The EMBO Journal Table of Contents for 17 October 2016; Vol. 35, No. 20

17 October 2016 | Volume 35, Number 20 Submit Table of Contents News & Views Articles Corrigendum Volume 35, Number 20 News & Views Pore formation by GSDMD is the effector mechanism of pyroptosis During pyroptosis, an N‐terminal cleavage fragment of gasdermin D relocates to the plasma membrane, forming pores that trigger pro‐inflammatory cell death. Moritz M Gaidt and Veit Hornung Published online 29.08.2016 Articles Contribution of intertwined loop to membrane association revealed by Zika virus full‐length NS1 structure The crystal structure of the Zika virus NS1 protein reveals an extended intertwined loop forming a hydrophobic “spike” that contributes to cellular membrane association. Xiaoying Xu, Hao Song, Jianxun Qi, Yuqian Liu, Haiyuan Wang, Chao Su, Yi Shi, and George F Gao Published online 30.08.2016 TUT‐DIS3L2 is a mammalian surveillance pathway for aberrant structured non‐coding RNAs Aberrant RNAs originating from all three nuclear RNA polymerases are targeted by a TUT/DIS3L2 surveillance system, implicating Perlman syndrome exoribonuclease DIS3L2 as a key player in uridylation‐mediated cytoplasmic RNA decay. Dmytro Ustianenko, Josef Pasulka, Zuzana Feketova, Lukas Bednarik, Dagmar Zigackova, Andrea Fortova, Mihaela Zavolan, and Stepanka Vanacova Published online 19.09.2016 FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma A GSK3‐dependent phosphodegron controls ubiquitination of the oncogenic transcription factor SOX9 via the tumor suppressor FBW7 and provides a potential therapeutic target. Aldwin Suryo Rahmanto, Vasil Savov, Andrä Brunner, Sara Bolin, Holger Weishaupt, Alena Malyukova, Gabriela Rosén, Matko Čančer, Sonja Hutter, Anders Sundström, Daisuke Kawauchi, David TW Jones, Charles Spruck, Michael D Taylor, Yoon‐Jae Cho, Stefan M Pfister, Marcel Kool, Andrey Korshunov, Fredrik J Swartling, and Olle Sangfelt Published online 13.09.2016 Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis Loss of APP in the adult brain impairs dendritic spine dynamics and plasticity leading to cognitive deficits. Chengyu Zou, Sophie Crux, Stephane Marinesco, Elena Montagna, Carmelo Sgobio, Yuan Shi, Song Shi, Kaichuan Zhu, Mario M Dorostkar, Ulrike C Müller, and Jochen Herms Published online 29.08.2016 An essential step of kinetochore formation controlled by the SNARE protein Snap29 Snap29 is a SNARE and as such it mediates membrane fusion events. Additionally, Snap29 is shown here to have a role in kinetochore formation that is independent from its function as a SNARE. Elena Morelli, Valeria Mastrodonato, Galina V Beznoussenko, Alexandre A Mironov, Emiliana Tognon, and Thomas Vaccari Published online 19.09.2016 The effects of proteasomal inhibition on synaptic proteostasis A systematic proteome analysis reveals that degradation rates for most synaptic proteins are not affected by inhibiting the ubiquitin‐proteasome system. Vicky Hakim, Laurie D Cohen, Rina Zuchman, Tamar Ziv, and Noam E Ziv Published online 09.09.2016 Corrigendum The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth Ruzica Bago, Eeva Sommer, Pau Castel, Claire Crafter, Fiona P Bailey, Natalia Shpiro, José Baselga, Darren Cross, Patrick A Eyers, and Dario R Alessi Published online 16.10.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.