andrew Bassett, Susanne M. Kooistra, Karl Agger, Kristian Helin, Edith Heard and Neil Brockdorff | | | The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental regulation of the genome in multicellular organisms. Here the authors describe how the PRC2 cofactor Jarid2 mediates the recruitment of the PRC2 complex to chromatin via interaction with H2AK119u1. | | | 28 November 2016 | doi: 10.1038/ncomms13661 | | |
| Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis OPEN | | | Stephen L. Pinkosky, Roger S. Newton, Emily A. Day, Rebecca J. Ford, Sarka Lhotak, Richard C. Austin, Carolyn M. Birch, Brennan K. Smith, Sergey Filippov, Pieter H.E. Groot, Gregory R. Steinberg and Narendra D. Lalwani | | | Statins are lipid-lowering drugs that prevent cardiovascular disease but tolerability is limited by severe side effects in muscles. Here the authors elucidate a liver-specific activation mechanism for bempedoic acid, a novel cholesterol-lowering drug, and show how it effectively reduces LDL-C and atherosclerotic burden in mice, but does not cause myotoxicty. | | | 28 November 2016 | doi: 10.1038/ncomms13457 | | |
| Topological magnetoplasmon OPEN | | | Dafei Jin, Ling Lu, Zhong Wang, Chen Fang, John D. Joannopoulos, Marin Soljačić, Liang Fu and Nicholas X. Fang | | | The two dimensional magnetoplasmon edge state has been observed for a long time, but its nature is yet to be uncovered. Here, Jin et al. report that such a state is actually topological protected, analogous to the chiral Majorana edge state in a p-wave topological superconductor. | | | 28 November 2016 | doi: 10.1038/ncomms13486 | | |
| Reconfigurable exciton-plasmon interconversion for nanophotonic circuits OPEN | | | Hyun Seok Lee, Dinh Hoa Luong, Min Su Kim, Youngjo Jin, Hyun Kim, Seokjoon Yun and Young Hee Lee | | | Here the authors demonstrate functionality for on-chip optical communications via reconfigurable exciton-plasmon interconversion in 200 nm-diameter silver nanowires overlapping onto two-dimensional transition metal dichalcogenide transistors. | | | 28 November 2016 | doi: 10.1038/ncomms13663 | | |
| Simultaneous Faraday filtering of the Mollow triplet sidebands with the Cs-D1 clock transition OPEN | | | Simone Luca Portalupi, Matthias Widmann, Cornelius Nawrath, Michael Jetter, Peter Michler, Jörg Wrachtrup and Ilja Gerhardt | | | Hybrid quantum systems combine efficient high-quality quantum dot sources with atomic vapours that can serve as precise frequency standards or quantum memories. Here, Portalupi et al. demonstrate an optimized atomic Cs-Faraday filter working with single photons emitted from a semiconductor quantum dot. | | | 25 November 2016 | doi: 10.1038/ncomms13632 | | |
| MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment OPEN | | | RaeAnna Wilson, Cristina Espinosa-Diez, Nathan Kanner, Namita Chatterjee, Rebecca Ruhl, Christina Hipfinger, Sunil J. Advani, Jie Li, Omar F. Khan, Aleksandra Franovic, Sara M. Weis, Sushil Kumar, Lisa M. Coussens, Daniel G. Anderson, Clark C. Chen, David A. Cheresh and Sudarshan Anand | | | The tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here the authors show that radiation induced miR-103 downregulates TREX1 in endothelial cells, decreases angiogenesis and leads to the secretion of proinflammatory mediators that reduce tumour growth. | | | 25 November 2016 | doi: 10.1038/ncomms13597 | | |
| Transduction of group I mGluR-mediated synaptic plasticity by β-arrestin2 signalling OPEN | | | Andrew G. Eng, Daniel A. Kelver, Tristan P. Hedrick and Geoffrey T. Swanson | | | mGluRs are known to undergo non-canonical signalling regulation, although the underlying mechanisms are unclear. Here, the authors identify a role for β-arrestin2, but not β-arrestin1, in group I mGluR-mediated plasticity at hippocampal synapses. | | | 25 November 2016 | doi: 10.1038/ncomms13571 | | |
| Global warming-induced upper-ocean freshening and the intensification of super typhoons OPEN | | | Karthik Balaguru, Gregory R. Foltz, L. Ruby Leung and Kerry A. Emanuel | | | Super typhoons pose significant societal threats, yet their future behaviour due to rainfall-driven stratification changes remains unexplored. Here, observations and climate models reveal increased precipitation and subsequent freshening will likely intensify future super typhoons in the western N. Pacific. | | | 25 November 2016 | doi: 10.1038/ncomms13670 | | |
| A redox mechanism underlying nucleolar stress sensing by nucleophosmin OPEN | | | Kai Yang, Ming Wang, Yuzheng Zhao, Xuxu Sun, Yi Yang, Xie Li, Aiwu Zhou, Huilin Chu, Hu Zhou, Jianrong Xu, Mian Wu, Jie Yang and Jing Yi | | | Nucleoplasmic translocation of NPM1 is integral to nucleolar stress sensing. Here, the authors show that nucleolar oxidation is a general cellular stress response, and that oxidation-related glutathionylation of NPM1 triggers its translocation and facilitates p53 activation. | | | 25 November 2016 | doi: 10.1038/ncomms13599 | | |
| Generation of single photons with highly tunable wave shape from a cold atomic ensemble OPEN | | | Pau Farrera, Georg Heinze, Boris Albrecht, Melvyn Ho, Matías Chávez, Colin Teo, Nicolas Sangouard and Hugues de Riedmatten | | | Generation of narrowband pure and storable single photons is an enabling step towards hybrid quantum networks interconnecting different systems. Here the authors report on a heralded single photon source based on a cold ensemble of atoms with controllable emission time and high photon shape tunability. | | | 25 November 2016 | doi: 10.1038/ncomms13556 | | |
| The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog OPEN | | | Jiali Jin, Jian Liu, Cong Chen, Zhenping Liu, Cong Jiang, Hongshang Chu, Weijuan Pan, Xinbo Wang, Lingqiang Zhang, Bin Li, Cizhong Jiang, Xin Ge, Xin Xie and Ping Wang | | | Nanog regulates embryonic stem cell (ESC) pluripotency but what controls Nanog protein stability is unclear. Here, the authors show that in mouse ESCs, Nanog protein is ubiquitinated and stabilized by the deubiquitinase USP21, which in turn is regulated by extrinsic signals, STAT3 and ERK. | | | 25 November 2016 | doi: 10.1038/ncomms13594 | | |
| Demonstration of a chip-based optical isolator with parametric amplification OPEN | | | Shiyue Hua, Jianming Wen, Xiaoshun Jiang, Qian Hua, Liang Jiang and Min Xiao | | | Non-reciprocal optical elements usually require the presence of magnetic fields, which makes chip integration difficult. Here, Hua et al. demonstrate a non-magnetic optical isolator with bidirectional injection on a silicon platform utilizing parametric amplification in four-wave mixing. | | | 25 November 2016 | doi: 10.1038/ncomms13657 | | |
| A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells OPEN | | | Le Qu, Zhenjie Wu, Yaoming Li, Zhipeng Xu, Bing Liu, Feng Liu, Yi Bao, Dengshuang Wu, Jiayi Liu, Anbang Wang, Xiaoyuan Chu, Yinghao Sun, Cheng Chen, Zhengyu Zhang and Linhui Wang | | | Renal tumour-initiating cells (T-ICs) contribute to tumour initiation and progression. Here, the authors show that lncARSR regulates TICs by blocking LATS1-induced YAP phosphorylation facilitating YAP nuclear translocation, which promotes lncARSR transcription, thus forming a feed-forward circuit to promote TIC expansion. | | | 25 November 2016 | doi: 10.1038/ncomms12692 | | |
