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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors OPEN | | | R. A. Pearson, A. Gonzalez-Cordero, E. L. West, J. R. Ribeiro, N. Aghaizu, D. Goh, R. D. Sampson, A. Georgiadis, P. V. Waldron, Y. Duran, A. Naeem, M. Kloc, E. Cristante, K. Kruczek, K. Warre-Cornish, J. C. Sowden, A. J. Smith and R. R. Ali | | | Transplantation of healthy photoreceptor cells has been shown to rescue blindness. Here, the authors show that rather than donor cells integrating into the host retina, the predominant mechanism underlying this rescue involves exchange of cytoplasmic material between donor and host cells in vivo. | | | 04 October 2016 | doi: 10.1038/ncomms13029 | | |
| Divergent effects of central melanocortin signalling on fat and sucrose preference in humans OPEN | | | Agatha A. van der Klaauw, Julia M. Keogh, Elana Henning, Cheryl Stephenson, Sarah Kelway, Victoria M. Trowse, Naresh Subramanian, Stephen O’Rahilly, Paul C. Fletcher and I. Sadaf Farooqi | | | Hypothalamic melanocortin-4-receptors (MC4R) regulate food preference in rodents, but their role in humans is unclear. Here, the authors perform food preference and liking tests in humans with MC4R mutations and find that they prefer fatty food more, but sweet food less, than people without MC4R mutations. | | | 04 October 2016 | doi: 10.1038/ncomms13055 | | |
| Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange OPEN | | | Tiago Santos-Ferreira, Sílvia Llonch, Oliver Borsch, Kai Postel, Jochen Haas and Marius Ader | | | Integration of transplanted photoreceptors into the host retina has been assumed as the underlying mechanism for vision improvement in pre-clinical studies. Here, the authors show that the majority of transplanted photoreceptors do not structurally integrate but exchange intercellular material with host cells. | | | 04 October 2016 | doi: 10.1038/ncomms13028 | | |
| Global cooling as a driver of diversification in a major marine clade OPEN | | | Katie E. Davis, Jon Hill, Tim I. Astrop and Matthew A. Wills | | | In many groups of organisms, speciation rates are higher when global temperatures are warmer. Here, Davis et al. find that marine crustaceans in the Anomura clade have higher speciation rates during cooler periods, whereas their freshwater relatives have the more typical relationship of higher speciation rates in warmer periods. | | | 04 October 2016 | doi: 10.1038/ncomms13003 | | |
| Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure OPEN | | | David S. Park, Akshay Shekhar, Christopher Marra, Xianming Lin, Carolina Vasquez, Sergio Solinas, Kevin Kelley, Gregory Morley, Mitchell Goldfarb and Glenn I. Fishman | | | Fever is a defence mechanism against infection, but it may also cause abnormal heart rhythm via unknown mechanism. Here the authors identify FHF2 protein as a key regulator of myocardial excitability that protects the heart against conduction failure in response to an increase in body temperature. | | | 04 October 2016 | doi: 10.1038/ncomms12966 | | |
| Magnetodielectric detection of magnetic quadrupole order in Ba(TiO)Cu4(PO4)4 with Cu4O12 square cupolas OPEN | | | K. Kimura, P. Babkevich, M. Sera, M. Toyoda, K. Yamauchi, G. S. Tucker, J. Martius, T. Fennell, P. Manuel, D. D. Khalyavin, R. D. Johnson, T. Nakano, Y. Nozue, H. M. Rønnow and T. Kimura | | | Experimental knowledge of magnetoelectric (ME) activity from magnetic multipole moments has so far been limited. Here, Kimura et al. show that a magnetic square cupola cluster such as Cu4O12 realized in Ba(TiO)Cu4(PO4)4 is a promising structural unit carrying ME-active magnetic quadrupole moments. | | | 04 October 2016 | doi: 10.1038/ncomms13039 | | |
| Multicolour synthesis in lanthanide-doped nanocrystals through cation exchange in water OPEN | | | Sanyang Han, Xian Qin, Zhongfu An, Yihan Zhu, Liangliang Liang, Yu Han, Wei Huang and Xiaogang Liu | | | De novo synthesis is the primary way to tune the emission colour of lanthanide-doped upconversion nanocrystals. Here, the authors introduce post-synthetic cation exchange as a strategy to access multiple colours of luminescent nanocrystals, preserving the size and morphology of the original template. | | | 04 October 2016 | doi: 10.1038/ncomms13059 | | |
| Novel near-infrared emission from crystal defects in MoS2 multilayer flakes OPEN | | | F. Fabbri, E. Rotunno, E. Cinquanta, D. Campi, E. Bonnini, D. Kaplan, L. Lazzarini, M. Bernasconi, C. Ferrari, M. Longo, G. Nicotra, A. Molle, V. Swaminathan and G. Salviati | | | Impurities and vacancies are commonly found within the crystalline lattice of transition metal dichalcogenides, however they are usually seen as detrimental for their optical properties. Here, the authors demonstrate that sulfur vacancies in MoS2 can give rise to a near-infrared emission peak. | | | 04 October 2016 | doi: 10.1038/ncomms13044 | | |
| Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize OPEN | | | Stephen R. Adams, Howard C. Yang, Elamprakash N. Savariar, Joe Aguilera, Jessica L. Crisp, Karra A. Jones, Michael A. Whitney, Scott M. Lippman, Ezra E. W. Cohen, Roger Y. Tsien and Sunil J. Advani | | | Drugs that sensitize tumour cells to ionizing radiation are prized because they can overcome resistance to radiotherapy. Here, the authors show that anti-tubulin drugs conjugated to cetuximab or trastuzumab can radiosensitize EGFR- or HER2-expressing tumors by increasing DNA damage and cell death due to ionizing radiation. | | | 04 October 2016 | doi: 10.1038/ncomms13019 | | |
| Structure of the Neisseria meningitidis Type IV pilus OPEN | | | Subramania Kolappan, Mathieu Coureuil, Xiong Yu, Xavier Nassif, Edward H. Egelman and Lisa Craig | | | Type IV pili are present on a wide range of bacterial pathogens and mediate diverse functions. Here the authors report a high resolution crystal structure of the pilin subunit PilE, and a cryoEM reconstruction of the Type IV pilus filament from N. meningitidis that offer insight into pilus assembly and functions. | | | 04 October 2016 | doi: 10.1038/ncomms13015 | | |
| Structural insights into the assembly and regulation of distinct viral capsid complexes OPEN | | | Subir Sarker, María C. Terrón, Yogesh Khandokar, David Aragão, Joshua M. Hardy, Mazdak Radjainia, Manuel Jiménez-Zaragoza, Pedro J. de Pablo, Fasséli Coulibaly, Daniel Luque, Shane R. Raidal and Jade K. Forwood | | | Circoviruses are the simplest viruses known to autonomously replicate in vertebrates. Here the authors present three structures for distinct macromolecular assemblies of the capsid protein from the beak and feather disease virus that provides insights into the regulation of viral capsid assembly. | | | 04 October 2016 | doi: 10.1038/ncomms13014 | | |
| Neofunctionalization of zona pellucida proteins enhances freeze-prevention in the eggs of Antarctic notothenioids OPEN | | | Lixue Cao, Qiao Huang, Zhichao Wu, Dong-dong Cao, Zhanling Ma, Qianghua Xu, Peng Hu, Yanxia Fu, Yu Shen, Jiulin Chan, Cong-zhao Zhou, Wanying Zhai and Liangbiao Chen | | | Despite subzero temperature of their surroundings, eggs of Antarctic notothenioid fishes do not freeze. This study shows the expansion of genes related to freezing temperature in notothenioid which also acquired of ice melting-promoting zona pellucida proteins with specific structural properties. | | | 04 October 2016 | doi: 10.1038/ncomms12987 | | |
