Nature Communications - 30 March 2016

Weekly Content Alert Nature Communications is now fully open access. Read more. 30 March 2016  Featured image: Akanyeti et al.reveal that the undulations of swimming fish are optimized for propulsion, flow sensing and respiration. Latest content: Articles Corrigenda Journal homepage Recommend to library Web feed   Advertisement npj Systems Biology and Applications is a new online, open access, multi- and cross- disciplinary journal dedicated to publishing finest research on systems biology and all its approaches. Read the latest featured article:  Not just a colourful metaphor: modelling the landscape of cellular development using Hopfield networks   Advertisement Nature Conference on FLEXIBLE ELECTRONICS — CHALLENGES AND OPPORTUNITIES  June 6-8, 2016 | Nanjing, China Presented by: Nanjing Tech University | Institute of Advanced Materials (IAM) Nature Communications | Nature  REGISTER NOW!       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Fish mouths as engineering structures for vortical cross-step filtration OPEN S. Laurie Sanderson, Erin Roberts, Jillian Lineburg and Hannah Brooks Suspension-feeding fish, such as goldfish and whale sharks, retain prey without clogging their oral filter. Using a cross-step filtration model based on fish morphology, Sanderson et al. show how vortices generated by this design could trap and transport particles even smaller than the filter pores. 29 March 2016 | doi: 10.1038/ncomms11092 Biological Sciences  Fluids and plasma physics  Zoology  Energy cost and return for hunting in African wild dogs and cheetahs OPEN Tatjana Y. Hubel, Julia P. Myatt, Neil R. Jordan, Oliver P. Dewhirst, J. Weldon McNutt and Alan M. Wilson The long-distance hunting behaviour of African wild dogs is thought to be energetically costly. Here, Hubel et al. show that multiple opportunistic short-distance hunts and group feeding make African wild dogs in mixed woodland savannah energetically robust. 29 March 2016 | doi: 10.1038/ncomms11034 Biological Sciences  Ecology  Zoology  Additive opportunistic capture explains group hunting benefits in African wild dogs OPEN Tatjana Y. Hubel, Julia P. Myatt, Neil R. Jordan, Oliver P. Dewhirst, J. Weldon McNutt and Alan M. Wilson African wild dogs hunt collaboratively over long distances in grassland plains. Hubel et al. use high-resolution GPS to show that in their remaining habitat of mixed woodland savannah, African wild dogs use multiple opportunistic short-distance hunts, with no evidence of cooperative chasing. 29 March 2016 | doi: 10.1038/ncomms11033 Biological Sciences  Ecology  Zoology  Unpredictable environments lead to the evolution of parental neglect in birds OPEN Shana M. Caro, Ashleigh S. Griffin, Camilla A. Hinde and Stuart A. West The response of parents to offspring begging behaviour is hugely variable in birds, but what mediates this response is not known. In a meta-analysis across 143 species, Caro et al. show that variation in offspring begging and parental care is a function of environmental quality and predictability. 29 March 2016 | doi: 10.1038/ncomms10985 Biological Sciences  Ecology  Evolution  Zoology  Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential OPEN Helen Bolton, Sarah J. L. Graham, Niels Van der Aa, Parveen Kumar, Koen Theunis, Elia Fernandez Gallardo, Thierry Voet and Magdalena Zernicka-Goetz The developmental potential of mosaic embryos of euploid and aneuploid cells is unknown. Here, the authors create a mouse model of chromosome mosaicism, showing that aneuploid cells in the fetus are eliminated by apoptosis and developmental potential is dependent on the presence of sufficient euploid cells. 29 March 2016 | doi: 10.1038/ncomms11165 Biological Sciences  Cell biology  Developmental biology  Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1 OPEN Chi Lam Au Yeung, Ngai-Na Co, Tetsushi Tsuruga, Tsz-Lun Yeung, Suet-Ying Kwan, Cecilia S. Leung, Yong Li, Edward S. Lu, Kenny Kwan, Kwong-Kwok Wong, Rosemarie Schmandt, Karen H. Lu and Samuel C. Mok The tumor microenviroment can influence cancer progression and response to therapy. In this study, the authors show that miR21 is transferred through exosomes from cancer-associated fibroblasts and adipocytes to ovarian cancer cells where it modulates drug resistance by its direct target APAF1. 29 March 2016 | doi: 10.1038/ncomms11150 Biological Sciences  Cancer  Cell biology  Microelectromechanical reprogrammable logic device OPEN M. A. A. Hafiz, L. Kosuru and M. I. Younis Microelectromechanical resonators behave as logic gates thanks to the tunability of their resonance frequencies. Here, the authors combine the mechanical response to electrothermal frequency modulation to demonstrate 2- and 3-bit reprogrammable logic gates at room temperature and under modest vacuum. 29 March 2016 | doi: 10.1038/ncomms11137 Physical Sciences  Applied physics  Condensed matter  Nanotechnology  Positioning of centrioles is a conserved readout of Frizzled planar cell polarity signalling OPEN Jose Maria Carvajal-Gonzalez, Angel-Carlos Roman and Marek Mlodzik Planar cell polarity (PCP) contributes to cellular orientation during development but how this is regulated in Drosophila is unclear. Here, the authors identify Frizzled-PCP signalling as regulating polarised centriole positioning in the wing disc. 29 March 2016 | doi: 10.1038/ncomms11135 Biological Sciences  Cell biology  Developmental biology  Structure of the full-length TRPV2 channel by cryo-EM OPEN Kevin W. Huynh, Matthew R. Cohen, Jiansen Jiang, Amrita Samanta, David T. Lodowski, Z. Hong Zhou and Vera Y. Moiseenkova-Bell Transient receptor potential (TRP) proteins are Ca2+-permeable cation channels activated by a range of chemical and physical stimuli. Here the authors describe a cryo-EM structure of the full-length TRPV2 channel that provides insight into the regulation of the TRPV subfamily of channels. 29 March 2016 | doi: 10.1038/ncomms11130 Biological Sciences  Biophysics  Neuroscience  Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance OPEN Kelley R. Healey, Yanan Zhao, Winder B. Perez, Shawn R. Lockhart, Jack D. Sobel, Dimitrios Farmakiotis, Dimitrios P. Kontoyiannis, Dominique Sanglard, Saad J. Taj-Aldeen, Barbara D. Alexander, Cristina Jimenez-Ortigosa, Erika Shor and David S. Perlin The fungal pathogen Candida glabrata readily acquires resistance to multiple types of antifungal drugs. Here, Healey et al. show that C. glabrata clinical isolates often carry mutations in a gene involved in DNA mismatch repair, and this is associated with increased propensity to develop antifungal resistance. 29 March 2016 | doi: 10.1038/ncomms11128 Biological Sciences  Genetics  Microbiology  The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures OPEN Elliot H. Smith, Jyun-you Liou, Tyler S. Davis, Edward M. Merricks, Spencer S. Kellis, Shennan A. Weiss, Bradley Greger, Paul A. House, Guy M. McKhann II, Robert R. Goodman, Ronald G. Emerson, Lisa M. Bateman, Andrew J. Trevelyan and Catherine A. Schevon Epileptic brains display inhibitory restraint as manifested by the spread of synchronized activities being delayed in timing. Here, Elliot Smith and colleagues show fast-moving traveling wave that originates from the edge of ictal wavefront with subsequent depolarization and multiunit firing in the seizing brain regions in epileptic patients. 29 March 2016 | doi: 10.1038/ncomms11098 Biological Sciences  Neuroscience  Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture OPEN Simon Stritt, Paquita Nurden, Remi Favier, Marie Favier, Silvia Ferioli, Sanjeev K. Gotru, Judith M M. van Eeuwijk, Harald Schulze, Alan T. Nurden, Michele P. Lambert, Ernest Turro, Stephanie Burger-Stritt, Masayuki Matsushita, Lorenz Mittermeier, Paola Ballerini, Susanna Zierler, Michael A. Laffan, Vladimir Chubanov, Thomas Gudermann, Bernhard Nieswandt et al. Although Mg2+ is vital for platelet activation and aggregation, its regulation in these cells is still largely unknown. Here, the authors show that TRPM7, a cation channel and a protein kinase, regulates thrombopoiesis and platelet size by affecting the cytoskeleton of these cells in mice and humans. 29 March 2016 | doi: 10.1038/ncomms11097 Biological Sciences  Cell biology  Medical research  The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy OPEN Tamer M. A. Mohamed, Riham Abou-Leisa, Nicholas Stafford, Arfa Maqsood, Min Zi, Sukhpal Prehar, Florence Baudoin-Stanley, Xin Wang, Ludwig Neyses, Elizabeth J. Cartwright and Delvac Oceandy Restricting hypertrophic heart growth in response to pathologic overload is an unmet therapeutic need. Here, the authors show that blocking Ca2+ signaling controlled by the transport protein PMCA4 in cardiac fibroblasts enhances secretion of a potent Wnt signaling inhibitor, sFRP2, and prevents the development of pathologic cardiac hypertrophy in mice. 29 March 2016 | doi: 10.1038/ncomms11074 Biological Sciences  Medical research  Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error OPEN Qiao Fan, Virginie J. M. Verhoeven, Robert Wojciechowski, Veluchamy A. Barathi, Pirro G. Hysi, Jeremy A. Guggenheim, René Höhn, Veronique Vitart, Anthony P. Khawaja, Kenji Yamashiro, S Mohsen Hosseini, Terho Lehtimäki, Yi Lu, Toomas Haller, Jing Xie, Cécile Delcourt, Mario Pirastu, Juho Wedenoja, Puya Gharahkhani, Cristina Venturini et al. This report by the Consortium for Refractive Error and Myopia uses gene-environment-wide interaction study (GEWIS) to identify genetic loci that affect environmental influence in myopia development, and identifies ethnic specific genetic loci that attribute to eye refractive errors. 29 March 2016 | doi: 10.1038/ncomms11008 Biological Sciences  Genetics  Computations of uncertainty mediate acute stress responses in humans OPEN Archy O. de Berker, Robb B. Rutledge, Christoph Mathys, Louise Marshall, Gemma F. Cross, Raymond J. Dolan and Sven Bestmann Acute stress has broad physiological and behavioural consequences, yet the precise factors that generate stress responses are not known. Here, de Berker and colleagues demonstrate that acute stress responses dynamically track environmental uncertainty and predict ability to learn under uncertain threat. 29 March 2016 | doi: 10.1038/ncomms10996 Biological Sciences  Neuroscience  Interplanar coupling-dependent magnetoresistivity in high-purity layered metals OPEN N. Kikugawa, P. Goswami, A. Kiswandhi, E. S. Choi, D. Graf, R. E. Baumbach, J. S. Brooks, K. Sugii, Y. Iida, M. Nishio, S. Uji, T. Terashima, P.M.C. Rourke, N. E. Hussey, H. Takatsu, S. Yonezawa, Y. Maeno and L. Balicas In Weyl semimetals, unusual electronic transport phenomena are predicted to occur, such as an axial anomaly which violates the conservation of chiral fermions. Here, the authors evidence such behaviour via the occurrence of negative magnetoresistance in layered high-purity non-magnetic metals. 29 March 2016 | doi: 10.1038/ncomms10903 Physical Sciences  Condensed matter  Ephrin-B3 coordinates timed axon targeting and amygdala spinogenesis for innate fear behaviour OPEN Xiao-Na Zhu, Xian-Dong Liu, Suya Sun, Hanyi Zhuang, Jing-Yu Yang, Mark Henkemeyer and Nan-Jie Xu The molecular mechanism underlying initial circuit wiring in amygdala is poorly understood. Here the authors show that ephrin-B3 is required for axon targeting and amygdala spinogenesis during a critical period in development, and plays an important role in amygdala mediated fear responses. 24 March 2016 | doi: 10.1038/ncomms11096 Biological Sciences  Neuroscience  Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression OPEN Joshua C. Brown, Amber Petersen, Ling Zhong, Miranda L. Himelright, Jessica A. Murphy, Randall S. Walikonis and Nashaat Z. Gerges BRAG1 mutations are linked to synaptic deficits and X-chromosome linked intellectual disability. Here, the authors show that BRAG1 mediates activity-dependent removal of synaptic AMPA receptors via Arf-GEF activity and PDZ interactions, and is required for maintaining AMPAR-mediated synaptic transmission. 24 March 2016 | doi: 10.1038/ncomms11080 Biological Sciences  Cell biology  Neuroscience  Towards controlled polymer brushes via a self-assembly-assisted-grafting-to approach OPEN Tian Zhou, Hao Qi, Lin Han, Dmitri Barbash and Christopher Y. Li Polymer brushes, whereby single layers of polymers are tethered to surfaces, can be made by various methods but greater control over their fabrication is desirable. Here, by pre-assembling polymer chains into 2D crystalline sheets, the authors achieve high precision and unprecedented grafting densities. 24 March 2016 | doi: 10.1038/ncomms11119 Chemical Sciences  Materials science  Nanotechnology  ELL targets c-Myc for proteasomal degradation and suppresses tumour growth OPEN Yu Chen, Chi Zhou, Wei Ji, Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Jiangang Zhou and Wuhan Xiao The expression of the oncogene Myc is carefully controlled and dysregulation often leads to cancer. Here, the authors describe an E3 ligase for Myc—ELL—and show that it likely controls the ubiquitination and degradation of Myc. 24 March 2016 | doi: 10.1038/ncomms11057 Biological Sciences  Cancer  Cell biology  Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness OPEN Elizabeth Hinde, Elvis Pandžić, Zhengmin Yang, Ivan H. W. Ng, David A. Jans, Marie A. Bogoyevitch, Enrico Gratton and Katharina Gaus Oligomerisation of transcription factors regulates their translocation into the nucleus, DNA