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TABLE OF CONTENTS
|  |  |  | Volume 7, September 2016 |  | In this issue News and Commentaries Review Original Articles Correspondence | |  |  |  | | Advertisement |  | Cell Death & Disease is an online-only, open access journal seeking to promote diverse and integrated areas of experimental and internal medicine with its specialities, including cancer, cancer metabolism, immunity and neuroscience. Explore the benefits of submitting your next research article. |  | | |  |  | News and Commentaries | Top |  | Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signalingStephen M Condon Cell Death Dis 2016 7: e2385; 10.1038/cddis.2016.283 Full Text |  |  |  | Lipid-derived reactive aldehydes link oxidative stress to cell senescenceAmy C Flor and Stephen J Kron Cell Death Dis 2016 7: e2366; 10.1038/cddis.2016.275 Full Text |  |  |  | Oxidative downmodulation of T cell-mediated cytotoxicityGuido H Wabnitz and Yvonne Samstag Cell Death Dis 2016 7: e2373; 10.1038/cddis.2016.273 Full Text |  | Review | Top |  | Long noncoding RNAs in the progression, metastasis, and prognosis of osteosarcomaZuozhang Yang, Xiaojuan Li, Yihao Yang, Zewei He, Xin Qu and Ya Zhang Cell Death Dis 2016 7: e2389; 10.1038/cddis.2016.272 Abstract | Full Text |  | Original Articles | Top |  | Activation of necroptosis in human and experimental cholestasisMarta B Afonso, Pedro M Rodrigues, André L Simão, Dimitry Ofengeim, Tânia Carvalho, Joana D Amaral, Maria M Gaspar, Helena Cortez-Pinto, Rui E Castro, Junying Yuan and Cecília M P Rodrigues Cell Death Dis 2016 7: e2390; 10.1038/cddis.2016.280 Abstract | Full Text |  |  |  | Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in miceRebecca A Bilardi, Natasha S Anstee, Stefan P Glaser, Mikara Robati, Cassandra J Vandenberg and Suzanne Cory Cell Death Dis 2016 7: e2351; 10.1038/cddis.2016.258 Abstract | Full Text |  |  |  | BNC2 is a putative tumor suppressor gene in high-grade serous ovarian carcinoma and impacts cell survival after oxidative stressLaura Cesaratto, Eleonora Grisard, Michela Coan, Luigi Zandonà, Elena De Mattia, Elena Poletto, Erika Cecchin, Fabio Puglisi, Vincenzo Canzonieri, Maria Teresa Mucignat, Antonella Zucchetto, Gabriele Stocco, Alfonso Colombatti, Milena S Nicoloso and Riccardo Spizzo Cell Death Dis 2016 7: e2374; 10.1038/cddis.2016.278 Abstract | Full Text |  |  |  | Adipose-derived mesenchymal stem cells promote the survival of fat grafts via crosstalk between the Nrf2 and TLR4 pathwaysXiaosong Chen, Liu Yan, Zhihui Guo, Zhaohong Chen, Ying Chen, Ming Li, Chushan Huang, Xiaoping Zhang and Liangwan Chen Cell Death Dis 2016 7: e2369; 10.1038/cddis.2016.261 Abstract | Full Text |  |  |  | Short-term EGFR blockade enhances immune-mediated cytotoxicity of EGFR mutant lung cancer cells: rationale for combination therapiesCharli Dominguez, Kwong-Yok Tsang and Claudia Palena Cell Death Dis 2016 7: e2380; 10.1038/cddis.2016.297 Abstract | Full Text |  |  |  | Kinase-independent function of RIP1, critical for mature T-cell survival and proliferationJohn P Dowling, Yubo Cai, John Bertin, Peter J Gough and Jianke Zhang Cell Death Dis 2016 7: e2379; 