Scientific Reports Biology Table of Contents e-alert: 23 February 2016

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23 February 2016      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Nature Publishing Group offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. Visit our website for further advice on the funding options available, and guidance in approaching funders and institutions, or email openaccess@nature.com for more information.                  Biological Sciences               An ecological method to understand agricultural standardization in peach orchard ecosystems ▶     Nian-Feng Wan, Ming-Yi Zhang, Jie-Xian Jiang et al.     While the worldwide standardization of agricultural production has been advocated and recommended, relatively little research has focused on the ecological significance of such a …             Graphene oxide-assisted non-immobilized SELEX of okdaic acid aptamer and the analytical application of aptasensor ▶     Huajie Gu, Nuo Duan, Shijia Wu et al.     Okadaic acid (OA) is a low-molecular-weight marine toxin from shellfish that causes abdominal pain, vomiting and diarrhea, i.e., diarrheic shellfish poisoning. In this study, a …             Arginine side chain interactions and the role of arginine as a gating charge carrier in voltage sensitive ion channels ▶     Craig T. Armstrong, Philip E. Mason, J. L. Ross Anderson et al.     Gating charges in voltage-sensing domains (VSD) of voltage-sensitive ion channels and enzymes are carried on arginine side chains rather than lysine. This arginine preference may …             Differential Odour Coding of Isotopomers in the Honeybee Brain ▶     Marco Paoli, Andrea Anesi, Renzo Antolini et al.     The shape recognition model of olfaction maintains that odorant reception probes physicochemical properties such as size, shape, electric charge, and hydrophobicity of the …             Straightforward and sensitive RT-qPCR based gene expression analysis of FFPE samples ▶     Fjoralba Zeka, Katrien Vanderheyden, Els De Smet et al.     Fragmented RNA from formalin-fixed paraffin-embedded (FFPE) tissue is a known obstacle to gene expression analysis. In this study, the impact of RNA integrity, gene-specific …             Complementary Post Transcriptional Regulatory Information is Detected by PUNCH-P and Ribosome Profiling ▶     Hadas Zur, Ranen Aviner, Tamir Tuller     Two novel approaches were recently suggested for genome-wide identification of protein aspects synthesized at a given time. Ribo-Seq is based on sequencing all the ribosome …             Autotetraploid cell Line induced by SP600125 from crucian carp and its developmental potentiality ▶     Yonghua Zhou, Mei Wang, Minggui Jiang et al.     Polyploidy has many advantages over diploidy, such as rapid growth, sterility, and disease resistance, and has been extensively applied in agriculture and aquaculture. Though …             Unraveling and engineering the production of 23,24-bisnorcholenic steroids in sterol metabolism ▶     Li-Qin Xu, Yong-Jun Liu, Kang Yao et al.     The catabolism of sterols in mycobacteria is highly important due to its close relevance in the pathogenesis of pathogenic strains and the biotechnological applications of …             Corrigendum: Site Specific Genetic Incorporation of Azidophenylalanine in Schizosaccharomyces pombe ▶     Nan Shao, N. Sadananda Singh, Susan E. Slade et al.                 Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) ▶     Vincent J. Munster, Danielle R. Adney, Neeltje van Doremalen et al.     The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the zoonotic potential of Betacoronaviruses. Investigations into the origin of MERS-CoV have …             In silico selection of an aptamer to estrogen receptor alpha using computational docking employing estrogen response elements as aptamer-alike molecules ▶     Rajesh Ahirwar, Smita Nahar, Shikha Aggarwal et al.     Aptamers, the chemical-antibody substitute to conventional antibodies, are primarily discovered through SELEX technology involving multi-round selections and enrichment. …             Long 5′ untranslated regions regulate the RNA stability of the deep-sea filamentous phage SW1 ▶     Huahua Jian, Lei Xiong, Guanpeng Xu et al.     Virus production in the deep-sea environment has been found to be high, and viruses have been suggested to play significant roles in the overall functioning of this ecosystem. …             Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9 ▶     Junfeng Jiang, Li Zhang, Xingliang Zhou et al.     Chromosomal translocation is the most common form of chromosomal abnormality and is often associated with congenital genetic disorders, infertility, and cancers. The lack of …             Entry of PIP3-containing polyplexes into MDCK epithelial cells by local apical-basal polarity reversal ▶     Cuifeng Wang, Edwin de Jong, Klaas A. Sjollema et al.     The polarized architecture of epithelium presents a barrier to therapeutic drug/gene carriers, which is mainly due to a limited (apical) internalization of the carrier systems. …             Cellular microenvironment modulates the galvanotaxis of brain tumor initiating cells ▶     Yu-Ja Huang, Gwendolyn Hoffmann, Benjamin Wheeler et al.     Galvanotaxis is a complex process that represents the collective outcome of various contributing mechanisms, including asymmetric ion influxes, preferential activation of …             AAV Gene Therapy for MPS1-associated Corneal Blindness ▶     Melisa Vance, Telmo Llanga, Will Bennett et al.     Although cord blood transplantation has significantly extended the lifespan of mucopolysaccharidosis type 1 (MPS1) patients, over 95% manifest cornea clouding with about 50% …             A large-scale perspective on stress-induced alterations in resting-state networks ▶     Adi Maron-Katz, Sharon Vaisvaser, Tamar Lin et al.     Stress is known to induce large-scale neural modulations. However, its neural effect once the stressor is removed and how it relates to subjective experience are not fully …             Intraspecific and heteroplasmic variations, gene losses and inversions in the chloroplast genome of Astragalus membranaceus ▶     Wanjun Lei, Dapeng Ni, Yujun Wang et al.     Astragalus membranaceus is an important medicinal plant in Asia. Several of its varieties have been used interchangeably as raw materials for commercial production. High …             Ocean acidification increases copper toxicity differentially in two key marine invertebrates with distinct acid-base responses ▶     Ceri Lewis, Robert P. Ellis, Emily Vernon et al.     Ocean acidification (OA) is expected to indirectly impact biota living in contaminated coastal environments by altering the bioavailability and potentially toxicity of many …             The modification of Gat1p in nitrogen catabolite repression to enhance non-preferred nitrogen utilization in Saccharomyces cerevisiae ▶     Xinrui Zhao, Huijun Zou, Jian Chen et al.     In Saccharomyces cerevisiae, when preferred nitrogen sources are present, the metabolism of non-preferred nitrogen is repressed. Previous work showed that this metabolic …             Transport of pyruvate into mitochondria is involved in methylmercury toxicity ▶     Jin-Yong Lee, Yosuke Ishida, Tsutomu Takahashi et al.     We have previously demonstrated that the overexpression of enzymes involved in the production of pyruvate, enolase 2 (Eno2) and D-lactate dehydrogenase (Dld3) renders yeast …             Biochemical characterization of extra- and intracellular endoxylanse from thermophilic bacterium Caldicellulosiruptor kronotskyensis ▶     Xiaojing Jia, Weibo Qiao, Wenli Tian et al.     Caldicellulosiruptor kronotskyensis grows on lignocellulosic biomass by the catalysis of intrinsic glycoside hydrolase, and has potential application for consolidated …             Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction ▶     Masataka Santoh, Seigo Sanoh, Masashi Takagi et al.     Acetaminophen (APAP) is extensively used as an analgesic and antipyretic drug. APAP is partly metabolized to N-acetyl-p-benzoquinone imine, a reactive metabolite, by cytochrome …             No rapid audiovisual recalibration in adults on the autism spectrum ▶     Marco Turi, Themelis Karaminis, Elizabeth Pellicano et al.     Autism spectrum disorders (ASD) are characterized by difficulties in social cognition, but are also associated with atypicalities in sensory and perceptual processing. Several …             Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells ▶     Hye-Min Kim, Ji-Woo Kim, Youngjun Choi et al.     Although hepatocyte-like cells derived from human pluripotent stem cells (hPSC-HLCs) are considered a promising model for predicting hepatotoxicity, their application has been …             Graphene oxide-dependent growth and self-aggregation into a hydrogel complex of exoelectrogenic bacteria ▶     Naoko Yoshida, Yasushi Miyata, Kasumi Doi et al.     Graphene oxide (GO) is reduced by certain exoelectrogenic bacteria, but its effects on bacterial growth and metabolism are a controversial issue. This study aimed to determine …             Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons ▶     Ji Hye Park, Chung Kwon Kim, Sang Bae Lee et al.     Although the essential role of protein kinase B (PKB)/Akt in cell survival signaling has been clearly established, the mechanism by which Akt mediates the cellular response to …             Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery ▶     Giulia Vignaroli, Pierpaolo Calandro, Claudio Zamperini et al.     Pyrazolo[3,4-d]pyrimidines are a class of compounds with a good activity against several cancer cell lines. Despite the promising anticancer activity, these molecules showed a …             Inter-Strain Differences in Default Mode Network: A Resting State fMRI Study on Spontaneously Hypertensive Rat and Wistar Kyoto Rat ▶     Sheng-Min Huang, Yi-Ling Wu, Shin-Lei Peng et al.     Genetic divergences among mammalian strains are presented phenotypically in various aspects of physical appearance such as body shape and facial features. Yet how genetic …             Particle alignment reliability in single particle electron cryomicroscopy: a general approach ▶     J. Vargas, J. Otón, R. Marabini et al.     Electron Microscopy is reaching new capabilities thanks to the combined effect of new technologies and new image processing methods. However, the reconstruction process is still …             Cryptochrome 1 in Retinal Cone Photoreceptors Suggests a Novel Functional Role in Mammals ▶     Christine Nießner, Susanne Denzau, Erich Pascal Malkemper et al.     Cryptochromes are a ubiquitous group of blue-light absorbing flavoproteins that in the mammalian retina have an important role in the circadian clock. In birds, cryptochrome 1a …             Mammalian interspecies substitution of immune modulatory alleles by genome editing ▶     Simon G. Lillico, Chris Proudfoot, Tim J. King et al.     We describe a fundamentally novel feat of animal genetic engineering: the precise and efficient substitution of an agronomic haplotype into a domesticated species. Zinc finger …             GATA3 inhibits GCM1 activity and trophoblast cell invasion ▶     Yueh Ho Chiu, Hungwen Chen     Development of human placenta involves the invasion of trophoblast cells from anchoring villi into the maternal decidua. Placental transcription factor GCM1 regulates trophoblast …             Viruliferous rate of small brown planthopper is a good indicator of rice stripe disease epidemics ▶     Dun-Chun He, Jiasui Zhan, Zhao-Bang Cheng et al.     Rice stripe virus (RSV), its vector insect (small brown planthopper, SBPH) and climatic conditions in Jiangsu, China were monitored between 2002 and 2012 to determine key biotic …             An automated framework for 3D serous pigment epithelium detachment segmentation in SD-OCT images ▶     Zhuli Sun, Haoyu Chen, Fei Shi et al.     Pigment epithelium detachment (PED) is an important clinical manifestation of multiple chorioretinal diseases, which can cause loss of central vision. In this paper, an automated …             Host kinin B1 receptor plays a protective role against melanoma progression ▶     Andrea G. Maria, Patrícia Dillenburg-Pilla, Rosana I. Reis et al.     