Tuesday, November 29, 2016

Nature Cell Biology contents: December 2016 Volume 18 Number 12, pp 1261 - 1367

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TABLE OF CONTENTS

December 2016 Volume 18, Issue 12

Obituary
News and Views
Articles
Letter
Erratum
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Obituary

Top

Andrzej K. Tarkowski 1933-2016   p1261
Magdalena Zernicka-Goetz
doi:10.1038/ncb3446

News and Views

Top

IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3   pp1263 - 1265
Lucia E. Rameh and Ashley M. Mackey
doi:10.1038/ncb3440
Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli.

See also: Article by Choi et al.

Getting a grip on collective cell migration   pp1265 - 1267
Tamal Das and Joachim P. Spatz
doi:10.1038/ncb3447
Many cell types in our body move in a collective manner, which requires individual cells to align their movements relative to that of their neighbours. A mechanism is now described in which cadherin-rich protrusions are extended from leading migrating cells and engulfed by follower cells to guide collective migration.

See also: Article by Hayer et al.

Remodelling germ cells by intercellular cannibalism   pp1267 - 1268
Jennifer K. Heppert and Bob Goldstein
doi:10.1038/ncb3449
Work from the early 1980s reported strange lobes protruding from Caenorhabditis elegans germ cell precursors. However, the fate and potential significance of these lobes remained unexplored for decades. Now, neighbouring endodermal cells are shown to sever and digest these lobes, in an unexpected process of 'intercellular cannibalism', which could play an important part in regulating primordial germ cells.

See also: Article by Abdu et al.

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Articles

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Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors   pp1269 - 1280
Michael M. Kaminski, Jelena Tosic, Catena Kresbach, Hannes Engel, Jonas Klockenbusch et al.
doi:10.1038/ncb3437
Kaminski et al. demonstrate that combined expression of the transcription factors Emx2, Hnf1b, Hnf4a and Pax8 converts mouse and human fibroblasts into induced renal tubular epithelial cells.

Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation   pp1281 - 1291
Nitya Ramkumar, Tatiana Omelchenko, Nancy F. Silva-Gagliardi, C. Jane McGlade, Jan Wijnholds et al.
doi:10.1038/ncb3442
Ramkumar et al. demonstrate that Crumbs2 is required in the cells of the primitive streak to promote cell ingression during the epithelial-to-mesenchymal transition, and maintains the integrity of the epiblast.

Asymmetric division coordinates collective cell migration in angiogenesis   pp1292 - 1301
Guilherme Costa, Kyle I. Harrington, Holly E. Lovegrove, Donna J. Page, Shilpa Chakravartula et al.
doi:10.1038/ncb3443
Costa et al. show that asymmetric positioning of the mitotic spindle during endothelial tip cell divisions produces daughter cells of different sizes and the ensuing asymmetry of Vegfr distribution drives Notch-independent tip/stalk cell selection.

Developmentally programmed germ cell remodelling by endodermal cell cannibalism   pp1302 - 1310
Yusuff Abdu, Chelsea Maniscalco, John M. Heddleston, Teng-Leong Chew and Jeremy Nance
doi:10.1038/ncb3439
Caenorhabditis elegans primordial germ cells (PGCs) transiently extend large lobes, which are found to be actively removed and digested by endodermal cells to alter PGC content in a process dependent on actin and dynamin.

See also: News and Views by Heppert & Goldstein

Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells   pp1311 - 1323
Arnold Hayer, Lin Shao, Mingyu Chung, Lydia-Marie Joubert, Hee Won Yang et al.
doi:10.1038/ncb3438
Hayer et al. observe that collectively migrating endothelial cells extend rear VE-cadherin-rich membrane structures that are engulfed by follower cells, correlating spatially with the direction of movement.

See also: News and Views by Das & Spatz

Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases   pp1324 - 1335
Suyong Choi, Andrew C. Hedman, Samar Sayedyahossein, Narendra Thapa, David B. Sacks et al.
doi:10.1038/ncb3441
Anderson et al. show that IQ-motif-containing GTPase-activating protein 1 (IQGAP1) acts as a scaffold for the phosphoinositide kinases that mediate the sequential phosphorylation of phosphoinositides to generate PtdIns(3,4,5)P3 and downstream signalling.

See also: News and Views by Rameh & Mackey

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression   pp1336 - 1345
Yekaterina A. Miroshnikova, Janna K. Mouw, J. Matthew Barnes, Michael W. Pickup, Johnathan N. Lakins et al.
doi:10.1038/ncb3429
Weaver and colleagues report that enrichment of the extracellular matrix with tenascin C promotes aggressiveness of IDH1-mutant glioblastoma by activating a HIF1α-controlled mechanosignalling feedback loop.

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours   pp1346 - 1356
Leander Blaas, Fabio Pucci, Hendrik A. Messal, Agneta B. Andersson, E. Josue Ruiz et al.
doi:10.1038/ncb3434
Blaas et al. traced Lgr6+ cells during mammary gland formation, homeostasis, pregnancy and tumorigenesis, and found that they represent a population of unipotent progenitors that contribute to alveologenesis and can initiate luminal mammary tumours.

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Letter

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SCAI promotes DNA double-strand break repair in distinct chromosomal contexts   pp1357 - 1366
Rebecca Kring Hansen, Andreas Mund, Sara Lund Poulsen, Maria Sandoval, Karolin Klement et al.
doi:10.1038/ncb3436
Hansen et al. find that SCAI (suppressor of cancer cell invasion) is a 53BP1-binding protein that acts to repair in heterochromatin and to facilitate meiotic recombination in germ cells.

Erratum

Top

Erratum: Activating ATR, the devil's in the dETAA1l   p1367
Wojciech Niedzwiedz
doi:10.1038/ncb3448

Top
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