Nature Biotechnology Contents: Volume 34 pp 997 - 1076

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Register free today!   TABLE OF CONTENTS October 2016 Volume 34, Issue 10 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Research Careers and Recruitment Advertisement nature.com webcasts Nature Publishing Group presents a custom webcast on: Releasable purification of monocytes for human dendritic cell generation Watch on-demand today Sponsored by:  Quad Technologies Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Insight: Intestinal Microbiota in Health and Disease:  This Insight explores human development biology and how intestinal microbiota is associated closely with health and disease.  Click here to access the free Nature Insight available for 6 months Produced with support from Yakult Honsha Co., Ltd.     Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement nature.com webcasts Springer Nature presents a custom webcast on Advancements in single-cell RNA-seq: differential expression analysis and immune profiling November 3, 2016; 9AM PDT, 12PM EDT, 4PM GMT, 5PM CET Learn about the latest advancements in single-cell RNA-seq and its application in whole transcriptome analysis and immune profiling.  Register for FREE Sponsored by  Takara Bio USA, Inc.   Advertisement An open access, online-only, multidisciplinary research journal dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms. Explore the benefits of submitting your next research article.    Editorial Top An incredible fudge   p997 doi:10.1038/nbt.3705 Although a US law mandating disclosure of GM ingredients provides food companies with a way out of the labeling rabbit hole, appeasing the anti-GM movement will likely backfire. News Top Early clinical data raise the bar for hemophilia gene therapies   pp999 - 1001 Elie Dolgin doi:10.1038/nbt1016-999 Big win possible for Ionis/Biogen antisense drug in muscular atrophy   pp1002 - 1003 Ken Garber doi:10.1038/nbt1016-1002 Bayer bids $66 billion for Monsanto   p1003 Emily Waltz doi:10.1038/nbt1016-1003 Surprise rejection for Amgen's D-peptide   p1004 Cormac Sheridan doi:10.1038/nbt1016-1004a Seres's pioneering microbiome drug fails mid-stage trial   pp1004 - 1005 Mark Ratner doi:10.1038/nbt1016-1004b Allergan enriches skin portfolio   p1005 doi:10.1038/nbt1016-1005 BMS bets on targeting IL-8 to enhance cancer immunotherapies   pp1006 - 1007 Elie Dolgin doi:10.1038/nbt1016-1006 Around the world in a month   p1007 doi:10.1038/nbt1016-1007 Synthetic biology firms pivot from biofuels to cheap biologics   p1008 Cormac Sheridan doi:10.1038/nbt1016-1008 Advertisement nature.com webcasts Springer Nature presents a custom webcast on: Reveal hidden genetic variation by combining long-read target capture with SMRT Sequencing Date: Thursday October 13, 2016 Time: 8AM PDT, 11AM EDT, 4PM BST, 5PM CEST Register for FREE Sponsored by: PacBio   Bioentrepreneur Top Data Page Top 20 translational researchers of 2015   p1009 Brady Huggett and Kathryn Paisner doi:10.1038/nbt.3686 Podcast First Rounders Podcast: Nancy J Kelley   p1009 doi:10.1038/nbt.3688 Opinion and Comment Top Correspondence A community-based model of rapid autopsy in end-stage cancer patients   pp1010 - 1014 Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff et al. doi:10.1038/nbt.3674 Bypassing GMO regulations with CRISPR gene editing   pp1014 - 1015 Jungeun Kim and Jin-Soo Kim doi:10.1038/nbt.3680 Commentary Lost in the citation valley   pp1016 - 1018 Gerard Pasterkamp, Imo Hoefer and Berent Prakken doi:10.1038/nbt.3691 Changing the academic reward system to improve translational medicine should start by moving away from a myopic focus on publications. Features Top Rekindling cancer vaccines   pp1019 - 1024 Malorye Allison Branca doi:10.1038/nbt.3690 Interest in cancer vaccines is being reignited by a greater understanding of tumor immunology and the potential of combining immunogens with new breakthrough immunotherapies. Patents The emerging patent landscape of CRISPR-Cas gene editing technology   pp1025 - 1031 Knut J Egelie, Gregory D Graff, Sabina P Strand and Berit Johansen doi:10.1038/nbt.3692 Early views on the control of the CRISPR-Cas disruptive