Nature Communications - 23 March 2016

Weekly Content Alert Nature Communications is now fully open access. Read more. 23 March 2016  Featured image: Cremer et al. report a single-aerosol photoacoustics setup for quantitative investigation of aerosol photokinetics, demonstrating size-dependent rate enhancements. Latest content: Correspondence Articles Corrigendum Erratum Journal homepage Recommend to library Web feed   Advertisement Nature Outlook Cognitive Health This Nature Outlook investigates some of the strategies that can be used to keep our brains in top form when faced with social and biological factors that induce deterioration. Available free online. Produced with support from: Nestlé Research     Advertisement ESO, CNIO and NRCO Conference on FAMILIAL CANCER Presented by: European School of Oncology | Centro Nacional de Investigaciones Oncológicas | Nature Reviews Clinical Oncology May 19-20, 2016 | Madrid, Spain REGISTER NOW!       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Correspondence     Correspondence: Reassessing the contribution of natural gas to US CO2 emission reductions since 2007 OPEN 18 March 2016 | doi: 10.1038/ncomms10648     Correspondence: Reply to ‘Reassessing the contribution of natural gas to US CO2 emission reductions since 2007’ OPEN 18 March 2016 | doi: 10.1038/ncomms10693       Latest Articles View all Articles     A hormone-related female anti-aphrodisiac signals temporary infertility and causes sexual abstinence to synchronize parental care OPEN Katharina C. Engel, Johannes Stökl, Rebecca Schweizer, Heiko Vogel, Manfred Ayasse, Joachim Ruther and Sandra Steiger Parents are faced with the dilemma whether to invest in their current offspring, or potential future young. Here, Engel et al. show that nutritionally-dependent young induce temporary infertility in female burying beetles, which in turn is signalled to the male partner via a hormone-related anti-aphrodisiac. 22 March 2016 | doi: 10.1038/ncomms11035 Biological Sciences  Ecology  Evolution  Zoology  Genetic link between renal birth defects and congenital heart disease OPEN Jovenal T. San Agustin, Nikolai Klena, Kristi Granath, Ashok Panigrahy, Eileen Stewart, William Devine, Lara Strittmatter, Julie A. Jonassen, Xiaoqin Liu, Cecilia W. Lo and Gregory J. Pazour Using forward genetic screen in fetal mice, Gregory Pazour and colleagues describe mutants affecting kidney/urinary tract development. The authors also show that mutants that cause kidney defects overlaps with those leading to congenital heart defects, thus linking renal anomalies and congenital heart disease. 22 March 2016 | doi: 10.1038/ncomms11103 Biological Sciences  Developmental biology  Genetics  Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain OPEN Hiromu Monai, Masamichi Ohkura, Mika Tanaka, Yuki Oe, Ayumu Konno, Hirokazu Hirai, Katsuhiko Mikoshiba, Shigeyoshi Itohara, Junichi Nakai, Youichi Iwai and Hajime Hirase While transcranical direct current stimulation (tDCS) is used in clinical setting, its cellular mechanism of action is unclear. Here, Hajime Hirase and colleagues visualize cellular response in mouse brain to tDCS and show robust astrocyte activation that coincide with plasticity changes. 22 March 2016 | doi: 10.1038/ncomms11100 Biological Sciences  Neuroscience  Zbtb20 promotes astrocytogenesis during neocortical development OPEN Motoshi Nagao, Toru Ogata, Yasuhiro Sawada and Yukiko Gotoh Astrocytes in the brain are derived from neural precursor cells (NPCs). Here, Motoshi Nagao and colleagues show that the transcription repressor Zbtb20 regulates astrocyte specification in the mouse neocortex. 22 March 2016 | doi: 10.1038/ncomms11102 Biological Sciences  Developmental biology  Neuroscience  Direct evidence of two interatomic relaxation mechanisms in argon dimers ionized by electron impact OPEN Xueguang Ren, Elias Jabbour Al Maalouf, Alexander Dorn and Stephan Denifl Inter-particle reactions in weakly bound systems are often difficult to pinpoint by detecting exclusively the kinetic energy of the produced ions. Here the authors present a full-coincidence experiment, where inter-particle reaction channels are determined by the measurement of all outgoing particles. 22 March 2016 | doi: 10.1038/ncomms11093 Physical Sciences  Atomic and molecular physics  Physical chemistry  Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria OPEN Sesh A. Sundararaman, Lindsey J. Plenderleith, Weimin Liu, Dorothy E. Loy, Gerald H. Learn, Yingying Li, Katharina S. Shaw, Ahidjo Ayouba, Martine Peeters, Sheri Speede, George M. Shaw, Frederic D. Bushman, Dustin Brisson, Julian C. Rayner, Paul M. Sharp and Beatrice H. Hahn African apes harbour six Plasmodium species, one of which gave rise to the human malaria parasite. Here, Sundaraman et al. use selective whole-genome amplification to determine genome sequences from two chimpanzee Plasmodium species, shedding light on the evolutionary origin of the human parasite. 22 March 2016 | doi: 10.1038/ncomms11078 Biological Sciences  Evolution  Genetics  Microbiology  Cyanobacterial symbionts diverged in the late Cretaceous towards lineage-specific nitrogen fixation factories in single-celled phytoplankton OPEN Francisco M. Cornejo-Castillo, Ana M. Cabello, Guillem Salazar, Patricia Sánchez-Baracaldo, Gipsi Lima-Mendez, Pascal Hingamp, Adriana Alberti, Shinichi Sunagawa, Peer Bork, Colomban de Vargas, Jeroen Raes, Chris Bowler, Patrick Wincker, Jonathan P. Zehr, Josep M. Gasol, Ramon Massana and Silvia G. Acinas Nitrogen fixation in oceans is facilitated by associations between marine phytoplankton and cyanobacteria such as UCYN-A. Here, Cornejo-Castillo et al. show that UCYN-A diversified in the late Cretaceous under strong purifying selection to become lineage-specific symbiont partners with different prymnesiophytes. 