10.1038/cddis.2016.307 Abstract | Full Text |  |  |  | Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse modelAnja Drinkut, Karsten Tillack, Durga P Meka, Jorg B Schulz, Sebastian Kügler and Edgar R Kramer Cell Death Dis 2016 7: e2359; 10.1038/cddis.2016.263 Abstract | Full Text |  |  |  | Nitric oxide-mediated apoptosis of neutrophils through caspase-8 and caspase-3-dependent mechanismMegha Dubey, Sheela Nagarkoti, Deepika Awasthi, Abhishek K Singh, Tulika Chandra, J Kumaravelu, Manoj K Barthwal and Madhu Dikshit Cell Death Dis 2016 7: e2348; 10.1038/cddis.2016.248 Abstract | Full Text |  |  |  | miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathwaysZhi Hong Fang, Si Li Wang, Jin Tao Zhao, Zhi Juan Lin, Lin Yan Chen, Rui Su, Si Ting Xie, Bing Z Carter and Bing Xu Cell Death Dis 2016 7: e2371; 10.1038/cddis.2016.256 Abstract | Full Text |  |  |  | Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cellsQi Gao, Kexin Chen, Lu Gao, Yang Zheng and Yong-Guang Yang Cell Death Dis 2016 7: e2368; 10.1038/cddis.2016.155 Abstract | Full Text |  |  |  | Mesenchymal stem cells stimulate intestinal stem cells to repair radiation-induced intestinal injuryWei Gong, Mengzheng Guo, Zhibo Han, Yan Wang, Ping Yang, Chang Xu, Qin Wang, Liqing Du, Qian Li, Hui Zhao, Feiyue Fan and Qiang Liu Cell Death Dis 2016 7: e2387; 10.1038/cddis.2016.276 Abstract | Full Text |  |  |  | TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpointsXiaoyun Guo, Haifeng Yin, Yi Chen, Lei Li, Jing Li and Qinghang Liu Cell Death Dis 2016 7: e2381; 10.1038/cddis.2016.294 Abstract | Full Text |  |  |  | Nitric oxide released from JS-K induces cell death by mitotic catastrophe as part of necrosis in glioblastoma multiformeJessica Günzle, Nadja Osterberg, Joseph E Saavedra and Astrid Weyerbrock Cell Death Dis 2016 7: e2349; 10.1038/cddis.2016.254 Abstract | Full Text |  |  |  | Kinsenoside screening with a microfluidic chip attenuates gouty arthritis through inactivating NF-κB signaling in macrophages and protecting endothelial cellsQiao Han, Wang Bing, Yin Di, Li Hua, Li Shi-he, Zheng Yu-hua, Han Xiu-guo, Wang Yu-gang, Fan Qi-ming, Yang Shih-mo and Tang Ting-ting Cell Death Dis 2016 7: e2350; 10.1038/cddis.2016.255 Abstract | Full Text |  |  |  | Epstein-Barr virus-encoded miR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103Baoyu He, Weiming Li, Yingfen Wu, Fang Wei, Zhaojian Gong, Hao Bo, Yumin Wang, Xiayu Li, Bo Xiang, Can Guo, Qianjin Liao, Pan Chen, Xuyu Zu, Ming Zhou, Jian Ma, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng Cell Death Dis 2016 7: e2353; 10.1038/cddis.2016.253 Abstract | Full Text |  |  |  | RBM24 suppresses cancer progression by upregulating miR-25 to target MALAT1 in nasopharyngeal carcinomaWen-Feng Hua, Qian Zhong, Tian-Liang Xia, Qi Chen, Mei-Yin Zhang, Ai-Jun Zhou, Zi-Wei Tu, Chen Qu, Man-Zhi Li, Yun-Fei Xia, Hui-Yun Wang, Dan Xie, Francois-Xavier Claret, Er-Wei Song and Mu-Sheng Zeng Cell Death Dis 2016 7: e2352; 10.1038/cddis.2016.252 Abstract | Full Text |  |  |  | Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotypePaola Infante, Romina Alfonsi, Cinzia Ingallina, Deborah Quaglio, Francesca Ghirga, Ilaria D'Acquarica, Flavia