Nature Reviews Cancer contents October 2016 Volume 16 Number 10 pp613-673

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TABLE OF CONTENTS
October 2016 Volume 16 Number 10		Advertisement
Impact Factor 34.244 *	In this issue Foreword Research Highlights Focus on: Tumour metabolism Reviews Also this month  Featured article: From Krebs to clinic: glutamine metabolism to cancer therapy Brian J. Altman, Zachary E. Stine & Chi V. Dang	Nature Reviews Cancer Focus on Tumour Metabolism This Focus explores the dynamic and varied metabolism in tumour cells, discussing the importance of these pathways for many tumorigenic processes, such as tumour progression, survival, growth, epigenetic changes and how these can be translated to the clinic.  Access the Focus free online. Produced with support from  Agios Pharmaceuticals, Inc.
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FOREWORD		Top
The current state of cancer metabolism Rob A. Cairns & Tak W. Mak p613 | doi:10.1038/nrc.2016.100 This Foreword introduces the nine Review articles in our Focus on Tumour Metabolism and discusses the main areas of tumour metabolism for further research. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Tumour metabolism: The sugar-free, full-fat diet p615 | doi:10.1038/nrc.2016.99 Acidosis reprograms the metabolism of cancer cells toward fatty acid oxidation by downregulating acetyl-CoA carboxylase ACC2 through histone deacetylation PDF Tumour metabolism: Feeding your friends p616 | doi:10.1038/nrc.2016.96 Sousa et al. demonstrate a reciprocal metabolic cross-talk between pancreatic stellate cells (PSCs) and pancreatic tumour cells whereby secreted autophagic alanine from PSCs is taken up by tumour cells and used as an alternative carbon source to support tumour growth. PDF Tumour metabolism: Adapting to harsh conditions p616 | doi:10.1038/nrc.2016.98 Chae et al. show that mitochondrially-localized AKT phosphorylates pyruvate dehydrogenase kinase 1 (PDK1) to promote tumour cell growth and survival in hypoxic conditions. PDF IN BRIEF Tumour metabolism: Metabolic flexibility | Tumour metabolism: Functions of fumarate | Tumour evolution: Evolving resistance in Tasmanian devils | Genetics: Transcribing for the enemy PDF Cancer JOBS of the week Postdoctoral Fellow – Prostate Cancer Biology University of Maryland Postdoctoral Research Fellow in Medicinal Chemistry for Cancer Drug Discovery University of Michigan Postdoctoral Training Fellow – Clonal Evolution of Colorectal Cancer (x2) Institute of Cancer Research (ICR) Postdoctoral Fellow - Prostate Cancer Biology Weill Cornell Medicine Faculty Position in Pharmacology and Cancer Biology Duke University School of Medicine More Science jobs from
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Focus on: Tumour metabolism REVIEWS Top From Krebs to clinic: glutamine metabolism to cancer therapy Brian J. Altman, Zachary E. Stine & Chi V. Dang p619 | doi:10.1038/nrc.2016.71 This Review provides an overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, exploring the recent potential applications of basic science discoveries in the clinical setting. Abstract | Full Text | PDF Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? Nissim Hay p635 | doi:10.1038/nrc.2016.77 The reprogramming of glucose metabolism in cancer cells, which have increased flux through glycolysis and related pathways, offers the promise of targeted inhibitors to selectively eradicate cancer cells either by themselves or as adjuvants to existing therapeutic modalities. Abstract | Full Text | PDF Serine and one-carbon metabolism in cancer Ming Yang & Karen H. Vousden p650 | doi:10.1038/nrc.2016.81 Serine supports many biosynthetic pathways, including the one-carbon cycle. This Review discusses how cancer cells acquire and use serine, and explores novel therapeutic approaches to limit serine metabolism. Abstract | Full Text | PDF Oxygen availability and metabolic adaptations Michael S. Nakazawa, Brian Keith & M. Celeste Simon p663 | doi:10.1038/nrc.2016.84 The availability of oxygen and nutrients changes during tumour evolution, which can have an effect on gene expression and diverse metabolic reactions as cells try to adapt to the new environment. In this Review the authors summarize how these metabolic adaptations are integrated in hypoxic tumour cells and their role in disease progression. Abstract | Full Text | PDF
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