22 March 2016 | doi: 10.1038/ncomms11071 Biological Sciences  Ecology  Evolution  Oceanography  Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration OPEN Mikaël M. Martino, Kenta Maruyama, Gisela A. Kuhn, Takashi Satoh, Osamu Takeuchi, Ralph Müller and Shizuo Akira TLR and IL-1R1 ligands are danger signals released following tissue injury and during the healing response. Here, the authors show that IL-1β signalling via IL-1R1/MyD88 inhibits the Akt/GSK-3β/β-catenin pathway in mesenchymal stem cells, which suppresses their mobilization, proliferation, and differentiation into osteoblasts, processes necessary for bone regeneration. 22 March 2016 | doi: 10.1038/ncomms11051 Biological Sciences  Cell biology  Developmental biology  Medical research  Discovery of abnormal lithium-storage sites in molybdenum dioxide electrodes OPEN Jeong Kuk Shon, Hyo Sug Lee, Gwi Ok Park, Jeongbae Yoon, Eunjun Park, Gyeong Su Park, Soo Sung Kong, Mingshi Jin, Jae-Man Choi, Hyuk Chang, Seokgwang Doo, Ji Man Kim, Won-Sub Yoon, Chanho Pak, Hansu Kim and Galen D. Stucky Electrode materials with high energy density are important for the development of Li-ion batteries. Here, the authors report a molybdenum dioxide anode with abnormal lithium storage sites, exhibiting a discharge capacity twice its theoretical value by utilizing two different storage mechanisms. 22 March 2016 | doi: 10.1038/ncomms11049 Chemical Sciences  Materials science  Nanotechnology  Physical chemistry  Direct evidence for sequence-dependent attraction between double-stranded DNA controlled by methylation OPEN Jejoong Yoo, Hajin Kim, Aleksei Aksimentiev and Taekjip Ha Theoretical studies suggest that homologous DNA duplexes can preferentially associate with one another in the absence of proteins. Here, the authors show that GC-rich DNA with methylated cytosine and AT-rich DNA duplexes associate more strongly than GC-rich duplexes regardless of the sequence homology. 22 March 2016 | doi: 10.1038/ncomms11045 Biological Sciences  Biochemistry  Biophysics  Molecular biology  Nucleation of amorphous shear bands at nanotwins in boron suboxide OPEN Qi An, K. Madhav Reddy, Jin Qian, Kevin J. Hemker, Ming-Wei Chen and William A. Goddard III Grain boundaries affect the physical properties of metals but their influence on covalent solids is less well established. Here, the authors use scanning transmission electron microscopy and quantum mechanics to understand deformation mechanisms in perfect and twinned boron suboxide crystals. 22 March 2016 | doi: 10.1038/ncomms11001 Physical Sciences  Materials science  Calcium-based multi-element chemistry for grid-scale electrochemical energy storage OPEN Takanari Ouchi, Hojong Kim, Brian L. Spatocco and Donald R. Sadoway Calcium is an attractive but poorly studied material for the negative electrode in a rechargeable battery. Here, the authors use a multi-cation binary electrolyte along with an alloyed negative electrode to make a calcium-based rechargeable battery with enhanced stability and reduced operating temperature. 22 March 2016 | doi: 10.1038/ncomms10999 Chemical Sciences  Materials science  Physical chemistry  MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression OPEN Jeongeun Hyun, Sihyung Wang, Jieun Kim, Kummara Madhusudana Rao, Soo Yong Park, Ildoo Chung, Chang-Sik Ha, Sang-Woo Kim, Yang H. Yun and Youngmi Jung Liver fibrosis is a pathogenic driver of many liver diseases, so understanding its regulation might open the door to new therapies. Here the authors perform a screen for miRNA candidates and identify that miR-378 inhibits liver fibrosis in mice by interfering with Hedgehog signalling in hepatic stellate cells. 22 March 2016 | doi: 10.1038/ncomms10993 Biological Sciences  Medical research  Different states of synaptotagmin regulate evoked versus spontaneous release OPEN Hua Bai, Renhao Xue, Huan Bao, Leili Zhang, Arun Yethiraj, Qiang Cui and Edwin R. Chapman Synaptotagmin contains tandem Ca2+-binding C2-domains that interact with target membranes to trigger exocytosis. Here, Bai et al. manipulate the relative orientation of these two domains using a synthetic polyproline linker and show that a parallel orientation is most effective for membrane interaction and exocytosis. 22 March 2016 | doi: 10.1038/ncomms10971 Biological Sciences  Biophysics  Neuroscience  Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals OPEN Shuhei Nakamura, Özlem Karalay, Philipp S. Jäger, Makoto Horikawa, Corinna Klein, Kayo Nakamura, Christian Latza, Sven E. Templer, Christoph Dieterich and Adam Antebi Removal of the C. elegans germline substantially increases organismal lifespan. Here, Nakamura et al. show that the transcription factors MML-1 and MXL-2 coordinate this process in that they reduce TOR signalling and increase autophagy by regulating activity of HLH-30. 22 March 2016 | doi: 10.1038/ncomms10944 Biological Sciences  Medical research  miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage OPEN David W. Salzman, Kotoka Nakamura, Sunitha Nallur, Michelle T. Dookwah, Chanatip Metheetrairut, Frank J. Slack and Joanne B. Weidhaas MiR-34 is a tumour suppressor microRNA known to be upregulated by p53 after DNA damage and plays a critical role in cell cycle arrest and apoptosis. Here the authors show the cell maintains an inactive pool of miR-34 which is rapidly activated after damage via ATM-dependent phosphorylation. 21 March 2016 | doi: 10.1038/ncomms10954 Biological Sciences  Molecular biology  Open-source image reconstruction of super-resolution structured illumination microscopy data in ImageJ OPEN Marcel Müller, Viola Mönkemöller, Simon Hennig, Wolfgang Hübner and Thomas Huser Reconstruction of super resolution structured illumination microscopy (SR-SIM) datasets typically relies upon commercial software. Here Müller et al. present an open-source ImageJ plugin to facilitate reconstruction of SR-SIM data from a broad range of microscopy platforms. 