enabling technology and access for follow-on commercial applications. Recent patents in neurotechnology and neuroengineering   p1032 doi:10.1038/nbt.3706 Advertisement In January 2017 Cell Press will take over publishing the Molecular Therapy family of journals. To keep receiving e-alerts for these titles, please visit http://www.cell.com/molecular-therapy-family/home  News and Views Top Quantifying the human proteome   pp1033 - 1034 Amanda G Paulovich and Jeffrey R Whiteaker doi:10.1038/nbt.3695 An atlas of targeted mass spectrometry coordinates provides a starting point for measuring the unmodified human proteome. Research Highlights   p1034 doi:10.1038/nbt.3699 Rewiring Escherichia coli for carbon-dioxide fixation   pp1035 - 1036 Cheryl A Kerfeld doi:10.1038/nbt.3693 Engineering bacteria to convert carbon dioxide into sugar may enable diverse biotechnological applications. DNA cages target quantum dots   p1036 Joao H. Duarte doi:10.1038/nbt.3694 Biotechnology JOBS of the week Assistant Professor in Landscape Genomics: Department of Biological Sciences Texas Tech University More Science jobs from Biotechnology EVENT Green for Good IV: Biotechnology of Plant Products June 19, 2017 Czech Republic More science events from Research Top Articles Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes   pp1037 - 1045 Amalie Kai Bentzen, Andrea Marion Marquard, Rikke Lyngaa, Sunil Kumar Saini, Sofie Ramskov et al. doi:10.1038/nbt.3662 Detection of more than 1,000 different T-cell specificities in parallel facilitates identification of cancer and autoimmune antigens. Expression of an insecticidal fern protein in cotton protects against whitefly   pp1046 - 1051 Anoop Kumar Shukla, Santosh Kumar Upadhyay, Manisha Mishra, Sharad Saurabh, Rahul Singh et al. doi:10.1038/nbt.3665 Cotton plants are protected from the sap-sucking whitefly and a viral disease it transmits by transgenic expression of an insecticidal fern protein. High-throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays   pp1052 - 1059 Nathan Cermak, Selim Olcum, Francisco Feijo Delgado, Steven C Wasserman, Kristofor R Payer et al. doi:10.1038/nbt.3666 Heterogeneity in growth phenotypes and drug susceptibility in bacterial and mammalian cells are assayed at the single-cell level using multiplexed resonant mass sensors. Letters Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions   pp1060 - 1065 Sumiyo Morita, Hirofumi Noguchi, Takuro Horii, Kazuhiko Nakabayashi, Mika Kimura et al. doi:10.1038/nbt.3658 DNA methyl groups are selectively removed at target loci using inactive Cas9 fused to a SunTag-based peptide repeat that recruits the enzymatic activity. Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase   pp1066 - 1071 Peder S Olofsson, Benjamin E Steinberg, Roozbeh Sobbi, Maureen A Cox, Mohamed N Ahmed et al. doi:10.1038/nbt.3663 A CD4 T-cell population expressing choline acetyltransferase is shown to contribute to blood pressure regulation. Errata Erratum: Stabilizing prospects for a universal flu vaccine   p1072 Markus Elsner doi:10.1038/nbt1016-1072a Erratum: Will Europe toast GM wheat for gluten sufferers?   p1072 Lucas Laursen doi:10.1038/nbt1016-1072b Corrigenda Corrigendum: Secure cloud computing for genomic data   p1072 Somalee Datta, Keith Bettinger and Michael Snyder doi:10.1038/nbt1016-1072c Corrigendum: Genetic improvement of tomato by targeted control of fruit softening   p1072 Selman Uluisik, Natalie H Chapman, Rebecca Smith, Mervin Poole, Gary Adams et al. doi:10.1038/nbt1016-1072d Careers and Recruitment Top Learn new languages to get ahead   pp1073 - 1074 Alexander Birbrair doi:10.1038/nbt.3698 A knowledge of languages enables connections that open up new opportunities in the sciences. People People   p1076 doi:10.1038/nbt.3707 Advertisement nature.com webcasts Join us for our upcoming webcast with live Q&A:  PAIN TARGETING MECHANISMS Presented by BioPharma Dealmakers Date: Thursday, October 6, 2016 Time: 8AM PDT, 11AM EDT, 4PM BST, 5PM CEST REGISTER FOR FREE Sponsored by: Algomedix, Inc. | Cara Therapeutics, Inc. | Myoscience | Nektar Therapeutics     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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