| Massive yet grossly underestimated global costs of invasive insects OPEN | | | Corey J. A. Bradshaw, Boris Leroy, Céline Bellard, David Roiz, Céline Albert, Alice Fournier, Morgane Barbet-Massin, Jean-Michel Salles, Frédéric Simard and Franck Courchamp | | | Invasive insects impose many economic costs, for example by consuming crops and spreading disease. Here, Bradshaw et al. compile a database of the costs of invasive insects and conservatively estimate that the yearly global cost (in 2014-equivalent US dollars) is at least $70 billion for goods and services and $6.9 billion for human health. | | | 04 October 2016 | doi: 10.1038/ncomms12986 | | |
| Structure of ubiquitylated-Rpn10 provides insight into its autoregulation mechanism OPEN | | | Tal Keren-Kaplan, Lee Zeev Peters, Olga Levin-Kravets, Ilan Attali, Oded Kleifeld, Noa Shohat, Shay Artzi, Ori Zucker, Inbar Pilzer, Noa Reis, Michael H. Glickman, Shay Ben-Aroya and Gali Prag | | | Ubiquitin (Ub) receptors are responsible for the recognition of ubiquitylated proteins. Here the authors describe the crystal structure of the ubiquitylated form of the Ub-receptor Rpn10, which suggest that ubiquitylation of Rpn10 promotes its dissociation from the proteasome. | | | 04 October 2016 | doi: 10.1038/ncomms12960 | | |
| Contextuality without nonlocality in a superconducting quantum system OPEN | | | Markus Jerger, Yarema Reshitnyk, Markus Oppliger, Anton Potočnik, Mintu Mondal, Andreas Wallraff, Kenneth Goodenough, Stephanie Wehner, Kristinn Juliusson, Nathan K. Langford and Arkady Fedorov | | | Tests of the Bell-Kochen-Specker theorem aim at showing that the measurement statistics of a single qutrit are incompatible with noncontextual realism. Here, the authors use a superconducting qutrit with deterministic readouts to violate a noncontextuality inequality, ruling out several loopholes. | | | 04 October 2016 | doi: 10.1038/ncomms12930 | | |
| Comparative survey of the relative impact of mRNA features on local ribosome profiling read density OPEN | | | Patrick B. F. O’Connor, Dmitry E. Andreev and Pavel V. Baranov | | | Ribosome profiling data can suffer from uneven coverage which hampers estimation of elongation rates. Connor et al. present an enhanced data smoothing method for Ribo-seq data and highlight significant variability in sequence determinants of ribosome density in publicly available data sets. | | | 04 October 2016 | doi: 10.1038/ncomms12915 | | |
| Oscillating edge states in one-dimensional MoS2 nanowires OPEN | | | Hai Xu, Shuanglong Liu, Zijing Ding, Sherman J. R. Tan, Kah Meng Yam, Yang Bao, Chang Tai Nai, Man-Fai Ng, Jiong Lu, Chun Zhang and Kian Ping Loh | | | Unusual properties arise in transition metal dichalcogenides as dimensionality decreases. Here, the authors introduce a templated growth approach to precisely control the width of MoS2 nanowires on a substrate, allowing them to reveal a relationship between size and electronic properties. | | | 04 October 2016 | doi: 10.1038/ncomms12904 | | |
| Self-amplified photo-induced gap quenching in a correlated electron material OPEN | | | S. Mathias, S. Eich, J. Urbancic, S. Michael, A. V. Carr, S. Emmerich, A. Stange, T. Popmintchev, T. Rohwer, M. Wiesenmayer, A. Ruffing, S. Jakobs, S. Hellmann, P. Matyba, C. Chen, L. Kipp, M. Bauer, H. C. Kapteyn, H. C. Schneider, K. Rossnagel et al. | | | The non-equilibrium dynamics of correlated electron materials are still poorly understood. Here, the authors use time- and angle-resolved photoemission spectroscopy to show that carrier multiplication is important in initial non-equilibrium dynamics of 1T-TiSe2 and depends on the size of the energy gap. | | | 04 October 2016 | doi: 10.1038/ncomms12902 | | |
| A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways OPEN | | | Tianzhi Huang, Angel A. Alvarez, Rajendra P. Pangeni, Craig M. Horbinski, Songjian Lu, Sung-Hak Kim, C. David James, Jeffery J. Raizer, John A. Kessler, Cameron W. Brenann, Erik P. Sulman, Gaetano Finocchiaro, Ming Tan, Ryo Nishikawa, Xinghua Lu, Ichiro Nakano, Bo Hu and Shi-Yuan Cheng | | | Glioblastoma (GBM) is classified as proneural (PN), neural, mesenchymal (MES) and classical GBM. Here the authors show that Wnt signalling, miR-125b and miR-20b establish a regulatory circuitry including FZD6 which distinguishes PN from the MES subtype. | | | 04 October 2016 | doi: 10.1038/ncomms12885 | | |
| Comparative and parallel genome-wide association studies for metabolic and agronomic traits in cereals OPEN | | | Wei Chen, Wensheng Wang, Meng Peng, Liang Gong, Yanqiang Gao, Jian Wan, Shouchuang Wang, Lei Shi, Bin Zhou, Zongmei Li, Xiaoxi Peng, Chenkun Yang, Lianghuan Qu, Xianqing Liu and Jie Luo | | | The plant metabolome is often considered as a bridge between genomic and phenotypic variation. Here, the authors perform metabolic and phenotypic genome-wide association studies in rice grain, and compare to prior studies on rice leaf and maize kernel, to demonstrate a new strategy to investigate complex traits. | | | 04 October 2016 | doi: 10.1038/ncomms12767 | | |
| Self-assembled fibre optoelectronics with discrete translational symmetry OPEN | | | Michael Rein, Etgar Levy, Alexander Gumennik, Ayman F. Abouraddy, John Joannopoulos and Yoel Fink | | | The thermal-draw technique offers fibre devices with a multiplicity of geometries, but these are constrainted to being translationally symmetric. Here, the authors disrupt this symmetry by applying selective capillary instability, resulting in electrically connected spherical photodetecting elements. | | | 04 October 2016 | doi: 10.1038/ncomms12807 | | |
| A universal test for gravitational decoherence OPEN | | | C. Pfister, J. Kaniewski, M. Tomamichel, A. Mantri, R. Schmucker, N. McMahon, G. Milburn and S. Wehner | | | Whether gravity causes decoherence is a natural question on the way of making quantum physics compatible with the theory of gravity. Here the authors devise a general method to estimate gravitational decoherence in any no-signalling physical theory, which holds even if quantum mechanics would be modified. | | | 03 October 2016 | doi: 10.1038/ncomms13022 | | |
| Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers OPEN | | | Jin-Ah Kim, Ying Tan, Xian Wang, Xixi Cao, Jamunarani Veeraraghavan, Yulong Liang, Dean P. Edwards, Shixia Huang, Xuewen Pan, Kaiyi Li, Rachel Schiff and Xiao-Song Wang | | | Luminal B oestrogen receptor positive breast cancers are generally aggressive tumors with poor outcomes. Here, the authors show that the kinase TLK2 is amplified and overexpressed in these tumors and correlates with reduced survival, TLK2 inhibition induces apoptosis in vitro and improves survival in mice. | | | 03 October 2016 | doi: 10.1038/ncomms12991 | | |
