Nature Reviews Neuroscience contents November 2016 Volume 17 Number 11 pp 667 - 717

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November 2016 Volume 17 Number 11		Advertisement
2015 2-year Impact Factor 29.298 Journal Metrics 2-year Median 22	In this issue Comment Research Highlights Progress Reviews Also this month Article series: Scaling up neuroscience  Featured article: Circuit modules linking internal states and social behaviour in flies and mice David J. Anderson	nature.com webcasts Springer Nature presents a custom webcast on: uDISCO for whole organs and organisms: A new way of large sample imaging Date: Thursday October 27, 2016 Time: 8AM PDT, 11AM EDT, 4PM BST, 5PM CEST Register for FREE Sponsored by: Bitplane LaVision Biotech Andor Technology
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Article series: Scaling up neuroscience Comment: Blending computational and experimental neuroscience Patricia S. Churchland & Terrence J. Sejnowski p667 | doi:10.1038/nrn.2016.114 Churchland and Sejnowski consider how the BRAIN Initiative will bring together theoretical and experimental neuroscience to drive the development of conceptual frameworks of brain function. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Adult neurogenesis: Encouraging integration p669 | doi:10.1038/nrn.2016.136 Adult neurogenesis in the hippocampus is regulated by existing hippocampal connectivity and can be manipulated to enhance memory function in aged mice. PDF Neuronal development: Signalling synaptogenesis p670 | doi:10.1038/nrn.2016.137 Early in development, GABA released from interneurons is excitatory and induces the formation of functional inhibitory and excitatory synapses in cortical layer 2/3. PDF Reward: Calculating error p670 | doi:10.1038/nrn.2016.139 Inputs to the ventral tegmental area, which computes the reward prediction error, carry diverse signals about the actual and expected reward from distributed areas. PDF Neurodegenerative disease: A mechanism for missing memory 70 | doi:10.1038/nrn.2016.142 A loss of cholinergic inputs to the hippocampus in a mouse model of Alzheimer disease leads to memory deficits by affecting interneurons in the oriens lacunosum moleculare. PDF IN BRIEF Neuronal development: Forcing axon pathfinding | Neurogenetics: Accelerating towards mental illness | Synaptic plasticity: TARP target | Neuroimmunology: Waking the immune system PDF Nature Reviews Neuroscience JOBS of the week Post-Doctoral Fellow in Neuroscience Washington University School of Medicine Post-Doctoral Fellow in Neuroscience, Optogenetics, and Imaging Washington University School of Medicine Neuroscience Faculty Member-University of Illinois at Urbana Champaign University of Illinois at Urbana/Champaign Faculty Position In Theoretical Neuroscience Cold Spring Harbor Laboratory (CSHL) Postdoctoral position in Neuroscience: Neural Circuits underlying behavior Max Planck Society, caesar More Science jobs from Nature Reviews Neuroscience EVENT 2nd International Brain Stimulation Conference 05.03.17 Barcelona, Spain More science events from
PROGRESS		Top
Topoisomerases and the regulation of neural function Peter J. McKinnon p673 | doi:10.1038/nrn.2016.101 Topoisomerases catalyse DNA-strand breaks that help to relieve torsional stress and maintain cellular homeostasis. Here, McKinnon describes the importance of topoisomerase function for the normal operation of the nervous system and considers how aberrant topoisomerase activity can contribute to neurologic disease. Abstract | Full Text | PDF
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REVIEWS		Top
Spatial genome organization and cognition Prashanth Rajarajan, Sergio Espeso Gil, Kristen J. Brennand & Schahram Akbarian p681 | doi:10.1038/nrn.2016.124 Promoter-enhancer loopings and other features of the 3D genome are dynamically regulated in the brain. In this Review, Akbarian and colleagues discuss how neuronal and glial gene expression is governed by the 3D genome, with implications for cognition and neuropsychiatric disease. Abstract | Full Text | PDF
Circuit modules linking internal states and social behaviour in flies and mice David J. Anderson p692 | doi:10.1038/nrn.2016.125 Small populations of interneurons in mice and in Drosophila melanogaster have been shown to control both mating and aggression. Here, David Anderson proposes that these neuron populations may represent a conserved or analogous circuit node that controls reproductive behaviours in animals by promoting internal motivational, arousal or drive states. Abstract | Full Text | PDF
Lasting impact of general anaesthesia on the brain: mechanisms and relevance Laszlo Vutskits & Zhongcong Xie p705 | doi:10.1038/nrn.2016.128 Some epidemiological studies suggest associations between general anaesthesia and long-term cognitive dysfunction in children and the elderly, although these remain to be proven. Here, Vutskits and Xie review the evidence for general anaesthetic-induced cognitive impairment in young and old rodents and non-human primates, and the potential underlying mechanisms. Abstract | Full Text | PDF
Mind-wandering as spontaneous thought: a dynamic framework Kalina Christoff et al. p718 | doi:10.1038/nrn.2016.113 Mind-wandering is often defined as task-unrelated or stimulus-unrelated thought. In this Review, Christoff and colleagues present a definition for mind-wandering that places more emphasis on the dynamic nature of this process. They also examine the brain networks underlying mind-wandering and its involvement in various brain disorders. Abstract | Full Text | PDF
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