binding affinity and sequence specificity. Here, Hinde et al. present a microscopy analysis, pair correlation of molecular brightness, that tracks the molecular mobility of different oligomeric species in the same cell. 24 March 2016 | doi: 10.1038/ncomms11047 Biological Sciences  Cell biology  Molecular biology  Function and evolution of local repeats in the Firre locus OPEN Ezgi Hacisuleyman, Chinmay J. Shukla, Catherine L. Weiner and John L. Rinn Mammalian genomes contain multiple repetitive sequences such as transposable elements and local repeats. Here, the authors show that the conserved long non-coding RNA Firre contains repeats that act as nuclear retention signals and a DNA enhancer element. 24 March 2016 | doi: 10.1038/ncomms11021 Biological Sciences  Cell biology  Molecular biology  Observational evidence for enhanced magnetic activity of superflare stars OPEN Christoffer Karoff, Mads Faurschou Knudsen, Peter De Cat, Alfio Bonanno, Alexandra Fogtmann-Schulz, Jianning Fu, Antonio Frasca, Fadil Inceoglu, Jesper Olsen, Yong Zhang, Yonghui Hou, Yuefei Wang, Jianrong Shi and Wei Zhang Superflares are large explosive events on stellar surfaces, much larger than solar flares, but it remains unclear whether they share the same origin. Here, the authors analysed 48 superflare stars and determine the relation between their chromospheric activity and the occurrence of superflares. 24 March 2016 | doi: 10.1038/ncomms11058 Physical Sciences  Astronomy  Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons OPEN Ernest Palomer, Javier Carretero, Stefano Benvegnù, Carlos G. Dotti and Mauricio G. Martin In neurons, brain-derived neurotrophic factor (BDNF) transcription is activated by synaptic activity, in part by epigenetic regulation of its promoter regions. Here the authors characterize histone modifications in response to NMDA treatment that result in different kinetics of Bdnf activation from its different promoter regions. 24 March 2016 | doi: 10.1038/ncomms11081 Biological Sciences  Cell biology  Neuroscience  Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 OPEN Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, Tomoatsu Kimura and Noriyuki Tsumaki Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically induced mouse model of osteoarthritis. 24 March 2016 | doi: 10.1038/ncomms10959 Biological Sciences  Medical research  Jack-of-all-trades effects drive biodiversity–ecosystem multifunctionality relationships in European forests OPEN Fons van der Plas, Peter Manning, Eric Allan, Michael Scherer-Lorenzen, Kris Verheyen, Christian Wirth, Miguel A. Zavala, Andy Hector, Evy Ampoorter, Lander Baeten, Luc Barbaro, Jürgen Bauhus, Raquel Benavides, Adam Benneter, Felix Berthold, Damien Bonal, Olivier Bouriaud, Helge Bruelheide, Filippo Bussotti, Monique Carnol et al. How biodiversity is linked to multiple ecosystem functions is not fully understood. Here, the authors show that a new mechanism, which they term the 'jack-of-all-trades' effect, best explains patterns of tree diversity and ecosystem multifunctionality in European forests. 24 March 2016 | doi: 10.1038/ncomms11109 Biological Sciences  Ecology  Pairwise detection of site-specific receptor phosphorylations using single-molecule blotting OPEN Kyung Lock Kim, Daehyung Kim, Seongsil Lee, Su-Jeong Kim, Jung Eun Noh, Joung-Hun Kim, Young Chan Chae, Jong-Bong Lee and Sung Ho Ryu Current methods to measure post-translational modifications of receptor tyrosine kinases provide ensemble results. Here the authors develop a single-molecule blotting (SiMBlot) assay that detects site-specific phosphorylation patterns at the single-molecule level. 24 March 2016 | doi: 10.1038/ncomms11107 Biological Sciences  Biotechnology  Cell biology  Fish optimize sensing and respiration during undulatory swimming OPEN O. Akanyeti, P. J. M. Thornycroft, G. V. Lauder, Y. R. Yanagitsuru, A. N. Peterson and J. C. Liao Head movements of swimming fishes are thought to exist only because of recoil of the oscillating tail. Here, Akanyeti et al. show that by controlling the timing of head movements, fish can improve their swimming efficiency while simultaneously optimizing sensing and respiration. 