Tuesday, November 29, 2016

Nature Cell Biology contents: December 2016 Volume 18 Number 12, pp 1261 - 1367

If you are unable to see the message below, click here to view.
Nature Cell Biology


Introducing the Eclipse Ti2 Inverted Microscope from Nikon.
With its unprecedented 25mm field of view, you can capture twice as much
data with a single image. The 4th generation Perfect Focus System combined
with a completely redesigned Z-drive provide a super-stable imaging platform
with high-precision focusing for demanding applications.

For more info, go to www.nikon-ti2.com and stop by Nikon's booth at ASCB.

December 2016 Volume 18, Issue 12

News and Views
Deeper and Broader Analysis of the Metabolome

No one type of analytical separation or detection technique is capable of characterizing the entire metabolome at once. A suite of technologies can offer broader and deeper analyses into the metabolome - from sample collection to interpretation. 

Learn more
about solutions designed to meet your metabolomics goals.

Recommend to library
Nature Outlook: Lysosomal Storage Disorders

Lysosomal storage disorders are individually rare but collectively common. The study of these diseases is not only leading to better treatments, but also revealing many of the secrets of this underappreciated organelle. 

Access the Outlook >

Produced with support from: 
Alexion Pharmaceuticals, Inc.
Ultragenyx Pharmaceutical Inc.

Produced with support of a grant from:
Shire plc
BioMarin Pharmaceutical Inc

In January 2017 Cell Press will take over publishing the Molecular Therapy family of journals. To keep receiving e-alerts for these titles, please visit http://www.cell.com/molecular-therapy-family/home



Andrzej K. Tarkowski 1933-2016   p1261
Magdalena Zernicka-Goetz

News and Views


IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3   pp1263 - 1265
Lucia E. Rameh and Ashley M. Mackey
Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli.

See also: Article by Choi et al.

Getting a grip on collective cell migration   pp1265 - 1267
Tamal Das and Joachim P. Spatz
Many cell types in our body move in a collective manner, which requires individual cells to align their movements relative to that of their neighbours. A mechanism is now described in which cadherin-rich protrusions are extended from leading migrating cells and engulfed by follower cells to guide collective migration.

See also: Article by Hayer et al.

Remodelling germ cells by intercellular cannibalism   pp1267 - 1268
Jennifer K. Heppert and Bob Goldstein
Work from the early 1980s reported strange lobes protruding from Caenorhabditis elegans germ cell precursors. However, the fate and potential significance of these lobes remained unexplored for decades. Now, neighbouring endodermal cells are shown to sever and digest these lobes, in an unexpected process of 'intercellular cannibalism', which could play an important part in regulating primordial germ cells.

See also: Article by Abdu et al.

Cell Biology
JOBS of the week
Director of the Stem Cell Biology Program
University of Illinois at Chicago - Pharmacology
Scientific Editor, Cell Press
Postdoctoral Scientist in Molecular genetics of human T cell development
Ghent University
Postdoc Positions in Cell Biology and Molecular Neuroscience Laboratory
Lee Kong Chian School of Medicine, Joint medical school between, Imperial College London and Nanyang Technological University in Singapore
Scientist (Ph.D)-Stem cell and ovarian tissue Engineering
Fuent Biotechnology (shanghai) Co.,Ltd.
More Science jobs from
Cell Biology
Genome rearrangements and mutation signatures in development and cancer
Boston, USA
More science events from
Need access to Nature Plants at your workplace or institution? Site license access offers full online content plus added benefits! 

Recommend site license access to your librarian.



Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors   pp1269 - 1280
Michael M. Kaminski, Jelena Tosic, Catena Kresbach, Hannes Engel, Jonas Klockenbusch et al.
Kaminski et al. demonstrate that combined expression of the transcription factors Emx2, Hnf1b, Hnf4a and Pax8 converts mouse and human fibroblasts into induced renal tubular epithelial cells.

Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation   pp1281 - 1291
Nitya Ramkumar, Tatiana Omelchenko, Nancy F. Silva-Gagliardi, C. Jane McGlade, Jan Wijnholds et al.
Ramkumar et al. demonstrate that Crumbs2 is required in the cells of the primitive streak to promote cell ingression during the epithelial-to-mesenchymal transition, and maintains the integrity of the epiblast.

Asymmetric division coordinates collective cell migration in angiogenesis   pp1292 - 1301
Guilherme Costa, Kyle I. Harrington, Holly E. Lovegrove, Donna J. Page, Shilpa Chakravartula et al.
Costa et al. show that asymmetric positioning of the mitotic spindle during endothelial tip cell divisions produces daughter cells of different sizes and the ensuing asymmetry of Vegfr distribution drives Notch-independent tip/stalk cell selection.

Developmentally programmed germ cell remodelling by endodermal cell cannibalism   pp1302 - 1310
Yusuff Abdu, Chelsea Maniscalco, John M. Heddleston, Teng-Leong Chew and Jeremy Nance
Caenorhabditis elegans primordial germ cells (PGCs) transiently extend large lobes, which are found to be actively removed and digested by endodermal cells to alter PGC content in a process dependent on actin and dynamin.

See also: News and Views by Heppert & Goldstein

Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells   pp1311 - 1323
Arnold Hayer, Lin Shao, Mingyu Chung, Lydia-Marie Joubert, Hee Won Yang et al.
Hayer et al. observe that collectively migrating endothelial cells extend rear VE-cadherin-rich membrane structures that are engulfed by follower cells, correlating spatially with the direction of movement.

See also: News and Views by Das & Spatz

Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases   pp1324 - 1335
Suyong Choi, Andrew C. Hedman, Samar Sayedyahossein, Narendra Thapa, David B. Sacks et al.
Anderson et al. show that IQ-motif-containing GTPase-activating protein 1 (IQGAP1) acts as a scaffold for the phosphoinositide kinases that mediate the sequential phosphorylation of phosphoinositides to generate PtdIns(3,4,5)P3 and downstream signalling.

See also: News and Views by Rameh & Mackey

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression   pp1336 - 1345
Yekaterina A. Miroshnikova, Janna K. Mouw, J. Matthew Barnes, Michael W. Pickup, Johnathan N. Lakins et al.
Weaver and colleagues report that enrichment of the extracellular matrix with tenascin C promotes aggressiveness of IDH1-mutant glioblastoma by activating a HIF1α-controlled mechanosignalling feedback loop.

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours   pp1346 - 1356
Leander Blaas, Fabio Pucci, Hendrik A. Messal, Agneta B. Andersson, E. Josue Ruiz et al.
Blaas et al. traced Lgr6+ cells during mammary gland formation, homeostasis, pregnancy and tumorigenesis, and found that they represent a population of unipotent progenitors that contribute to alveologenesis and can initiate luminal mammary tumours.

Nature Index 2016 Australia & New Zealand

Nature Index 2016 Australia and New Zealand highlights the quality natural science research within these countries. This supplement examines the cities and institutions that largely contribute to the research as well as the factors that drive their success. 

Access the free supplement for six months!



SCAI promotes DNA double-strand break repair in distinct chromosomal contexts   pp1357 - 1366
Rebecca Kring Hansen, Andreas Mund, Sara Lund Poulsen, Maria Sandoval, Karolin Klement et al.
Hansen et al. find that SCAI (suppressor of cancer cell invasion) is a 53BP1-binding protein that acts to repair in heterochromatin and to facilitate meiotic recombination in germ cells.



Erratum: Activating ATR, the devil's in the dETAA1l   p1367
Wojciech Niedzwiedz

Springer Nature presents a custom webcast on: Nutrition and brain health

Date: Thursday December 1, 2016

Register for the webcast and live Q&A session

Sponsored by:
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our customer feedback department

Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

nature publishing group

No comments: