The EMBO Journal Table of Contents for 15 March 2016; Vol. 35, No. 6

15 March 2016 | Volume 35, Number 6 Submit Table of Contents News & Views Review Articles Volume 35, Number 6 News & Views Emancipation from transcriptional latency: unphosphorylated STAT5 as guardian of hematopoietic differentiation In canonical Jak–STAT signaling, Jak activates the transcription factor STAT by tyrosine phosphorylation. Now, unphosphorylated STAT5 is shown to directly repress transcription of a different set of target genes, mostly in proximity of CTCF sites, to control hematopoietic differentiation. Thomas Decker Published online 18.02.2016 The cis‐regulatory switchboard of pancreatic ductal cancer A new genomewide study identifies cis‐ and trans‐regulatory elements in pancreatic ductal carcinoma, thus shedding light on the mechanisms underlying tumour progression. Jorge Ferrer and Francisco X Real Published online 18.02.2016 Review Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic Phosphatidylinositol 3‐phosphates exhibit different effects depending on their subcellular localization. This review discusses their roles as well as the mechanisms that control their spatiotemporal biosynthesis and turnover. Andrea L Marat and Volker Haucke Published online 17.02.2016 Articles Cytokine‐induced megakaryocytic differentiation is regulated by genome‐wide loss of a uSTAT transcriptional program In the unphosphorylated state, STAT5 represses a transcription program that restrains megakaryocyte differentiation. Cytokine‐induced STAT5 tyrosine phosphorylation triggers genome‐wide relocation to STAT consensus sites, including regulators of apoptosis and proliferation. Hyun Jung Park, Juan Li, Rebecca Hannah, Simon Biddie, Ana I Leal‐Cervantes, Kristina Kirschner, David Flores Santa Cruz, Veronika Sexl, Berthold Göttgens, and Anthony R Green Published online 23.12.2015 Dissection of transcriptional and cis‐regulatory control of differentiation in human pancreatic cancer By combining expression profiling, epigenomic footprinting and loss‐of‐function experiments, this work catalogues the differential usage of transcription factors and enhancers during tumor progression in human pancreatic ductal adenocarcinoma (PDAC). Giuseppe R Diaferia, Chiara Balestrieri, Elena Prosperini, Paola Nicoli, Paola Spaggiari, Alessandro Zerbi, and Gioacchino Natoli Published online 14.01.2016 Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency The LIF/STAT3 pathway promotes naïve pluripotency and proliferation in embryonic stem cells. To do this, in addition to its nuclear role, STAT3 translocates to the mitochondrion, regulates mitochondrial transcription and enhances mitochondrial respiration. Elena Carbognin, Riccardo M Betto, Maria E Soriano, Austin G Smith, and Graziano Martello Published online 22.02.2016 Sororin actively maintains sister chromatid cohesion Sororin is required for sister chromatid cohesion by stabilizing vertebrate cohesin on chromatin after DNA replication. The interaction of sororin with cohesin only occurs on replicated chromatin and is short‐lived. Rene Ladurner, Emanuel Kreidl, Miroslav P Ivanov, Heinz Ekker, Maria Helena Idarraga‐Amado, Georg A Busslinger, Gordana Wutz, David A Cisneros, and Jan‐Michael Peters Published online 22.02.2016 Pseudouridines in U2 snRNA stimulate the ATPase activity of Prp5 during spliceosome assembly Activation of the DEAD‐box helicase Prp5 requires pseudouridine formation, shedding light on the regulatory potential of such increasingly recognized RNA modifications. Guowei Wu, Hironori Adachi, Junhui Ge, David Stephenson, Charles C Query, and Yi‐Tao Yu Published online 12.02.2016 Wnt‐induced deubiquitination FoxM1 ensures nucleus β‐catenin transactivation Wnt signaling stabilizes FoxM1, suppressing its phosphorylation by GSK3 and promoting its interaction with USP5. FoxM1 in turn interacts with beta‐catenin and abolishes the inhibitory effect of ICAT, leading to Wnt target‐gene expression and tumor cell proliferation. Yaohui Chen, Yu Li, Jianfei Xue, Aihua Gong, Guanzhen Yu, Aidong Zhou, Kangyu Lin, Sicong Zhang, Nu Zhang, Cara J Gottardi, and Suyun Huang Published online 24.02.2016 Neutralization of pro‐inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis A novel approach for blocking TLR2 signaling modulates immune cell activation and reduces disease severity during acute gut inflammation. Liraz Shmuel‐Galia, Tegest Aychek, Avner Fink, Ziv Porat, Batya Zarmi, Biana Bernshtein, Ori Brenner, Steffen Jung, and Yechiel Shai Published online 15.02.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.