24 March 2016 | doi: 10.1038/ncomms11044 Biological Sciences  Zoology  Coherent population transfer between uncoupled or weakly coupled states in ladder-type superconducting qutrits OPEN H. K. Xu, C. Song, W. Y. Liu, G. M. Xue, F. F. Su, H. Deng, Ye Tian, D. N. Zheng, Siyuan Han, Y. P. Zhong, H. Wang, Yu-xi Liu and S. P. Zhao Quantum state engineering necessitates transfer between quantum states. Here the authors demonstrate coherent population transfer between un- or weakly-coupled states of solid state systems, superconducting Xmon and phase qutrits, using stimulated Raman adiabatic passage and microwave driving. 24 March 2016 | doi: 10.1038/ncomms11018 Physical Sciences  Condensed matter  Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40 OPEN Robert Janowski, Gitta A. Heinz, Andreas Schlundt, Nina Wommelsdorf, Sven Brenner, Andreas R. Gruber, Michael Blank, Thorsten Buch, Raymund Buhmann, Mihaela Zavolan, Dierk Niessing, Vigo Heissmeyer and Michael Sattler Roquin is an RNA-binding protein that prevents autoimmunity by limiting expression of receptors such as Ox40. Here, the authors identify an RNA structure that they describe as an alternative decay element, and they characterise its interaction with Roquin using structural and biochemical techniques. 24 March 2016 | doi: 10.1038/ncomms11032 Biological Sciences  Biochemistry  Immunology  Molecular biology  Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation OPEN Paolo Arosio, Thomas C. T. Michaels, Sara Linse, Cecilia Månsson, Cecilia Emanuelsson, Jenny Presto, Jan Johansson, Michele Vendruscolo, Christopher M. Dobson and Tuomas P. J. Knowles Molecular chaperones are recognized to interfere with protein aggregation, yet the underlying mechanisms are largely unknown. Here, the authors develop a kinetic model that reveals the variety of distinct microscopic mechanisms through which molecular chaperones act to suppress amyloid formation. 24 March 2016 | doi: 10.1038/ncomms10948 Biological Sciences  Biochemistry  Biophysics  Chemical biology  Understanding silicate hydration from quantitative analyses of hydrating tricalcium silicates OPEN Elizaveta Pustovgar, Rahul P. Sangodkar, Andrey S. Andreev, Marta Palacios, Bradley F. Chmelka, Robert J. Flatt and Jean-Baptiste d’Espinose de Lacaillerie Despite its importance to the cement industry, tricalcium silicate hydration, with its sequence of induction, acceleration and deceleration steps, still hosts many open questions. Here, 29Si nuclear magnetic resonance provides new information on the silicate polymerization mechanism and its kinetics. 24 March 2016 | doi: 10.1038/ncomms10952 Chemical Sciences  Analytical chemistry  Inorganic chemistry  Materials science  LIG4 mediates Wnt signalling-induced radioresistance OPEN Sohee Jun, Youn-Sang Jung, Han Na Suh, Wenqi Wang, Moon Jong Kim, Young Sun Oh, Esther M. Lien, Xi Shen, Yoshihisa Matsumoto, Pierre D. McCrea, Lei Li, Junjie Chen and Jae-Il Park The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a direct target of β-catenin and it specifically mediates non-homologous end joining repair in colorectal cancer cells. 24 March 2016 | doi: 10.1038/ncomms10994 Biological Sciences  Cancer  Cell biology  Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells OPEN Amit Grover, Alejandra Sanjuan-Pla, Supat Thongjuea, Joana Carrelha, Alice Giustacchini, Adriana Gambardella, Iain Macaulay, Elena Mancini, Tiago C. Luis, Adam Mead, Sten Eirik W. Jacobsen and Claus Nerlov With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcription factor contributes to the age-dependent platelet bias. 24 March 2016 | doi: 10.1038/ncomms11075 Biological Sciences  Developmental biology  Medical research  DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation OPEN Junji Koya, Keisuke Kataoka, Tomohiko Sato, Masashige Bando, Yuki Kato, Takako Tsuruta-Kishino, Hiroshi Kobayashi, Kensuke Narukawa, Hiroyuki Miyoshi, Katsuhiko Shirahige and Mineo Kurokawa DNMT3A mutations are known to cause acute myeloid leukaemia. Here, Koya et al. show that DNMT3A R882H mutation causes monoblastic transformation and haematopoietic stem cell accumulation in a methylation-independent manner, by suppressing the polycomb repressive complex 1, causing transcriptional silencing. 24 March 2016 | doi: 10.1038/ncomms10924 Biological Sciences  Cell biology  Cortical contributions to the auditory frequency-following response revealed by MEG OPEN Emily B. J. Coffey, Sibylle C. Herholz, Alexander M. P. Chepesiuk, Sylvain Baillet and Robert J. Zatorre Auditory brainstem response (ABR) is used to study temporal encoding of auditory information in music and language. This study utilizes magnetoencephalography to localize both cortical and subcortical origins of the sustained frequency following response (FFR), the ABR component that encodes the periodicity of sound. 