Melanoma is a very aggressive tumor that arises from melanocytes. Late stage and widely spread diseases do not respond to standard therapeutic approaches. The kallikrein-kinin …             Traumatic Brain Injury Causes Aberrant Migration of Adult-Born Neurons in the Hippocampus ▶     Sara Ibrahim, Weipeng Hu, Xiaoting Wang et al.     Traumatic brain injury (TBI) promotes neural stem/progenitor cell (NSC) proliferation in an attempt to initiate innate repair mechanisms. However, all immature neurons in the CNS …             Long distance dispersal and vertical gene flow in the Caribbean brooding coral Porites astreoides ▶     Xaymara M. Serrano, Iliana B. Baums, Tyler B. Smith et al.     To date, most assessments of coral connectivity have emphasized long-distance horizontal dispersal of propagules from one shallow reef to another. The extent of vertical …             Reactive oxygen species regulate leaf pulvinus abscission zone cell separation in response to water-deficit stress in cassava ▶     Wenbin Liao, Gan Wang, Yayun Li et al.     Cassava (Manihot esculenta Crantz) plant resists water-deficit stress by shedding leaves leading to adaptive water-deficit condition. Transcriptomic, physiological, cellular, …             Interactive effects between gaze direction and facial expression on attentional resources deployment: the task instruction and context matter ▶     Paola Ricciardelli, Luisa Lugli, Antonello Pellicano et al.     In three experiments, we tested whether the amount of attentional resources needed to process a face displaying neutral/angry/fearful facial expressions with direct or averted …             SGT1 is required in PcINF1/SRC2-1 induced pepper defense response by interacting with SRC2-1 ▶     Zhi-qin Liu, Yan-yan Liu, Lan-ping Shi et al.     PcINF1 was previously found to induce pepper defense response by interacting with SRC2-1, but the underlying mechanism remains uninvestigated. Herein, we describe the involvement …             Interplay of histidine residues of the Alzheimer’s disease Aβ peptide governs its Zn-induced oligomerization ▶     Andrey N. Istrate, Sergey A. Kozin, Sergey S. Zhokhov et al.     Conformational changes of Aβ peptide result in its transformation from native monomeric state to the toxic soluble dimers, oligomers and insoluble aggregates that are hallmarks …             Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance ▶     Xiulan Chen, Shimeng Xu, Shasha Wei et al.     Accumulated studies demonstrate that saturated fatty acids (FAs) such as palmitic acid (PA) inhibit insulin signaling in skeletal muscle cells and monounsaturated fatty acids …             Glucose is a key driver for GLUT1-mediated nanoparticles internalization in breast cancer cells ▶     Leonardo Venturelli, Silvia Nappini, Michela Bulfoni et al.     The mesenchymal state in cancer is usually associated with poor prognosis due to the metastatic predisposition and the hyper-activated metabolism. Exploiting cell glucose …             Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf ▶     Takahiro Ogawa, Yukihiro Kodera, Dai Hirata et al.     Identification of biologically active natural compounds that promote health and longevity, and understanding how they act, will provide insights into aging and metabolism, and …             PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific Genes ▶     Yuzuru Sasamoto, Ryuhei Hayashi, Sung-Joon Park et al.     PAX6 is the key transcription factor involved in eye development in humans, but the differential functions of the two PAX6 isoforms, isoform-a and isoform-b, are largely unknown. …             Natural variation in non-coding regions underlying phenotypic diversity in budding yeast ▶     Francisco Salinas, Carl G. de Boer, Valentina Abarca et al.     Linkage mapping studies in model organisms have typically focused their efforts in polymorphisms within coding regions, ignoring those within regulatory regions that may …             Mechanical characterization of the P56 mouse brain under large-deformation dynamic indentation ▶     David B. MacManus, Baptiste Pierrat, Jeremiah G. Murphy et al.     The brain is a complex organ made up of many different functional and structural regions consisting of different types of cells such as neurons and glia, as well as complex …             Insight into Coenzyme A cofactor binding and the mechanism of acyl-transfer in an acylating aldehyde dehydrogenase from Clostridium phytofermentans ▶     Laura R. Tuck, Kirsten Altenbach, Thiau Fu Ang et al.     The breakdown of fucose and rhamnose released from plant cell walls by the cellulolytic soil bacterium Clostridium phytofermentans produces toxic aldehyde intermediates. To …             Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy ▶     Cinzia Giordano, Ines Barone, Valentina Vircillo et al.     Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the …             Heterogeneity induces rhythms of weakly coupled circadian neurons ▶     Changgui Gu, Xiaoming Liang, Huijie Yang et al.     The main clock located in the suprachiasmatic nucleus (SCN) regulates circadian rhythms in mammals. The SCN is composed of approximately twenty thousand heterogeneous …             Forests and ozone: productivity, carbon storage, and feedbacks ▶     Bin Wang, Herman H. Shugart, Jacquelyn K. Shuman et al.     Tropospheric ozone is a serious air-pollutant, with large impacts on plant function. This study demonstrates that tropospheric ozone, although it damages plant metabolism, does …             Impact of sustainable feeds on omega-3 long-chain fatty acid levels in farmed Atlantic salmon, 2006–2015 ▶     M. Sprague, J.R. Dick, D.R. Tocher     As the global population and its demand for seafood increases more of our fish will come from aquaculture. Farmed Atlantic salmon are a global commodity and, as an oily fish, …             Sparse cliques trump scale-free networks in coordination and competition ▶     David A. Gianetto, Babak Heydari     Cooperative behavior, a natural, pervasive and yet puzzling phenomenon, can be significantly enhanced by networks. Many studies have shown how global network characteristics …             Nano-thick calcium oxide armed titanium: boosts bone cells against methicillin-resistant Staphylococcus aureus ▶     Huiliang Cao, Hui Qin, Yaochao Zhao et al.     Since the use of systemic antibiotics for preventing acute biomaterial-associated infections (BAIs) may build up bacterial resistance and result in huge medical costs and …             A combination of serum iron, ferritin and transferrin predicts outcome in patients with intracerebral hemorrhage ▶     Guang Yang, Rong Hu, Chao Zhang et al.     Association of a high-serum ferritin with poor outcome showed that iron might play a detrimental role in the brain after intracerebral hemorrhage (ICH). Here, we investigated …             Computer-aided multiple-head 3D printing system for printing of heterogeneous organ/tissue constructs ▶     Jin Woo Jung, Jung-Seob Lee, Dong-Woo Cho     Recently, much attention has focused on replacement or/and enhancement of biological tissues via the use of cell-laden hydrogel scaffolds with an architecture that mimics the …             Modulation of E-cadherin expression promotes migration ability of esophageal cancer cells ▶     Shujun Li, Xuebo Qin, Song Chai et al.     Losing the E-cadherin plays an important role in the metastasis of cancer. The regulation of the expression of E-cadherin is unclear. Circadian rhythm alteration is associated …             Oscillating primary transcripts harbor miRNAs with circadian functions ▶     Haifang Wang, Zenghua Fan, Meng Zhao et al.     The roles of miRNAs as important post-transcriptional regulators in the circadian clock have been suggested in several studies. But the search for circadian miRNAs has led to …             Truncated yet functional viral protein produced via RNA polymerase slippage implies underestimated coding capacity of RNA viruses ▶     Yuka Hagiwara-Komoda, Sun Hee Choi, Masanao Sato et al.     RNA viruses use various strategies to condense their genetic information into small genomes. Potyviruses not only use the polyprotein strategy, but also embed an open reading …             Ultraviolet-visible study on acid-base equilibria of aporphine alkaloids with antiplasmodial and antioxidant activities from Alseodaphne corneri and Dehaasia longipedicellata ▶     Azeana Zahari, Abdulwali Ablat, Noridayu Omer et al.     The UV-vis spectra of isocorydine 1, norisocorydine 2 and boldine 3 were studied in 2% v/v acetonitrile, at constant ionic strength (0.1 M NaCl, 35 degree Celsius). The pKa …             TPhP exposure disturbs carbohydrate metabolism, lipid metabolism, and the DNA damage repair system in zebrafish liver ▶     Zhongkun Du, Yan Zhang, Guowei Wang et al.     Triphenyl phosphate is a high production volume organophosphate flame retardant that has been detected in multiple environmental media at increasing concentrations. The …             Ultrasound triggered image-guided drug delivery to inhibit vascular reconstruction via paclitaxel-loaded microbubbles ▶     Xu Zhu, Jun Guo, Cancan He et al.     Paclitaxel (PTX) has been recognized as a promising drug for intervention of vascular reconstructions. However, it is still difficult to achieve local drug delivery in a …             EGCG in Green Tea Induces Aggregation of HMGB1 Protein through Large Conformational Changes with Polarized Charge Redistribution ▶     Xuan-Yu Meng, Baoyu Li, Shengtang Liu et al.     As a major effective component in green tea, (−)-epigallocatechin-3-gallate (EGCG)’s potential benefits to human health have been widely investigated. Recent experimental …             Progestins alter photo-transduction cascade and circadian rhythm network in eyes of zebrafish (Danio rerio) ▶     Yanbin Zhao, Karl Fent     Environmental progestins are implicated in endocrine disruption in vertebrates. Additional targets that may be affected in organisms are poorly known. Here we report that …             Prognostic role of Gli1 expression in solid malignancies: a meta-analysis ▶     Ji Cheng, Jinbo Gao, Kaixiong Tao et al.     Gli1 is a downstream transcriptional factor of Sonic hedgehog pathway in mammalians, and has been recognized as a proliferative indicator of carcinogenesis. However, its actual …             Overexpression of Suprabasin is Associated with Proliferation and Tumorigenicity of Esophageal Squamous Cell Carcinoma ▶     Jinrong Zhu, Geyan Wu, Qingyuan Li et al.     Suprabasin is a recently identified oncoprotein that is upregulated in multiple cancers. However, the clinical significance and biological role of suprabasin in human esophageal …             HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development ▶     Zhaoliang Su, Pan Zhang, Ying Yu et al.     Macrophages can be reprogramming, such as the classical activated macrophage, M1 or alternative activated macrophages, M2 phenotype following the milieu danger signals, …             Histone acetyltransferease p300 modulates TIM4 expression in dendritic cells ▶     Bo Yang, Lin-Jing Li, Ling-Zhi Xu et al.     TIM4 (T cell immunoglobulin mucin domain molecule-4) plays a critical role in the initiation of skewed T helper (Th) 2 polarization. The factors regulating TIM4 expression are …             Memantine Improves Attentional Processes in Fragile X-Associated Tremor/Ataxia Syndrome: Electrophysiological Evidence from a Randomized Controlled Trial ▶     Jin-Chen Yang, Annette Rodriguez, Ashley Royston et al.     Progressive cognitive deficits are common in patients with fragile X-associated tremor/ataxia syndrome (FXTAS), with no targeted treatment yet established. In this substudy of …             miR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1 ▶     Xiaoyi Li, Deyong Kong, Heming Chen et al.     Atherosclerosis (AS) is chronic inflammation in response to lipid accumulation. MicroRNA-155 (miR-155) is being increasingly studied to evaluate its potential as diagnostic …             High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury ▶     Athanasios Didangelos, Michele Puglia, Michaela Iberl et al.     Spinal cord injury is characterized by acute cellular and axonal damage followed by aggressive inflammation and pathological tissue remodelling. The biological mediators …             Short and long time effects of low temperature Plasma Activated Media on 3D multicellular tumor spheroids ▶     Florian Judée, Céline Fongia, Bernard Ducommun et al.     