The EMBO Journal Table of Contents for 1 April 2016; Vol. 35, No. 7

1 April 2016 | Volume 35, Number 7 Submit Table of Contents News & Views Articles Corrigendum Volume 35, Number 7 News & Views Starting too soon: upstream reading frames repress downstream translation The analysis of ribosome profiling data across three vertebrate species demonstrates the global effect of uORF‐dependent translational control of gene expression. Anna M McGeachy and Nicholas T Ingolia Published online 19.02.2016 Mitochondria and senescence: new actors for an old play A new study reveals a causal role of mitochondria for cellular senescence phenotypes and ageing. Nicolás Herranz and Jesús Gil Published online 23.02.2016 DNA binding to SMC ATPases—trapped for release ABC‐type ATPases play essential roles in DNA repair and cell division. Independent studies on the structure of the Rad50–DNA complex and cohesion regulation suggest a conserved regulatory paradigm. Herwig Schüler and Camilla Sjögren Published online 11.03.2016 Articles Upstream ORFs are prevalent translational repressors in vertebrates Upstream open reading frames (uORFs) are found in many genes, but their functional impact is unclear. This study explores their abundant translation, conservation, and potent role in shaping the vertebrate translational landscape. Timothy G Johnstone, Ariel A Bazzini, and Antonio J Giraldez Published online 19.02.2016 Mitochondria are required for pro‐ageing features of the senescent phenotype Cellular senescence serves as an important anticancer growth arrest mechanism, but also contributes to ageing. This study shows that mitochondria are necessary for the pro‐inflammatory phenotype during senescence and that senescence can be induced by mitochondrial biogenesis. Clara Correia‐Melo, Francisco DM Marques, Rhys Anderson, Graeme Hewitt, Rachael Hewitt, John Cole, Bernadette M Carroll, Satomi Miwa, Jodie Birch, Alina Merz, Michael D Rushton, Michelle Charles, Diana Jurk, Stephen WG Tait, Rafal Czapiewski, Laura Greaves, Glyn Nelson, Mohammad Bohlooly‐Y, Sergio Rodriguez‐Cuenca, Antonio Vidal‐Puig, Derek Mann, Gabriele Saretzki, Giovanni Quarato, Douglas R Green, Peter D Adams, Thomas von Zglinicki, Viktor I Korolchuk, and João F Passos Published online 04.02.2016 ATP‐dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex The X‐ray structure of the ATP loaded Mre11/Rad50 DNA repair complex shows that DNA runs along a groove between the Rad50 dimers. ATP hydrolysis causes DNA melting and a conformational change, allowing access to Mre11 active site. Yaqi Liu, Sihyun Sung, Youngran Kim, Fuyang Li, Gwanghyun Gwon, Aera Jo, Ae‐Kyoung Kim, Taeyoon Kim, Ok‐kyu Song, Sang Eun Lee, and Yunje Cho Published online 30.12.2015 Structural mechanism of ATP‐dependent DNA binding and DNA end bridging by eukaryotic Rad50 The structure of the DNA double‐strand break repair protein Rad50 in complex with DNA reveals how ATP‐dependent dimerization of its ABC ATPase domain generates a positively charged platform for binding DNA. Florian Ulrich Seifert, Katja Lammens, Gabriele Stoehr, Brigitte Kessler, and Karl‐Peter Hopfner Published online 19.02.2016 Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin‐binding IFT‐B2 complex Thought to be peripheral components of the IFT‐B complex, IFT172, 80, 57, 54, and 20 form a stable sub‐complex (IFT‐B2). IFT‐B2 interacts with tubulin/microtubules and connects them to the core IFT‐B1 complex through interaction with IFT88/52. Michael Taschner, Kristina Weber, André Mourão, Melanie Vetter, Mayanka Awasthi, Marc Stiegler, Sagar Bhogaraju, and Esben Lorentzen Published online 24.02.2016 Corrigendum ATP‐driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling Rajashree A Deshpande, Gareth J Williams, Oliver Limbo, R Scott Williams, Jeff Kuhnlein, Ji‐Hoon Lee, Scott Classen, Grant Guenther, Paul Russell, John A Tainer, and Tanya T Paull Published online 31.03.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.