24 March 2016 | doi: 10.1038/ncomms11070 Biological Sciences  Neuroscience  CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil OPEN Helena Almqvist, Hanna Axelsson, Rozbeh Jafari, Chen Dan, André Mateus, Martin Haraldsson, Andreas Larsson, Daniel Martinez Molina, Per Artursson, Thomas Lundbäck and Pär Nordlund Drugs therapeutic efficacy relies on their capability of binding the relevant targets in a physiological environment, which has so far been hard to measure. Here, the authors present a compound library screen based on a target engagement assay that reports on protein stability upon ligands binding in cell. 24 March 2016 | doi: 10.1038/ncomms11040 Biological Sciences  Biophysics  Chemical biology  Medicinal chemistry  Regulation of cell-to-cell variability in divergent gene expression OPEN Chao Yan, Shuyang Wu, Christopher Pocetti and Lu Bai Gene expression noise affects cell fitness and development. Here, Yan et al. show that co-regulated divergent gene pairs (DGPs) suppress uncorrelated gene expression noise due to more synchronized transcription firing, and differentially regulated DGPs enhance gene expression noise due to transcription leakage. 24 March 2016 | doi: 10.1038/ncomms11099 Biological Sciences  Biophysics  Molecular biology  Geometry-invariant resonant cavities OPEN I. Liberal, A. M. Mahmoud and N. Engheta Resonant cavities are a ubiquitous building block in science and technology. Here, Liberal et al. demonstrate theoretically the existence of resonators whose eigenfrequencies are invariant with respect to geometrical deformations of their external boundaries, by exploiting the unusual properties of zero-index metamaterials. 24 March 2016 | doi: 10.1038/ncomms10989 Physical Sciences  Materials science  Optical physics  Including trait-based early warning signals helps predict population collapse OPEN Christopher F. Clements and Arpat Ozgul Predicting population collapse by monitoring key early warning signals in time-series data may highlight when interventions are needed. Here, the authors show that including information on phenotypic traits like body size can more accurately predict critical transitions than abundance data alone. 24 March 2016 | doi: 10.1038/ncomms10984 Biological Sciences  Ecology  FoxO1-mediated autophagy is required for NK cell development and innate immunity OPEN Shuo Wang, Pengyan Xia, Guanling Huang, Pingping Zhu, Jing Liu, Buqing Ye, Ying Du and Zusen Fan Natural killer cells are a major component of the innate immune response. Here, Wang et al. show that natural killer cell development requires robust activation of autophagy at the immature stage where it acts to remove damaged mitochondria and reduces levels of reactive oxygen species. 24 March 2016 | doi: 10.1038/ncomms11023 Biological Sciences  Cell biology  Immunology  Sequence features accurately predict genome-wide MeCP2 binding in vivo OPEN H. Tomas Rube, Wooje Lee, Miroslav Hejna, Huaiyang Chen, Dag H. Yasui, John F. Hess, Janine M. LaSalle, Jun S. Song and Qizhi Gong MeCP2 is critical for proper brain development, and mutations in the gene encoding MeCP2 are responsible for several neurological disorders. Here, the authors show that the previously reported genome-wide preference of MeCP2 to methylated CpGs is in part due to MeCP2's affinity to GC-rich chromatin. 24 March 2016 | doi: 10.1038/ncomms11025 Biological Sciences  Genetics  Molecular biology  Imaging multicellular specimens with real-time optimized tiling light-sheet selective plane illumination microscopy OPEN Qinyi Fu, Benjamin L. Martin, David Q. Matus and Liang Gao Selective plane illumination microscopy (SPIM) is capable of high-resolution, high-speed 3D imaging of single cells, but application to multicellular samples is challenging. Here the authors develop tiling light sheet SPIM to image large multicellular specimens in 3D with subcellular resolution. 23 March 2016 | doi: 10.1038/ncomms11088 Biological Sciences  Biotechnology  Cell biology  Challenging nickel-catalysed amine arylations enabled by tailored ancillary ligand design OPEN Christopher M. Lavoie, Preston M. MacQueen, Nicolas L. Rotta-Loria, Ryan S. Sawatzky, Andrey Borzenko, Alicia J. Chisholm, Breanna K. V. Hargreaves, Robert McDonald, Michael J. Ferguson and Mark Stradiotto The development of highly effective Earth-abundant catalysts for C(sp 2)-N cross-coupling represents an on-going challenge in synthetic chemistry. Here, the authors report a nickel complex containing a bisphosphine ancillary ligand allowing room-temperature couplings of amines and ammonia with a range of electrophiles. 