This work investigates the regionalized antiproliferative effects of plasma-activated medium (PAM) on colon adenocarcinoma multicellular tumor spheroid (MCTS), a model that …             Non-ionizing radiofrequency electromagnetic waves traversing the head can be used to detect cerebrovascular autoregulation responses ▶     M. Oziel, M. Hjouj, C. A. Gonzalez et al.     Monitoring changes in non-ionizing radiofrequency electromagnetic waves as they traverse the brain can detect the effects of stimuli employed in cerebrovascular autoregulation …             Use of lead-210 as a novel tracer for lead (Pb) sources in plants ▶     Handong Yang, Peter G. Appleby     Lead (Pb) released from anthropogenic sources and stored in environmental repositories can be a potential source for secondary pollution. Here we develop a novel approach for …             A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment ▶     Lili Jiang, Dan Zang, Songgang Yi et al.     MicroRNAs (miRs) play pivotal roles in carcinogenesis and endoplasmic reticulum (ER) that performs the folding, modification and trafficking of proteins targeted to the secretory …             Integrative topological analysis of mass spectrometry data reveals molecular features with clinical relevance in esophageal squamous cell carcinoma ▶     She-Gan Gao, Rui-Min Liu, Yun-Gang Zhao et al.     Combining MS-based proteomic data with network and topological features of such network would identify more clinically relevant molecules and meaningfully expand the repertoire …             Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent ▶     Susanne Kossatz, Christian Brand, Stanley Gutiontov et al.     Earlier and more accurate detection of oral squamous cell carcinoma (OSCC) is essential to improve the prognosis of patients and to reduce the morbidity of surgical therapy. …             Parallel expression profiling of hepatic and serum microRNA-122 associated with clinical features and treatment responses in chronic hepatitis C patients ▶     Azeem Mehmood Butt, Arsalan Jamil Raja, Shafiqa Siddique et al.     MicroRNAs (miRNAs) are small, non-coding RNAs that regulate a variety of biological processes. Recently, human liver-specific miRNA miR-122 has been reported to facilitate …             Microfluidic model of the platelet-generating organ: beyond bone marrow biomimetics ▶     Antoine Blin, Anne Le Goff, Aurélie Magniez et al.     We present a new, rapid method for producing blood platelets in vitro from cultured megakaryocytes based on a microfluidic device. This device consists in a wide array of …             Single-Walled Carbon Nanotubes Inhibit the Cytochrome P450 Enzyme, CYP3A4 ▶     Ramy El-Sayed, Kunal Bhattacharya, Zonglin Gu et al.     We report a detailed computational and experimental study of the interaction of single-walled carbon nanotubes (SWCNTs) with the drug-metabolizing cytochrome P450 enzyme, CYP3A4. …             CD36 is a co-receptor for hepatitis C virus E1 protein attachment ▶     Jun-Jun Cheng, Jian-Rui Li, Meng-Hao Huang et al.     The cluster of differentiation 36 (CD36) is a membrane protein related to lipid metabolism. We show that HCV infection in vitro increased CD36 expression in either surface or …             Purity matters: A workflow for the valid high-resolution lipid profiling of mitochondria from cell culture samples ▶     Lisa Kappler, Jia Li, Hans-Ulrich Häring et al.     Subcellular lipidomics is a novel field of research that requires the careful combination of several pre-analytical and analytical steps. To define a reliable strategy for …             Multi-stability of circadian phase wave within early postnatal suprachiasmatic nucleus ▶     Byeongha Jeong, Jin Hee Hong, Hyun Kim et al.     The suprachiasmatic nucleus (SCN) is a group of cells that functions as a biological master clock. In different SCN cells, oscillations of biochemical markers such as the …             Does selection in a challenging environment produce Nile tilapia genotypes that can thrive in a range of production systems? ▶     Ngo Phu Thoa, Nguyen Huu Ninh, Wayne Knibb et al.     This study assessed whether selection for high growth in a challenging environment of medium salinity produces tilapia genotypes that perform well across different production …             cGMP Signalling Mediates Water Sensation (Hydrosensation) and Hydrotaxis in Caenorhabditis elegans ▶     Wei Wang, Li-Wei Qin, Tai-Hong Wu et al.     Animals have developed the ability to sense the water content in their habitats, including hygrosensation (sensing humidity in the air) and hydrosensation (sensing the water …             Surface Molecularly Imprinted Polymer of Chitosan Grafted Poly(methyl methacrylate) for 5-Fluorouracil and Controlled Release ▶     Xue-Fang Zheng, Qi Lian, Hua Yang et al.     The molecular surface imprinted graft copolymer of chitosan with methyl methacrylate (MIP-CS-g-PMMA) were prepared by free radical polymerization with 5-fluorouracil (5-FU) as …             A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum ▶     Matthew L. Jones, Sujaan Das, Hugo Belda et al.     Conditional genome engineering in the human malaria pathogen Plasmodium falciparum remains highly challenging. Here we describe a strategy for facile and rapid functional …             Selection of highly efficient sgRNAs for CRISPR/Cas9-based plant genome editing ▶     Gang Liang, Huimin Zhang, Dengji Lou et al.     The CRISPR/Cas9-sgRNA system has been developed to mediate genome editing and become a powerful tool for biological research. Employing the CRISPR/Cas9-sgRNA system for genome …             Microfluidic Screening of Electric Fields for Electroporation ▶     Paulo A. Garcia, Zhifei Ge, Jeffrey L. Moran et al.     Electroporation is commonly used to deliver molecules such as drugs, proteins, and/or DNA into cells, but the mechanism remains poorly understood. In this work a rapid …             DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis ▶     Tsung-Ying He, De-Wei Wu, Po-Lin Lin et al.     DDX3, a subunit of CK1ε, phosphorylates Dvl2 to promote β-catenin activation. Overexpression of the Dvl2 protein results in potent activation of β-catenin/TCF signaling in …             Critical role of the C5a-activated neutrophils in high-fat diet-induced vascular inflammation ▶     Mizuko Osaka, Shunsuke Ito, Masaki Honda et al.     Exceed and chronic high-fat diet (HFD) contributes to the diagnosis and development of atherosclerosis, obesity, and metabolic syndrome. However, the key molecular component(s) …             Self-Adaptive Spike-Time-Dependent Plasticity of Metal-Oxide Memristors ▶     M. Prezioso, F. Merrikh Bayat, B. Hoskins et al.     Metal-oxide memristors have emerged as promising candidates for hardware implementation of artificial synapses – the key components of high-performance, analog neuromorphic …             Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization ▶     Songbo Xie, Juan Qin, Shiyu Liu et al.     The centrosome is crucial for mitotic fidelity, and centrosome aberrations are associated with genomic instability and tumorigenesis. The centrosomal protein Cep70 has been …             Long-term ex vivo maintenance of testis tissues producing fertile sperm in a microfluidic device ▶     Mitsuru Komeya, Hiroshi Kimura, Hiroko Nakamura et al.     In contrast to cell cultures, particularly to cell lines, tissues or organs removed from the body cannot be maintained for long in any culture conditions. Although it is apparent …             Bacillus amyloliquefaciens SQR9 induces dendritic cell maturation and enhances the immune response against inactivated avian influenza virus ▶     Lulu Huang, Tao Qin, YinYan Yin et al.     The objective of this study was to evaluate the stimulatory effects of Bacillus amyloliquefaciens SQR9 on dendritic cells (DCs) and to verify its ability to enhance the immune …             Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast ▶     Xiaoying Sun, Go Hirai, Masashi Ueki et al.     Uptake of poor nitrogen sources such as branched-chain amino acids is repressed in the presence of high-quality nitrogen sources such as NH4+ and glutamate (Glu), which is called …             Plant essential oils and potassium metabisulfite as repellents for Drosophila suzukii (Diptera: Drosophilidae) ▶     Justin M. Renkema, Derek Wright, Rose Buitenhuis et al.     Spotted wing drosophila, Drosophila suzukii, is a globally invasive pest of soft-skinned fruit. Females oviposit into ripening fruit and larvae cause direct destruction of …             Smoking Induced Hemolysis: Spectral and microscopic investigations ▶     Vadivel Masilamani, Khalid AlZahrani, Sandhanasamy Devanesan et al.     Smoking is one of the major causes of lifestyle associated mortality and morbidity such as cancer of the oral cavity and lungs, and also cardiovascular diseases. In this study, …             Retinal Ganglion Cell Loss is Delayed Following Optic Nerve Crush in NLRP3 Knockout Mice ▶     Zhen Puyang, Liang Feng, Hui Chen et al.     The NLRP3 inflammasome, a sensor for a variety of pathogen- and host-derived threats, consists of the adaptor ASC (Apoptosis-associated Speck-like protein containing a Caspase …             Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells ▶     Mathieu Daynac, Lise Morizur, Alexandra Chicheportiche et al.     Although neural stem cells (NSCs) sustain continuous neurogenesis throughout the adult lifespan of mammals, they progressively exhibit proliferation defects that contribute to a …             Genome analysis of the kiwifruit canker pathogen Pseudomonas syringae pv. actinidiae biovar 5 ▶     Takashi Fujikawa, Hiroyuki Sawada     Pseudomonas syringae pv. actinidiae (Psa) is a destructive pathogen of kiwifruit bacterial canker disease, causing severe economic losses to kiwifruit industry worldwide. Biovar …             Risk Prediction Modeling of Sequencing Data Using a Forward Random Field Method ▶     Yalu Wen, Zihuai He, Ming Li et al.     With the advance in high-throughput sequencing technology, it is feasible to investigate the role of common and rare variants in disease risk prediction. While the new technology …             Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop ▶     Jinbo Cheng, Yajin Liao, Lujun Zhou et al.     Type I interferon (IFN-I) is critical for a host against viral and bacterial infections via induction of hundreds of interferon-stimulated genes (ISGs), but the mechanism …             Combined Secretomics and Transcriptomics Revealed Cancer-Derived GDF15 is Involved in Diffuse-Type Gastric Cancer Progression and Fibroblast Activation ▶     Takayuki Ishige, Motoi Nishimura, Mamoru Satoh et al.     Gastric cancer is classified into two subtypes, diffuse and intestinal. The diffuse-type gastric cancer (DGC) has poorer prognosis, and the molecular pathology is not yet fully …             An MRI-based classification scheme to predict passive access of 5 to 50-nm large nanoparticles to tumors ▶     Anastassia Karageorgis, Sandrine Dufort, Lucie Sancey et al.     Nanoparticles are useful tools in oncology because of their capacity to passively accumulate in tumors in particular via the enhanced permeability and retention (EPR) effect. …             Antibiotic binding of STY3178, a yfdX protein from Salmonella Typhi ▶     Paramita Saha, Camelia Manna, Santasabuj Das et al.     The yfdX family proteins are known for long time to occur in various virulent bacteria including their multidrug resistant (MDR) strains, without any direct assigned function for …             High frequency of +1 programmed ribosomal frameshifting in Euplotes octocarinatus ▶     Ruanlin Wang, Jie Xiong, Wei Wang et al.     Programmed −1 ribosomal frameshifting (−1 PRF) has been identified as a mechanism to regulate the expression of many viral genes and some cellular genes. The slippery site of −1 …             Neural basis of uncertain cue processing in trait anxiety ▶     Meng Zhang, Chao Ma, Yanyan Luo et al.     Individuals with high trait anxiety form a non-clinical group with a predisposition for an anxiety-related bias in emotional and cognitive processing that is considered by some …             A block mixture model to map eQTLs for gene clustering and networking ▶     Ningtao Wang, Kirk Gosik, Runze Li et al.     To study how genes function in a cellular and physiological process, a general procedure is to classify gene expression profiles into categories based on their similarity and …             Late regulation of immune genes and microRNAs in circulating leukocytes in a pig model of influenza A (H1N2) infection ▶     Louise Brogaard, Peter M. H. Heegaard, Lars E. Larsen et al.     