Nature Reviews Cancer contents November 2016 Volume 16 Number 11 pp675-749

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TABLE OF CONTENTS
November 2016 Volume 16 Number 11		Advertisement
Impact Factor 34.244 *	In this issue Research Highlights Focus on: Tumour metabolism Reviews Also this month  Featured article: Altered metabolite levels in cancer: implications for tumour biology and cancer therapy Lucas B. Sullivan, Dan Y. Gui & Matthew G. Vander Heiden	Determine the Metabolic Phenotype of Your Cells The Agilent Seahorse XF Cell Energy Phenotype Test uses as few as 15,000 cells, and the Agilent Seahorse XFp Analyzer, to identify your cells' metabolic phenotype, as well as their metabolic potential — the relative utilization of mitochondrial respiration and glycolysis. http://bit.ly/1Caw9Eq
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RESEARCH HIGHLIGHTS Top Tumour metabolism: Translating the undruggable target p675 | doi:10.1038/nrc.2016.107 Three studies demonstrate the preclinical potential of a novel class of hypoxia-inducible factor 2α (HIF2α) antagonists in the treatment of von Hippel–Lindau (pVHL)-deficient clear cell renal cell carcinoma. PDF Tumour metabolism: Reflecting their origins p676 | doi:10.1038/nrc.2016.106 Mayers, Torrence et al. show that lung tumours driven by oncogenic KRAS and loss of p53 depend on branched-chain amino acid metabolism, whereas pancreatic tumours driven by the same genetic defects do not. PDF Tumour metabolism: Lactic acid: not just a waste product? p676 | doi:10.1038/nrc.2016.109 Brand and colleagues show that increased tumour lactate dehydrogenase A (LDHA)-mediated lactic acid production dampens activation and cytokine production of infiltrating T and natural killer (NK) cells allowing tumours to escape immune detection and promoting tumour growth. PDF Tumour metabolism: Building up and breaking down fatty acids p677 | doi:10.1038/nrc.2016.111 Two studies have looked at the roles of fatty acid synthesis and oxidation, and their therapeutic potential, in cancer. PDF Cell differentiation: Pushing differentiation p678 | doi:10.1038/nrc.2016.110 Cell differentiation blockade in the early stages of AML can be overcome by inhibiting dihydroorotate dehydrogenase PDF IN BRIEF Tumour metabolism: Location matters | Immunotherapy: Checkpoint barriers | Tumour metabolism: Targeting proline metabolism? | Immunology: Skin inflammation predisposes to cancer PDF Cancer JOBS of the week Professor, Term Tenure - Department of Cancer Systems Imaging The University of Texas MD Anderson Cancer Center Chief, Cancer Data Science Laboratory, Tenure Eligible Position National Institutes of Health (NIH), National Cancer Institute (NCI) Cancer Biologist Wake Forest Baptist Medical Center, Comprehensive Cancer Center Principal Scientist - Imaging, Cancer Immunotherapy F. Hoffmann-La Roche AG 858160 Group Leader Position in Pancreatic Cancer (fixed-term, 6 years) Faculty of Health and Medical Sciences, the Danish Stem Cell Center, University of Copenhagen More Science jobs from
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Focus on: Tumour metabolism REVIEWS Top Altered metabolite levels in cancer: implications for tumour biology and cancer therapy Lucas B. Sullivan, Dan Y. Gui & Matthew G. Vander Heiden p680 | doi:10.1038/nrc.2016.85 Altered cancer cell metabolism can result in intracellular metabolite concentration changes. This Review discusses the mechanisms that lead to metabolite concentration changes in cancer cells, the consequences of these changes and how they might be exploited to improve cancer therapy. Abstract | Full Text | PDF Metabolic control of epigenetics in cancer Adam Kinnaird, Steven Zhao, Kathryn E. Wellen & Evangelos D. Michelakis p694 | doi:10.1038/nrc.2016.82 Alterations in the epigenome and metabolism bidirectionally regulate molecular rewiring in cancer cells. This Review discusses how metabolic remodelling can contribute to tumour epigenetic alterations, thereby affecting cancer cell differentiation, proliferation and/or apoptosis as well as therapeutic responses. Abstract | Full Text | PDF The metabolic fate of acetate in cancer Zachary T. Schug, Johan Vande Voorde & Eyal Gottlieb p708 | doi:10.1038/nrc.2016.87 This Review discusses how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention. Abstract | Full Text | PDF The interplay between cell signalling and the mevalonate pathway in cancer Peter J. Mullen et al. p718 | doi:10.1038/nrc.2016.76 The mevalonate (MVA) pathway is an essential metabolic pathway that is affected by many oncogenic signalling pathways. This Review discusses the opportunity to immediately target the MVA pathway in cancer with agents approved for other therapeutic uses, such as statins. Abstract | Full Text | PDF The multifaceted roles of fatty acid synthesis in cancer Florian Röhrig & Almut Schulze p732 | doi:10.1038/nrc.2016.89 Lipid metabolism, especially fatty acid (FA) synthesis, is essential for membrane biosynthesis, energy storage and the generation of signalling molecules. This Review explores how FA synthesis promotes tumorigenesis and tumour progression and might be targeted therapeutically. Abstract | Full Text | PDF | Supplementary information
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Corrigendum: From Krebs to clinic: glutamine metabolism to cancer therapy Brian J. Altman, Zachary E. Stine & Chi V. Dang p749 | doi:10.1038/nrc.2016.114 Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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