The EMBO Journal Table of Contents for 15 September 2016; Vol. 35, No. 18

15 September 2016 | Volume 35, Number 18 Submit Table of Contents News & Views Articles Retraction Volume 35, Number 18 News & Views One more factor joins the plot: Pbx1 regulates differentiation and survival of midbrain dopaminergic neurons The homeobox transcription factor Pbx1 regulates dopaminergic neuronal development and protects them from oxidative stress. Diogo S Castro Published online 17.08.2016 Mitochondrial DNA mutations in iPS cells: mtDNA integrity as standard iPSC selection criteria? Two recent studies show that reprogramming can lead to enrichment of mitochondrial DNA mutations in human induced pluripotent stem cells (hiPSCs), contributing to intra‐person hiPSC functional variability. Riikka H Hämäläinen Published online 28.07.2016 Articles A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease The homeobox factor PBX1 directly represses or activates key genes involved in specification, survival, and oxidative stress protection of midbrain dopaminergic neurons. J Carlos Villaescusa, Bingsi Li, Enrique M Toledo, Pia Rivetti di Val Cervo, Shanzheng Yang, Simon RW Stott, Karol Kaiser, Saiful Islam, Daniel Gyllborg, Rocio Laguna‐Goya, Michael Landreh, Peter Lönnerberg, Anna Falk, Tomas Bergman, Roger A Barker, Sten Linnarsson, Licia Selleri, and Ernest Arenas Published online 28.06.2016 Natural underlying mtDNA heteroplasmy as a potential source of intra‐person hiPSC variability Low level of natural heteroplasmy in mitochondrial DNA in parental fibroblasts can be revealed during nuclear reprogramming in both healthy and diseased individuals and is a potential source of intra‐person hiPSC variability. Ester Perales‐Clemente, Alexandra N Cook, Jared M Evans, Samantha Roellinger, Frank Secreto, Valentina Emmanuele, Devin Oglesbee, Vamsi K Mootha, Michio Hirano, Eric A Schon, Andre Terzic, and Timothy J Nelson Published online 19.07.2016 Golgi membrane‐associated degradation pathway in yeast and mammals A novel Golgi membrane‐associated degradation (GOMED) pathway is activated when PI(4)P‐dependent Golgi‐to‐plasma membrane anterograde trafficking is disrupted in autophagy‐deficient yeast and mammalian cells. Hirofumi Yamaguchi, Satoko Arakawa, Toku Kanaseki, Takeshi Miyatsuka, Yoshio Fujitani, Hirotaka Watada, Yoshihide Tsujimoto, and Shigeomi Shimizu Published online 10.08.2016 Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism‐like phenotype in mice Mouse knockout of FBXO7, associated with early‐onset Parkinson's disease, affects the assembly state of proteasomes and causes motor impairments strikingly resembling those seen in patients. Siv Vingill, David Brockelt, Camille Lancelin, Lars Tatenhorst, Guergana Dontcheva, Christian Preisinger, Nicola Schwedhelm‐Domeyer, Sabitha Joseph, Miso Mitkovski, Sandra Goebbels, Klaus‐Armin Nave, Jörg B Schulz, Till Marquardt, Paul Lingor, and Judith Stegmüller Published online 05.08.2016 IGFBP1 increases β‐cell regeneration by promoting α‐ to β‐cell transdifferentiation In a zebrafish screen, insulin‐like growth factor binding protein 1 (Igfbp1) promotes β‐cell regeneration. Igfbp1 potentiates α‐ to β‐cell transdifferentiation in fish, mouse, and human islets. In humans, high IGFBP1 levels correlate with reduced type‐2 diabetes risk. Jing Lu, Ka‐Cheuk Liu, Nadja Schulz, Christos Karampelias, Jérémie Charbord, Agneta Hilding, Linn Rautio, Philippe Bertolino, Claes‐Göran Östenson, Kerstin Brismar, and Olov Andersson Published online 11.08.2016 A fidelity mechanism in DNA polymerase lambda promotes error‐free bypass of 8‐oxo‐dG Crystal structures of Pol λ reveal a uniquely flexible active site, allowing it to bypass bulky lesion irrespective of their conformation in base excision repair, while still discriminating conformations at the extension step. Matthew J Burak, Kip E Guja, Elena Hambardjieva, Burak Derkunt, and Miguel Garcia‐Diaz Published online 01.08.2016 Retraction Retraction: ‘A pair of transposon‐derived proteins regulate active DNA demethylation in Arabidopsis’ Qi Li, Wei Yuan, Xiaokang Wang, Yannan Liu, Xinyi Ma, Han Sun, Jinjin Tong, Xueyuan Tian, Yan Li, and Weiqiang Qian Published online 28.07.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.