MicroRNAs (miRNAs) are a class of short regulatory RNA molecules which are implicated in modulating gene expression. Levels of circulating, cell-associated miRNAs in response to …             Characters related to higher starch accumulation in cassava storage roots ▶     You-Zhi Li, Jian-Yu Zhao, San-Min Wu et al.     Cassava (Manihot esculenta) is valued mainly for high content starch in its roots. Our understanding of mechanisms promoting high starch accumulation in the roots is, however, …             Expression partitioning of homeologs and tandem duplications contribute to salt tolerance in wheat (Triticum aestivum L.) ▶     Yumei Zhang, Zhenshan Liu, Abul Awlad Khan et al.     Salt stress dramatically reduces crop yield and quality, but the molecular mechanisms underlying salt tolerance remain largely unknown. To explore the wheat transcriptional …             Divergence time estimates and the evolution of major lineages in the florideophyte red algae ▶     Eun Chan Yang, Sung Min Boo, Debashish Bhattacharya et al.     The Florideophyceae is the most abundant and taxonomically diverse class of red algae (Rhodophyta). However, many aspects of the systematics and divergence times of the group …             Comparative genomics and functional analysis of the 936 group of lactococcal Siphoviridae phages ▶     James Murphy, Francesca Bottacini, Jennifer Mahony et al.     Genome sequencing and comparative analysis of bacteriophage collections has greatly enhanced our understanding regarding their prevalence, phage-host interactions as well as the …             Characterization of a natural triple-tandem c-di-GMP riboswitch and application of the riboswitch-based dual-fluorescence reporter ▶     Hang Zhou, Cao Zheng, Jianmei Su et al.     c-di-GMP riboswitches are structured RNAs located in the 5′-untranslated regions (5′-UTRs) of mRNAs that regulate expression of downstream genes in response to changing …             Long-term High Fat Ketogenic Diet Promotes Renal Tumor Growth in a Rat Model of Tuberous Sclerosis ▶     Arkadiusz D. Liśkiewicz, Daniela Kasprowska, Anna Wojakowska et al.     Nutritional imbalance underlies many disease processes but can be very beneficial in certain cases; for instance, the antiepileptic action of a high fat and low carbohydrate …             Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis ▶     Ninkovic Jana, Anand Vidhu, Dutta Raini et al.     Opioid drug abusers have a greater susceptibility to gram positive (Gram (+)) bacterial infections. However, the mechanism underlying opioid modulation of Gram (+) versus Gram …             L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade ▶     P. Jourdain, I. Allaman, K. Rothenfusser et al.     Converging experimental data indicate a neuroprotective action of L-Lactate. Using Digital Holographic Microscopy, we observe that transient application of glutamate (100 μM; …             Activation of the TGFβ pathway impairs endothelial to haematopoietic transition ▶     Özge Vargel, Yang Zhang, Kinga Kosim et al.     The endothelial to haematopoietic transition (EHT) is a key developmental process where a drastic change of endothelial cell morphology leads to the formation of blood stem and …             Basal ganglia correlates of fatigue in young adults ▶     Seishu Nakagawa, Hikaru Takeuchi, Yasuyuki Taki et al.     Although the prevalence of chronic fatigue is approximately 20% in healthy individuals, there are no studies of brain structure that elucidate the neural correlates of fatigue …             Discovering gene re-ranking efficiency and conserved gene-gene relationships derived from gene co-expression network analysis on breast cancer data ▶     Marilena M. Bourdakou, Emmanouil I. Athanasiadis, George M. Spyrou     Systemic approaches are essential in the discovery of disease-specific genes, offering a different perspective and new tools on the analysis of several types of molecular …             Effects of agricultural practices on organic matter degradation in ditches ▶     Ellard R. Hunting, J. Arie Vonk, C.J.M. Musters et al.     Agricultural practices can result in differences in organic matter (OM) and agricultural chemical inputs in adjacent ditches, but its indirect effects on OM composition and its …             Volatile Oil of Acori Graminei Rhizoma-Induced Apoptosis and Autophagy are dependent on p53 Status in Human Glioma Cells ▶     Lu Chen, Zhuyun Jiang, Hui Ma et al.     Acori Graminei Rhizoma is well known for the beneficial effects on CNS disorders in traditional medicine. Though it is frequently prescribed in formulations for brain tumors, the …             Mesenchymal stem cells promote colorectal cancer progression through AMPK/mTOR-mediated NF-κB activation ▶     Xiao-Bing Wu, Yang Liu, Gui-Hua Wang et al.     Mesenchymal stem cells (MSCs) exert a tumor-promoting effect in a variety of human cancers. This study was designed to identify the molecular mechanisms related to the …             A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly ▶     Maia Godonoga, Ting-Yu Lin, Azusa Oshima et al.     DNA aptamers have potential for disease diagnosis and as therapeutics, particularly when interfaced with programmable molecular technology. Here we have combined DNA aptamers …             Early detection of germinated wheat grains using terahertz image and chemometrics ▶     Yuying Jiang, Hongyi Ge, Feiyu Lian et al.     In this paper, we propose a feasible tool that uses a terahertz (THz) imaging system for identifying wheat grains at different stages of germination. The THz spectra of the main …             Hydrophobic bile acids relax rat detrusor contraction via inhibiting the opening of the Na+/Ca2+ exchanger ▶     Jingzhen Zhu, Xingyou Dong, Qian Liu et al.     Hydrophobic bile acids (BAs) are thought to inhibit smooth muscle contractility in several organs. The present study was undertaken to investigate the effects of hydrophobic BAs …             Construction of pH-responsive and up-conversion luminescent NaYF4:Yb3+/Er3+@SiO2@PMAA nanocomposite for colon targeted drug delivery ▶     Boshi Tian, Shaohua Liu, Wei Lu et al.     Colon-targeted drug delivery system has attracted much interest because it can improve therapeutic efficacy and reduce the side effect in practical clinic. Herein, we constructed …             Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner ▶     Jyoti Joshi Mundra, Jinlong Jian, Priyal Bhagat et al.     Progranulin (PGRN), a pleiotrophic growth factor, is known to play an important role in the maintenance and regulation of the homeostatic dynamics of normal tissue development, …             Combined strategies for optimal detection of the contact point in AFM force-indentation curves obtained on thin samples and adherent cells ▶     Núria Gavara     Atomic Force Microscopy (AFM) is a widely used tool to study cell mechanics. Current AFM setups perform high-throughput probing of living cells, generating large amounts of …             Extracellular Forces Cause the Nucleus to Deform in a Highly Controlled Anisotropic Manner ▶     Kristina Haase, Joan K. L. Macadangdang, Claire H. Edrington et al.     Physical forces arising in the extra-cellular environment have a profound impact on cell fate and gene regulation; however the underlying biophysical mechanisms that control this …             Preventive obesity agent montmorillonite adsorbs dietary lipids and enhances lipid excretion from the digestive tract ▶     Pengfei Xu, Shu Dai, Jing Wang et al.     Western diets are typically high in fat and are associated with long-term complications such as obesity and hepatic steatosis. Because of the enjoyable taste of high-fat diets …             Acute ecotoxicology of natural oil and gas condensate to coral reef larvae ▶     Andrew P. Negri, Diane L. Brinkman, Florita Flores et al.     Risks posed by oil spills to coral reefs are difficult to evaluate, partially due to the absence of studies that adequately assess toxicity to relevant coral reef species. Here …             Establishment of a Novel Primary Human Skeletal Myoblast Cellular Model for Chikungunya Virus Infection and Pathogenesis ▶     Khairunnisa’ Mohamed Hussain, Regina Ching Hua Lee, Mary Mah-Lee Ng et al.     Chikungunya virus (CHIKV) is a re-emerging arbovirus known to cause chronic myalgia and arthralgia and is now considered endemic in countries across Asia and Africa. The tissue …             An embryonic atrazine exposure results in reproductive dysfunction in adult zebrafish and morphological alterations in their offspring ▶     Sara E. Wirbisky, Gregory J. Weber, Maria S. Sepúlveda et al.     The herbicide atrazine, a suspected endocrine disrupting chemical (EDC), frequently contaminates potable water supplies. Studies suggest alterations in the neuroendocrine system …             Isolation and partial characterization of a highly divergent lineage of hantavirus from the European mole (Talpa europaea) ▶     Se Hun Gu, Mukesh Kumar, Beata Sikorska et al.     Genetically distinct hantaviruses have been identified in five species of fossorial moles (order Eulipotyphla, family Talpidae) from Eurasia and North America. Here, we report …             A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution ▶     Christoph Klenk, Janosch Ehrenmann, Marco Schütz et al.     Structural and biophysical studies as well as drug screening approaches on G protein-coupled receptors (GPCRs) have been largely hampered by the poor biophysical properties and …             Comparative genomics of mitochondria in chlorarachniophyte algae: endosymbiotic gene transfer and organellar genome dynamics ▶     Goro Tanifuji, John M. Archibald, Tetsuo Hashimoto     Chlorarachniophyte algae possess four DNA-containing compartments per cell, the nucleus, mitochondrion, plastid and nucleomorph, the latter being a relic nucleus derived from a …             Dnd knockout ablates germ cells and demonstrates germ cell independent sex differentiation in Atlantic salmon ▶     Anna Wargelius, Sven Leininger, Kai Ove Skaftnesmo et al.     Introgression of farmed salmon escapees into wild stocks is a major threat to the genetic integrity of wild populations. Using germ cell-free fish in aquaculture may mitigate …             Assessing Cell-to-Cell DNA Methylation Variability on Individual Long Reads ▶     Wei Qu, Tatsuya Tsukahara, Ryohei Nakamura et al.     Understanding cell-to-cell variability in cytosine methylation is essential for understanding cellular perturbation and its molecular machinery. However, conventional methylation …             Docking and molecular dynamics simulations of the ternary complex nisin2:lipid II ▶     Sam Mulholland, Eleanor R. Turpin, Boyan B. Bonev et al.     Lanthionine antibiotics are an important class of naturally-occurring antimicrobial peptides. The best-known, nisin, is a commercial food preservative. However, structural and …             Impacts of different climate change regimes and extreme climatic events on an alpine meadow community ▶     Juha M. Alatalo, Annika K. Jägerbrand, Ulf Molau     Climate variability is expected to increase in future but there exist very few experimental studies that apply different warming regimes on plant communities over several years. …             Autosomal recessive retinitis pigmentosa with homozygous rhodopsin mutation E150K and non-coding cis-regulatory variants in CRX-binding regions of SAMD7 ▶     Kristof Van Schil, Marcus Karlstetter, Alexander Aslanidis et al.     The aim of this study was to unravel the molecular pathogenesis of an unusual retinitis pigmentosa (RP) phenotype observed in a Turkish consanguineous family. Homozygosity …             Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases ▶     Francesca Marino, Aditya Mojumdar, Chiara Zucchelli et al.     The RecQ4 helicase belongs to the ubiquitous RecQ family but its exact role in the cell is not completely understood. In addition to the helicase domain, RecQ4 has a unique …             Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice ▶     Sota Kodama, Yasuhiro Nakano, Koji Hirata et al.     Endocrine and exocrine pancreas tissues are both derived from the posterior foregut endoderm, however, the interdependence of these two cell types during their formation is not …             Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease ▶     Leah C. Graham, Jeffrey M. Harder, Ileana Soto et al.     