The EMBO Journal Table of Contents for 1 February 2016; Vol. 35, No. 3

1 February 2016 | Volume 35, Number 3 Submit Table of Contents News & Views Review Articles Corrigendum Volume 35, Number 3 News & Views Agile CD22 nanoclusters run rings around fenced BCR Super‐resolution imaging approaches reveal how fast diffusion allows few molecules of CD22 to sample and inhibit a large number of immobile B‐cell receptor nanoclusters. David Depoil and Michael L Dustin Published online 08.01.2016 Review Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion This review outlines the distinct secretory mechanism and organelles by which astrocytes secrete factors important for CNS development, homeostasis and cognitive function, as well as their contribution to health and diseases. Alexei Verkhratsky, Michela Matteoli, Vladimir Parpura, Jean‐Pierre Mothet, and Robert Zorec Published online 12.01.2016 Articles Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling Super‐resolution microscopy and in silico simulations reveal efficient scanning of the B‐cell membrane as the basis for CD22's ability to keep BCR signalling in check. Francesca Gasparrini, Christoph Feest, Andreas Bruckbauer, Pieta K Mattila, Jennifer Müller, Lars Nitschke, Dennis Bray, and Facundo D Batista Published online 15.12.2015 TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic A mammalian TRAPPIII‐like complex and its interactor, the RabGAP TBC1D14, regulate Golgi function and Atg9‐vesicle trafficking to control autophagosome formation. Christopher A Lamb, Stefanie Nühlen, Delphine Judith, David Frith, Ambrosius P Snijders, Christian Behrends, and Sharon A Tooze Published online 28.12.2015 Microtubule‐binding protein doublecortin‐like kinase 1 (DCLK1) guides kinesin‐3‐mediated cargo transport to dendrites While kinesin motors selectively move into axons, kinesin‐3 and kinesin‐4 can also target dendrites. Microtubule‐binding protein doublecortin‐like kinase 1 (DCLK1) provides local cues to steer polarized movement of kinesin‐3 into dendrites. Joanna Lipka, Lukas C Kapitein, Jacek Jaworski, and Casper C Hoogenraad Published online 12.01.2016 Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α‐mediated stress signaling Protein unfolding stress leads to eIF2α phosphorylation, which is counteracted by protein phosphatase‐1 (PP1). This study shows that ROS‐generating NADPH oxidase‐4 inactivates PP1 at the ER via metal center oxidation, allowing for an enhanced stress signaling response and cell survival. Celio XC Santos, Anne D Hafstad, Matteo Beretta, Min Zhang, Chris Molenaar, Jola Kopec, Dina Fotinou, Thomas V Murray, Andrew M Cobb, Daniel Martin, Maira Zeh Silva, Narayana Anilkumar, Katrin Schröder, Catherine M Shanahan, Alison C Brewer, Ralf P Brandes, Eric Blanc, Maddy Parsons, Vsevelod Belousov, Richard Cammack, Robert C Hider, Roberto A Steiner, and Ajay M Shah Published online 07.01.2016 TET‐catalyzed oxidation of intragenic 5‐methylcytosine regulates CTCF‐dependent alternative splicing Variations in methylcytosine oxidation state are controlled by the activity of the TET enzymes. TET1/2 activity at intragenic regions allows for enhanced CTCF binding and stimulates the inclusion of alternative exons, thus adding further complexity to the splicing code. Ryan J Marina, David Sturgill, Marc A Bailly, Morgan Thenoz, Garima Varma, Maria F Prigge, Kyster K Nanan, Sanjeev Shukla, Nazmul Haque, and Shalini Oberdoerffer Published online 28.12.2015 Convergence of cMyc and β‐catenin on Tcf7l1 enables endoderm specification Induction of definitive endoderm during mammalian development requires inhibition of GSK3 to trigger parallel cMyc and β‐catenin‐dependent repression of the transcriptional repressor Tcf7l1. Gillian Morrison, Roberta Scognamiglio, Andreas Trumpp, and Austin Smith Published online 16.12.2015 Corrigendum The adaptor protein p40phox as a positive regulator of the superoxide‐producing phagocyte oxidase Futoshi Kuribayashi, Hiroyuki Nunoi, Kaori Wakamatsu, Shohko Tsunawaki, Kazuki Sato, Takashi Ito, and Hideki Sumimoto Published online 31.01.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.