| Fundamental rate-loss trade-off for the quantum internet OPEN | | | Koji Azuma, Akihiro Mizutani and Hoi-Kwong Lo | | | In a future quantum internet, entanglement or a secret key should be efficiently provided between two points via intermediate nodes connected by optical channels. Here the authors derive general rate-loss trade-off for such protocols, that is applicable to any network topology. | | | 25 November 2016 | doi: 10.1038/ncomms13523 | | |
| Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease OPEN | | | N. T. Ventham, N. A. Kennedy, A. T. Adams, R. Kalla, S. Heath, K. R. O'Leary, H. Drummond, IBD BIOM consortium, IBD CHARACTER consortium, D. C. Wilson, I. G. Gut, E. R. Nimmo & J. Satsangi Gordan Lauc, Harry Campbell, Dermot P. B. McGovern, Vito Annese, Vlatka Zoldoš, Iain K. Permberton, Manfred Wuhrer, Daniel Kolarich, Daryl L. Fernandes, Evropi Theorodorou, Victoria Merrick, Daniel I. Spencer et al. | | | Epigenetic perturbations may be an important factor in diseases where both genes and environment play a role. Here, Ventham and colleagues show that DNA methylation changes in inflammatory bowel disease are related to the underlying genotype, and are associated with cell-specific changes to gene expression. | | | 25 November 2016 | doi: 10.1038/ncomms13507 | | |
| Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression OPEN | | | Swathi V. Iyer, Atul Ranjan, Harold K. Elias, Alejandro Parrales, Hiromi Sasaki, Badal C. Roy, Shahid Umar, Ossama W. Tawfik and Tomoo Iwakuma | | | The ability of cancer cells to survive in anchorage-independent conditions correlates with cancer aggressiveness. Here, by screening a human whole-genome shRNA library for the ability of osteosarcoma cells to form spheres in vitro, the authors identify a role for TMIGD3 isoform 1 in suppressing the metastatic potential of osteosarcoma. | | | 25 November 2016 | doi: 10.1038/ncomms13561 | | |
| Work extraction from quantum systems with bounded fluctuations in work OPEN | | | Jonathan G. Richens and Lluis Masanes | | | Describing thermodynamic processes, fluctuations of work are typically not considered bounded. Here the authors show that in some processes they diverge, making the processes unphysical, and construct a framework to quantify work extraction and work of formation of arbitrary quantum states with bounded fluctuations. | | | 25 November 2016 | doi: 10.1038/ncomms13511 | | |
| Astrocytic GABA transporter activity modulates excitatory neurotransmission OPEN | | | Kim Boddum, Thomas P. Jensen, Vincent Magloire, Uffe Kristiansen, Dmitri A. Rusakov, Ivan Pavlov and Matthew C. Walker | | | Astrocytes monitor and regulate both excitatory and inhibitory synaptic activity. Here, the authors identify a novel form of neuronal-glia communication, by which astrocytes detect rises in GABA via the GABA transporter GAT-3; this results in adenosine release that acts presynaptically to inhibit neural glutamatergic signalling. | | | 25 November 2016 | doi: 10.1038/ncomms13572 | | |
| Tuning charge and correlation effects for a single molecule on a graphene device OPEN | | | Sebastian Wickenburg, Jiong Lu, Johannes Lischner, Hsin-Zon Tsai, Arash A. Omrani, Alexander Riss, Christoph Karrasch, Aaron Bradley, Han Sae Jung, Ramin Khajeh, Dillon Wong, Kenji Watanabe, Takashi Taniguchi, Alex Zettl, A.H. Castro Neto, Steven G. Louie and Michael F. Crommie | | | The development of single-molecule electronics calls for precise tuning of the electronic properties of individual molecules that go beyond two-terminal control. Here, Wickenburg et al. show gate-tunable switch of charge states of an isolated molecule using a graphene-based field-effect transistor. | | | 25 November 2016 | doi: 10.1038/ncomms13553 | | |
