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|  | The November/December 2016 issue contains a Special Feature on Novel aspects of autoimmunity. Major scientific advances often arise at the interface of disciplines, or are made possible by transformative technological advances. Progress in our understanding of the basis of autoimmunity over recent years provides great examples of this, and we have selected four of these to highlight in this ICB Special Feature. Together these articles reveal how recent technological advances have revealed important mechanisms underlying autoimmune disease, mechanisms that can now be examined in humans as well as mouse models. Our increasing ability to conduct in-depth studies in humans promises to continue to unlock the mysteries underlying autoimmunity, with inevitable benefits to patients with these diseases. Immunology & Cell Biology thanks the coordinators of this Special Feature – Ken Smith and Arthur Kaser – for their planning and input. |  | TABLE OF CONTENTS
|  |  |  | Volume 94, Issue 10 (November/December 2016) |  | In this issue Editorial News and Commentaries Outstanding Observation Editorial Reviews Perspective Original Articles Short Communication | |  |  | Editorial | Top |  | Immunology & Cell Biology Publication of the Year Awards 2015Gabrielle Belz Immunol Cell Biol 2016 94: 901-902; 10.1038/icb.2016.86 Full Text |  | News and Commentaries | Top |  | IL-1β/CD14 pathway induces IL-17 production: Dendritic cells activated with IL-1β set Th17 cells on fire by CD14-mediated mechanismsJimena Tosello Boari and Eva V Acosta Rodriguez Immunol Cell Biol 2016 94: 903-904; advance online publication, October 11, 2016; 10.1038/icb.2016.87 Full Text See also: Outstanding Observation by Ilarregui et al. |  |  |  | Mediating signaling response to actin-mediated forces: Cas-L is causal in the T-cell response to forces triggered by antigen presentationYe Chen and Sarah M Russell Immunol Cell Biol 2016 94: 905-906; advance online publication, September 20, 2016; 10.1038/icb.2016.79 Full Text See also: Original Article by Santos et al. |  | Outstanding Observation | Top |  | New roles for CD14 and IL-β linking inflammatory dendritic cells to IL-17 production in memory CD4+ T cellsJuan M Ilarregui, Astrid J van Beelen, Cynthia M Fehres, Sven C M Bruijns, Juan J García-Vallejo and Yvette van Kooyk Immunol Cell Biol 2016 94: 907-916; advance online publication, August 23, 2016; 10.1038/icb.2016.66 Abstract | Full Text See also: News and Commentary by Tosello BoariAcosta Rodriguez |  | Editorial | Top |  | Novel aspects of autoimmunityKenneth GC Smith and Arthur Kaser Immunol Cell Biol 2016 94: 917; 10.1038/icb.2016.90 Full Text | PDF |  | Reviews | Top |  | Germinal centers and autoimmune disease in humans and miceAnthony L DeFranco Immunol Cell Biol 2016 94: 918-924; advance online publication, August 26, 2016; 10.1038/icb.2016.78 Abstract | Full Text |  |  |  | Immunometabolism and autoimmunityJenny Freitag, Luciana Berod, Thomas Kamradt and Tim Sparwasser Immunol Cell Biol 2016 94: 925-934; advance online publication, October 11, 2016; 10.1038/icb.2016.77 Abstract | Full Text |  |  |  | T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseasesEoin F McKinney and Kenneth GC Smith Immunol Cell Biol 2016 94: 935-942; 10.1038/icb.2016.81 Abstract | Full Text |  |  |  | Rare phenotypes in the understanding of autoimmunityYvonne Zeissig, Britt-Sabina Petersen, Andre Franke, Richard S Blumberg and Sebastian Zeissig Immunol Cell Biol 2016 94: 943-948; advance online publication, October 11, 2016; 10.1038/icb.2016.76 Abstract | Full Text |  | Perspective | Top |  | IgG subclass co-expression brings harmony to the quartet model of murine IgG functionAndrew M Collins Immunol Cell Biol 2016 94: 949-954; advance online publication, August 9, 2016; 10.1038/icb.2016.65 Abstract | Full Text |  | Original Articles | Top |  | Plasmin and regulators of plasmin activity control the migratory capacity and adhesion of human T cells and dendritic cells by regulating cleavage of the chemokine CCL21Natalie Lorenz, Evert Jan Loef, Inken D Kelch, Daniel J Verdon, Moyra M Black, Martin J Middleditch, David R Greenwood, E Scott Graham, Anna ES Brooks, P Rod Dunbar and Nigel P Birch Immunol Cell Biol 2016 94: 955-963; advance online publication, June 15, 2016; 10.1038/icb.2016.56 Abstract | Full Text |  |  |  | Autophagy and proteasome interconnect to coordinate cross-presentation through MHC class I pathway in B cellsVijayendra Dasari, Sweera Rehan, Siok-Keen Tey, Mark J Smyth, Corey Smith and Rajiv Khanna Immunol Cell Biol 2016 94: 964-974; advance online publication, June 14, 2016; 10.1038/icb.2016.59 Abstract | Full Text |  |  |  | Distinct recirculation potential of CD69+CD103− and CD103+ thymic memory CD8+ T cellsSimone L Park, Laura K Mackay and Thomas Gebhardt Immunol Cell Biol 2016 94: 975-980; advance online publication, June 22, 2016; 10.1038/icb.2016.60 Abstract | Full Text |  |  |  | Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability OPENLuís C Santos, David A Blair, Sudha Kumari, Michael Cammer, Thomas Iskratsch, Olivier Herbin, Konstantina Alexandropoulos, Michael L Dustin and Michael P Sheetz Immunol Cell Biol 2016 94: 981-993; advance online publication, June 30, 2016; 10.1038/icb.2016.61 Abstract | Full Text See also: News and Commentary by ChenRussell |  | Short Communication | Top |  | Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases OPENJulie Jurczyluk, Marcia A Munoz, Oliver P Skinner, Ryan C Chai, Naveid Ali, Umaimainthan Palendira, Julian MW Quinn, Alexandra Preston, Stuart G Tangye, Andrew J Brown, Elizabeth Argent, John B Ziegler, Sam Mehr and Michael J Rogers Immunol Cell Biol 2016 94: 994-999; advance online publication, July 5, 2016; 10.1038/icb.2016.58 Abstract | Full Text |  |  |  |  | Advertisement |  | Brought to you by the editorial team of Immunology & Cell Biology, Clinical & Translational Immunology is an open access, fully peer-reviewed journal devoted to publishing cutting-edge advances in biomedical research for scientists and physicians.
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