21 March 2016 | doi: 10.1038/ncomms10980 Biological Sciences  Biophysics  Biotechnology  Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures OPEN Yi Lu, Cheng Zhong, Lulu Wang, Pengfei Wei, Wei He, Kang Huang, Yi Zhang, Yang Zhan, Guoping Feng and Liping Wang The network mechanism supporting seizure spread in temporal lobe epilepsy (TLE) is only partially understood. Using optogenetic methods, Lu et al. identify a feed-forward propagation pathway of ictal discharges from the dentate gyrus/hilus to the medial entorhinal cortex in a mouse model of TLE. 21 March 2016 | doi: 10.1038/ncomms10962 Biological Sciences  Neuroscience  Morphodynamics of submarine channel inception revealed by new experimental approach OPEN Jan de Leeuw, Joris T. Eggenhuisen and Matthieu J. B. Cartigny Suspended sediment currents travel through channels on the ocean floor to deliver enormous volumes of sediment to the deep ocean. Here, using a new approach for scaled laboratory experiments, the authors show how feedback between these currents and their deposits drive the formation of these submarine channels. 21 March 2016 | doi: 10.1038/ncomms10886 Earth Sciences  Geology and geophysics  Oceanography  Active temporal multiplexing of indistinguishable heralded single photons OPEN C. Xiong, X. Zhang, Z. Liu, M. J. Collins, A. Mahendra, L. G. Helt, M. J. Steel, D. -Y. Choi, C. J. Chae, P. H. W. Leong and B. J. Eggleton Deterministically generated single photons are useful for quantum communications, but the processes that create such light are often non-deterministic. Here, the authors enhance the single-photon output probability by multiplexing photons from four temporal modes using fibre-integrated optics. 21 March 2016 | doi: 10.1038/ncomms10853 Physical Sciences  Optical physics  Nonlinear optomechanical measurement of mechanical motion OPEN G. A. Brawley, M. R. Vanner, P. E. Larsen, S. Schmid, A. Boisen and W. P. Bowen The measurement of non-linear mechanical degrees-of-freedom provides a pathway to explore quantum behaviour at macroscopic scales. Here, Brawley et al. report the observation of displacement-squared thermal motion of a micro-mechanical resonator by exploiting the intrinsic non-linearity of the radiation-pressure interaction. 21 March 2016 | doi: 10.1038/ncomms10988 Physical Sciences  Optical physics  Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans OPEN Lotte C. Houtepen, Christiaan H. Vinkers, Tania Carrillo-Roa, Marieke Hiemstra, Pol A. van Lier, Wim Meeus, Susan Branje, Christine M. Heim, Charles B. Nemeroff, Jonathan Mill, Leonard C. Schalkwyk, Menno P. Creyghton, René S. Kahn, Marian Joëls, Elisabeth B. Binder and Marco P. M. Boks Exposure to childhood trauma is a major risk factor for the development of almost all psychiatric disorders. By epigenome-wide studies, here, Houtepen et al. show that DNA methylation at a locus in the Kit ligand gene (KITLG) mediates the relationship between childhood trauma and cortisol stress reactivity. 21 March 2016 | doi: 10.1038/ncomms10967 Biological Sciences  Genetics  Molecular biology  Neuroscience  Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation OPEN Xue Yuan, Jay Cao, Xiaoning He, Rosa Serra, Jun Qu, Xu Cao and Shuying Yang Primary cilia are highly conserved microtubule-based organelles that play essential roles in several cellular processes including osteogenesis. Here the authors show that intraflagellar protein IFT80 regulates osteoblast differentiation by balancing signalling though the canonical and non-canonical Hedgehog pathways. 21 March 2016 | doi: 10.1038/ncomms11024 Biological Sciences  Cell biology  Exciton localization in solution-processed organolead trihalide perovskites OPEN Haiping He, Qianqian Yu, Hui Li, Jing Li, Junjie Si, Yizheng Jin, Nana Wang, Jianpu Wang, Jingwen He, Xinke Wang, Yan Zhang and Zhizhen Ye The recombination dynamics of photogenerated carriers in organolead trihalide perovskites are not well understood. Here, He et al. report that the recombination of photogenerated carriers in solution-processed methylammonium-lead-halide films is dominated by excitons weakly localized in band tail states. 21 March 2016 | doi: 10.1038/ncomms10896 Physical Sciences  Materials science  Nanotechnology  Optical physics  Optical micromanipulation of nanoparticles and cells inside living zebrafish OPEN Patrick Lie Johansen, Federico Fenaroli, Lasse Evensen, Gareth Griffiths and Gerbrand Koster Manipulating the interactions of cells with their environment is usually done with cells in vitro, which does not reflect the complex in vivo system. Here the authors demonstrate micromanipulation of microparticles, bacteria and immune cells within live zebrafish using optical tweezers. 21 March 2016 | doi: 10.1038/ncomms10974 Biological Sciences  Biophysics  Nanotechnology  Cajal bodies are linked to genome conformation OPEN Qiuyan Wang, Iain A. Sawyer, Myong-Hee Sung, David Sturgill, Sergey P. Shevtsov, Gianluca Pegoraro, Ofir Hakim, Songjoon Baek, Gordon L. Hager and Miroslav Dundr Nuclear bodies can nucleate at sites of active transcription and are beneficial for efficient gene expression. Here, the authors show that Cajal bodies, a prominent type of nuclear body, contribute to genome organization with global effects on gene expression and RNA splicing fidelity. 21 March 2016 | doi: 10.1038/ncomms10966 Biological Sciences  Cell biology  Molecular biology  Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis OPEN Silvia Guglietta, Andrea Chiavelli, Elena Zagato, Carsten Krieg, Sara Gandini, Paola Simona Ravenda, Barbara Bazolli, Bao Lu, Giuseppe Penna and Maria Rescigno It is unclear whether cancer-related hypercoagulation and neutrophilia contribute to tumorigenesis. In this study, the authors find that activation of the complement cascade causes hypercoagulation that leads to polarization of neutrophils in a mouse model of intestinal cancer, and show that blocking complement activation can reduce tumour formation. 21 March 2016 | doi: 10.1038/ncomms11037 Biological Sciences  Cancer  Immunology  A strategy for sequence control in vinyl polymers via iterative controlled radical cyclization OPEN Yusuke Hibi, Makoto Ouchi and Mitsuo Sawamoto The ultimate control in polymer synthesis, precise monomer sequencing, is a highly sought after but complex problem. Here, the authors employ a repetitive and iterative intramolecular cyclization reaction, via a radical intermediate, to generate sequence-controlled vinyl oligomers. 21 March 2016 | doi: 10.1038/ncomms11064 Chemical Sciences  Materials science  Organic chemistry  Li(V0.5Ti0.5)S2 as a 1 V lithium intercalation electrode OPEN Steve J. Clark, Da Wang, A. Robert Armstrong and Peter G. Bruce Lithium sulfides have been previously investigated as 1 V anodes for Li-ion batteries, but suffered from significant performance issues. Here, the authors report on a 1 V lithium sulfide electrode with noteworthy performance, demonstrating that sulfide-based electrodes may merit further exploration. 21 March 2016 | doi: 10.1038/ncomms10898 Chemical Sciences  Inorganic chemistry  Materials science  Physical chemistry  Collaboration between primitive cell membranes and soluble catalysts OPEN Katarzyna P. Adamala, Aaron E. Engelhart and Jack W. Szostak Early cells likely consisted of fatty acid vesicles enclosing magnesium-dependent ribozymes. Here, the authors show that fatty acid derivatives can form vesicles that, unlike those formed from only unmodified fatty acids, are stable in the presence of magnesium and could support ribozyme catalysis. 21 March 2016 | doi: 10.1038/ncomms11041 Biological Sciences  Chemical biology  Organic chemistry  Systems biology  Controllable positive exchange bias via redox-driven oxygen migration OPEN Dustin A. Gilbert, Justin Olamit, Randy K. Dumas, B. J. Kirby, Alexander J. Grutter, Brian B. Maranville, Elke Arenholz, Julie A. Borchers and Kai Liu Direct observation of ionic motion in buried metal/oxide interfaces and its correlation with physical properties is a challenging task. Here, the authors observe oxygen migration in a model system with controllable positive exchange bias, due to the redox-driven formation of a ferromagnetic interfacial layer. 21 March 2016 | doi: 10.1038/ncomms11050 Physical Sciences  Applied physics  Condensed matter  Materials science  Versatile protein tagging in cells with split fluorescent protein OPEN Daichi Kamiyama, Sayaka Sekine, Benjamin Barsi-Rhyne, Jeffrey Hu, Baohui Chen, Luke A. Gilbert, Hiroaki Ishikawa, Manuel D. Leonetti, Wallace F. Marshall, Jonathan S. Weissman and Bo Huang Tagging proteins with fluorescent proteins is a powerful method for both imaging and non-imaging applications. Here the authors use the eleventh β-strand of sfGFP and sfCherry as epitope tags for multicolour imaging and amplified signals by tandem arrangement; shortness of the tag enabled introduction into genomic loci using CRISPR/Cas9. 18 March 2016 | doi: 10.1038/ncomms11046 Biological Sciences  Cell biology  Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance OPEN Yasuaki Kabe, Takanori Nakane, Ikko Koike, Tatsuya Yamamoto, Yuki Sugiura, Erisa Harada, Kenji Sugase, Tatsuro Shimamura, Mitsuyo Ohmura, Kazumi Muraoka, Ayumi Yamamoto, Takeshi Uchida, So Iwata, Yuki Yamaguchi, Elena Krayukhina, Masanori Noda, Hiroshi Handa, Koichiro Ishimori, Susumu Uchiyama, Takuya Kobayashi et al. PGRMC1 binds to EGFR and cytochromes P450, and is known to be involved in cancer proliferation and in drug resistance. Here, the authors determine the structure of the cytosolic domain of PGRMC1, which forms a dimer via haem–haem stacking, and propose how this interaction could be involved in its function. 18 March 2016 | doi: 10.1038/ncomms11030 Biological Sciences  Biochemistry  Cancer  ARPES view on surface and bulk hybridization phenomena in the antiferromagnetic Kondo lattice CeRh2Si2 OPEN S. Patil, A. Generalov, M. Güttler, P. Kushwaha, A. Chikina, K. Kummer, T. C. Rödel, A. F. Santander-Syro, N. Caroca-Canales, C. Geibel, S. Danzenbächer, Yu. Kucherenko, C. Laubschat, J. W. Allen and D. V. Vyalikh In rare-earth intermetallics, interaction between localized 4f electrons and itinerant electrons can result in exotic states of matter. Here, the authors use photoemission spectroscopy to reveal and study this interaction in the bulk and at the surface of the Kondo lattice antiferromagnet CeRh2Si2. 18 March 2016 | doi: 10.1038/ncomms11029 Physical Sciences  Condensed matter  Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis OPEN Shenyi Yin, Yu Fan, Hanshuo Zhang, Zhihua Zhao, Yang Hao, Juan Li, Changhong Sun, Junyu Yang, Zhenjun Yang, Xiao Yang, Jian Lu and Jianzhong Jeff Xi MiR-122 levels correlate with metastasis in human liver cancer but not in mouse models. Here the authors show that miR-122 targets TGFßR1 in mice but TGFß1 in humans, that swapping this specificity affects metastasis, and that many other receptor-ligand pairs are differentially targeted by miRNAs across species. 