Bernardi, Laura Di Magno, Gianluca Canettieri, Isabella Screpanti, Alberto Gulino, Bruno Botta, Mattia Mori and Lucia Di Marcotullio Cell Death Dis 2016 7: e2376; 10.1038/cddis.2016.195 Abstract | Full Text |  |  |  | Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agentsOlaf Klingbeil, Ralf Lesche, Kathy A Gelato, Bernard Haendler and Pascale Lejeune Cell Death Dis 2016 7: e2365; 10.1038/cddis.2016.271 Abstract | Full Text |  |  |  | Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress responseAkhilesh Kumar, Michael D Birnbaum, Devang M Patel, William M Morgan, Jayanti Singh, Antoni Barrientos and Fangliang Zhang Cell Death Dis 2016 7: e2378; 10.1038/cddis.2016.284 Abstract | Full Text |  |  |  | MiR-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3aYimeng Li, Ao Li, Jingfang Wu, Yingzi He, Huiqian Yu, Renjie Chai and Huawei Li Cell Death Dis 2016 7: e2362; 10.1038/cddis.2016.246 Abstract | Full Text |  |  |  | Nuclear translocation of annexin 1 following oxygen-glucose deprivation–reperfusion induces apoptosis by regulating Bid expression via p53 bindingXing Li, Yin Zhao, Qian Xia, Lu Zheng, Lu Liu, Baoming Zhao and Jing Shi Cell Death Dis 2016 7: e2356; 10.1038/cddis.2016.259 Abstract | Full Text |  |  |  | Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse modelQiang Liu, Longgui Chen, Jennifer M Atkinson, David F Claxton and Hong-Gang Wang Cell Death Dis 2016 7: e2361; 10.1038/cddis.2016.264 Abstract | Full Text |  |  |  | miR-612 suppresses stem cell-like property of hepatocellular carcinoma cells by modulating Sp1/Nanog signalingYang Liu, Dong-Li Liu, Li-Li Dong, Duo Wen, Dong-Min Shi, Jian Zhou, Jia Fan and Wei-Zhong Wu Cell Death Dis 2016 7: e2377; 10.1038/cddis.2016.282 Abstract | Full Text |  |  |  | Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosisIzhar Livne-Bar, Susy Lam, Darren Chan, Xiaoxin Guo, Idil Askar, Adrian Nahirnyj, John G Flanagan and Jeremy M Sivak Cell Death Dis 2016 7: e2386; 10.1038/cddis.2016.277 Abstract | Full Text |  |  |  | 4-cholesten-3-one suppresses lung adenocarcinoma metastasis by regulating translocation of HMGB1, HIF1α and Caveolin-1Jinben Ma, Guobin Fu, Jing Wu, Shaoxian Han, Lishan Zhang, Ming Yang, Yong Yu, Mengyuan Zhang, Yanliang Lin and Yibing Wang Cell Death Dis 2016 7: e2372; 10.1038/cddis.2016.281 Abstract | Full Text |  |  |  | HSV-1-induced activation of NF-κB protects U937 monocytic cells against both virus replication and apoptosisFrancesca Marino-Merlo, Emanuela Papaianni, Maria Antonietta Medici, Beatrice Macchi, Sandro Grelli, Claudia Mosca, Christoph Borner and Antonio Mastino Cell Death Dis 2016 7: e2354; 10.1038/cddis.2016.250 Abstract | Full Text |  |  |  | CHK1 and RAD51 activation after DNA damage is regulated via urokinase receptor/TLR4 signalingPavan B Narayanaswamy, Sergey Tkachuk, Hermann Haller, Inna Dumler and Yulia Kiyan Cell Death Dis 2016 7: e2383; 10.1038/cddis.2016.291 Abstract | Full Text |  |  |  | Omentin protects against LPS-induced ARDS through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt/eNOS-dependent mechanismDi Qi, Xumao Tang, Jing He, Daoxin Wang, Yan Zhao, Wang Deng, Xinyu Deng, Guoqi Zhou, Jing Xia, Xi Zhong