Nature Chemistry Contents November 2016 Volume 8 Number 10 pp 987 - 1084

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Advertisement Solve our challenge and win $200,000.  Identify novel small molecules that bind glucose and improve diabetes treatments. Visit our challenge here. TABLE OF CONTENTS November 2016 Volume 8, Issue 11 Editorial Thesis Corrections Interview News and Views Review Articles Corrigendum In Your Element Advertisement nature.com webcasts Springer Nature presents a custom webcast on Investigating the AKT-mTOR Pathway with Targeted Mass Spectrometry Applications Date: Wednesday October 26, 2016 Time: 8AM PDT, 11AM EDT, 4PM BST, 5PM CEST Register at:   Sponsored by: Thermo Fisher Scientific  Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Lithium-ion batteries are efficient energy storage devices that have transformed personal electronics. However, questions still remain as to whether they will realise their full market potential. Find out more about the key challenges facing their development here.   Advertisement Covering the evolution of science since 1869, Nature has a multidisciplinary global scientific network of readers. Join a community of great minds and be part of the discussion with a personal subscription from £65 (UK), $93 (US), €84 (EU).     Advertisement npj Clean Water: open for submissions  An open access, online-only journal, dedicated to publishing high-quality papers that describe the significant and cutting-edge research that continues to ensure the supply of clean water to populations. Explore the benefits of submitting your next manuscript.   Editorial Top Frameworks for commercial success   p987 doi:10.1038/nchem.2661 Taking chemical technology from the bench to the consumer is a formidable challenge, but it is how research can ultimately benefit wider society. Companies are now beginning to incorporate metal-organic frameworks into commercial products, heralding a new era for the field. Thesis Top Slow chemistry   pp988 - 989 Bruce Gibb doi:10.1038/nchem.2652 Researchers should spend more time doing science than cataloguing every last detail about how they get it done, argues Bruce Gibb. Corrections Top Correction   p989 doi:10.1038/nchem.2646 Interview Top MOFs move to market   pp990 - 991 Thomas Faust doi:10.1038/nchem.2656 Omar Farha (Chief Science Officer & technical founder) and Ben Hernandez (Chief Executive Officer) of NuMat Technologies, talk to Nature Chemistry about the release of one of the first MOF-based commercial products and the challenges the journey posed. News and Views Top DNA charge transfer: Hot holes break the speed limit   pp992 - 993 D. N. Beratan and D. H. Waldeck doi:10.1038/nchem.2655 Charge transfer through DNA has been well studied over recent decades from both a biological and electronics perspective. It has now been shown that charge transfer can be accelerated one hundredfold by using highly energetic 'hot holes', revealing a new mechanism that could help to create useful electronic biomaterials. See also: Article by Renaud et al. Organometallic chemistry: Heavyweight isomer brings stability   pp993 - 995 David Scheschkewitz doi:10.1038/nchem.2654 Due to its high reactivity, vinylidene [mdash] the sole 'electron-precise' isomer of acetylene [mdash] is only known to exist in the gas phase. Now, a stable base-free digermanium version of a vinylidene has been isolated by the clever use of suitable substituents. See also: Article by Rit et al. Actinide chemistry: New compounds on the Bk menu   p995 Marshall Brennan doi:10.1038/nchem.2659 Nanomaterials: Two sides to every particle   p996 Victoria Richards doi:10.1038/nchem.2658 Chemistry JOBS of the week PhD Positions in Chemistry and Neuroscience, LMU Munich Klinikum der Universität München More Science jobs from Chemistry EVENT Flow Chemistry Europe 2017 7th Feb - 8th Feb 2017 Cambridge, UK More science events from Correction Top Correction   p996 doi:10.1038/nchem.2667 Review Top Materials and methods for delivery of biological drugs   pp997 - 1007 Alexander N. Zelikin, Carsten Ehrhardt and Anne Marie Healy doi:10.1038/nchem.2629 Biological drugs can offer high potency and selectivity; however, this class of therapeutics often shows poor stability upon oral administration and during subsequent circulation. This Review highlights the materials and methods used to deliver biological drugs, and discusses how these approaches can improve their pharmacokinetics. Advertisement Nature Reviews Chemistry — Stay Informed The second physical sciences title in the Nature Reviews portfolio, Nature Reviews Chemistry aims to build on the success of Nature Chemistry and emulate the principles of authoritative, high-quality content and exceptional editorial standards that are the hallmark of the Nature Reviews titles. Register for the Nature Reviews Chemistry e-alert and stay informed about the latest news and research in topics covering the breadth of pure and applied chemistry. Sign up for the e-alert   Articles Top Peptide tessellation yields micrometre-scale collagen triple helices   pp1008 - 1014 I. Caglar Tanrikulu, Audrey Forticaux, Song Jin and Ronald T. Raines doi:10.1038/nchem.2556 Natural collagen contains triple helices that are approximately 1,000 residues in length and cannot be formed by chemical synthesis. Now, short collagen-mimetic peptides that self-assemble into three-stranded helices have been designed. These peptides are inspired by the mathematics of tessellations, and the triple helices formed via this approach match or exceed the length of those found in natural collagen. Deep-hole transfer leads to ultrafast charge migration in DNA hairpins   pp1015 - 1021 Nicolas Renaud, Michelle A. Harris, Arunoday P. N. Singh, Yuri A. Berlin, Mark A. Ratner et al. doi:10.1038/nchem.2590 Charge transfer in DNA is of fundamental interest in chemistry and biochemistry and has possible applications in nano-electronics. Now it has been shown, through a combined experimental and