18 March 2016 | doi: 10.1038/ncomms11012 Biological Sciences  Cancer  Evolution  A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer OPEN Pavithra L. Chavali, Gayathri Chandrasekaran, Alexis R. Barr, Péter Tátrai, Chris Taylor, Evaggelia K. Papachristou, C. Geoffrey Woods, Sreenivas Chavali and Fanni Gergely Centrosome clustering allows survival of cells with amplified centrosomes at the cost of chromosome instability. Here, Chavali et al. show that the centrosome component CEP215 collaborates with the kinesin motor HSET both to maintain spindle poles connections and to cluster centrosomes. 18 March 2016 | doi: 10.1038/ncomms11005 Biological Sciences  Cancer  Cell biology  Molecular biology  Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus OPEN Quanjiang Ji, Peter J. Chen, Guangrong Qin, Xin Deng, Ziyang Hao, Zdzislaw Wawrzak, Won-Sik Yeo, Jenny Winjing Quang, Hoonsik Cho, Guan-Zheng Luo, Xiaocheng Weng, Qiancheng You, Chi-Hao Luan, Xiaojing Yang, Taeok Bae, Kunqian Yu, Hualiang Jiang and Chuan He The WalKR signal transduction system is involved in extracellular signal recognition, but the details of this function are not well established. Here, the authors report the crystal structure of this two-component system alongside the characterisation of a small-molecule activator. 18 March 2016 | doi: 10.1038/ncomms11000 Biological Sciences  Biochemistry  Microbiology  Lithium-coated polymeric matrix as a minimum volume-change and dendrite-free lithium metal anode OPEN Yayuan Liu, Dingchang Lin, Zheng Liang, Jie Zhao, Kai Yan and Yi Cui Lithium metal is a promising anode for batteries, but problems such as volume change and dendrite growth currently prevent it from practical usage. Here, the authors overcome these problems by infusing molten lithium into a polymeric matrix via a lithiophilic coating to make a stable nanoporous lithium electrode. 18 March 2016 | doi: 10.1038/ncomms10992 Chemical Sciences  Materials science  Nanotechnology  Spin–orbit coupling of light in asymmetric microcavities OPEN L. B. Ma, S. L. Li, V. M. Fomin, M. Hentschel, J. B. Götte, Y. Yin, M. R. Jorgensen and O. G. Schmidt Optical spin–orbit coupling is known to occur in open systems such as helical waveguides. Here, the authors enable spin–orbit coupling of light confined to a closed path within an asymmetric optical microcavity and demonstrate a non-cyclic Berry phase acquired in a non-Abelian evolution. 18 March 2016 | doi: 10.1038/ncomms10983 Physical Sciences  Optical physics  Actin nucleation at the centrosome controls lymphocyte polarity OPEN Dorian Obino, Francesca Farina, Odile Malbec, Pablo J. Sáez, Mathieu Maurin, Jérémie Gaillard, Florent Dingli, Damarys Loew, Alexis Gautreau, Maria-Isabel Yuseff, Laurent Blanchoin, Manuel Théry and Ana-Maria Lennon-Duménil Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al. show that in lymphocytes centrosome-associated Arp2/3 nucleates actin that tethers the centrosome to the nucleus; activation depletes Arp2/3 from the centrosome and frees it from the nucleus. 18 March 2016 | doi: 10.1038/ncomms10969 Biological Sciences  Cell biology  Regulation at a distance of biomolecular interactions using a DNA origami nanoactuator OPEN Yonggang Ke, Travis Meyer, William M. Shih and Gaetan Bellot The construction of nano-machines requires building nano-scale structures with controllable functions. Here the authors use DNA origami to construct an allosteric actuator which can act as signal propagator and an environmental sensor. 18 March 2016 | doi: 10.1038/ncomms10935 Biological Sciences  Molecular biology  Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells OPEN Noelia Madroñal, José M. Delgado-García, Azahara Fernández-Guizán, Jayanta Chatterjee, Maja Köhn, Camilla Mattucci, Apar Jain, Theodoros Tsetsenis, Anna Illarionova, Valery Grinevich, Cornelius T. Gross and Agnès Gruart Dentate gyrus (DG) is critical for memory formation in the hippocampus but its role in memory retrieval is unclear. Here, Gross and colleagues, show that granule cells in DG are not required for memory retrieval but for maintenance, and inhibiting them with a drug leads to rapid loss of memory. 18 March 2016 | doi: 10.1038/ncomms10923 Biological Sciences  Neuroscience  Cross-modal representations of first-hand and vicarious pain, disgust and fairness in insular and cingulate cortex OPEN Corrado Corradi-Dell’Acqua, Anita Tusche, Patrik Vuilleumier and Tania Singer Anterior insula (AI) and medial anterior cingulate cortex (mACC) are activated by self and vicarious pain, disgust and fairness, yet the overlap of these representations are not known. Here the authors provide evidence for shared neural codes in the left AI and mACC and distinct codes in the right AI. 18 March 2016 | doi: 10.1038/ncomms10904 Biological Sciences  Neuroscience  Phase-selective entrainment of nonlinear oscillator ensembles OPEN Anatoly Zlotnik, Raphael Nagao, István Z. Kiss and Jr-Shin Li Organizing and manipulating dynamic processes is important to understand and influence many natural phenomena. Here, the authors present a method to design entrainment signals that create stable phase patterns in heterogeneous nonlinear oscillators, and verify it in electrochemical reactions. 18 March 2016 | doi: 10.1038/ncomms10788 Physical Sciences  Condensed matter  Theoretical physics  A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation OPEN Xin Liu, Chen-Song Zhang, Chang Lu, Sheng-Cai Lin, Jia-Wei Wu and Zhi-Xin Wang The important MAPK family of signalling proteins is controlled by MAPK phosphatases (MKPs). Here, the authors report the structure of MKP7 bound to JNK1 and characterise the conserved MKP-MAPK interaction. 18 March 2016 | doi: 10.1038/ncomms10879 Biological Sciences  Biochemistry  Human adaptation and population differentiation in the light of ancient genomes OPEN Felix M. Key, Qiaomei Fu, Frédéric Romagné, Michael Lachmann and Aida M. Andrés Detecting the targets of positive selection in the human genome is challenging. Here, the authors combine modern and ancient genomes to show that alleles strongly differentiated between Africans and Europeans mediated local adaptation in European populations, and were mostly contributed by ancient hunter-gatherers. 