| Unsupervised vector-based classification of single-molecule charge transport data OPEN | | | Mario Lemmer, Michael S. Inkpen, Katja Kornysheva, Nicholas J. Long and Tim Albrecht | | | The stochastic nature of single-molecule charge transport measurements requires collection of large data sets to capture their full complexity. Here, the authors adopt strategies from machine learning for the unsupervised classification of single-molecule charge transport data without a priori assumptions. | | | 03 October 2016 | doi: 10.1038/ncomms12922 | | |
| The backtracking survey propagation algorithm for solving random K-SAT problems OPEN | | | Raffaele Marino, Giorgio Parisi and Federico Ricci-Tersenghi | | | The K-satisfability problem is a combinatorial discrete optimization problem, which for K=3 is NP-complete, and whose random formulation is of interest for understanding computational complexity. Here, the authors introduce the backtracking survey propagation algorithm for studying it for K=3 and K=4. | | | 03 October 2016 | doi: 10.1038/ncomms12996 | | |
| Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits OPEN | | | Noham Wolpe, James N. Ingram, Kamen A. Tsvetanov, Linda Geerligs, Rogier A. Kievit, Richard N. Henson, Daniel M. Wolpert, null null, Lorraine K. Tyler, Carol Brayne, Edward Bullmore, Andrew Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Fiona E. Matthews, William Marslen-Wilson, Meredith A. Shafto, Karen Campbell, Teresa Cheung et al. | | | Decline in sensorimotor skills with age may be due to an overreliance on the prediction of the sensory consequences of one’s actions. Here the authors show that sensorimotor attenuation increases with age, and that this is associated with structural and functional changes in frontostriatal circuits. | | | 03 October 2016 | doi: 10.1038/ncomms13034 | | |
| Large Fizeau’s light-dragging effect in a moving electromagnetically induced transparent medium OPEN | | | Pei-Chen Kuan, Chang Huang, Wei Sheng Chan, Sandoko Kosen and Shau-Yu Lan | | | Phase velocity of light can be slowed down when passing through a moving medium. Here the authors demonstrate a light dragging effect enhanced by three orders of magnitude over previous reports by using electromagnetically induced transparency in cold Rubidium atoms and utilize this effect for motion sensors. | | | 03 October 2016 | doi: 10.1038/ncomms13030 | | |
| Interplay between hydrophilicity and surface barriers on water transport in zeolite membranes OPEN | | | Matteo Fasano, Thomas Humplik, Alessio Bevilacqua, Michael Tsapatsis, Eliodoro Chiavazzo, Evelyn N. Wang and Pietro Asinari | | | Zeolite crystal with porous structure is predicted to be a good membrane material for water purification, but experiments show water uptake orders of magnitude smaller than the theory. Here, Fasano et al. attribute this disagreement to the additional diffusion resistance induced by surface defects. | | | 03 October 2016 | doi: 10.1038/ncomms12762 | | |
| Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system OPEN | | | Raymond H. J. Staals, Simon A. Jackson, Ambarish Biswas, Stan J. J. Brouns, Chris M. Brown and Peter C. Fineran | | | Prokaryotic CRISPR-Cas systems provide adaptive immunity against foreign nucleic acids by acquiring short, invader-derived sequences called spacers. Here, Staals et al. analyse millions of such events in a native CRISPR-Cas system, showing that newly acquired spacers provoke additional rounds of spacer acquisition. | | | 03 October 2016 | doi: 10.1038/ncomms12853 | | |
| Sensing surface mechanical deformation using active probes driven by motor proteins OPEN | | | Daisuke Inoue, Takahiro Nitta, Arif Md. Rashedul Kabir, Kazuki Sada, Jian Ping Gong, Akihiko Konagaya and Akira Kakugo | | | It is challenging to characterize the mechanical properties of soft surfaces owing to the coupling between surface deformation and elasticity of bulk materials. Here, Inoue et al. use motile cytoskeletal filaments as active probes, whose direction reflects the stress field experienced by the surface. | | | 03 October 2016 | doi: 10.1038/ncomms12557 | | |
| Projection-type see-through holographic three-dimensional display OPEN | | | Koki Wakunami, Po-Yuan Hsieh, Ryutaro Oi, Takanori Senoh, Hisayuki Sasaki, Yasuyuki Ichihashi, Makoto Okui, Yi-Pai Huang and Kenji Yamamoto | | | The design of holographic displays usually involves a trade-off between size and viewing angle. Here, the authors combine holographic projection with a digitally designed holographic optical element so that display size and the visual angle can be designed independently. | | | 03 October 2016 | doi: 10.1038/ncomms12954 | | |
| Localized force application reveals mechanically sensitive domains of Piezo1 OPEN | | | Jason Wu, Raman Goyal and Jörg Grandl | | | Piezo ion channels transduce mechanical forces into biological signals. Here, the authors use magnetic tweezers to pull specific regions of Piezo1, identifying mechanically sensitive domains that are essential for channel activation and inactivation. | | | 03 October 2016 | doi: 10.1038/ncomms12939 | | |
| Noise reduction facilitated by dosage compensation in gene networks OPEN | | | Weilin Peng, Ruijie Song and Murat Acar | | | Cells must function despite the noisiness of their processes by tolerating or reducing such variability. Here, the authors combine experiment and modelling to show that a network motif that mediates network-dosage compensation also reduces noise in network output, suggesting that noise is tuneable. | | | 03 October 2016 | doi: 10.1038/ncomms12959 | | |
| EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling OPEN | | | Fan Zhang, Bin Qi, Likai Wang, Bo Zhao, Siddharth Rode, Nathaniel D. Riggan, Joseph R. Ecker and Hong Qiao | | | The translocation of the C-terminal domain of EIN2 to the nucleus is essential for induction of gene expression in response to the plant hormone ethylene. Here, Zhang et al. show that EIN2 is required for ethylene-inducible elevation of histone acetylation marks associated with transcriptional activation. | | | 03 October 2016 | doi: 10.1038/ncomms13018 | | |
| SUMOylated NKAP is essential for chromosome alignment by anchoring CENP-E to kinetochores OPEN | | | Teng Li, Liang Chen, Juanxian Cheng, Jiang Dai, Yijiao Huang, Jian Zhang, Zhaoshan Liu, Ang Li, Na Li, Hongxia Wang, Xiaomin Yin, Kun He, Ming Yu, Tao Zhou, Xuemin Zhang and Qing Xia | | | The kinetochore-bound motor CENP-E plays a critical role in chromosome alignment. Here, the authors show that NF-κB activating protein (NKAP) dynamically localises to kinetochores, is SUMOylated during mitosis, and this modification is required for NKAP to bind CENP-E and localise CENP-E to the kinetochore. | | | 03 October 2016 | doi: 10.1038/ncomms12969 | | |
| Earth’s magnetosphere and outer radiation belt under sub-Alfvénic solar wind OPEN | | | Noé Lugaz, Charles J. Farrugia, Chia-Lin Huang, Reka M. Winslow, Harlan E. Spence and Nathan A. Schwadron | | | The interaction between the Earth’s magnetic field and the solar wind results in the formation of a collisionless bow shock. Here, the authors study an even in which the solar wind Mach number remained steadily below one, leading to the evanescence of the bow shock and loss of electrons in the outer belts. | | | 03 October 2016 | doi: 10.1038/ncomms13001 | | |