theoretical study, that the migration of positive charges through low-lying orbitals of nucleobases (deep-hole transfer) leads to charge transfer that is faster than previously considered transport regimes. See also: Article by Burton et al. A stable heavier group 14 analogue of vinylidene   pp1022 - 1026 Arnab Rit, Jesús Campos, Haoyu Niu and Simon Aldridge doi:10.1038/nchem.2597 Vinylidene, (H2C=C), is a short-lived structural isomer of acetylene. By employing bulky and strongly electron-donating boryl co-ligands, the synthesis of an analogous group 14 vinylidene compound is reported. The digermavinylidene, {(HCDippN)2B}2GeGe, (where Dipp = 2,6-iPr2C6H3), is synthesized via oxidation of the corresponding symmetrical Ge0 compound K2[(boryl)GeGe(boryl)]. See also: Article by Kiyonaka et al. Small-molecule control of protein function through Staudinger reduction   pp1027 - 1034 Ji Luo, Qingyang Liu, Kunihiko Morihiro and Alexander Deiters doi:10.1038/nchem.2573 A generally applicable small-molecule switch for protein function in live cells has been developed based on selective protein protection using unnatural amino acid mutagenesis and a bioorthogonal deprotection via Staudinger reduction. Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors   pp1035 - 1041 Xiao-Feng Xiong, Hang Zhang, Christina R. Underwood, Kasper Harpsøe, Thomas J. Gardella et al. doi:10.1038/nchem.2577 G proteins are the key mediators of G protein-coupled receptor signalling, facilitating a number of important physiological processes. Now, the total synthesis and structure–activity relationship studies have been reported for the only known selective Gq protein inhibitors, the natural cyclic depsipeptides YM-254890 and FR900359. Chemical compounds Translational, rotational and vibrational relaxation dynamics of a solute molecule in a non-interacting solvent   pp1042 - 1046 Michael P. Grubb, Philip M. Coulter, Hugo J. B. Marroux, Balazs Hornung, Ryan S. McMullen et al. doi:10.1038/nchem.2570 Spectral broadening generally conceals the signatures of rotational and translational motion in solution-phase spectra. Now, using highly inert perfluorocarbon solvents, spectral broadening has been minimized allowing the translational, rotational and vibrational relaxation dynamics of highly excited CN solute molecules to be observed simultaneously. Fast and selective ring-opening polymerizations by alkoxides and thioureas   pp1047 - 1053 Xiangyi Zhang, Gavin O. Jones, James L. Hedrick and Robert M. Waymouth doi:10.1038/nchem.2574 By simply deprotonating a neutral hydrogen-bond donor thiourea it is possible to generate a class of highly efficient and tunable thioimidates that can simultaneously activate a pro-nucleophile and an electrophile. These bifunctional thioimidates exhibit fast kinetics and high selectivity for ring-opening polymerizations of cyclic lactones and carbonates. Chemical compounds Nickel-centred proton reduction catalysis in a model of [NiFe] hydrogenase   pp1054 - 1060 Deborah Brazzolotto, Marcello Gennari, Nicolas Queyriaux, Trevor R. Simmons, Jacques Pécaut et al. doi:10.1038/nchem.2575 [NiFe] hydrogenases are enzymes containing nickel and iron centres that catalyse hydrogen evolution with performances that rival those of platinum catalysts. Now, a NiFe model complex has been reported that mimics the structure and the Ni-centred hydrogen evolution activity found at the active site of [NiFe] hydrogenases. Observation of trapped-hole diffusion on the surfaces of CdS nanorods   pp1061 - 1066 James K. Utterback, Amanda N. Grennell, Molly B. Wilker, Orion M. Pearce, Joel D. Eaves et al. doi:10.1038/nchem.2566 Photoexcited holes in CdS nanocrystals rapidly trap to the surface and although they are integral to nanocrystal photophysics and photochemistry, their dynamics have remained elusive. Time-resolved spectroscopy and theoretical modelling have now revealed that trapped holes in CdS nanorods are mobile and undergo a random walk on the nanocrystal surface. MIDA boronates are hydrolysed fast and slow by two different mechanisms   pp1067 - 1075 Jorge A. Gonzalez, O. Maduka Ogba, Gregory F. Morehouse, Nicholas Rosson, Kendall N. Houk et al. doi:10.1038/nchem.2571 The staged hydrolysis of N-methylimidodiacetic (MIDA) boronates is a prerequisite for their application in small-molecule constructions. Mechanistic studies now show that two distinct hydrolysis mechanisms operate in parallel, the partitioning — which is dependent on the pH, water activity and homogeneity of the medium — can be readily quantified by 18O incorporation. Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines   pp1076 - 1082 Ioannis V. Pavlidis, Martin S. Weiß, Maika Genz, Paul Spurr, Steven P. Hanlon et al. doi:10.1038/nchem.2578 A motif was identified in the scaffold of an (S)-selective transaminase that enables the asymmetric synthesis of bulky chiral amines. This motif is transferable to other enzymes with as low as 70% sequence identity. The biocatalysts developed show high stereoselectivity and their synthetic potential was confirmed in preparative scale synthesis. In Your Element Top Active actinium   p1084 Gauthier J.-P. Deblonde and Rebecca J. Abergel doi:10.1038/nchem.2653 Naturally scarce but synthetically accessible, Gauthier J.-P. Deblonde and Rebecca J. Abergel discuss element 89 and its emergence as a candidate radio-theranostic metal for cancer treatment. Corrigendum Top Corrigendum: Dearomative dihydroxylation with arenophiles   p1083 Emma H. Southgate, Jola Pospech, Junkai Fu, Daniel R. Holycross and David Sarlah doi:10.1038/nchem.2649 Top Advertisement npj Materials Degradation is a new open access journal that is now open for submissions. The journal publishes the finest content describing basic and applied research discoveries in the area of corrosion (degradation) and protection of materials.  Sign up for article e-alerts >>>   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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