18 March 2016 | doi: 10.1038/ncomms10775 Biological Sciences  Evolution  Genetics  Collective atomic scattering and motional effects in a dense coherent medium OPEN S. L. Bromley, B. Zhu, M. Bishof, X. Zhang, T. Bothwell, J. Schachenmayer, T. L. Nicholson, R. Kaiser, S. F. Yelin, M. D. Lukin, A. M. Rey and J. Ye Light scattering from a dense coherent medium is determined by the interplay of dispersive and radiative dipole–dipole interactions. Here, the authors control the motional effects that obscure the coherence of scattered light and study collective emission in a driven gas of cold strontium-88 atoms. 17 March 2016 | doi: 10.1038/ncomms11039 Physical Sciences  Atomic and molecular physics  Optical physics  Semiconductor-inspired design principles for superconducting quantum computing OPEN Yun-Pil Shim and Charles Tahan Superconducting circuits offer great promise for quantum computing, but implementations require careful shielding from control electronics. Here, the authors take inspirations from semiconductor spin-based qubits to design Josephson junctions quantum circuits whose qubits do not require microwave control. 17 March 2016 | doi: 10.1038/ncomms11059 Physical Sciences  Applied physics  Condensed matter  Theoretical physics  Polarized three-photon-pumped laser in a single MOF microcrystal OPEN Huajun He, En Ma, Yuanjing Cui, Jiancan Yu, Yu Yang, Tao Song, Chuan-De Wu, Xueyuan Chen, Banglin Chen and Guodong Qian Higher-order multi-photon pumped polarized lasers promise application in future optoelectronic and biomedical applications. Here, the authors demonstrate a polarized three-photon pumped (3PP) microcavity laser in a single host-guest composite MOF crystal via a controllable in situ self-assembly strategy. 17 March 2016 | doi: 10.1038/ncomms11087 Chemical Sciences  Applied physics  Inorganic chemistry  Optical physics  Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds OPEN Aaron L. Carlson, Neal K. Bennett, Nicola L. Francis, Apoorva Halikere, Stephen Clarke, Jennifer C. Moore, Ronald P. Hart, Kenneth Paradiso, Marius Wernig, Joachim Kohn, Zhiping P. Pang and Prabhas V. Moghe Human pluripotent stem cell derived neurons have the potential for cell replacement therapy for brain injury and disease but problems on transplantation need to be overcome. Here, the authors use a microtopographic scaffold to graft neurons into both hippocampal organoids and the mouse brain striatum. 17 March 2016 | doi: 10.1038/ncomms10862 Biological Sciences  Bioengineering  Cell biology  Exciton–exciton annihilation and biexciton stimulated emission in graphene nanoribbons OPEN Giancarlo Soavi, Stefano Dal Conte, Cristian Manzoni, Daniele Viola, Akimitsu Narita, Yunbin Hu, Xinliang Feng, Ulrich Hohenester, Elisa Molinari, Deborah Prezzi, Klaus Müllen and Giulio Cerullo Graphene nanoribbons confine electrons to just one dimension and this gives rise to strong electron–hole interactions. Here, the authors investigate the creation and recombination of biexcitons in these structures by ultrafast optical pulses using femtosecond transient absorption spectroscopy. 17 March 2016 | doi: 10.1038/ncomms11010 Physical Sciences  Condensed matter  Nanotechnology  Optical physics  Production of unstable proteins through the formation of stable core complexes OPEN Nicolas Levy, Sylvia Eiler, Karine Pradeau-Aubreton, Benoit Maillot, François Stricher and Marc Ruff Flexible or disordered domains often hinder the purification of proteins involved in functional interactions. Here the authors describe an approach that enables the production of stable and functional complexes of otherwise unstable proteins in quantities sufficient for structural and functional studies. 17 March 2016 | doi: 10.1038/ncomms10932 Biological Sciences  Biochemistry  Optically responsive supramolecular polymer glasses OPEN Diederik W. R. Balkenende, Christophe A. Monnier, Gina L. Fiore and Christoph Weder The ability to heal whilst maintaining original functionality is important for establishing materials with superior longevity. Here, the authors demonstrate a supramolecular polymeric coating which exhibits excellent optical and mechanical properties, even following damage repair. 17 March 2016 | doi: 10.1038/ncomms10995 Chemical Sciences  Materials science  Organic chemistry  VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation OPEN Yu-Tzu Shih and Yi-Ping Hsueh Protein homeostasis is crucial for maintaining a variety of cellular functions. Here the authors show that valosin-containing protein and its cofactors regulate tubular ER formation and protein synthesis efficiency, thereby control dendritic spine formation in neurons. 17 March 2016 | doi: 10.1038/ncomms11020 Biological Sciences  Cell biology  Neuroscience  Multiplexed single-molecule force spectroscopy using a centrifuge OPEN Darren Yang, Andrew Ward, Ken Halvorsen and Wesley P. Wong Single molecule force spectroscopy (SMFS) has limitations in throughput and the ability to repeatedly interrogate single bonds. Here the authors repurpose a benchtop centrifuge and use DNA nanoswitches to enable high throughput SMFS capable of repeatedly measuring forces of single molecular pairs. 17 March 2016 | doi: 10.1038/ncomms11026 Biological Sciences  Biophysics  Biotechnology  Enhanced superconductivity in atomically thin TaS2 OPEN Efrén Navarro-Moratalla, Joshua O. Island, Samuel Mañas-Valero, Elena Pinilla-Cienfuegos, Andres Castellanos-Gomez, Jorge Quereda, Gabino Rubio-Bollinger, Luca Chirolli, Jose Angel Silva-Guillén, Nicolás Agraït, Gary A. Steele, Francisco Guinea, Herre S. J. van der Zant and Eugenio Coronado As a material's thickness decreases towards the atomic-scale, dimensional confinement may promote behaviour not found in the bulk, with potential technological applications. Here, the authors study superconductivity in TaS2 as it is mechanically exfoliated towards the two-dimensional limit. 