| Transfer of optical orbital angular momentum to a bound electron OPEN | | | Christian T. Schmiegelow, Jonas Schulz, Henning Kaufmann, Thomas Ruster, Ulrich G. Poschinger and Ferdinand Schmidt-Kaler | | | The spatial structure of vortex laser beams associates angular momentum to photons, which, in addition to their spin, can be used to tailor light-matter interactions. Here, the authors excite an atomic transition with a vortex laser beam, showing that the transfer of angular momentum modifies selection rules. | | | 03 October 2016 | doi: 10.1038/ncomms12998 | | |
| Histone variant H3F3A promotes lung cancer cell migration through intronic regulation OPEN | | | Seong-Min Park, Eun-Young Choi, Mingyun Bae, Sunshin Kim, Jong Bae Park, Heon Yoo, Jung Kyoon Choi, Youn-Jae Kim, Seung-Hoon Lee and In-Hoo Kim | | | Histone variants act as transcriptional activators and repressors and have been linked to cancer progression. Park and Choi et al. show that the histone H3.3 overexpression is associated with early-stage lung cancer, and promotes cancer cell migration by upregulating a G-protein-coupled receptor. | | | 03 October 2016 | doi: 10.1038/ncomms12914 | | |
| The optical frequency comb fibre spectrometer OPEN | | | Nicola Coluccelli, Marco Cassinerio, Brandon Redding, Hui Cao, Paolo Laporta and Gianluca Galzerano | | | An ideal optical frequency-comb system should combine both single-line spectral resolution and a bandwidth broad enough to cover as many lines as possible. Here, the authors incorporate a fibre spectrometer to detect approximately 500 comb-lines with an instrument resolution of 120 megahertz. | | | 03 October 2016 | doi: 10.1038/ncomms12995 | | |
| Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants OPEN | | | Birgit Ploier, Lydia N. Caro, Takefumi Morizumi, Kalpana Pandey, Jillian N. Pearring, Michael A. Goren, Silvia C. Finnemann, Johannes Graumann, Vadim Y. Arshavsky, Jeremy S. Dittman, Oliver P. Ernst and Anant K. Menon | | | Retinitis pigmentosa is often caused by mutations that affect the activity or transport of rhodopsin, but some mutations cause disease even though an apparently functional protein is produced. Here the authors show that three such enigmatic mutants retain scramblase activity but are unable to dimerize. | | | 03 October 2016 | doi: 10.1038/ncomms12832 | | |
| A 17 GHz molecular rectifier OPEN | | | J. Trasobares, D. Vuillaume, D. Théron and N. Clément | | | Molecular electronics holds promise to overcome scaling limits of conventional technologies, but is currently limited to low frequency operation. Here, Trasobares et al. show radio frequencies of up to 17.8 GHz in a molecular diode based on ferrocenyl undecanethiol self-assembled monolayers on gold nanodots. | | | 03 October 2016 | doi: 10.1038/ncomms12850 | | |
| Organization of olfactory centres in the malaria mosquito Anopheles gambiae OPEN | | | Olena Riabinina, Darya Task, Elizabeth Marr, Chun-Chieh Lin, Robert Alford, David A. O'Brochta and Christopher J. Potter | | | Mosquitoes use olfactory cues to locate their host. Here, Riabinina et al. use genetic labelling of olfactory receptor neurons in the malaria vector Anopheles gambiae to show that these neurons project to the antennal lobe, a known insect olfactory centre, and the subesophageal zone, a region previously linked to gustatory processing. | | | 03 October 2016 | doi: 10.1038/ncomms13010 | | |
| The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions OPEN | | | Nicholas Jochumsen, Rasmus L. Marvig, Søren Damkiær, Rune Lyngklip Jensen, Wilhelm Paulander, Søren Molin, Lars Jelsbak and Anders Folkesson | | | Colistin is an antibiotic used in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis patients. Here, Jochumsen et al. reconstruct the pathways for the molecular evolution of colistin resistance in P. aeruginosa and show that the number of pathways is highly constrained by interactions among genes. | | | 03 October 2016 | doi: 10.1038/ncomms13002 | | |
| Nonlinear optical observation of coherent acoustic Dirac plasmons in thin-film topological insulators OPEN | | | Yuri D. Glinka, Sercan Babakiray, Trent A. Johnson, Mikel B. Holcomb and David Lederman | | | Coherent acoustic plasmons in time-domain measurements are rarely observed due to Landau damping. Here, Glinka et al. use transient second-harmonic generation to observe coherent acoustic Dirac plasmon modes survived in indirectly opposite-surface coupled Bi2Se3 films due to Dirac fermion tunnelling. | | | 30 September 2016 | doi: 10.1038/ncomms13054 | | |
| Acoustic omni meta-atom for decoupled access to all octants of a wave parameter space OPEN | | | Sukmo Koo, Choonlae Cho, Jun-ho Jeong and Namkyoo Park | | | For meta-atoms, achieving full access to the wave parameter space remains a problem. Here, Koo et al. outline the criteria for the decoupling of wave parameter from first principles, and realize an omni meta-atom that achieves independent, broad-range access to all octants of acoustic parameter space. | | | 30 September 2016 | doi: 10.1038/ncomms13012 | | |
| Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli OPEN | | | Leanid Laganenka, Remy Colin and Victor Sourjik | | | A small molecule (autoinducer 2, or AI-2) regulates biofilm formation and virulence in several bacteria, but its role in Escherichia coli is unknown. Here, Laganenka et al. show that chemotaxis towards self-produced AI-2 mediates autoaggregation and promotes stress resistance and biofilm formation in E. coli. | | | 30 September 2016 | doi: 10.1038/ncomms12984 | | |
| Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB OPEN | | | Tong Wang, Sally Martin, Tam H. Nguyen, Callista B. Harper, Rachel S. Gormal, Ramon Martínez-Mármol, Shanker Karunanithi, Elizabeth J. Coulson, Nick R. Glass, Justin J. Cooper-White, Bruno van Swinderen and Frédéric A. Meunier | | | Signalling endosomes are known to be essential for neuronal survival. Here the authors show that, in cultured hippocampal neurons and live Drosophila larval motor neurons, neuronal activity increases the retrograde flux of signalling endosomes, and this coupling depends on TrkB activation. | | | 30 September 2016 | doi: 10.1038/ncomms12976 | | |
| Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy OPEN | | | Jundong Shao, Hanhan Xie, Hao Huang, Zhibin Li, Zhengbo Sun, Yanhua Xu, Quanlan Xiao, Xue-Feng Yu, Yuetao Zhao, Han Zhang, Huaiyu Wang and Paul K. Chu | | | Black phosphorus is a biodegradable 2D material that has attracted growing interest in biomedicine. Here, the authors carry out in vitro and in vivo experiments to demonstrate that nanospheres loaded with black-phosphorus quantum dots perform as promising phothermal cancer therapy agents. | | | 30 September 2016 | doi: 10.1038/ncomms12967 | | |