and Shenglan Pu Cell Death Dis 2016 7: e2360; 10.1038/cddis.2016.265 Abstract | Full Text |  |  |  | Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosisDaniela Siegmund, Juliane Kums, Martin Ehrenschwender and Harald Wajant Cell Death Dis 2016 7: e2375; 10.1038/cddis.2016.285 Abstract | Full Text |  |  |  | Clearance of autophagy-associated dying retinal pigment epithelial cells – a possible source for inflammation in age-related macular degenerationM Szatmári-Tóth, E Kristóf, Z Veréb, S Akhtar, A Facskó, L Fésüs, A Kauppinen, K Kaarniranta and G Petrovski Cell Death Dis 2016 7: e2367; 10.1038/cddis.2016.133 Abstract | Full Text |  |  |  | Hsa-miR-623 suppresses tumor progression in human lung adenocarcinomaShuang Wei, Zun-yi Zhang, Sheng-ling Fu, Jun-gang Xie, Xian-sheng Liu, Yong-jian Xu, Jian-ping Zhao and Wei-ning Xiong Cell Death Dis 2016 7: e2388; 10.1038/cddis.2016.260 Abstract | Full Text |  |  |  | Circulating histones are major mediators of systemic inflammation and cellular injury in patients with acute liver failureZongmei Wen, Zhen Lei, Lu Yao, Ping Jiang, Tao Gu, Feng Ren, Yan Liu, Chunyan Gou, Xiuhui Li and Tao Wen Cell Death Dis 2016 7: e2391; 10.1038/cddis.2016.303 Abstract | Full Text |  |  |  | The Fra-1–miR-134–SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cellsJianmin Wu, Yimin Sun, Pei-Ying Zhang, Mengyao Qian, Hengchao Zhang, Xiao Chen, Di Ma, Yunsheng Xu, Xiaoming Chen and Kai-Fu Tang Cell Death Dis 2016 7: e2384; 10.1038/cddis.2016.289 Abstract | Full Text |  |  |  | Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis: role in pulmonary inflammation following LPSJie Yang, Yanfeng Zhao, Peng Zhang, Yuehua Li, Yong Yang, Yang Yang, Junjie Zhu, Xiao Song, Gening Jiang and Jie Fan Cell Death Dis 2016 7: e2363; 10.1038/cddis.2016.274 Abstract | Full Text |  |  |  | Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinomaJisheng Zhang, Xiaofei An, Yafei Han, Rui Ma, Kun Yang, Lu Zhang, Jingwei Chi, Wei Li, David Llobet-Navas, Yan Xu and Yan Jiang Cell Death Dis 2016 7: e2358; 10.1038/cddis.2016.262 Abstract | Full Text |  |  |  | Distal regulation of c-myb expression during IL-6-induced differentiation in murine myeloid progenitor M1 cellsJunfang Zhang, Bingshe Han, Xiaoxia Li, Juraj Bies, Penglei Jiang, Richard P Koller and Linda Wolff Cell Death Dis 2016 7: e2364; 10.1038/cddis.2016.267 Abstract | Full Text |  |  |  | miRNA-558 promotes gastric cancer progression through attenuating Smad4-mediated repression of heparanase expressionLiduan Zheng, Wanju Jiao, Huajie Song, Hongxia Qu, Dan Li, Hong Mei, Yajun Chen, Feng Yang, Huanhuan Li, Kai Huang and Qiangsong Tong Cell Death Dis 2016 7: e2382; 10.1038/cddis.2016.293 Abstract | Full Text |  | Correspondence | Top |  | Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethalityCunxian Fan, Wenjuan Pu, Xiaoxia Wu, Xixi Zhang, Lingjuan He, Bin Zhou and Haibing Zhang Cell Death Dis 2016 7: e2351; 10.1038/cddis.2016.251 Full Text |  |  |  |  | | Advertisement |  | Online-only and open access, Cell Death Discovery publishes scientifically sound research at the intersection of cell death and medicine. 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