17 March 2016 | doi: 10.1038/ncomms11043 Physical Sciences  Condensed matter  Observation of a shape resonance of the positronium negative ion OPEN Koji Michishio, Tsuneto Kanai, Susumu Kuma, Toshiyuki Azuma, Ken Wada, Izumi Mochizuki, Toshio Hyodo, Akira Yagishita and Yasuyuki Nagashima The Positronium negative ion is formed by two electrons bound to a positron, and experimental investigations of its states and energy levels are difficult due to its short lifetime. Here, the authors report on laser spectroscopy of positronium using a source of efficiently produced ions. 17 March 2016 | doi: 10.1038/ncomms11060 Physical Sciences  Atomic and molecular physics  Particle physics  Design and synthesis of the superionic conductor Na10SnP2S12 OPEN William D. Richards, Tomoyuki Tsujimura, Lincoln J. Miara, Yan Wang, Jae Chul Kim, Shyue Ping Ong, Ichiro Uechi, Naoki Suzuki and Gerbrand Ceder Solid electrolytes are an attractive alternative to the flammable organic solvents typically used in intercalation batteries. Here, the authors report the computation-assisted discovery and synthesis of Na10SnP2S12, a sodium electrolyte with room temperature conductivity of 0.4 mS cm−1. 17 March 2016 | doi: 10.1038/ncomms11009 Chemical Sciences  Materials science  Physical chemistry  Observation of Weyl nodes and Fermi arcs in tantalum phosphide OPEN N. Xu, H. M. Weng, B. Q. Lv, C. E. Matt, J. Park, F. Bisti, V. N. Strocov, D. Gawryluk, E. Pomjakushina, K. Conder, N. C. Plumb, M. Radovic, G. Autès, O. V. Yazyev, Z. Fang, X. Dai, T. Qian, J. Mesot, H. Ding and M. Shi et al. Weyl semimetals exhibit exotic properties owing to the presence of Weyl fermions. Here, Xu et al. show that tantalum phosphide is an ideal platform for studying the transport properties of these particles because its low-energy properties are dominated by a single type of Weyl fermion. 17 March 2016 | doi: 10.1038/ncomms11006 Physical Sciences  Condensed matter  Cellular forces and matrix assembly coordinate fibrous tissue repair OPEN Mahmut Selman Sakar, Jeroen Eyckmans, Roel Pieters, Daniel Eberli, Bradley J. Nelson and Christopher S. Chen Planar in vitro models for wound closure stress the role of lamellipodial protrusions and purse-string contraction. Here the authors develop a 3D biomimetic model for tissue repair and show a mode of stromal closure that relies on whole tissue deformations, cell migration and matrix deposition. 16 March 2016 | doi: 10.1038/ncomms11036 Biological Sciences  Cell biology  Connecting two proteins using a fusion alpha helix stabilized by a chemical cross linker OPEN Woo Hyeon Jeong, Haerim Lee, Dong Hyun Song, Jae-Hoon Eom, Sun Chang Kim, Hee-Seung Lee, Hayyoung Lee and Jie-Oh Lee Linking protein components in a controlled manner is crucial for assembling protein nanostructures with pre-determined architecture. Here, the authors use a chemical cross-linker to fuse the terminal helices of two proteins into a single one, forcing the protein domains in a specific orientation. 16 March 2016 | doi: 10.1038/ncomms11031 Biological Sciences  Biophysics  Chemical biology  Nanotechnology  Long-range magnetic coupling across a polar insulating layer OPEN W. M. Lü, Surajit Saha, X. Renshaw Wang, Z. Q. Liu, K. Gopinadhan, A. Annadi, S. W. Zeng, Z. Huang, B. C. Bao, C. X. Cong, M. Venkatesan, T. Yu, J. M. D. Coey, Ariando and T. Venkatesan Magnetic interactions in solids are usually short-range or else they involve itinerant electrons. Here, the authors evidence a long-range magnetic coupling mediated by orbital moments in a polar spacer layer of nonmagnetic insulating oxide, with a sign which oscillates with spacer thickness. 16 March 2016 | doi: 10.1038/ncomms11015 Physical Sciences  Condensed matter  Charge localization in a diamine cation provides a test of energy functionals and self-interaction correction OPEN Xinxin Cheng, Yao Zhang, Elvar Jónsson, Hannes Jónsson and Peter M. Weber Density functional theory is widely used throughout the chemical sciences, but suffers from over-emphasis on charge delocalisation. Here, the authors experimentally probe the energies of two states of a diamine cation and show how a self-interaction correction allows for the accurate prediction of both states. 16 March 2016 | doi: 10.1038/ncomms11013 Chemical Sciences  Physical chemistry  Tunable quasiparticle trapping in Meissner and vortex states of mesoscopic superconductors OPEN M. Taupin, I. M. Khaymovich, M. Meschke, A. S. Mel’nikov and J. P. Pekola Excessive excitation induced by overheating may deteriorate the resistance-free operation of superconductor-based devices. Here, Taupin et al. propose an effective control of excess quasiparticles and their spatial distribution in a mesoscopic superconducting disc by applying a small magnetic field. 16 March 2016 | doi: 10.1038/ncomms10977 Physical Sciences  Condensed matter  Nanotechnology  Contrasting scaling properties of interglacial and glacial climates OPEN Zhi-Gang Shao and Peter D. Ditlevsen Natural climate variability and persistency are reflected in the scaling properties of climate records. Here, the authors show that the scaling properties of interglacial and glacial climates are distinctively different: The former is monofractal while the latter is multifractal with much longer range memory. 