| A stable lithium-rich surface structure for lithium-rich layered cathode materials OPEN | | | Sangryun Kim, Woosuk Cho, Xiaobin Zhang, Yoshifumi Oshima and Jang Wook Choi | | | Surface modification of high-capacity lithium-rich layered oxides for improved capacity retention is an active area of battery materials research. Here authors demonstrate lithium-rich layered surfaces with a framework matching the host's, but with nickel atoms regularly arranged between layers. | | | 25 November 2016 | doi: 10.1038/ncomms13598 | | |
| Meta-adaptation in the auditory midbrain under cortical influence OPEN | | | Benjamin L. Robinson, Nicol S. Harper and David McAlpine | | | Neurons in the auditory midbrain are known to modify their firing rates in response to changes in sound intensity. Here the authors show that in guinea pigs, such modifications occur faster when neurons re-encounter the same environment, a phenomenon they term meta-adaptation. | | | 24 November 2016 | doi: 10.1038/ncomms13442 | | |
| The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities OPEN | | | Chu-Chiao Wu, Sunhee Lee, Srinivas Malladi, Miao-Der Chen, Nicholas J. Mastrandrea, Zhiwen Zhang and Shawn B. Bratton | | | Apoptotic initiator caspases are thought to be activated through homodimerization but this remains controversial. Here the authors demonstrate that caspase-9 can adopt two distinct conformations within the Apaf-1 apoptosome, each with distinct properties that contribute to the overall function of the complex. | | | 24 November 2016 | doi: 10.1038/ncomms13565 | | |
| Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain OPEN | | | Andrea Gumiero, Charlotte Conz, Genís Valentín Gesé, Ying Zhang, Felix Alexander Weyer, Karine Lapouge, Julia Kappes, Ulrike von Plehwe, Géza Schermann, Edith Fitzke, Tina Wölfle, Tamás Fischer, Sabine Rospert and Irmgard Sinning | | | In yeast, the heterodimeric ribosome-associated complex (RAC) acts in concert with the Hsp70 protein Ssb, forming a unique chaperone triad. Here the authors use structural and biochemical approaches to shed light on how translation and folding are coupled in eukaryotes. | | | 24 November 2016 | doi: 10.1038/ncomms13563 | | |
| Neutralization mechanism of a highly potent antibody against Zika virus OPEN | | | Shuijun Zhang, Victor A. Kostyuchenko, Thiam-Seng Ng, Xin-Ni Lim, Justin S. G. Ooi, Sebastian Lambert, Ter Yong Tan, Douglas G. Widman, Jian Shi, Ralph S. Baric and Shee-Mei Lok | | | There is a pressing need for therapeutic agents against Zika virus (ZIKV). Here the authors present cryoEM structures of a neutralizing antibody (C10) complexed with ZIKV that show C10 preventing structural changes required for virus entry into the cell, suggesting it might be effective in treating Zika infections. | | | 24 November 2016 | doi: 10.1038/ncomms13679 | | |
| An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes OPEN | | | Yun Sung Cho, Hyunho Kim, Hak-Min Kim, Sungwoong Jho, JeHoon Jun, Yong Joo Lee, Kyun Shik Chae, Chang Geun Kim, Sangsoo Kim, Anders Eriksson, Jeremy S. Edwards, Semin Lee, Byung Chul Kim, Andrea Manica, Tae-Kwang Oh, George M. Church and Jong Bhak | | | The utility of a universal reference sequence for human genome comparisons is dependent on the ethnic origins of the individuals being sequenced. Here the authors report a Korean reference genome and consensus variome, and show that an ethnically-relevant reference can improve variant detection. | | | 24 November 2016 | doi: 10.1038/ncomms13637 | | |
| Deterministic phase slips in mesoscopic superconducting rings OPEN | | | I. Petković, A. Lollo, L. I. Glazman and J. G. E. Harris | | | Understanding the decay of persistent current in superconducting rings remains obscure. Here, the authors show detailed agreement between measurements of the persistent current in isolated flux-biased rings and Ginzburg-Landau theory over a wide range of parameters, providing a quantitative picture of the free energy landscape. | | | 24 November 2016 | doi: 10.1038/ncomms13551 | | |