23 March 2016 | doi: 10.1038/ncomms11073 Chemical Sciences  Catalysis  Organic chemistry  Rotational manipulation of single cells and organisms using acoustic waves OPEN Daniel Ahmed, Adem Ozcelik, Nagagireesh Bojanala, Nitesh Nama, Awani Upadhyay, Yuchao Chen, Wendy Hanna-Rose and Tony Jun Huang The precise rotational manipulation of single cells is technically challenging and relies on the optical, magnetic and electrical properties of the biospecimen. Here the authors develop an acoustic-based, on-chip manipulation method that can rotate single microparticles, cells and organisms. 23 March 2016 | doi: 10.1038/ncomms11085 Biological Sciences  Biotechnology  Developmental biology  Acetylation of C/EBPα inhibits its granulopoietic function OPEN Deepak Bararia, Hui Si Kwok, Robert S. Welner, Akihiko Numata, Menyhárt B. Sárosi, Henry Yang, Sheena Wee, Sebastian Tschuri, Debleena Ray, Oliver Weigert, Elena Levantini, Alexander K. Ebralidze, Jayantha Gunaratne and Daniel G. Tenen C/EBPα is an essential transcription factor for myeloid lineage commitment. Here, the authors show that acetylation of C/EBPα at K298 and K302, mediated at least in part by GCN5, impairs C/EBPα DNA binding ability and modulates C/EBPα transcriptional activity. 23 March 2016 | doi: 10.1038/ncomms10968 Biological Sciences  Cancer  Molecular biology  VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread OPEN Xiujuan Li, Narendra Padhan, Elisabet O. Sjöström, Francis P. Roche, Chiara Testini, Naoki Honkura, Miguel Sáinz-Jaspeado, Emma Gordon, Katie Bentley, Andrew Philippides, Vladimir Tolmachev, Elisabetta Dejana, Radu V. Stan, Dietmar Vestweber, Kurt Ballmer-Hofer, Christer Betsholtz, Kristian Pietras, Leif Jansson and Lena Claesson-Welsh Signals through VEGF receptor 2 (VEGFR2) increase vascular permeability, promoting cancer progression. Here the authors show that a point mutation in VEGFR2 preventing its auto-phosphorylation leads to reduced metastatic spread and improved response to chemotherapy in tumor-bearing mice, without affecting tumor inflammation. 23 March 2016 | doi: 10.1038/ncomms11017 Biological Sciences  Cancer  Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells OPEN Florian Rubelt, Christopher R. Bolen, Helen M. McGuire, Jason A. Vander Heiden, Daniel Gadala-Maria, Mikhail Levin, Ghia M. Euskirchen, Murad R. Mamedov, Gary E. Swan, Cornelia L. Dekker, Lindsay G. Cowell, Steven H. Kleinstein and Mark M. Davis The diversity of antigen receptor specificities is largely generated by random recombination of its segments. Here the authors show, by genetic comparison of monozygotic twin lymphocyte subsets, that individual genetic and epigenetic biases also contribute to the shape of the B and T cell repertoires. 23 March 2016 | doi: 10.1038/ncomms11112 Biological Sciences  Genetics  Immunology  Rapid expulsion of microswimmers by a vortical flow OPEN Andrey Sokolov and Igor S. Aranson The control of microswimmers such as bacteria is important for emerging applications of active bioinspired materials. Here, the authors demonstrate the use of vortical shear to expel suspended motile bacteria from the vicinity of a rotating microparticle. 23 March 2016 | doi: 10.1038/ncomms11114 Physical Sciences  Fluids and plasma physics  High-sensitivity acoustic sensors from nanofibre webs OPEN Chenhong Lang, Jian Fang, Hao Shao, Xin Ding and Tong Lin Polymer nanofibres can be used to detect mechanical motion. Here, the authors use electrospun piezoelectric nanofibre webs to detect acoustic waves at frequencies below 500 Hz with a good sensitivity at low pressure levels, and study the impact of the fibres morphology and crystalline phase. 23 March 2016 | doi: 10.1038/ncomms11108 Physical Sciences  Materials science  Nanotechnology  Water electrolysis on La1−xSrxCoO3−δ perovskite electrocatalysts OPEN J. Tyler Mefford, Xi Rong, Artem M. Abakumov, William G. Hardin, Sheng Dai, Alexie M. Kolpak, Keith P. Johnston and Keith J. Stevenson Perovskite oxides are attractive candidates as catalysts for water electrolysis however their rational design is rare. Here, the authors report a series of cobaltite perovskites where the covalency of the Co-O bond and concentration of oxygen vacancies are controlled, and assess their catalytic performance. 