16 March 2016 | doi: 10.1038/ncomms10951 Earth Sciences  Climate science  Geology and geophysics  Buried iceberg scours reveal reduced North Atlantic Current during the stage 12 deglacial OPEN Andrew M. W. Newton, Mads Huuse and Simon H. Brocklehurst Reconstructing past ocean conditions, particularly current velocity, is difficult due to a lack of available proxies. Here, the authors present a set of well-preserved buried iceberg scours from the mid-Norwegian slope, from which they are able to infer North Atlantic current speeds during the third-last glacial. 16 March 2016 | doi: 10.1038/ncomms10927 Earth Sciences  Climate science  Oceanography  Photoacoustics of single laser-trapped nanodroplets for the direct observation of nanofocusing in aerosol photokinetics OPEN Johannes W. Cremer, Klemens M. Thaler, Christoph Haisch and Ruth Signorell Aerosol droplets have significant effects on atmospheric photochemistry, however measuring absorption from single droplets is a challenge. Here, the authors report a method to measure absorption of nanodroplets with attolitre sensitivity, showing rate enhancements for light focusing in photolysis reactions. 16 March 2016 | doi: 10.1038/ncomms10941 Chemical Sciences  Atmospheric science  Optical physics  Physical chemistry  Putting pressure on aromaticity along with in situ experimental electron density of a molecular crystal OPEN Nicola Casati, Annette Kleppe, Andrew P. Jephcoat and Piero Macchi Aromatic compounds display enhanced stability due to delocalized π-bonding. Here, the authors study an aromatic, molecular crystal under pressure using x-ray diffraction and calculations, and observe a reduction in π-bond delocalization under increasing pressure. 16 March 2016 | doi: 10.1038/ncomms10901 Chemical Sciences  Condensed matter  Organic chemistry  Physical chemistry  A phosphotyrosine switch regulates organic cation transporters OPEN Jason A. Sprowl, Su Sien Ong, Alice A. Gibson, Shuiying Hu, Guoqing Du, Wenwei Lin, Lie Li, Shashank Bharill, Rachel A. Ness, Adrian Stecula, Steven M. Offer, Robert B. Diasio, Anne T. Nies, Matthias Schwab, Guido Cavaletti, Eberhard Schlatter, Giuliano Ciarimboli, Jan H. M. Schellens, Ehud Y. Isacoff, Andrej Sali et al. Organic cation transporters are important drug transporters that influence therapeutic outcomes. Here, the authors find that these transporters are regulated by tyrosine phosphorylation and propose that tyrosine kinase inhibitors can influence drug transporter function through post-translational mechanisms. 16 March 2016 | doi: 10.1038/ncomms10880 Biological Sciences  Biochemistry  Medical research  Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin OPEN Ingrid Chamma, Mathieu Letellier, Corey Butler, Béatrice Tessier, Kok-Hong Lim, Isabel Gauthereau, Daniel Choquet, Jean-Baptiste Sibarita, Sheldon Park, Matthieu Sainlos and Olivier Thoumine The advent of fluorescence-based super-resolution microscopy has created a need for labeling strategies relying on small probes that minimally perturb protein function. Here the authors describe a labeling method that reduces protein tag and label sizes, allowing for accurate protein targeting and measurements of protein dynamics in tight cellular spaces. 16 March 2016 | doi: 10.1038/ncomms10773 Biological Sciences  Cell biology  Neuroscience  PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking OPEN Tsutomu Nakamura, Fumiko Arima-Yoshida, Fumika Sakaue, Yukiko Nasu-Nishimura, Yasuko Takeda, Ken Matsuura, Natacha Akshoomoff, Sarah N. Mattson, Paul D. Grossfeld, Toshiya Manabe and Tetsu Akiyama The molecular underpinning of autism is unclear. Here the authors show PX-RICS deficient mice exhibit autism-like social behavioural abnormalities and impaired GABAA receptor trafficking, and enhancing inhibitory synaptic transmission with a GABAA receptor agonist ameliorate the behavioural deficits. 16 March 2016 | doi: 10.1038/ncomms10861 Biological Sciences  Neuroscience    Nature Communications JOBS of the week PhD Student German Cancer Research Center (DKFZ). 15 PhD scholarships in MSC ITN network EDGE - Oxford, UK : Hannover, DE : Braunschweig, DE : Utrecht, NL : Turino, I EDGE ITN (locally employed at supervisor) Postdoctoral Fellow Colorado School of Mines Postdoctoral Researcher Fox Chase Cancer Center (FCCC) Postdoctoral Research Associate University of Illinois Chicago College of Medicine Postdoctoral Position Memorial Sloan Kettering Cancer Center (MSKCC) 5 PhD students Quantitative Biology LABEX INFORM- Aix-Marseille UNIVERSITE Marie Curie Early Stage Researchers University of Birmingham Up to 20 fully-funded three year PhD studentships Newcastle University Postdoctoral Scientist Medical Research Council More Science jobs from Nature Communications EVENT 14th Annual Meeting of Association for Cancer Immunotherapy 10.05.16 Mainz, Germany More science events from       Latest Corrigendum     Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data OPEN Bhaskar Dutta, Alaleh Azhir, Louis-Henri Merino, Yongjian Guo, Swetha Revanur, Piyush B. Madhamshettiwar, Ronald N. Germain, Jennifer A. Smith, Kaylene J. Simpson, Scott E. Martin, Eugen Buehler and Iain D. C. Fraser 21 March 2016 | doi: 10.1038/ncomms11214 Biological Sciences  Bioinformatics  Systems biology        Latest Erratum     Erratum: Graphene oxide/metal nanocrystal multilaminates as the atomic limit for safe and selective hydrogen storage OPEN Eun Seon Cho, Anne M. Ruminski, Shaul Aloni, Yi-Sheng Liu, Jinghua Guo and Jeffrey J. Urban 18 March 2016 | doi: 10.1038/ncomms11145 Chemical Sciences  Inorganic chemistry  Materials science  Nanotechnology      Advertisement Nature Outlook Urban Health & Well-Being This Nature Outlook explores some of the obstacles to a healthy, happy urban life — and the development of strategies to overcome them. 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