| A mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-Golgi OPEN | | | Corinne Stoetzel, Séverine Bär, Johan-Owen De Craene, Sophie Scheidecker, Christelle Etard, Johana Chicher, Jennifer R. Reck, Isabelle Perrault, Véronique Geoffroy, Kirsley Chennen, Uwe Strähle, Philippe Hammann, Sylvie Friant and Hélène Dollfus | | | VPS15 is known as a VPS34-associated protein that functions in intracellular trafficking and autophagy. Here the authors identify a role for VPS15 in ciliopathy and ciliary phenotypes, and show that it interacts with GM130 and functions in IFT20-dependent cis-Golgi to cilium trafficking. | | | 24 November 2016 | doi: 10.1038/ncomms13586 | | |
| Electromagnon dispersion probed by inelastic X-ray scattering in LiCrO2 OPEN | | | Sándor Tóth, Björn Wehinger, Katharina Rolfs, Turan Birol, Uwe Stuhr, Hiroshi Takatsu, Kenta Kimura, Tsuyoshi Kimura, Henrik M. Rønnow and Christian Rüegg | | | Whilst terahertz optical spectroscopy allows for the study of coupled spin and lattice excitations, it is limited in momentum space. Here, the authors use inelastic x-ray scattering to demonstrate strong magnon-phonon coupling and electromagnon excitations across the Brillouin zone of LiCrO2. | | | 24 November 2016 | doi: 10.1038/ncomms13547 | | |
| Global gain modulation generates time-dependent urgency during perceptual choice in humans OPEN | | | Peter R. Murphy, Evert Boonstra and Sander Nieuwenhuis | | | Decision-making balances the benefits of additional information with the cost of time, but it is unclear whether humans adjust this balance within individual decisions. Here, authors show that we do make such adjustments to suit contextual demands and suggest that these are driven by modulation of neural gain. | | | 24 November 2016 | doi: 10.1038/ncomms13526 | | |
| ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins OPEN | | | Carolina Villarroya-Beltri, Francesc Baixauli, María Mittelbrunn, Irene Fernández-Delgado, Daniel Torralba, Olga Moreno-Gonzalo, Sara Baldanta, Carlos Enrich, Susana Guerra and Francisco Sánchez-Madrid | | | Multivesicular bodies (MVB) are endosomal compartments that can either fuse with the plasma membrane for the secretion of exosomes, or fuse with the lysosome and be degraded along with their contents. Here, the authors show that ISGylation of the MVB protein TSG101 impairs exosome secretion and acts as a regulator of MVB fate. | | | 24 November 2016 | doi: 10.1038/ncomms13588 | | |
| Tunable inertia of chiral magnetic domain walls OPEN | | | Jacob Torrejon, Eduardo Martinez and Masamitsu Hayashi | | | The controlled motion of magnetic domain walls in nanowire conduits forms the basis of emerging memory and information processing devices. Here, the authors report a pulse-length dependent quasi-static velocity of current-driven chiral domain walls, showing that their inertia is tunable. | | | 24 November 2016 | doi: 10.1038/ncomms13533 | | |
| The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization OPEN | | | Feng Zhang, Claudia Prahst, Thomas Mathivet, Laurence Pibouin-Fragner, Jiasheng Zhang, Gael Genet, Raymond Tong, Alexandre Dubrac and Anne Eichmann | | | Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosphorylation of its receptor Vegfr2 on Y949. | | | 24 November 2016 | doi: 10.1038/ncomms13517 | | |
| Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice OPEN | | | Gustavo Monnerat, Micaela L. Alarcón, Luiz R. Vasconcellos, Camila Hochman-Mendez, Guilherme Brasil, Rosana A. Bassani, Oscar Casis, Daniela Malan, Leonardo H. Travassos, Marisa Sepúlveda, Juan Ignacio Burgos, Martin Vila-Petroff, Fabiano F. Dutra, Marcelo T. Bozza, Claudia N. Paiva, Adriana Bastos Carvalho, Adriana Bonomo, Bernd K. Fleischmann, Antonio Carlos Campos de Carvalho and Emiliano Medei et al. | | | Ventricular arrhythmia is a leading cause of death in patients with diabetes. Here the authors show that inflammasome activation and ILK-1β production in cardiac macrophages cause arrhythmia in diabetic mice, which can be successfully treated using agonists to IL-1β receptor or NLRP3 inhibitors. | | | 24 November 2016 | doi: 10.1038/ncomms13344 | | |
| Optically switched magnetism in photovoltaic perovskite CH3NH3(Mn:Pb)I3 OPEN | | | B. Náfrádi, P. Szirmai, M. Spina, H. Lee, O. V. Yazyev, A. Arakcheeva, D. Chernyshov, M. Gibert, L. Forró and E. Horváth | | | Functional behaviour can emerge in materials in which magnetic order is determined by the interplay of localised and itinerant magnetic interactions. Here the authors tune such magnetic order in a photovoltaic perovskite by tuning the electronic carrier concentration under visible light illumination. | | | 24 November 2016 | doi: 10.1038/ncomms13406 | | |
| Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP OPEN | | | Carol Sheppard, Fabian Blombach, Adam Belsom, Sarah Schulz, Tina Daviter, Katherine Smollett, Emilie Mahieu, Susanne Erdmann, Philip Tinnefeld, Roger Garrett, Dina Grohmann, Juri Rappsilber and Finn Werner | | | How archaeal viruses perturb host transcription machinery is poorly understood. Here, the authors provide evidence that the archaeo-viral transcription factor ORF145/RIP targets host RNA polymerase, repressing its activity. | | | 24 November 2016 | doi: 10.1038/ncomms13595 | | |
| A DNA dual lock-and-key strategy for cell-subtype-specific siRNA delivery OPEN | | | Kewei Ren, Ying Liu, Jie Wu, Yue Zhang, Jing Zhu, Min Yang and Huangxian Ju | | | Delivery of siRNA to target cells is essential for in vivo gene therapy. Here the authors demonstrate an oligonucleotide aptamer that targets therapeutic siRNA to a specific cell type. | | | 24 November 2016 | doi: 10.1038/ncomms13580 | | |
| A CMOS silicon spin qubit OPEN | | | R. Maurand, X. Jehl, D. Kotekar-Patil, A. Corna, H. Bohuslavskyi, R. Laviéville, L. Hutin, S. Barraud, M. Vinet, M. Sanquer and S. De Franceschi | | | Silicon is a promising material for realization of quantum processors, particularly as it could be naturally integrated with classical control hardware based on CMOS technology. Here the authors report a silicon qubit device made with an industry-standard fabrication process on a CMOS platform. | | | 24 November 2016 | doi: 10.1038/ncomms13575 | | |
| Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells OPEN | | | Melissa F. Brereton, Maria Rohm, Kenju Shimomura, Christian Holland, Sharona Tornovsky-Babeay, Daniela Dadon, Michaela Iberl, Margarita V. Chibalina, Sheena Lee, Benjamin Glaser, Yuval Dor, Patrik Rorsman, Anne Clark and Frances M. Ashcroft | | | Diabetes is characterized by prolonged hyperglycaemia and tissue damage in pancreatic islets. Here, Brereton et al. show that chronic high glucose levels lead to glycogen accumulation in β-cells, associated with reduced autophagy, impaired metabolism, insulin granule depletion and apoptosis. | | | 24 November 2016 | doi: 10.1038/ncomms13496 | | |
| Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression OPEN | | | Ni Li, David C. Johnson, Niels Weinhold, James B. Studd, Giulia Orlando, Fabio Mirabella, Jonathan S. Mitchell, Tobias Meissner, Martin Kaiser, Hartmut Goldschmidt, Kari Hemminki, Gareth J. Morgan and Richard S. Houlston | | | Genome wide association studies have identified multiple risk loci for multiple myeloma. Here, the authors show that the expression of CDCA7L is associated with patient survival and expression of the gene is influenced by a risk variant at 7p15.3, which creates a transcription factor binding site for IRF4. | | | 24 November 2016 | doi: 10.1038/ncomms13656 | | |
