Nature Cell Biology contents: April 2016 Volume 18 Number 4, pp 349 - 457

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TABLE OF CONTENTS April 2016 Volume 18, Issue 4 Perspective Review News and Views Articles Letters Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Read the latest key research on aging and age-related diseases from npj Aging and Mechanisms of Disease, a new open access journal published in partnership with the Japanese Society of Anti-Aging Medicine (JAAM). Yeast longevity: Living longer with heavy isotopes  Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation    Perspective Top Tissue-specific designs of stem cell hierarchies   pp349 - 355 Jane E. Visvader and Hans Clevers doi:10.1038/ncb3332 Visvader and Clevers discuss how stem cells from different tissues, such as the intestine, mammary gland and skeletal muscle, follow different strategies and hierarchies to maintain their complex, tissue-specific balance. Review Top The ever-expanding role of HIF in tumour and stromal biology   pp356 - 365 Edward L. LaGory and Amato J. Giaccia doi:10.1038/ncb3330 LaGory and Giaccia discuss the effects of hypoxia and its downstream responses in cancer and stromal cells. News and Views Top Blood, blebs and lumen expansion   pp366 - 367 Michal Reichman-Fried and Erez Raz doi:10.1038/ncb3334 A powerful combination of cell labelling, genetic tools and rapid imaging techniques in vivo has now led to a high-resolution description of lumen formation during angiogenesis in zebrafish. The study reveals a haemodynamic-force-driven and myosin-II-dependent cellular mechanism (termed inverse membrane blebbing) as the basis for lumen expansion in unicellular and multicellular angiogenic sprouts. See also: Letter by Gebala et al. Multiple cilia suppress tumour formation   pp368 - 369 Charles Eberhart doi:10.1038/ncb3331 Primary cilia are cellular structures that have important functions in development and disease. The suppression of multiciliate differentiation of choroid plexus precursors, and maintenance of a single primary cilium by Notch1, is now shown to be involved in choroid plexus tumour formation. See also: Article by Li et al. Articles Top C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4   pp371 - 381 Bruno Di Stefano, Samuel Collombet, Janus Schou Jakobsen, Michael Wierer, Jose Luis Sardina et al. doi:10.1038/ncb3326 Graf and colleagues find that B cells exposed to a pulse of C/EBPα and the Yamanaka factors convert into elite-type cells that rapidly and efficiently reprogram into iPSCs, in a process that involves upregulation of Lsd1, Brd4 and Klf4. Cell Biology JOBS of the week Postdoctoral Positions in Stem Cell and Cancer Biology Columbia University Medical Center Postdoctoral Fellowship in Biomedical Science (Cancer Research) Institute for Cancer Genetics Columbia University Medical Center Junior Group Leader in the systems biology programme CRG � Centre for Genomic Regulation PhD Student German Cancer Research Center (DKFZ). Post-doctoral Fellowship in Diabetes Boston Children's Hospital and Harvard Medical School More Science jobs from Cell Biology EVENT 4th Advances in Stem Cell Biology Course 27th June - 9th July 2016 Paris, France More science events from Advertisement nature.com webcasts Nature Publishing Group presents a custom webcast on: Analyzing immune cell communities on a massive scale with single-cell RNA-Seq Speaker: Cole Trapnell, Assistant Professor, University of Washington Thursday April 21, 2016 11AM PDT, 2PM EDT Register for the webcast and live Q&A session Sponsored by: 10x Genomics     How the kinetochore couples microtubule force and centromere stretch to move chromosomes   pp382 - 392 Aussie Suzuki, Benjamin L. Badger, Julian Haase, Tomoo Ohashi, Harold P. Erickson et al. doi:10.1038/ncb3323 Using mathematical simulations and a FRET tension sensor inserted into the microtubule-binding complex Ndc80, Suzuki and colleagues obtain insights into how force is generated at the budding yeast kinetochore. SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture   pp393 - 403 Manuel Hilbert, Akira Noga, Daniel Frey, Virginie Hamel, Paul Guichard et al. doi:10.1038/ncb3329 Centrioles are formed from a nine-fold symmetric cartwheel structure. Using mutants of the cartwheel protein SAS-6, which alters cartwheel symmetry, Hirono, Gonczy, Steinmetz and colleagues show that the microtubule wall also determines centriole shape. A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation   pp404 - 417 Xinran Li, Nicholas Rydzewski, Ahmad Hider, Xiaoli Zhang, Junsheng Yang et al. doi:10.1038/ncb3324 Following autophagy induction, lysosomes move to the perinuclear region. Xu and colleagues delineate a pathway involving PtdIns(3,5)P2-mediated activation of the TRPML1 channel and the Ca2+ sensor ALG-2 in this process. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells   pp418 - 430 Li Li, Katie B. Grausam, Jun Wang, Melody P. Lun, Jasmin Ohli et al. doi:10.1038/ncb3327 Zhao and colleagues model choroid plexus tumorigenesis in mice, and report that Notch-mediated suppression of multiciliate differentiation promotes tumour initiation from roof plate progenitor cells in response to epithelium-derived Shh signalling. See also: News and Views by Eberhart LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress   pp431 - 442 Xiaowen Liu, Zhen-Dong Xiao, Leng Han, Jiexin Zhang, Szu-Wei Lee et al. doi:10.1038/ncb3328 Liu et al. show that, in response to energy stress, the NBR2 long non-coding RNA binds AMPK and promotes its activity to reduce cancer cell proliferation. Conversely, loss of NBR2 inhibits AMPK, leading to mTOR activation and tumour growth. Letters Top Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo   pp443 - 450 Veronique Gebala, Russell Collins, Ilse Geudens, Li-Kun Phng and Holger Gerhardt doi:10.1038/ncb3320 Using live imaging of zebrafish angiogenesis, Gerhardt and colleagues observe blood-flow-regulated inverse membrane blebbing during lumen expansion, and show that actomyosin contractility is needed for both bleb retraction and lumen formation. See also: News and Views by Reichman-Fried & Raz Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs   pp451 - 457 Yasuo Yamazaki, Lucy Palmer, Cyrille Alexandre, Satoshi Kakugawa, Karen Beckett et al. doi:10.1038/ncb3325 Vincent and colleagues show in Drosophila wing imaginal discs that the signalling molecule Wingless is synthesized and secreted at the apical surface, and is re-internalized to be transcytosed basally, where its signalling occurs. 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