| Feralisation targets different genomic loci to domestication in the chicken OPEN | | | M. Johnsson, E. Gering, P. Willis, S. Lopez, L. Van Dorp, G. Hellenthal, R. Henriksen, U. Friberg and D. Wright | | | Feralisation or the reintroduction of domestic animals into the wild population requires adaptation to survive. Here, the authors analyse the genetics of domestic chickens released into the wild and identify genomic regions that are selected for during feralisation. | | | 30 September 2016 | doi: 10.1038/ncomms12950 | | |
| Stille coupling via C–N bond cleavage OPEN | | | Dong-Yu Wang, Masatoshi Kawahata, Ze-Kun Yang, Kazunori Miyamoto, Shinsuke Komagawa, Kentaro Yamaguchi, Chao Wang and Masanobu Uchiyama | | | The Stille reaction is a long-standing method for the construction of carbon-carbon bonds by coupling aryl halides with organotin compounds. Here the authors report a Stille coupling between aryl ammonium salts and arylstannanes catalysed by nickel. | | | 30 September 2016 | doi: 10.1038/ncomms12937 | | |
| SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory OPEN | | | Kimiko Shimizu, Yodai Kobayashi, Erika Nakatsuji, Maya Yamazaki, Shigeki Shimba, Kenji Sakimura and Yoshitaka Fukada | | | Learning and memory are subject to circadian variation, though the molecular mechanisms behind this are unclear. Here, the authors show SCOP, a regulator of hippocampal memory, undergoes circadian changes in CA1 membrane raft dynamics and contributes to time-dependent changes in long-term memory. | | | 30 September 2016 | doi: 10.1038/ncomms12926 | | |
| Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue OPEN | | | Rita Martello, Mario Leutert, Stephanie Jungmichel, Vera Bilan, Sara C. Larsen, Clifford Young, Michael O. Hottiger and Michael L. Nielsen | | | ADP-ribosylation is a reversible post-translational protein modification involved in many cellular processes. Here the authors describe a sensitive approach for the analysis of ADP-ribosylation sites under physiologic conditions and identify lysine residues as in vivo targets of ADP-ribosylation. | | | 30 September 2016 | doi: 10.1038/ncomms12917 | | |
| Adsorbate-induced lifting of substrate relaxation is a general mechanism governing titania surface chemistry OPEN | | | David Silber, Piotr M. Kowalski, Franziska Traeger, Maria Buchholz, Fabian Bebensee, Bernd Meyer and Christof Wöll | | | Molecules on a metal surface may be modified by the presence of oxide layers, but further mechanistic understanding is still required. Here the authors show for methanol on rutile TiO2(110) that strongly bonded adsorbates lift surface relaxations, leading to substrate-mediated interaction between adsorbates. | | | 30 September 2016 | doi: 10.1038/ncomms12888 | | |
| Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM OPEN | | | Matthew G. Iadanza, Anna J. Higgins, Bob Schiffrin, Antonio N. Calabrese, David J. Brockwell, Alison E. Ashcroft, Sheena E. Radford and Neil A. Ranson | | | The β-barrel assembly machinery (BAM complex) is a key mediator of outer membrane protein biogenesis in Gram-negative bacteria. Here the authors report a cryo-EM structure of the intact BAM complex that suggests that lateral gate opening is a necessary part of the BAM functional cycle. | | | 30 September 2016 | doi: 10.1038/ncomms12865 | | |
| An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy OPEN | | | Mitsuo Kato, Mei Wang, Zhuo Chen, Kirti Bhatt, Hyung Jung Oh, Linda Lanting, Supriya Deshpande, Ye Jia, Jennifer Y.C. Lai, Christopher L. O’Connor, YiFan Wu, Jeffrey B. Hodgin, Robert G. Nelson, Markus Bitzer and Rama Natarajan | | | Nephropathy is a common and hard-to-treat consequence of diabetes. Here Kato et al. show that a megacluster of microRNAs regulates early development of diabetic nephropathy in mice, and that inhibition of the cluster's host long non-coding RNA transcript attenuates disease symptoms, suggesting a new therapy for diabetic nephropathy. | | | 30 September 2016 | doi: 10.1038/ncomms12864 | | |
| The Google matrix controls the stability of structured ecological and biological networks OPEN | | | Lewi Stone | | | May showed that ecosystem stability decreases above some threshold complexity. Here, Stone generalizes May’s random matrix approach to realistic species interaction networks through a Google-matrix reduction scheme, and provides an explanation for why feasible ecological networks are usually stable. | | | 30 September 2016 | doi: 10.1038/ncomms12857 | | |
| Tuning graphitic oxide for initiator- and metal-free aerobic epoxidation of linear alkenes OPEN | | | Samuel Pattisson, Ewa Nowicka, Upendra N. Gupta, Greg Shaw, Robert L. Jenkins, David J. Morgan, David W. Knight and Graham J. Hutchings | | | Graphitic oxide is readily produced by the oxidation of graphite. Here the authors show that the amount and nature of the oxidant can be used to tune the properties of graphitic oxide, and furthermore report a carbocatalyst for alkene epoxidation without the need for metal or initiators. | | | 30 September 2016 | doi: 10.1038/ncomms12855 | | |
| Giant superconducting fluctuations in the compensated semimetal FeSe at the BCS–BEC crossover OPEN | | | S. Kasahara, T. Yamashita, A. Shi, R. Kobayashi, Y. Shimoyama, T. Watashige, K. Ishida, T. Terashima, T. Wolf, F. Hardy, C. Meingast, H. v. Löhneysen, A. Levchenko, T. Shibauchi and Y. Matsuda | | | The crossover between the weak-coupling limit and strong-coupling limit provides important information for quantum bound states of interacting fermions. Here, Kasahara et al. report thermodynamic evidence for prevailing phase fluctuations of superconductivity, highlighting unusual normal state in the BCS-BEC crossover regime. | | | 30 September 2016 | doi: 10.1038/ncomms12843 | | |
| Incipient ferroelectricity of water molecules confined to nano-channels of beryl OPEN | | | B. P. Gorshunov, V. I. Torgashev, E. S. Zhukova, V. G. Thomas, M. A. Belyanchikov, C. Kadlec, F. Kadlec, M. Savinov, T. Ostapchuk, J. Petzelt, J. Prokleška, P. V. Tomas, E. V. Pestrjakov, D. A. Fursenko, G. S. Shakurov, A. S. Prokhorov, V. S. Gorelik, L. S. Kadyrov, V. V. Uskov, R. K. Kremer et al. | | | Ferroelectric orders hardly exist in liquid or ice state of water, despite its enormous molecular electrical polarizability. Here, Gorshunov et al. report incipient ferroelectricity in chains of interacting water molecules by placing them in the structural channels of a beryl crystal. | | | 30 September 2016 | doi: 10.1038/ncomms12842 | | |
| Phototaxis of synthetic microswimmers in optical landscapes OPEN | | | Celia Lozano, Borge ten Hagen, Hartmut Löwen and Clemens Bechinger | | | The capability to move towards or away from light sources, namely phototaxis, is an essential feature of many microorganisms like bacteria or motile cells. Lozano et al. show an artificial phototaxis system that enables autonomous navigation of colloidal Janus spheres in a laser-generated light landscape. | | | 30 September 2016 | doi: 10.1038/ncomms12828 | | |
| CO2 fixation by anaerobic non-photosynthetic mixotrophy for improved carbon conversion OPEN | | | Shawn W. Jones, Alan G. Fast, Ellinor D. Carlson, Carrissa A. Wiedel, Jennifer Au, Maciek R. Antoniewicz, Eleftherios T. Papoutsakis and Bryan P. Tracy | | | Microbial fermentation yield is limited by CO2 loss in glycolysis. Here, the authors engineered Clostridium ljungdahlii for the anaerobic, non-photosynthetic mixotrophy production of acetone, increasing carbon product yield while reducing CO2 emissions from a biogenic feedstock fermentation. | | | 30 September 2016 | doi: 10.1038/ncomms12800 | | |
| Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis OPEN | | | Robert M. Vogel, Amir Erez and Grégoire Altan-Bonnet | | | Many drugs are small molecule inhibitors of cell signalling. Through single cell analysis and mathematical modelling here the authors show that cell-to-cell variability diversifies inhibition response into digital and analogue, and that the two translate into distinct long-term functional responses. | | | 30 September 2016 | doi: 10.1038/ncomms12428 | | |
| Local quantum thermal susceptibility OPEN | | | Antonella De Pasquale, Davide Rossini, Rosario Fazio and Vittorio Giovannetti | | | In thermodynamics, thermal properties of systems are obtained from averaging procedures which smooth out local details. Here, the authors introduce the concept of local quantum thermal susceptibility, a measure for the best achievable accuracy of estimation of temperature via local measurements. | | | 29 September 2016 | doi: 10.1038/ncomms12782 | | |
| Topographic generation of submesoscale centrifugal instability and energy dissipation OPEN | | | Jonathan Gula, M. Jeroen Molemaker and James C. McWilliams | | | Most of the ocean kinetic energy is contained in the large scale geostrophic currents and the pathways of energy toward dissipation are still in question. Here, the authors show that flow-topography interactions can generate submesoscale wakes and provide an efficient route to energy dissipation. | | | 29 September 2016 | doi: 10.1038/ncomms12811 | | |
| Spatially inhomogeneous electron state deep in the extreme quantum limit of strontium titanate OPEN | | | Anand Bhattacharya, Brian Skinner, Guru Khalsa and Alexey V. Suslov | | | At sufficiently strong magnetic fields and low temperatures, electrons assume a quasi-one-dimensional quantum state that is challenging to observe. Here, Bhattacharya et al. report on electron transport in lightly-doped single crystals of SrTiO3 deep in this extreme quantum limit. | | | 29 September 2016 | doi: 10.1038/ncomms12974 | | |
| Enrichment of hydroxylated C24- and C26-acyl-chain sphingolipids mediates PIN2 apical sorting at trans-Golgi network subdomains OPEN | | | Valérie Wattelet-Boyer, Lysiane Brocard, Kristoffer Jonsson, Nicolas Esnay, Jérôme Joubès, Frédéric Domergue, Sébastien Mongrand, Natasha Raikhel, Rishikesh P. Bhalerao, Patrick Moreau and Yohann Boutté | | | Sphingolipids in the trans-Golgi network have been implicated in polar trafficking. Here Wattelet-Boyer et al. show that hydroxylated C24- and C26-acyl-chain sphingolipids are enriched in trans-Golgi network subdomains that are critical for polar sorting of the PIN2 auxin carrier in plant cells. | | | 29 September 2016 | doi: 10.1038/ncomms12788 | | |
| Thorium–phosphorus triamidoamine complexes containing Th–P single- and multiple-bond interactions OPEN | | | Elizabeth P. Wildman, Gábor Balázs, Ashley J. Wooles, Manfred Scheer and Stephen T. Liddle | | | Despite the burgeoning field of uranium-ligand multiple bond chemistry, analogous thorium compounds remain scarce. Here, the authors synthesize and characterize a series of thorium complexes with multiple bonds to phosphorus, and probe their 5f versus 6d orbital bonding character. | | | 29 September 2016 | doi: 10.1038/ncomms12884 | | |
| Quantum decoherence dynamics of divacancy spins in silicon carbide OPEN | | | Hosung Seo, Abram L. Falk, Paul V. Klimov, Kevin C. Miao, Giulia Galli and David D. Awschalom | | | The length of time a qubit can store information is linked to its coherence time. Here, the authors demonstrate that industrially important crystals comprising more than one species can host qubits with unexpectedly long coherence times. | | | 29 September 2016 | doi: 10.1038/ncomms12935 | | |
| Structural and quantum chemical analysis of exciton coupling in homo- and heteroaggregate stacks of merocyanines OPEN | | | David Bialas, André Zitzler-Kunkel, Eva Kirchner, David Schmidt and Frank Würthner | | | Exciton coupling between organic dyes is important for opto-electronic and photovoltaic devices and it is well-known that strong coupling occurs between equal chromophores. Here, Würthner and others show quadruple dye stacks that have strong exciton coupling between different chromophores within a heteroaggregate. | | | 29 September 2016 | doi: 10.1038/ncomms12949 | | |
| Engineering island-chain silicon nanowires via a droplet mediated Plateau-Rayleigh transformation OPEN | | | Zhaoguo Xue, Mingkun Xu, Yaolong Zhao, Jimmy Wang, Xiaofan Jiang, Linwei Yu, Junzhuan Wang, Jun Xu, Yi Shi, Kunji Chen and Pere Roca i Cabarrocas | | | The ability to program periodic morphology into nanowires affords control over photonic and electronic transport properties. Here, the authors stimulate Plateau-Rayleigh transformations in silicon nanowires through an oscillating catalyst droplet, resulting in nanowires with island-chain morphology. | | | 29 September 2016 | doi: 10.1038/ncomms12836 | | |
| ICER is requisite for Th17 differentiation OPEN | | | Nobuya Yoshida, Denis Comte, Masayuki Mizui, Kotaro Otomo, Florencia Rosetti, Tanya N. Mayadas, José C. Crispín, Sean J. Bradley, Tomohiro Koga, Michihito Kono, Maria P. Karampetsou, Vasileios C. Kyttaris, Klaus Tenbrock and George C. Tsokos | | | ICER is a CREM splice variant that represses CREM/CREB signalling. Here the authors use human cells and mouse models of various autoimmune diseases to show that ICER is central to pathogenic Th17 cell differentiation in autoimmunity. | | | 29 September 2016 | doi: 10.1038/ncomms12993 | | |
| Aromatic thiol-mediated cleavage of N–O bonds enables chemical ubiquitylation of folded proteins OPEN | | | Caroline E. Weller, Abhinav Dhall, Feizhi Ding, Edlaine Linares, Samuel D. Whedon, Nicholas A. Senger, Elizabeth L. Tyson, John D. Bagert, Xiaosong Li, Ohara Augusto and Champak Chatterjee | | | Chemical approaches to site-specifically ubiquitylate a target protein allow investigation of the biochemical effects of this modification, but they often destabilize the protein. Here, the authors report on a synthetic conjugation strategy that leads to protein ubiquitylation in non-denaturing conditions. | | | 29 September 2016 | doi: 10.1038/ncomms12979 | | |
| Quantized conductance doubling and hard gap in a two-dimensional semiconductor–superconductor heterostructure OPEN | | | M. Kjaergaard, F. Nichele, H. J. Suominen, M. P. Nowak, M. Wimmer, A. R. Akhmerov, J. A. Folk, K. Flensberg, J. Shabani, C. J. Palmstrøm and C. M. Marcus | | | Interface transparency between 2D semiconductors and superconductors is a longstanding problem, seriously hindering potential applications. Here, using a new hybrid system, Kjaergaard et al. report quantized conductance doubling and a hard superconducting gap measured via a quantum point contact, indicating a near pristine interface. | | | 29 September 2016 | doi: 10.1038/ncomms12841 | | |
| FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase OPEN | | | Khanh V. Doan, Ann W. Kinyua, Dong Joo Yang, Chang Mann Ko, Sang Hyun Moh, Ko Eun Shong, Hail Kim, Sang-Kyu Park, Dong-Hoon Kim, Inki Kim, Ji-Hye Paik, Ronald A. DePinho, Seul Gi Yoon, Il Yong Kim, Je Kyung Seong, Yun-Hee Choi and Ki Woo Kim | | | Dopaminergic neurons are important for regulating energy homeostasis. Here, the authors show the transcription factor FoxO1 negatively regulates tyrosine hydroxylase expression in midbrain dopaminergic neurons, and plays an important role in regulation of glucose homeostasis, energy expenditure, and resistance to diet-induced obesity. | | | 29 September 2016 | doi: 10.1038/ncomms12733 | | |
| Unsupervised learning in probabilistic neural networks with multi-state metal-oxide memristive synapses OPEN | | | Alexander Serb, Johannes Bill, Ali Khiat, Radu Berdan, Robert Legenstein and Themis Prodromakis | | | Artificial neural networks exhibit learning abilities and can perform tasks which are tricky for conventional computing systems, such as pattern recognition. Here, Serb et al. show experimentally that memristor arrays can learn reversibly from noisy data thanks to sophisticated learning rules. | | | 29 September 2016 | doi: 10.1038/ncomms12611 | | |
| Large optical nonlinearity of ITO nanorods for sub-picosecond all-optical modulation of the full-visible spectrum OPEN | | | Peijun Guo, Richard D. Schaller, Leonidas E. Ocola, Benjamin T. Diroll, John B. Ketterson and Robert P. H. Chang | | | Optical nonlinearity in metallic nanostructures has been exploited for all-optical signal switching. Here, Guo et al. report on the optical nonlinearity of indium tin oxide nanorod arrays in the dielectric range induced by pumping in the metallic range, enabling modulation of the full-visible spectrum. | | | 29 September 2016 | doi: 10.1038/ncomms12892 | | |
| Highly tunable refractive index visible-light metasurface from block copolymer self-assembly OPEN | | | Ju Young Kim, Hyowook Kim, Bong Hoon Kim, Taeyong Chang, Joonwon Lim, Hyeong Min Jin, Jeong Ho Mun, Young Joo Choi, Kyungjae Chung, Jonghwa Shin, Shanhui Fan and Sang Ouk Kim | | | Wider control of the refractive index is desired for new optical applications. Here the authors manipulate block copolymer self-assembled nanopatterns via shrinkage in order to control the refractive index. They achieve an index above 3 over 1,000 nm bandwidth. | | | 29 September 2016 | doi: 10.1038/ncomms12911 | | |
| Experimental evidence of pollination in marine flowers by invertebrate fauna OPEN | | | Brigitta I. van Tussenbroek, Nora Villamil, Judith Márquez-Guzmán, Ricardo Wong, L. Verónica Monroy-Velázquez and Vivianne Solis-Weiss | | | Marine plants reproduce by hydrophilly, that is, the movement of pollen by water. Here, the authors show that invertebrates can also carry pollen from male to female Thalassia testudinum plants. | | | 29 September 2016 | doi: 10.1038/ncomms12980 | | |
| Confocal reference free traction force microscopy OPEN | | | Martin Bergert, Tobias Lendenmann, Manuel Zündel, Alexander E. Ehret, Daniele Panozzo, Patrizia Richner, David K. Kim, Stephan J. P. Kress, David J. Norris, Olga Sorkine-Hornung, Edoardo Mazza, Dimos Poulikakos and Aldo Ferrari | | | Traction force microscopy is an effective method of measuring forces between cells and their environment, but requires removing the cells to obtain a reference image. Here the authors use nanodrip printing of quantum dots into compliant substrates to provide a regular array of fiducial spots, removing the need for a reference image. | | | 29 September 2016 | doi: 10.1038/ncomms12814 | | |
| Young asteroidal fluid activity revealed by absolute age from apatite in carbonaceous chondrite OPEN | | | Ai-Cheng Zhang, Qiu-Li Li, Hisayoshi Yurimoto, Naoya Sakamoto, Xian-Hua Li, Sen Hu, Yang-Ting Lin and Ru-Cheng Wang | | | Chondritic meteorites formed in the early solar system and may tell us about primary processes at that time. Here, Zhang et al. report an absolute 207Pb/206Pb isochron age (4,450±50 Ma) of apatite from a carbonaceous chondrite constraining timing of fluid activity in meteorites. | | | 29 September 2016 | doi: 10.1038/ncomms12844 | | |
| ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism OPEN | | | Zhe Tian, Keishi Miyata, Tsuyoshi Kadomatsu, Haruki Horiguchi, Hiroyuki Fukushima, Shugo Tohyama, Yoshihiro Ujihara, Takahiro Okumura, Satoshi Yamaguchi, Jiabin Zhao, Motoyoshi Endo, Jun Morinaga, Michio Sato, Taichi Sugizaki, Shunshun Zhu, Kazutoyo Terada, Hisashi Sakaguchi, Yoshihiro Komohara, Motohiro Takeya, Naoki Takeda et al. | | | Heart responds to increased workload by enlarging cardiomyocytes to preserve function, but in pathologies hypertrophy leads to heart failure. Here the authors show that ANGPTL2 activity in the heart is critical for determining beneficial vs. pathological hypertrophy via its effect on AKT-SERCA2a signaling and myocardial energy. | | | 28 September 2016 | doi: 10.1038/ncomms13016 | | |
| Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity OPEN | | | Wen Fong Ooi, Manjie Xing, Chang Xu, Xiaosai Yao, Muhammad Khairul Ramlee, Mei Chee Lim, Fan Cao, Kevin Lim, Deepak Babu, Lai-Fong Poon, Joyce Lin Suling, Aditi Qamra, Astrid Irwanto, James Qu Zhengzhong, Tannistha Nandi, Ai Ping Lee-Lim, Yang Sun Chan, Su Ting Tay, Ming Hui Lee, James O. J. Davies et al. | | | Gene expression is regulated by enhancers and super-enhancers, which can be identified by chromatin profiling. Here, the authors surveyed gastric cancer samples and cell lines to identify enhancer elements exhibiting somatic alterations. | | | 28 September 2016 | doi: 10.1038/ncomms12983 | | |
| Scalable loading of a two-dimensional trapped-ion array OPEN | | | Colin D. Bruzewicz, Robert McConnell, John Chiaverini and Jeremy M. Sage | | | Two-dimensional arrays of trapped ion qubits are attractive platforms for quantum information processing, but rapid reloading remains a challenge. Here the authors use a continuous flux of pre-cooled neutral atoms to achieve fast loading of single ions without affecting the coherence of adjacent qubits. | | | 28 September 2016 | doi: 10.1038/ncomms13005 | | |
| Return of naturally sourced Pb to Atlantic surface waters OPEN | | | Luke Bridgestock, Tina van de Flierdt, Mark Rehkämper, Maxence Paul, Rob Middag, Angela Milne, Maeve C. Lohan, Alex R. Baker, Rosie Chance, Roulin Khondoker, Stanislav Strekopytov, Emma Humphreys-Williams, Eric P. Achterberg, Micha J. A. Rijkenberg, Loes J. A. Gerringa and Hein J. W. de Baar | | | Anthropogenic lead (Pb) has overwhelmed natural Pb sources for over a century, yet the phasing out of leaded petrol in the early 2000s has renewed hope. Here, Bridgestock et al. use Pd isotopes to reassess the origins of Pd deposited in the tropical North Atlantic and reveal a significant natural source. | | | 28 September 2016 | doi: 10.1038/ncomms12921 | | |
| Forward design of a complex enzyme cascade reaction OPEN | | | Christoph Hold, Sonja Billerbeck and Sven Panke | | | Building multi-component enzymatic processes in one pot is challenged by the inherent complexity of each biochemical system. Here, the authors use online mass spectroscopy and engineering systems theory to achieve forward design of a ten-membered reaction cascade. | | | 28 September 2016 | doi: 10.1038/ncomms12971 | | |