Studies have assessed individual components of a western diet, but no study has assessed the long-term, cumulative effects of a western diet on aging and Alzheimer’s disease …             Temporal dynamics of Puumala hantavirus infection in cyclic populations of bank voles ▶     Liina Voutilainen, Eva R. Kallio, Jukka Niemimaa et al.     Understanding the dynamics of zoonotic pathogens in their reservoir host populations is a prerequisite for predicting and preventing human disease epidemics. The human infection …             How to be a dioecious fig: Chemical mimicry between sexes matters only when both sexes flower synchronously ▶     M. Hossaert-McKey, M. Proffit, C. C. L. Soler et al.     In nursery pollination mutualisms, which are usually obligate interactions, olfactory attraction of pollinators by floral volatile organic compounds (VOCs) is the main step in …             miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart ▶     Na Li, Cheol Hwangbo, Irina M. Jaba et al.     Myocardial hypertrophy is an adaptive response to hemodynamic demands. Although angiogenesis is critical to support the increase in heart mass with matching blood supply, it may …             Liver X receptor α is essential for the capillarization of liver sinusoidal endothelial cells in liver injury ▶     Yan Xing, Tingting Zhao, Xiaoyan Gao et al.     Liver X receptors (LXRs) play essential roles in lipogenesis, anti-inflammatory action and hepatic stellate cells (HSCs) activation in the liver. However, the effects of LXRs on …             Corrigendum: Contractile dynamics change before morphological cues during fluorescence illumination ▶     S. G. Knoll, W. W. Ahmed, T. A. Saif                 GeneiASE: Detection of condition-dependent and static allele-specific expression from RNA-seq data without haplotype information ▶     Daniel Edsgärd, Maria Jesus Iglesias, Sarah-Jayne Reilly et al.     Allele-specific expression (ASE) is the imbalance in transcription between maternal and paternal alleles at a locus and can be probed in single individuals using massively …             Increased biomass productivity in green algae by tuning non-photochemical quenching ▶     Silvia Berteotti, Matteo Ballottari, Roberto Bassi     Photosynthetic microalgae have a high potential for the production of biofuels and highly valued metabolites. However, their current industrial exploitation is limited by a …             G6PDH activity highlights the operation of the cyclic electron flow around PSI in Physcomitrella patens during salt stress ▶     Shan Gao, Zhenbing Zheng, Li Huan et al.     Photosynthetic performances and glucose-6-phosphate dehydrogenase (G6PDH) activity in Physcomitrella patens changed greatly during salt stress and recovery. In P. patens, the …             The N-terminal sequence of the extrinsic PsbP protein modulates the redox potential of Cyt b559 in photosystem II ▶     Taishi Nishimura, Ryo Nagao, Takumi Noguchi et al.     The PsbP protein, an extrinsic subunit of photosystem II (PSII) in green plants, is known to induce a conformational change around the catalytic Mn4CaO5 cluster securing the …             Overstatement in happiness reporting with ordinal, bounded scale ▶     Saori C. Tanaka, Katsunori Yamada, Ryo Kitada et al.     There are various methods by which people can express subjective evaluations quantitatively. For example, happiness can be measured on a scale from 1 to 10, and has been …             Extremely Low Frequency Electromagnetic Fields Facilitate Vesicle Endocytosis by Increasing Presynaptic Calcium Channel Expression at a Central Synapse ▶     Zhi-cheng Sun, Jian-long Ge, Bin Guo et al.     Accumulating evidence suggests significant biological effects caused by extremely low frequency electromagnetic fields (ELF-EMF). Although exo-endocytosis plays crucial physical …             Recurrent Spiking Networks Solve Planning Tasks ▶     Elmar Rueckert, David Kappel, Daniel Tanneberg et al.     A recurrent spiking neural network is proposed that implements planning as probabilistic inference for finite and infinite horizon tasks. The architecture splits this problem …             Population structure and minimum core genome typing of Legionella pneumophila ▶     Tian Qin, Wen Zhang, Wenbin Liu et al.     Legionella pneumophila is an important human pathogen causing Legionnaires’ disease. In this study, whole genome sequencing (WGS) was used to study the characteristics and …             Mark4 promotes oxidative stress and inflammation via binding to PPARγ and activating NF-κB pathway in mice adipocytes ▶     Zhenjiang Liu, Lu Gan, Yizhe Chen et al.     MAP/Microtubule affinity-regulating kinase 4 (Mark4) plays an important role in the regulation of microtubule organization, adipogenesis and apoptosis. However, the role of Mark4 …             Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling ▶     Kohji Yamada, Yoichi Miyamoto, Akira Tsujii et al.     Importin α1 is involved in nuclear import as a receptor for proteins with a classical nuclear localization signal (cNLS). Here, we report that importin α1 is localized to the …             A novel transcription factor gene FHS1 is involved in the DNA damage response in Fusarium graminearum ▶     Hokyoung Son, Minmin Fu, Yoonji Lee et al.     Cell cycle regulation and the maintenance of genome integrity are crucial for the development and virulence of the pathogenic plant fungus Fusarium graminearum. To identify …             New England harbor seal H3N8 influenza virus retains avian-like receptor specificity ▶     Islam T. M. Hussein, Florian Krammer, Eric Ma et al.     An influenza H3N8 virus, carrying mammalian adaptation mutations, was isolated from New England harbor seals in 2011. We sought to assess the risk of its human transmissibility …             FLP-4 neuropeptide and its receptor in a neuronal circuit regulate preference choice through functions of ASH-2 trithorax complex in Caenorhabditis elegans ▶     Yonglin Yu, Lingtong Zhi, Xiangmin Guan et al.     Preference choice on food is an important response strategy for animals living in the environment. Using assay system of preference choice on bacterial foods, OP50 and PA14, we …             Pollinator-prey conflicts in carnivorous plants: When flower and trap properties mean life or death ▶     Ashraf M. El-Sayed, John A. Byers, David M. Suckling     Insect-pollinated carnivorous plants are expected to have higher fitness if they resolve pollinator-prey conflicts by sparing insects pollinating their flowers while trapping …             Building the Leviathan – Voluntary centralisation of punishment power sustains cooperation in humans ▶     Jörg Gross, Zsombor Z. Méder, Sanae Okamoto-Barth et al.     The prevalence of cooperation among humans is puzzling because cooperators can be exploited by free riders. Peer punishment has been suggested as a solution to this puzzle, but …             Digit-only sauropod pes trackways from China – evidence of swimming or a preservational phenomenon? ▶     Lida Xing, Daqing Li, Peter L. Falkingham et al.     For more than 70 years unusual sauropod trackways have played a pivotal role in debates about the swimming ability of sauropods. Most claims that sauropods could swim have been …             Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells ▶     Wei Lu, Shu Ya Huang, Le Su et al.     Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) are key regulators of multiple biological processes by altering gene expression at various levels. …             A Radio-genomics Approach for Identifying High Risk Estrogen Receptor-positive Breast Cancers on DCE-MRI: Preliminary Results in Predicting OncotypeDX Risk Scores ▶     Tao Wan, B. Nicolas Bloch, Donna Plecha et al.     To identify computer extracted imaging features for estrogen receptor (ER)-positive breast cancers on dynamic contrast en-hanced (DCE)-MRI that are correlated with the low and …             Dynamics and plasticity of the epithelial to mesenchymal transition induced by miR-200 family inhibition ▶     Takeshi Haraguchi, Masayuki Kondo, Ryo Uchikawa et al.     Whereas miR-200 family is known to be involved in the epithelial-to-mesenchymal transition (EMT), a crucial biological process observed in normal and pathological contexts, it …             Ancestry variation and footprints of natural selection along the genome in Latin American populations ▶     Lian Deng, Andrés Ruiz-Linares, Shuhua Xu et al.     Latin American populations stem from the admixture of Europeans, Africans and Native Americans, which started over 400 years ago and had lasted for several centuries. Extreme …             An approach to quantifying 3D responses of cells to extreme strain ▶     Yuhui Li, Guoyou Huang, Moxiao Li et al.     The tissues of hollow organs can routinely stretch up to 2.5 times their length. Although significant pathology can arise if relatively large stretches are sustained, the …             A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei ▶     Ian M. C. Fleming, Zdeněk Paris, Kirk W. Gaston et al.     Most eukaryotic ribosomes contain 26/28S, 5S, and 5.8S large subunit ribosomal RNAs (LS rRNAs) in addition to the 18S rRNA of the small subunit (SS rRNA). However, in …             Image processing methods to elucidate spatial characteristics of retinal microglia after optic nerve transection ▶     Yudong Zhang, Bo Peng, Shuihua Wang et al.     Microglia are the mononuclear phagocytes with various functions in the central nervous system, and the morphologies of microglia imply the different stages and functions. In …             A Modular Assembly Platform for Rapid Generation of DNA Constructs ▶     Elliot H. Akama-Garren, Nikhil S. Joshi, Tuomas Tammela et al.     Traditional cloning methods have limitations on the number of DNA fragments that can be simultaneously manipulated, which dramatically slows the pace of molecular assembly. Here …             Caveolae Restrict Tiger Frog Virus Release in HepG2 cells and Caveolae-Associated Proteins Incorporated into Virus Particles ▶     Jian He, Yi-Wen Zheng, Yi-Fan Lin et al.     Caveolae are flask-shaped invaginations of the plasma membrane. Caveolae play important roles in the process of viruses entry into host cells, but the roles of caveolae at the …             GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification ▶     Vin Yee Chung, Tuan Zea Tan, Ming Tan et al.     Epithelial-mesenchymal transition (EMT), a biological process by which polarized epithelial cells convert into a mesenchymal phenotype, has been implicated to contribute to the …             Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress ▶     Peng Zhang, Lujun Zhou, Chunli Pei et al.     Secreted Wnts play diverse roles in a non-cell-autonomous fashion. However, the cell-autonomous effect of unsecreted Wnts remains unknown. Endoplasmic reticulum (ER) stress is …             Improving seedless kelp (Saccharina japonica) during its domestication by hybridizing gametophytes and seedling-raising from sporophytes ▶     Xiaojie Li, Zhuangzhi Zhang, Shancun Qu et al.     Dongfang no.7 (Saccharina japonica) was bred and maintained by hybridizing gametophytes, self-crossing the best individuals, selecting the best self-crossing line and …             Facile fabrication of rice husk based silicon dioxide nanospheres loaded with silver nanoparticles as a rice antibacterial agent ▶     Jianghu Cui, You Liang, Desong Yang et al.     Bacterial leaf blight of rice caused by Xanthomonas oryzae pv. oryzae (Xoo) is a major disease of rice, leading to reduction in production by 10–50%. In order to control this …             Cryptococcus neoformans Intracellular Proliferation and Capsule Size Determines Early Macrophage Control of Infection ▶     Aleksandra Bojarczuk, Katie A. Miller, Richard Hotham et al.     Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients. Many questions remain regarding the function of macrophages in normal clearance of …             Inhibition of preS1-hepatocyte interaction by an array of recombinant human antibodies from naturally recovered individuals ▶     Anurag Sankhyan, Chandresh Sharma, Durgashree Dutta et al.     