Nature Reviews Genetics Contents November 2016 Volume 17 Number 11 pp657-714

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TABLE OF CONTENTS
November 2016 Volume 17 Number 11
2015 2-year Impact Factor 35.898 Journal Metrics 2-year Median 32	In this issue Research Highlights Reviews Perspectives Also this month Article series: Applications of next-generation sequencing  Featured article: Organization and function of the 3D genome Boyan Bonev & Giacomo Cavalli
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RESEARCH HIGHLIGHTS Top Population genomics: Off the beaten track p657 | doi:10.1038/nrg.2016.135 PDF Disease genetics: Under pressure [mdash] genetics of hypertension p658 | doi:10.1038/nrg.2016.128 PDF Mobile elements: Putting the brakes on ageing p658 | doi:10.1038/nrg.2016.129 PDF Genetic screens: A global map of genetic interactions p659 | doi:10.1038/nrg.2016.136 PDF Metagenomics: Marine genomics goes viral p660 | doi:10.1038/nrg.2016.130 PDF Genetic engineering: Allele-specific genome editing of disease loci p660 | doi:10.1038/nrg.2016.131 PDF
REVIEWS		Top
Organization and function of the 3D genome Boyan Bonev & Giacomo Cavalli p661 | doi:10.1038/nrg.2016.112 In this article the authors review current knowledge on chromatin architecture and the molecular mechanisms that underlie it. They discuss how three-dimensional (3D) organization of chromatin relates to gene expression, development and disease, and consider its effect on genome evolution. Abstract | Full Text | PDF
Detecting circular RNAs: bioinformatic and experimental challenges Linda Szabo & Julia Salzman p679 | doi:10.1038/nrg.2016.114 Circular RNAs (circRNAs) are pervasively expressed in eukaryotic genomes, representing the major transcript isoform for many genes. In this article, the authors review sources of experimental and bioinformatic biases that complicate the accurate discovery of circRNAs and discuss statistical approaches used by published algorithms to address these biases. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Transition states and cell fate decisions in epigenetic landscapes Naomi Moris, Cristina Pina & Alfonso Martinez Arias p693 | doi:10.1038/nrg.2016.98 Formal representations of Waddington's epigenetic landscape represent cell fate decisions as smooth, continuous events in which cells follow predetermined trajectories. Here, the authors provide an alternative interpretation and posit that fate decisions are discontinuous, stochastic events within cell lineages. Abstract | Full Text | PDF
OPINION Article series: Applications of next-generation sequencing Genetic drift, selection and the evolution of the mutation rate Michael Lynch et al. p704 | doi:10.1038/nrg.2016.104 Mutation is the source of genetic diversity on which natural selection acts, therefore understanding the rates of mutations is crucial for understanding evolutionary trajectories. In this Opinion article, the authors discuss how emerging experimental mutation-rate data from genome-wide sequencing studies, combined with population-genetic theory, can provide unifying explanations for the diversity in mutation rates between species and across genomic locations. Abstract | Full Text | PDF | Supplementary information
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*2015 Journal Citation Report (Thomson Reuters, 2016)

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