| Proliferation of Listeria monocytogenesL-form cells by formation of internal and external vesicles OPEN | | | Patrick Studer, Titu Staubli, Noémi Wieser, Patrick Wolf, Markus Schuppler and Martin J. Loessner | | | L-forms are cell wall-deficient bacteria that divide through unusual mechanisms, potentially resembling those of primitive cells. Here the authors describe how Listeria monocytogenes L-forms proliferate by generation of internal and external vesicles. | | | 23 November 2016 | doi: 10.1038/ncomms13631 | | |
| All-gas-phase synthesis of UiO-66 through modulated atomic layer deposition OPEN | | | Kristian Blindheim Lausund and Ola Nilsen | | | Thin films of metal-organic frameworks (MOFs) are promising for catalysis, gas storage, and microelectronics. Here, the authors introduce a vapour-phase synthesis of UiO-66 thin films, beginning with modulated atomic layer deposition of porous, amorphous films, followed by acetic acid vapour-enabled crystallization to the MOF structure. | | | 23 November 2016 | doi: 10.1038/ncomms13578 | | |
| Unlocking sperm chromatin at fertilization requires a dedicated egg thioredoxin in Drosophila OPEN | | | Samantha Tirmarche, Shuhei Kimura, Raphaëlle Dubruille, Béatrice Horard and Benjamin Loppin | | | In many animals, sperm DNA compaction is achieved by disulfide bonds between the sperm nuclear proteins that replace the histones. Here, the authors provide evidence that Drosophila maternal thioredoxin Deadhead is required to unlock the sperm chromatin upon fertilization. | | | 23 November 2016 | doi: 10.1038/ncomms13539 | | |
| A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape OPEN | | | Janina S. Ried, Janina Jeff M., Audrey Y. Chu, Jennifer L. Bragg-Gresham, Jenny van Dongen, Jennifer E. Huffman, Tarunveer S. Ahluwalia, Gemma Cadby, Niina Eklund, Joel Eriksson, Tõnu Esko, Mary F. Feitosa, Anuj Goel, Mathias Gorski, Caroline Hayward, Nancy L. Heard-Costa, Anne U. Jackson, Eero Jokinen, Stavroula Kanoni, Kati Kristiansson et al. | | | Past genome-wide associate studies have identified hundreds of genetic loci that influence body size and shape when examined one trait at a time. Here, Jeff and colleagues develop an aggregate score of various body traits, and use meta-analysis to find new loci linked to body shape. | | | 23 November 2016 | doi: 10.1038/ncomms13357 | | |
| PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis OPEN | | | Giulia Mana, Fabiana Clapero, Emiliano Panieri, Valentina Panero, Ralph T. Böttcher, Hui-Yuan Tseng, Federico Saltarin, Elena Astanina, Katarzyna I. Wolanska, Mark R. Morgan, Martin J. Humphries, Massimo M. Santoro, Guido Serini and Donatella Valdembri | | | During vascular development, fibronectin (FN) is polymerized at the basolateral side of endothelial cells. Here Mana et al. propose a model where PPFIA1 drives recycling of the FN receptor, a5β1 integrin, to the cell surface and enables polar secretion and fibrillogenesis of newly synthesized FN. | | | 23 November 2016 | doi: 10.1038/ncomms13546 | | |
| VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination OPEN | | | Yuki Miyamoto, Tomohiro Torii, Akito Tanoue and Junji Yamauchi | | | The vascular cell adhesion molecule VCAM1 plays a role in the immune system but is also expressed in oligodendrocytes. Here, the authors find VCAM1 interacts with neuronal α4 integrin to regulate oligodendrocyte differentiation and thereby myelination, an effect mediated by downstream CD69 signalling. | | | 23 November 2016 | doi: 10.1038/ncomms13478 | | |