Neutralizing monoclonal antibodies are being found to be increasingly useful in viral infections. In hepatitis B infection, antibodies are proven to be useful for passive …             Effects of memory on the shapes of simple outbreak trees ▶     Giacomo Plazzotta, Christopher Kwan, Michael Boyd et al.     Genomic tools, including phylogenetic trees derived from sequence data, are increasingly used to understand outbreaks of infectious diseases. One challenge is to link …             Hedonic sensitivity to low-dose ketamine is modulated by gonadal hormones in a sex-dependent manner ▶     Samantha K. Saland, Kristin J. Schoepfer, Mohamed Kabbaj     We recently reported a greater sensitivity of female rats to rapid antidepressant-like effects of ketamine compared to male rats, and that ovarian-derived estradiol (E2) and …             Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release ▶     Johanna Snäll, Anna Linnér, Julia Uhlmann et al.     Neutrophils are critical for the control of bacterial infections, but they may also contribute to disease pathology. Here we explore neutrophil responses, in particular the …             Genome-wide transcriptional responses of Alteromonas naphthalenivorans SN2 to contaminated seawater and marine tidal flat sediment ▶     Hyun Mi Jin, Hye Im Jeong, Kyung Hyun Kim et al.     A genome-wide transcriptional analysis of Alteromonas naphthalenivorans SN2 was performed to investigate its ecophysiological behavior in contaminated tidal flats and seawater. …             TRPV-1-mediated elimination of residual iPS cells in bioengineered cardiac cell sheet tissues ▶     Katsuhisa Matsuura, Hiroyoshi Seta, Yuji Haraguchi et al.     The development of a suitable strategy for eliminating remaining undifferentiated cells is indispensable for the use of human-induced pluripotent stem (iPS) cell-derived cells in …             The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways ▶     Carmen del Río, Carmen Navarrete, Juan A. Collado et al.     Scleroderma is a group of rare diseases associated with early and transient inflammation and vascular injury, followed by fibrosis affecting the skin and multiple internal …             Emerging role of lipid droplets in Aedes aegypti immune response against bacteria and Dengue virus ▶     Ana Beatriz Ferreira Barletta, Liliane Rosa Alves, Maria Clara L. Nascimento Silva et al.     In mammals, lipid droplets (LDs) are ubiquitous organelles that modulate immune and inflammatory responses through the production of lipid mediators. In insects, it is unknown …             Human Vascular Microphysiological System for in vitro Drug Screening ▶     C. E. Fernandez, R. W. Yen, S. M. Perez et al.     In vitro human tissue engineered human blood vessels (TEBV) that exhibit vasoactivity can be used to test human toxicity of pharmaceutical drug candidates prior to pre-clinical …             Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase ▶     Junko Morita, Kuniyuki Kano, Kazuki Kato et al.     Choline is an essential nutrient for all living cells and is produced extracellularly by sequential degradation of phosphatidylcholine (PC). However, little is known about how …             Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways ▶     Hussain El Hasasna, Alaaeldin Saleh, Halima Al Samri et al.     Recently, we reported that Rhus coriaria exhibits anticancer activities by promoting cell cycle arrest and autophagic cell death of the metastatic triple negative MDA-MB-231 …             Amelioration of intracellular stress and reduction of neural tube defects in embryos of diabetic mice by phytochemical quercetin ▶     Lixue Cao, Chengyu Tan, Fantong Meng et al.     Diabetes mellitus in early pregnancy causes birth defects, including neural tube defects (NTDs). Hyperglycemia increases production of nitric oxide (NO) through NO synthase 2 …             How Tissue Mechanical Properties Affect Enteric Neural Crest Cell Migration ▶     N.R. Chevalier, E. Gazguez, L. Bidault et al.     Neural crest cells (NCCs) are a population of multipotent cells that migrate extensively during vertebrate development. Alterations to neural crest ontogenesis cause several …             Rapamycin attenuates acute lung injury induced by LPS through inhibition of Th17 cell proliferation in mice ▶     Zhao Yan, Zhang Xiaoyu, Song Zhixin et al.     Th17 cells have been confirmed to increase neutrophils through cytokine secretions. ALI/ARDS are characterized as neutrophil infiltration in inflammation cases; however, there is …             TNFα induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18–1/syntaxin1/SNAP-25 mediated fusion ▶     Jianghui Meng, Jiafu Wang, Martin Steinhoff et al.     Transient receptor potential (TRP) A1 and V1 channels relay sensory signals, yet little is known about their transport to the plasmalemma during inflammation. Herein, TRPA1 and …             Biodegradation of DDT by Stenotrophomonas sp. DDT-1: Characterization and genome functional analysis ▶     Xiong Pan, Dunli Lin, Yuan Zheng et al.     A novel bacterium capable of utilizing 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) as the sole carbon and energy source was isolated from a contaminated soil which was …             α-methylacyl-CoA racemase (AMACR) expression in chordomas differentiates them from chondrosarcomas ▶     Sarit Aviel-Ronen, Oranit Zadok, Aya Vituri et al.     Aims: Chordomas and chondrosarcomas are malignant mesenchymal tumours with overlapping morphological and immunohistochemical (IHC) characteristics. Our aim was to evaluate the …             Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production ▶     Matthijs P. Groeneveld, Gemma V. Brierley, Nuno M. Rocha et al.     Loss of function of the insulin receptor (INSR) in humans produces severe insulin resistance. Unlike “common” insulin resistance, this is associated with elevated plasma levels …             Enrichment of G2/M cell cycle phase in human pluripotent stem cells enhances HDR-mediated gene repair with customizable endonucleases ▶     Diane Yang, Marissa A Scavuzzo, Jolanta Chmielowiec et al.     Efficient gene editing is essential to fully utilize human pluripotent stem cells (hPSCs) in regenerative medicine. Custom endonuclease-based gene targeting involves two …             Musical Creativity “Revealed” in Brain Structure: Interplay between Motor, Default Mode, and Limbic Networks ▶     David M. Bashwiner, Christopher J. Wertz, Ranee A. Flores et al.     Creative behaviors are among the most complex that humans engage in, involving not only highly intricate, domain-specific knowledge and skill, but also domain-general processing …             Conserved miR-26b enhances ovarian granulosa cell apoptosis through HAS2-HA-CD44-Caspase-3 pathway by targeting HAS2 ▶     Jiying Liu, Fei Tu, Wang Yao et al.     The hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. HAS2 is a key enzyme required for HA …             SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation ▶     Masamichi Doiguchi, Takeya Nakagawa, Yuko Imamura et al.     Histone acetylation plays a pivotal role in transcriptional regulation, and ATP-dependent nucleosome remodeling activity is required for optimal transcription from chromatin. …             Investigation of allosteric modulation mechanism of metabotropic glutamate receptor 1 by molecular dynamics simulations, free energy and weak interaction analysis ▶     Qifeng Bai, Xiaojun Yao     Metabotropic glutamate receptor 1 (mGlu1), which belongs to class C G protein-coupled receptors (GPCRs), can be coupled with G protein to transfer extracellular signal by …             Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1α activation ▶     Aditya Ambade, Abhishek Satishchandran, Gyongyi Szabo     Alcohol-related hepatocellular carcinoma (HCC) develops with advanced alcoholic liver disease and liver fibrosis. Using adult mice, we evaluate the effect of alcoholic …             Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death ▶     Yuan Fang, Tu Su, Xiaorong Qiu et al.     It is known that oxidative stress plays a pivotal role in age-related macular degeneration (AMD) pathogenesis. Alpha-mangostin is the main xanthone purified from mangosteen known …             Collective chemotaxis and segregation of active bacterial colonies ▶     M. Ben Amar     Still recently, bacterial fluid suspensions have motivated a lot of works, both experimental and theoretical, with the objective to understand their collective dynamics from …             Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss ▶     J. Di, L. S. Cohen, C. P. Corbo et al.     The hyperphosphorylated microtubule-associated protein tau is present in several neurodegenerative diseases, although the causal relationship remains elusive. Few mouse models …             Determination of thiol metabolites in human urine by stable isotope labeling in combination with pseudo-targeted mass spectrometry analysis ▶     Ping Liu, Chu-Bo Qi, Quan-Fei Zhu et al.     Precursor ion scan and multiple reaction monitoring scan (MRM) are two typical scan modes in mass spectrometry analysis. Here, we developed a strategy by combining stable isotope …             Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways ▶     Yingli Yu, Guibo Sun, Yun Luo et al.     Background: Recent reports suggested the involvement of oxidative stress- and endoplasmic reticulum stress (ERS)-associated pathways in the progression of ischemia/reperfusion …             Persistent activation of microglia and NADPH drive hippocampal dysfunction in experimental multiple sclerosis ▶     Massimiliano Di Filippo, Antonio de Iure, Carmela Giampà et al.     Cognitive impairment is common in multiple sclerosis (MS). Unfortunately, the synaptic and molecular mechanisms underlying MS-associated cognitive dysfunction are largely …             BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis ▶     Sjoukje D. Kuipers, Andrea Trentani, Adrian Tiron et al.     Adult neurogenesis in the hippocampus is a remarkable phenomenon involved in various aspects of learning and memory as well as disease pathophysiology. Brain-derived neurotrophic …             Calstabin 2: An important regulator for learning and memory in mice ▶     Qi Yuan, Ke-Yu Deng, Le Sun et al.     Calstabin2, also named FK506 binding protein 12.6 (FKBP12.6), is a subunit of ryanodine receptor subtype 2 (RyR2) macromolecular complex, which is an intracellular calcium …             BIRC3 is a novel driver of therapeutic resistance in Glioblastoma ▶     Dapeng Wang, Anders Berglund, Rajappa S. Kenchappa et al.     Genome-wide analysis of glioblastoma (GBM) reveals pervasive aberrations in apoptotic signaling pathways that collectively contribute to therapeutic resistance. Inhibitors of …             Laser induced mortality of Anopheles stephensi mosquitoes ▶     Matthew D. Keller, David J. Leahy, Bryan J. Norton et al.     Small, flying insects continue to pose great risks to both human health and agricultural production throughout the world, so there remains a compelling need to develop new vector …             Neuroimaging evidence of deficient axon myelination in Wolfram syndrome ▶     Heather M. Lugar, Jonathan M. Koller, Jerrel Rutlin et al.     Wolfram syndrome is a rare autosomal recessive genetic disease characterized by insulin dependent diabetes and vision, hearing and brain abnormalities which generally emerge in …             Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development ▶     Eri O. Maruyama, Heng Lin, Shang-Yi Chiu et al.     SUMO-specific protease 2 (SENP2) activities to remove SUMO from its substrates is essential for development of trophoblast stem cells, niches and lineages. Global deletion of …             Cryptococcus neoformans Thermotolerance to Avian Body Temperature Is Sufficient For Extracellular Growth But Not Intracellular Survival In Macrophages ▶     Simon A. Johnston, Kerstin Voelz, Robin C. May     Cryptococcus neoformans is a fatal fungal pathogen of humans that efficiently parasitises macrophages. Birds can be colonised by cryptococci and can transmit cryptococcosis to …             Peptide Reactivity of Isothiocyanates – Implications for Skin Allergy ▶     Isabella Karlsson, Kristin Samuelsson, David J. Ponting et al.     Skin allergy is a chronic condition that affects about 20% of the population of the western world. This disease is caused by small reactive compounds, haptens, able to penetrate …             The coevolution of overconfidence and bluffing in the resource competition game ▶     Kun Li, Attila Szolnoki, Rui Cong et al.     