23 March 2016 | doi: 10.1038/ncomms11053 Chemical Sciences  Catalysis  Materials science  Physical chemistry  Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA OPEN Johannes Kettunen, Ayşe Demirkan, Peter Würtz, Harmen H.M. Draisma, Toomas Haller, Rajesh Rawal, Anika Vaarhorst, Antti J. Kangas, Leo-Pekka Lyytikäinen, Matti Pirinen, René Pool, Antti-Pekka Sarin, Pasi Soininen, Taru Tukiainen, Qin Wang, Mika Tiainen, Tuulia Tynkkynen, Najaf Amin, Tanja Zeller, Marian Beekman et al. Circulating metabolites reflect human health and disease. Here, Kettunen et al. perform a genome-wide association study on 123 circulating metabolic traits and identify novel genetic loci influencing systemic metabolism. They also link new molecular pathways with a known cardiovascular risk factor Lp(a). 23 March 2016 | doi: 10.1038/ncomms11122 Biological Sciences  Genetics  Implementation of quantum and classical discrete fractional Fourier transforms OPEN Steffen Weimann, Armando Perez-Leija, Maxime Lebugle, Robert Keil, Malte Tichy, Markus Gräfe, René Heilmann, Stefan Nolte, Hector Moya-Cessa, Gregor Weihs, Demetrios N. Christodoulides and Alexander Szameit Fourier analysis has become a standard tool in contemporary science. Here, Weimann et al. report classical and quantum optical realizations of the discrete fractional Fourier transform, a generalization of the Fourier transform, with potential applications in integrated quantum computation. 23 March 2016 | doi: 10.1038/ncomms11027 Physical Sciences  Optical physics  Theoretical physics  Atomically ordered solute segregation behaviour in an oxide grain boundary OPEN Bin Feng, Tatsuya Yokoi, Akihito Kumamoto, Masato Yoshiya, Yuichi Ikuhara and Naoya Shibata Solute segregation is challenging to experimentally identify at the atomic scale. Here, the authors report the direct observation of atomic site-dependent solute segregation behaviour in an yttria-stabilized zirconia grain boundary by atomic-resolution energy-dispersive X-ray spectroscopy. 23 March 2016 | doi: 10.1038/ncomms11079 Physical Sciences  Condensed matter  Materials science  Physical chemistry    Nature Communications JOBS of the week Postdoctoral Research Assistant University of Dundee Postdoctoral Research Fellow Georgia Institute of Technology Postdoctoral Researcher / Scientist Indiana University - Indianapolis, IN Postdoctoral Fellow Medical College of Wisconsin Postdoctoral Fellow Memorial Sloan Kettering Cancer Center (MSKCC) Research Associate Imperial College London Post-doctoral research fellow University Hospital of Heidelberg Senior Research Technician University of Leeds Postdoctoral Fellowship Linköping University (LiU) Research Associate University of Bristol More Science jobs from Nature Communications EVENT Proteins and Peptides: Structure, Function and Biotechnology 22.07.16 Genève, Switzerland More science events from       Latest Corrigenda     Corrigendum: TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport OPEN Miriam Schmidts, Yuqing Hou, Claudio R. Cortés, Dorus A. Mans, Celine Huber, Karsten Boldt, Mitali Patel, Jeroen van Reeuwijk, Jean-Marc Plaza, Sylvia E. C. van Beersum, Zhi Min Yap, Stef J. F. Letteboer, S. Paige Taylor, Warren Herridge, Colin A. Johnson, Peter J. Scambler, Marius Ueffing, Hulya Kayserili, Deborah Krakow, Stephen M. King et al. 29 March 2016 | doi: 10.1038/ncomms11270 Biological Sciences  Cell biology  Genetics      Corrigendum: CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes OPEN Emma C. Mackley, Stephanie Houston, Clare L. Marriott, Emily E. Halford, Beth Lucas, Vuk Cerovic, Kara J. Filbey, Rick M. Maizels, Matthew R. Hepworth, Gregory F. Sonnenberg, Simon Milling and David R. Withers 29 March 2016 | doi: 10.1038/ncomms11186 Biological Sciences  Immunology      Advertisement Nature Reviews Nephrology: Poster on Hyperphosphataemia in CKD This poster outlines the pathophysiology of hyperphosphataemia in CKD and the potential adverse effects of excess phosphate on the heart, bone and vasculature. Available to download free online Produced with support from: Keryx Biopharmaceuticals, Inc.     Advertisement nature.com webcasts Nature Publishing Group presents a custom webcast on: Accelerate discoveries with cryo-electron microscopy structure determination Tuesday April 12, 2016 8AM PDT, 11AM EDT, 4PM BST, 5PM CEST Register for the webcast and live Q&A session Sponsored by: Intel Corporation     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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