| Deep phenotyping unveils hidden traits and genetic relations in subtle mutants OPEN | | | Adriana San-Miguel, Peri T. Kurshan, Matthew M. Crane, Yuehui Zhao, Patrick T. McGrath, Kang Shen and Hang Lu | | | Experimenter scoring of cellular imaging data can be biased. This study describes an automated and unbiased multidimensional phenotyping method that relies on machine learning and complex feature computation of imaging data, and identifies weak alleles affecting synapse morphology in live C. elegans. | | | 23 November 2016 | doi: 10.1038/ncomms12990 | | |
| Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease OPEN | | | Walid Mottawea, Cheng-Kang Chiang, Marcus Mühlbauer, Amanda E. Starr, James Butcher, Turki Abujamel, Shelley A. Deeke, Annette Brandel, Hu Zhou, Shadi Shokralla, Mehrdad Hajibabaei, Ruth Singleton, Eric I. Benchimol, Christian Jobin, David R. Mack, Daniel Figeys and Alain Stintzi | | | Crohn’s disease is associated with altered intestinal microbiota. Here, the authors show that the microbe Atopobium parvulum is associated with Crohn’s disease patients, triggers colitis in a mouse model, and that scavenging microbe-induced hydrogen sulfide improved symptoms in mice. | | | 23 November 2016 | doi: 10.1038/ncomms13419 | | |
| Rapid laccolith intrusion driven by explosive volcanic eruption OPEN | | | Jonathan M. Castro, Benoit Cordonnier, C. Ian Schipper, Hugh Tuffen, Tobias S. Baumann and Yves Feisel | | | Magmatic intrusions are thought to precede volcanic eruptions. However, Castro et al. present evidence that a laccolith was emplaced during the 2011 rhyolitic eruption of Cordón Caulle showing that eruptions may force the intrusion of magma into the shallow crust posing an unrecognized volcanic hazard. | | | 23 November 2016 | doi: 10.1038/ncomms13585 | | |
| Anomalously rotary polarization discovered in homochiral organic ferroelectrics OPEN | | | Peng-Fei Li, Yuan-Yuan Tang, Zhong-Xia Wang, Heng-Yun Ye, Yu-Meng You and Ren-Gen Xiong | | | Ferroelectric phase transitions are normally accompanied by structural changes in the materials. Here, Li et al. synthesize homochiral molecular crystals and utilize their ferroelectric transitions to achieve optical switches with different refractive indices for left- and right-handed polarizations. | | | 23 November 2016 | doi: 10.1038/ncomms13635 | | |
| PEP-19 modulates calcium binding to calmodulin by electrostatic steering OPEN | | | Xu Wang and John A. Putkey | | | The protein PEP-19 increases the rates of calcium binding to calmodulin. Here, the authors report the structure of PEP-19 bound to the C-terminal domain of calmodulin, and are able to propose a mechanism for the observed increased calcium association rate. | | | 23 November 2016 | doi: 10.1038/ncomms13583 | | |
| Functional implications of orientation maps in primary visual cortex OPEN | | | Erin Koch, Jianzhong Jin, Jose M. Alonso and Qasim Zaidi | | | Stimulus orientation in the primary visual cortex of primates and carnivores is mapped into a geometrical mosaic but the functional implications of these maps remain debated. Here the authors reveal an association between the structure of cortical orientation maps in cats, and the functions of local cortical circuits in processing patterns and contours. | | | 23 November 2016 | doi: 10.1038/ncomms13529 | | | | | | | | | | | | | Latest Corrigendum | | | | | | Corrigendum: Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB OPEN | | | Tong Wang, Sally Martin, Tam H. Nguyen, Callista B. Harper, Rachel S. Gormal, Ramon Martínez-Mármol, Shanker Karunanithi, Elizabeth J. Coulson, Nick R. Glass, Justin J. Cooper-White, Bruno van Swinderen and Frédéric A. Meunier | | | 23 November 2016 | doi: 10.1038/ncomms13768 | | | | | | | | | | Latest Retraction | | | | | | | | | |
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