Resources are often limited, therefore it is essential how convincingly competitors present their claims for them. Beside a player’s natural capacity, here overconfidence and …             Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich’s ataxia ▶     Joseph F. Nabhan, Kristy M. Wood, Varada P. Rao et al.     In Friedreich’s ataxia (FRDA) patients, diminished frataxin (FXN) in sensory neurons is thought to yield the predominant pathology associated with disease. In this study, we …             PNA lectin for purifying mouse acinar cells from the inflamed pancreas ▶     Xiangwei Xiao, Shane Fischbach, Joseph Fusco et al.     Better methods for purifying human or mouse acinar cells without the need for genetic modification are needed. Such techniques would be advantageous for the specific study of …             Accurate and molecular-size-tolerant NMR quantitation of diverse components in solution ▶     Hideyasu Okamura, Hiroshi Nishimura, Takashi Nagata et al.     Determining the amount of each component of interest in a mixture is a fundamental first step in characterizing the nature of the solution and to develop possible means of …             Erratum: Cross-modal and modality-specific expectancy effects between pain and disgust ▶     Gil Sharvit, Patrik Vuilleumier, Sylvain Delplanque et al.                 Three-dimensional spherical spatial boundary conditions differentially regulate osteogenic differentiation of mesenchymal stromal cells ▶     Yin-Ping Lo, Yi-Shiuan Liu, Marilyn G. Rimando et al.     The spatial boundary condition (SBC) arising from the surrounding microenvironment imposes specific geometry and spatial constraints that affect organogenesis and tissue …             Rapid multiplex detection of 10 foodborne pathogens with an up-converting phosphor technology-based 10-channel lateral flow assay ▶     Yong Zhao, Haoran Wang, Pingping Zhang et al.     The rapid high-throughput detection of foodborne pathogens is essential in controlling food safety. In this study, a 10-channel up-converting phosphor technology-based lateral …             A human β-III-spectrin spinocerebellar ataxia type 5 mutation causes high-affinity F-actin binding ▶     Adam W. Avery, Jonathan Crain, David D. Thomas et al.     Spinocerebellar ataxia type 5 (SCA5) is a human neurodegenerative disease that stems from mutations in the SPTBN2 gene encoding the protein β-III-spectrin. Here we investigated …             Enrichment and isolation of Flavobacterium strains with tolerance to high concentrations of cesium ion ▶     Souichiro Kato, Eri Goya, Michiko Tanaka et al.     Interest in the interaction of microorganisms with cesium ions (Cs+) has arisen, especially in terms of their potent ability for radiocesium bioaccumulation and their important …             A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries) ▶     Xue Ren, Guang-Li Yang, Wei-Feng Peng et al.     Horns are a cranial appendage found exclusively in Bovidae, and play important roles in accessing resources and mates. In sheep (Ovies aries), horns vary from polled to …             Identification of Mouse Mesenteric and Subcutaneous in vitro Adipogenic Cells ▶     Yugo Miyata, Michio Otsuki, Shunbun Kita et al.     Fat accumulation and the dysfunction of visceral white adipose tissue (WAT), but not subcutaneous WAT, cause abnormalities in whole body metabolic homeostasis. However, no …             Pitfalls of haplotype phasing from amplicon-based long-read sequencing ▶     Thomas W. Laver, Richard C. Caswell, Karen A. Moore et al.     The long-read sequencers from Pacific Bioscience (PacBio) and Oxford Nanopore Technologies (ONT) offer the opportunity to phase mutations multiple kilobases apart directly from …             Mind-Wandering Tends to Occur under Low Perceptual Demands during Driving ▶     Chin-Teng Lin, Chun-Hsiang Chuang, Scott Kerick et al.     Fluctuations in attention behind the wheel poses a significant risk for driver safety. During transient periods of inattention, drivers may shift their attention towards …             Endogenous hydrogen peroxide increases biofilm formation by inducing exopolysaccharide production in Acinetobacter oleivorans DR1 ▶     In-Ae Jang, Jisun Kim, Woojun Park     In this study, we investigated differentially expressed proteins in Acinetobacter oleivorans cells during planktonic and biofilm growth by using 2-dimensional gel electrophoresis …             Hyporesponsiveness to the anti-inflammatory action of interleukin-10 in type 2 diabetes ▶     Julianne C. Barry, Soroush Shakibakho, Cody Durrer et al.     Chronic low-grade inflammation contributes to the pathology and complications of type 2 diabetes (T2D). Interleukin-10 (IL10), an anti-inflammatory cytokine, is suggested to play …             Ubiquitin-specific protease 4 controls metastatic potential through β-catenin stabilization in brain metastatic lung adenocarcinoma ▶     Su Jin Hwang, Hye Won Lee, Hye Ree Kim et al.     Brain metastasis is the most common type of intracranial cancer and is the main cause of cancer-associated mortality. Brain metastasis mainly originates from lung cancer. Using a …             A novel gene delivery composite system based on biodegradable folate-poly (ester amine) polymer and thermosensitive hydrogel for sustained gene release ▶     Yi Yang, Hang Zhao, YanPeng Jia et al.     Local anti-oncogene delivery providing high local concentration of gene, increasing antitumor effect and decreasing systemic side effects is currently attracting interest in …             Astrocyte-derived phosphatidic acid promotes dendritic branching ▶     Yan-Bing Zhu, Weizhen Gao, Yongbo Zhang et al.     Astrocytes play critical roles in neural circuit formation and function. Recent studies have revealed several secreted and contact-mediated signals from astrocytes which are …             Effects of High Hydrostatic Pressure on Expression Profiles of In Vitro Produced Vitrified Bovine Blastocysts ▶     Zongliang Jiang, Patrick Harrington, Ming Zhang et al.     High hydrostatic pressure (HHP) has been used to pre-condition embryos before essential, yet potentially detrimental procedures such as cryopreservation. However, the mechanisms …             Laser capture microdissection of intestinal tissue from sea bass larvae using an optimized RNA integrity assay and validated reference genes ▶     M. Schaeck, W. De Spiegelaere, J. De Craene et al.     The increasing demand for a sustainable larviculture has promoted research regarding environmental parameters, diseases and nutrition, intersecting at the mucosal surface of the …             Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-β signaling pathway ▶     Dan Li, Caoqi Lei, Zhisheng Xu et al.     Foot-and-mouth disease virus (FMDV) is the etiological agent of FMD, which affects cloven-hoofed animals. The pathophysiology of FMDV has not been fully understood and the …             Molecular phylogeny, pathogenicity and toxigenicity of Fusarium oxysporum f. sp. lycopersici ▶     D. Nirmaladevi, M. Venkataramana, Rakesh K. Srivastava et al.     The present study aimed at the molecular characterization of pathogenic and non pathogenic F. oxysporum f. sp. lycopersici strains isolated from tomato. The causal agent isolated …             Interaction of EGFR to δ-catenin leads to δ-catenin phosphorylation and enhances EGFR signaling ▶     Yongfeng He, Taeyong Ryu, Nensi Shrestha et al.     Expression of δ-catenin reportedly increases during late stage prostate cancer. Furthermore, it has been demonstrated that expression of EGFR is enhanced in hormone refractory …             A collagen-binding EGFR antibody fragment targeting tumors with a collagen-rich extracellular matrix ▶     Hui Liang, Xiaoran Li, Bin Wang et al.     Many tumors over-express collagen, which constitutes the physical scaffold of tumor microenvironment. Collagen has been considered to be a target for cancer therapy. The …             Blue Light Modulates Murine Microglial Gene Expression in the Absence of Optogenetic Protein Expression ▶     Kevin P. Cheng, Elizabeth A. Kiernan, Kevin W. Eliceiri et al.     Neural optogenetic applications over the past decade have steadily increased; however the effects of commonly used blue light paradigms on surrounding, non-optogenetic …             Fluorescence microscopy image noise reduction using a stochastically-connected random field model ▶     S. A. Haider, A. Cameron, P. Siva et al.     Fluorescence microscopy is an essential part of a biologist’s toolkit, allowing assaying of many parameters like subcellular localization of proteins, changes in cytoskeletal …             Tracking the immunopathological response to Pseudomonas aeruginosa during respiratory infections ▶     Cristina Cigana, Nicola Ivan Lorè, Camilla Riva et al.     Repeated cycles of infections, caused mainly by Pseudomonas aeruginosa, combined with a robust host immune response and tissue injury, determine the course and outcome of cystic …             Exposure to salient, dynamic sensory stimuli during development increases distractibility in adulthood ▶     Itay Hadas, Ram Gal, Lihi Bokovza et al.     It has been suggested that excessive exposure of children to the dynamic and highly salient audio-visual stimuli conveyed by electronic media may induce attention-related …             Synergistic interactions of blood-borne immune cells, fibroblasts and extracellular matrix drive repair in an in vitro peri-implant wound healing model ▶     Melanie A Burkhardt, Jasmin Waser, Vincent Milleret et al.     Low correlations of cell culture data with clinical outcomes pose major medical challenges with costly consequences. While the majority of biomaterials are tested using in vitro …             ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β ▶     Agnieszka Robaszkiewicz, Chao Qu, Ewelina Wisnik et al.     While ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1, formerly PARP1) and its enzymatic activity have been shown to be important for reprogramming and differentiation of …             Early Failures Benefit Subsequent Task Performance ▶     Hideyoshi Igata, Takuya Sasaki, Yuji Ikegaya     Animals navigate using cognitive maps. However, how they adaptively exploit these maps in changing environments is not fully understood. In this study, we investigated the …             The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go ▶     Ying Xu, Cesare Orlandi, Yan Cao et al.     Transmission from photoreceptors to ON bipolar cells in mammalian retina is mediated by a sign-inverting cascade. Upon binding glutamate, the metabotropic glutamate receptor …             Fire blight disease reactome: RNA-seq transcriptional profile of apple host plant defense responses to Erwinia amylovora pathogen infection ▶     Tim Kamber, Jan P. Buchmann, Joël F. Pothier et al.     The molecular basis of resistance and susceptibility of host plants to fire blight, a major disease threat to pome fruit production globally, is largely unknown. RNA-sequencing …             ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs ▶     Michelle H. Lee, Anna G. Goralczyk, Rókus Kriszt et al.     Key to realizing the diagnostic and therapeutic potential of human brown/brite adipocytes is the identification of a renewable, easily accessible and safe tissue source of …             Integrated GlycoProteome Analyzer (I-GPA) for Automated Identification and Quantitation of Site-Specific N-Glycosylation ▶     Gun Wook Park, Jin Young Kim, Heeyoun Hwang et al.     Human glycoproteins exhibit enormous heterogeneity at each N-glycosite, but few studies have attempted to globally characterize the site-specific structural features. We have …             Reconstructing the plinian and co-ignimbrite sources of large volcanic eruptions: A novel approach for the Campanian Ignimbrite ▶     Alejandro Marti, Arnau Folch, Antonio Costa et al.     The 39 ka Campanian Ignimbrite (CI) super-eruption was the largest volcanic eruption of the past 200 ka in Europe. Tephra deposits indicate two distinct plume forming phases, …             Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development ▶     Sohinee Bhattacharyya, Mark A Rainey, Priyanka Arya et al.     Members of the four-member C-terminal EPS15-Homology Domain-containing (EHD) protein family play crucial roles in endocytic recycling of cell surface receptors from endosomes to …             The CodY regulator is essential for virulence in Streptococcus suis serotype 2 ▶     Liping Feng, Jiawen Zhu, Haitao Chang et al.     