Nature Reviews Immunology Contents November 2016 Volume 16 Number 11 pp 657-714

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TABLE OF CONTENTS
November 2016 Volume 16 Number 11		Advertisement
2015 2-year Impact Factor 39.416 Journal Metrics 2-year Median 31	In this issue Research Highlights Reviews Also this month  Featured article: Interleukin-33 in health and disease Foo Yew Liew, Jean-Philippe Girard & Heth Roderick Turnquist	nature.com webcasts Springer Nature presents a custom webcast on Advancements in single-cell RNA-seq: differential expression analysis and immune profiling November 3, 2016; 9AM PDT, 12PM EDT, 4PM GMT, 5PM CET Learn about the latest advancements in single-cell RNA-seq and its application in whole transcriptome analysis and immune profiling. Register for FREE Sponsored by  Takara Bio USA, Inc.
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nature.com webcasts Springer Nature presents a custom webcast on: Autophagy in the hematopoietic system Date: Wednesday November 16, 2016 Time: 8AM PST, 11AM EST, 4PM GMT, 5PM CEST  Register for FREE  Sponsored by:  Merck KGaA, Darmstadt, Germany. The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada
RESEARCH HIGHLIGHTS Top Dendritic cells: Sorting, sorted! p657 | doi:10.1038/nri.2016.115 Automated analyses of high-dimensional data can align dendritic cell subsets from different tissues and across species. PDF T cell development: Shaping organ-specific γδ T cells p658 | doi:10.1038/nri.2016.118 Epithelium-derived butyrophilin-like (BTNL) molecules can shape the local γδ T cell repertoire in a tissue-specific manner. PDF Tumour immunology: Suppressive metabolites p658 | doi:10.1038/nri.2016.119 Tumour-derived lactic acid dampens the activation and cytokine production of infiltrating T cells and natural killer cells, allowing tumours to escape immune detection and promoting tumour growth. PDF Regulatory T CELLS: Suppressing antibody production p659 | doi:10.1038/nri.2016.121 T follicular regulatory cells suppress antibody production through the induction of a unique suppressive state in T follicular helper cells and B cells. PDF JOURNAL CLUB Trafficking patterns of mononuclear phagocytes p660 | doi:10.1038/nri.2016.110 Gwendalyn Randolph describes a 1981 paper by Ross Gerrity that stimulated her career focus on the trafficking of mononuclear phagocytes. PDF Antibodies: Marking disease states in tuberculosis p660 | doi:10.1038/nri.2016.120 Antibodies from individuals with latent and active tuberculosis infections show distinct glycosylation patterns and Fc-dependent effector functions. PDF Immunology JOBS of the week Postdoctoral Fellow / Microbiology, Immunology & Biochemistry The University of Tennessee Health Science Center Postdoctoral Fellowship Immunology BRIGHAM AND WOMEN’S HOSPITAL HARVARD MEDICAL SCHOOL Postdoc in Immunology Klinikum der Universität München (3) Faculty Positions in Immunology Ohio State University MicroSurgeon Position in Transplant Immunology Cleveland Clinic Lerner Research Institute More Science jobs from Immunology EVENT Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology 19.03.17 Whistler, Canada More science events from
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REVIEWS		Top
Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis Ken Cadwell p661 | doi:10.1038/nri.2016.100 This article provides a comprehensive overview of the general functions of autophagy in immunity, the interactions between autophagy and immune signalling pathways and the role of autophagy-immune crosstalk in multicellular immune responses and disease. Abstract | Full Text | PDF
Interleukin-33 in health and disease Foo Yew Liew, Jean-Philippe Girard & Heth Roderick Turnquist p676 | doi:10.1038/nri.2016.95 The cytokine interleukin-33 was first identified as an inducer of type 2 immune responses. It has now been shown to have pleiotropic activities on multiple immune cell types and is involved in numerous infectious and inflammatory diseases, as described in this Review. Abstract | Full Text | PDF | Supplementary information
Regulation of T cell signalling by membrane lipids Wei Wu, Xiaoshan Shi & Chenqi Xu p690 | doi:10.1038/nri.2016.103 This Review describes the major lipid species found in the plasma membrane of mammalian cells and highlights the importance of these lipids for regulating T cell signalling. Recent studies have shown that drugs modulating the membrane lipid composition in T cells can alter their immune functions — the authors discuss the potential for such lipid-based immunotherapies in autoimmunity and cancer. Abstract | Full Text | PDF
PI3Kδ and primary immunodeficiencies Carrie L. Lucas et al. p702 | doi:10.1038/nri.2016.93 Gain- and loss-of-function mutations in phosphoinositide 3-kinase-δ (PI3Kδ) result in a primary immunodeficiency syndrome termed APDS. Understanding the function of PI3Kδ in adaptive immune responses — from studies of mouse models of these mutations and from patients with APDS — provides new insights on how mutations in PI3Kδ promote immunodeficiencies. Abstract | Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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