| Initiating and imaging the coherent surface dynamics of charge carriers in real space OPEN | | | K. R. Rusimova, N. Bannister, P. Harrison, D. Lock, S. Crampin, R. E. Palmer and P. A. Sloan | | | The charge injected from the tip of a scanning tunnelling microscope quickly spreads across the surface and can manipulate distant adsorbates. Here, the authors use this nonlocal manipulation to probe the ultrafast ballistic dynamics and coherent evolution of the injected charge carrier. | | | 28 September 2016 | doi: 10.1038/ncomms12839 | | |
| Wave-induced loss of ultra-relativistic electrons in the Van Allen radiation belts OPEN | | | Yuri Y. Shprits, Alexander Y. Drozdov, Maria Spasojevic, Adam C. Kellerman, Maria E. Usanova, Mark J. Engebretson, Oleksiy V. Agapitov, Irina S. Zhelavskaya, Tero J. Raita, Harlan E. Spence, Daniel N. Baker, Hui Zhu and Nikita A. Aseev | | | The processes that lead to losses of highly energetic particles from Earth’s radiation belts remain poorly understood. Here the authors compare observations and models of a 2013 event to show that electromagnetic ioncyclotron waves provide the dominant loss mechanism at ultra-relativistic energies. | | | 28 September 2016 | doi: 10.1038/ncomms12883 | | |
| Optical manipulation of single flux quanta OPEN | | | I. S. Veshchunov, W. Magrini, S. V. Mironov, A. G. Godin, J.-B. Trebbia, A. I. Buzdin, Ph. Tamarat and B. Lounis | | | Manipulation of individual superconducting vortices remains challenging and has been demonstrated only in a sophisticated way. Here, Veshchunov et al. realize a fast and precise manipulation of individual vortices using a far-field optical method, providing a simple way towards optical control of Josephson transport. | | | 28 September 2016 | doi: 10.1038/ncomms12801 | | |
| Raman gas self-organizing into deep nano-trap lattice OPEN | | | M. Alharbi, A. Husakou, M. Chafer, B. Debord, F. Gérôme and F. Benabid | | | Engineering the interaction between optical fields and gas-phase matters is important for spectroscopy and more general laser science and technology. Here, the authors demonstrate a method for light-trapping of molecular hydrogen in hollow-core photonic-crystal fibres, relying on Raman transition. | | | 28 September 2016 | doi: 10.1038/ncomms12779 | | |
| Robust upward dispersion of the neutron spin resonance in the heavy fermion superconductor Ce1−xYbxCoIn5 OPEN | | | Yu Song, John Van Dyke, I. K. Lum, B. D. White, Sooyoung Jang, Duygu Yazici, L. Shu, A. Schneidewind, Petr Čermák, Y. Qiu, M. B. Maple, Dirk K. Morr and Pengcheng Dai | | | The mechanism of collective magnetic excitations in unconventional superconductors remains controversial. Here, Song et al. show neutron spin resonance in a heavy fermion superconductor Ce1-xYbxCoIn5, implying magnon-like excitation rather than spin-exciton type. | | | 28 September 2016 | doi: 10.1038/ncomms12774 | | |
| Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene OPEN | | | Gijs van Ingen, Jin Li, André Goedegebure, Rahul Pandey, Yun Rose Li, Michael E. March, Vincent W. V. Jaddoe, Marina Bakay, Frank D. Mentch, Kelly Thomas, Zhi Wei, Xiao Chang, Heather S. Hain, André G. Uitterlinden, Henriette A. Moll, Cornelia M. van Duijn, Fernando Rivadeneira, Hein Raat, Robert J. Baatenburg de Jong, Patrick M. Sleiman et al. | | | Acute otitis media (AOM) is an acute infection of middle ear mucosa and among the most common pediatric diseases. Here, the authors performed a genome-wide association study to link a variant in the FNDC1 locus on 6q25.3 and differential methylation status of the FNDC1 gene with predisposition to AOM. | | | 28 September 2016 | doi: 10.1038/ncomms12792 | | |
| Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans OPEN | | | Kyung-Tae Lee, Yee-Seul So, Dong-Hoon Yang, Kwang-Woo Jung, Jaeyoung Choi, Dong-Gi Lee, Hyojeong Kwon, Juyeong Jang, Li Li Wang, Soohyun Cha, Gena Lee Meyers, Eunji Jeong, Jae-Hyung Jin, Yeonseon Lee, Joohyeon Hong, Soohyun Bang, Je-Hyun Ji, Goun Park, Hyo-Jeong Byun, Sung Woo Park et al. | | | Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis. Here, the authors study the roles played by 129 putative kinases in the growth and virulence of C. neoformans, identifying potential targets for development of anticryptococcal drugs. | | | 28 September 2016 | doi: 10.1038/ncomms12766 | | |
| Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments OPEN | | | Daniel Becker, Zuzanna Kaczmarska, Christoph Arkona, Robert Schulz, Carolin Tauber, Gerhard Wolber, Rolf Hilgenfeld, Miquel Coll and Jörg Rademann | | | Molecular fragments are useful tools in drug-discovery but they might be hard to identify due to their weak affinity to the targets. Here, the authors use a protein-templated assembly to design high affinity inhibitors of Coxsackie virus 3C protease, a pharmacological target against enteroviral infections. | | | 28 September 2016 | doi: 10.1038/ncomms12761 | | |
| Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter OPEN | | | Christian B. Billesbølle, Jonas S. Mortensen, Azmat Sohail, Solveig G. Schmidt, Lei Shi, Harald H. Sitte, Ulrik Gether and Claus J. Loland | | | The neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+ on neutrotrasmitter:sodium symporters function. | | | 28 September 2016 | doi: 10.1038/ncomms12755 | | |
| Sustainably powering wearable electronics solely by biomechanical energy OPEN | | | Jie Wang, Shengming Li, Fang Yi, Yunlong Zi, Jun Lin, Xiaofeng Wang, Youlong Xu and Zhong Lin Wang | | | Harvesting bio-mechanical energy is a promising route to powering wearable electronics, however design obstacles remain. Here the authors report on a triboelectric nanogenerator with optimized materials and design that can sustainably power an electronic watch and fitness tracker solely by human motion. | | | 28 September 2016 | doi: 10.1038/ncomms12744 | | | | | | | | | | | | | Latest Corrigendum | | | | | | | | | | | | Latest Errata | | | | | | Erratum: Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma OPEN | | | Ugur Eskiocak, Vijayashree Ramesh, Jennifer G. Gill, Zhiyu Zhao, Stacy W. Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Arthur E. Frankel, Timothy M. Johnson, Ralph J. DeBerardinis and Sean J. Morrison | | | 29 September 2016 | doi: 10.1038/ncomms13080 | | |
| | | | | Erratum: Survival trade-offs in plant roots during colonization by closely related beneficial and pathogenic fungi OPEN | | | Stéphane Hacquard, Barbara Kracher, Kei Hiruma, Philipp C. Münch, Ruben Garrido-Oter, Michael R. Thon, Aaron Weimann, Ulrike Damm, Jean-Félix Dallery, Matthieu Hainaut, Bernard Henrissat, Olivier Lespinet, Soledad Sacristán, Emiel Ver Loren van Themaat, Eric Kemen, Alice C. McHardy, Paul Schulze-Lefert and Richard J. O’Connell | | | 29 September 2016 | doi: 10.1038/ncomms13072 | | | Biological Sciences Genetics Microbiology Plant sciences | | | | | |
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