Nature Reviews Neuroscience contents April 2016 Volume 17 Number 4 pp 197-260

If you are unable to see the message below, click here to view.

Advertisement
Nature Outlook Cognitive Health This Nature Outlook investigates some of the strategies that can be used to keep our brains in top form when faced with social and biological factors that induce deterioration. Available free online. Produced with support from: Nestlé Research
TABLE OF CONTENTS
April 2016 Volume 17 Number 4
Impact Factor 31.427 *	In this issue Research Highlights Progress Reviews Perspectives Also this month  Featured article: Rhythms of the hippocampal network Laura Lee Colgin
Subscribe   Facebook   RSS   Recommend to library   Twitter
RESEARCH HIGHLIGHTS Top Neural repair: Networking for regeneration p197 | doi:10.1038/nrn.2016.29 A large collaborative study provides a comprehensive analysis of the core molecular networks that are modulated during peripheral axon regrowth after injury. PDF Behavioural Neuroscience: Only the lonely p198 | doi:10.1038/nrn.2016.26 Dopaminergic neurons of the dorsal raphe nucleus have a role in mediating the rebound sociability observed in mice following acute isolation from littermates, and this could represent a behavioural state that is similar to loneliness in humans. PDF Neural circuits: A circuit to sigh for p198 | doi:10.1038/nrn.2016.30 A new study identifies two peptidergic pathways that regulate sighing in rodents. PDF Psychiatric disorders: Linking genetic risk to pruning p199 | doi:10.1038/nrn.2016.20 Structural variations in the gene encoding complement component 4 — a protein linked to synaptic refinement — are associated with an increased schizophrenia risk. PDF Addiction: Road to aversion p200 | doi:10.1038/nrn.2016.25 Projections from the paraventricular thalamus to the nucleus accumbens mediate the somatic response and aversion to opiate withdrawal in mice. PDF IN BRIEF Neurodevelopmental disorders: Rescue strategy | Emotion: Waves of fear | Glia: Identity-driven PDF Neuroscience JOBS of the week Institute Senior Research Scientist Neuroscience Hit to Lead Medicinal Chemistry The University of Texas MD Anderson Cancer Center Scientific Director and professor of the School for Mental Health and Neuroscience (1,0 fte) Maastricht University (UM) Lab Head Ophthalmology Bayer HealthCare Postdoctoral Researcher University of California, San Diego ( UCSD ) Neurobiologist Rutgers University - New Brunswick More Science jobs from Neuroscience EVENT 5th Champalimaud Neuroscience Symposium 21.09.16 Lisbon, Portugal More science events from
PROGRESS		Top
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis Marco Colonna & Yaming Wang p201 | doi:10.1038/nrn.2016.7 A series of genetic studies has implicated the microglial immune receptor TREM2 in the pathogenesis of Alzheimer disease (AD). Here, Colonna and Wang describe recent studies that have begun to unpick the mechanisms by which TREM2 is involved in AD and discuss unanswered questions in the field. Abstract | Full Text | PDF
REVIEWS		Top
Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling Jinwei Zhu, Yuan Shang & Mingjie Zhang p209 | doi:10.1038/nrn.2016.18 Membrane-associated guanylate kinases (MAGUKs) are synaptic scaffold proteins involved in organizing protein complexes that are required for synaptic development and plasticity. Placing their focus on recent biochemical and structural data, Zhang and colleagues review the role of MAGUKs in synaptic protein complex formation and regulation. Abstract | Full Text | PDF | Supplementary information
Decoding the organization of spinal circuits that control locomotion Ole Kiehn p224 | doi:10.1038/nrn.2016.9 In vertebrates, assemblies of neurons in the spinal cord generate the precise timing and patterning of locomotor movements. In this Review, Ole Kiehn examines the organization and operation of these spinal locomotor networks in limbed and non-limbed animals. Abstract | Full Text | PDF
Rhythms of the hippocampal network Laura Lee Colgin p239 | doi:10.1038/nrn.2016.21 Local field potential recordings of the hippocampus reveal three types of neural activity rhythms: theta, sharp wave–ripples and gamma. In this Review, Colgin discusses recent findings from rodent studies that provide insight into the origin of these rhythms and their roles in memory and other behaviours. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration Dominic M. Walsh & Dennis J. Selkoe p251 | doi:10.1038/nrn.2016.13 There has been a surge in the number of papers discussing the idea that inter-neuronal spread of 'pathogenic' proteins contributes to neurodegenerative disease progression. Walsh and Selkoe provide a critical overview of the evidence for this mechanism, identify gaps in our knowledge and suggest experimental approaches to test the hypothesis. Abstract | Full Text | PDF
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2014 Journal Citation Report (Thomson Reuters, 2015)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.