The main role of CodY, a global regulatory protein in most low G + C gram-positive bacteria, is in transcriptional repression. To study the functions of CodY in Streptococcus suis…             Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation ▶     Chien-Hao Chiang, Cédric Grauffel, Lien-Szu Wu et al.     The RNA-binding protein TDP-43 forms intracellular inclusions in amyotrophic lateral sclerosis (ALS). While TDP-43 mutations have been identified in ALS patients, how these …             The physico-chemical properties and structural characteristics of artificial soil for cut slope restoration in Southwestern China ▶     Shunan Chen, Xiaoyan Ai, Tengyun Dong et al.     Cut slopes are frequently generated by construction work in hilly areas, and artificial soil is often sprayed onto them to promote ecological rehabilitation. The artificial soil …             Systematic microRNAome profiling reveals the roles of microRNAs in milk protein metabolism and quality: insights on low-quality forage utilization ▶     Diming Wang, Guanxiang Liang, Bing Wang et al.     In this study, we investigated the molecular regulatory mechanisms of milk protein production in dairy cows by studying the miRNAomes of five key metabolic tissues involved in …             The roles and impacts of human hunter-gatherers in North Pacific marine food webs ▶     Jennifer A. Dunne, Herbert Maschner, Matthew W. Betts et al.     There is a nearly 10,000-year history of human presence in the western Gulf of Alaska, but little understanding of how human foragers integrated into and impacted ecosystems …             A minimal conformational switching-dependent model for amyloid self-assembly ▶     Srivastav Ranganathan, Dhiman Ghosh, Samir K Maji et al.     Amyloid formation is associated with various pathophysiological conditions like Alzheimer’s and Parkinson’s diseases as well as many useful functions. The hallmark of amyloid …             Imbalance of Th17/Tregs in rats with smoke inhalation-induced acute lung injury ▶     Fan Zhang, Mian-yang Li, Ya-ting Lan et al.     T helper (Th) 17 cells and CD4+ CD25+ regulatory T (Treg) cells are supposed to be critically involved in regulating autoimmune and inflammatory diseases. The aim of this study …             External characteristic determination of eggs and cracked eggs identification using spectral signature ▶     Chuanqi Xie, Yong He     This study was carried out to use hyperspectral imaging technique for determining color (L*, a* and b*) and eggshell strength and identifying cracked chicken eggs. Partial least …             Controlled Immobilization Strategies to Probe Short Hyaluronan-Protein Interactions ▶     Burcu Baykal Minsky, Christiane H. Antoni, Heike Boehm     Well-controlled grafting of small hyaluronan oligosaccharides (sHA) enables novel approaches to investigate biological processes such as angiogenesis, immune reactions and cancer …             The c-Jun N-terminal kinase (JNK) pathway is activated in human interstitial cystitis (IC) and rat protamine sulfate induced cystitis ▶     Jiang Zhao, Liang Wang, Xingyou Dong et al.     The pathogenesis of bladder pain syndrome/interstitial cystitis (BPS/IC) is currently unclear. However, inflammation has been suggested to play an important role in BPS/IC. JNK …             Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance ▶     Raie T. Bekele, Ganesh Venkatraman, Rong-Zong Liu et al.     Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or …             Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects ▶     Stéphanie Michlig, Jenny Meylan Merlini, Maurice Beaumont et al.     Various lines of published evidence have already demonstrated the impact of TRPV1 agonists on energetic metabolism through the stimulation of the sympathetic nervous system …             Dose- and time-dependent effects of actomyosin inhibition on live mouse outflow resistance and aqueous drainage tissues ▶     MinHee K. Ko, Eun Kyoung Kim, Jose M. Gonzalez Jr et al.     Actomyosin contractility modulates outflow resistance of the aqueous drainage tissues and intraocular pressure, a key pathogenic factor of glaucoma. We established methodology to …             Serum Metabolic Profiling Reveals Altered Metabolic Pathways in Patients with Post-traumatic Cognitive Impairments ▶     Lunzhao Yi, Shuting Shi, Yang Wang et al.     Cognitive impairment, the leading cause of traumatic brain injury (TBI)-related disability, adversely affects the quality of life of TBI patients, and exacts a personal and …             Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1 ▶     Vehary Sakanyan, Philippe Hulin, Rodolphe Alves de Sousa et al.     Activation of cell signaling by reactive chemicals and pollutants is an important issue for human health. It has been shown that lipophilic nitro-benzoxadiazole (NBD) compounds …             A shape-anisotropic reflective polarizer in a stomatopod crustacean ▶     Thomas M. Jordan, David Wilby, Tsyr-Huei Chiou et al.     Many biophotonic structures have their spectral properties of reflection ‘tuned’ using the (zeroth-order) Bragg criteria for phase constructive interference. This is associated …             Inefficient DMN Suppression in Schizophrenia Patients with Impaired Cognitive Function but not Patients with Preserved Cognitive Function ▶     Li Zhou, Weidan Pu, Jingjuan Wang et al.     Previous studies have observed reduced suppression of the default mode network (DMN) during cognitive tasks in schizophrenia, suggesting inefficient DMN suppression is critical …             Light intensity affects the uptake and metabolism of glycine by pakchoi (Brassica chinensis L.) ▶     Qingxu Ma, Xiaochuang Cao, Lianghuan Wu et al.     The uptake of glycine by pakchoi (Brassica chinensis L.), when supplied as single N-source or in a mixture of glycine and inorganic N, was studied at different light intensities …             Raman spectroscopy identifies radiation response in human non-small cell lung cancer xenografts ▶     Samantha J. Harder, Martin Isabelle, Lindsay DeVorkin et al.     External beam radiation therapy is a standard form of treatment for numerous cancers. Despite this, there are no approved methods to account for patient specific radiation …             Ecological-network models link diversity, structure and function in the plankton food-web ▶     Domenico D’Alelio, Simone Libralato, Timothy Wyatt et al.     A planktonic food-web model including sixty-three functional nodes (representing auto- mixo- and heterotrophs) was developed to integrate most trophic diversity present in the …             Early malnutrition results in long-lasting impairments in pattern-separation for overlapping novel object and novel location memories and reduced hippocampal neurogenesis ▶     Georgina Pérez-García, Omar Guzmán-Quevedo, Raquel Da Silva Aragão et al.     Numerous epidemiological studies indicate that malnutrition during in utero development and/or childhood induces long-lasting learning disabilities and enhanced susceptibility to …             Tissue-based multiphoton analysis of actomyosin and structural responses in human trabecular meshwork ▶     Jose M. Gonzalez, Minhee K. Ko, Andrew Pouw et al.     The contractile trabecular meshwork (TM) modulates aqueous humor outflow resistance and intraocular pressure. The primary goal was to visualize and quantify human TM contractile …             Wnt11 Gene Therapy with Adeno-associated Virus 9 Improves Recovery from Myocardial Infarction by Modulating the Inflammatory Response ▶     Yoshihiro Morishita, Koichi Kobayashi, Ekaterina Klyachko et al.     Acute myocardial infarction induces activation of the acute phase response and infiltration of leukocytes to the infarcted area. Moreover, myocardium that is remote from ischemic …             Long-term safety and stability of angiogenesis induced by balanced single-vector co-expression of PDGF-BB and VEGF164 in skeletal muscle ▶     Roberto Gianni-Barrera, Maximilian Burger, Thomas Wolff et al.     Therapeutic angiogenesis by growth factor delivery is an attractive treatment strategy for ischemic diseases, yet clinical efficacy has been elusive. The angiogenic master …             A single residue substitution accounts for the significant difference in thermostability between two isoforms of human cytosolic creatine kinase ▶     Huihui Liu, Yan-Song Gao, Xiang-Jun Chen et al.     Creatine kinase (CK) helps maintain homeostasis of intracellular ATP level by catalyzing the reversible phosphotransfer between ATP and phosphocreatine. In humans, there are two …             Chemical control of xylem differentiation by thermospermine, xylemin, and auxin ▶     Kaori Yoshimoto, Hiroyoshi Takamura, Isao Kadota et al.     The xylem conducts water and minerals from the root to the shoot and provides mechanical strength to the plant body. The vascular precursor cells of the procambium differentiate …             LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development ▶     Morgane Boillot, Chun-Yao Lee, Camille Allene et al.     The secreted leucine-rich glioma inactivated 1 (LGI1) protein is an important actor for human seizures of both genetic and autoimmune etiology: mutations in LGI1 cause inherited …             An integrative approach to phylogeny reveals patterns of environmental distribution and novel evolutionary relationships in a major group of ciliates ▶     Ping Sun, John Clamp, Dapeng Xu et al.     Peritrichs are a major group of ciliates with worldwide distribution. Yet, its internal phylogeny remains unresolved owing to limited sampling. Additionally, ecological …             Cell contractility arising from topography and shear flow determines human mesenchymal stem cell fate ▶     Surabhi Sonam, Sharvari R. Sathe, Evelyn K.F. Yim et al.     Extracellular matrix (ECM) of the human Mesenchymal Stem Cells (MSCs) influences intracellular tension and is known to regulate stem cell fate. However, little is known about the …             BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine ▶     Zhongyang Liu, Feifei Guo, Yong Wang et al.     Traditional Chinese Medicine (TCM), with a history of thousands of years of clinical practice, is gaining more and more attention and application worldwide. And TCM-based new …             Conformational Flexibility of a Short Loop near the Active Site of the SARS-3CLpro is Essential to Maintain Catalytic Activity ▶     Chunmei Li, Xin Teng, Yifei Qi et al.     The SARS 3C-like proteinase (SARS-3CLpro), which is the main proteinase of the SARS coronavirus, is essential to the virus life cycle. This enzyme has been shown to be active as …             Lazy workers are necessary for long-term sustainability in insect societies ▶     Eisuke Hasegawa, Yasunori Ishii, Koichiro Tada et al.     Optimality theory predicts the maximization of productivity in social insect colonies, but many inactive workers are found in ant colonies. Indeed, the low short-term …             WBSMDA: Within and Between Score for MiRNA-Disease Association prediction ▶     Xing Chen, Chenggang Clarence Yan, Xu Zhang et al.     Increasing evidences have indicated that microRNAs (miRNAs) are functionally associated with the development and progression of various complex human diseases. However, the roles …             An ERp57-mediated disulphide exchange promotes the interaction between Burkholderia cenocepacia and epithelial respiratory cells ▶     Francesca Pacello, Melania D’Orazio, Andrea Battistoni     Previous studies have demonstrated that extracellular glutathione reduces the ability of the Cystic Fibrosis pathogen Burkholderia cenocepacia to infect primary or immortalized …             Non-canonical features of the Golgi apparatus in bipolar epithelial neural stem cells ▶     Elena Taverna, Felipe Mora-Bermúdez, Paulina J. Strzyz et al.     Apical radial glia (aRG), the stem cells in developing neocortex, are unique bipolar epithelial cells, extending an apical process to the ventricle and a basal process to the …             Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals ▶     Alexandra Montagner, Agata Korecka, Arnaud Polizzi et al.     The liver is a key organ of metabolic homeostasis with functions that oscillate in response to food intake. Although liver and gut microbiome crosstalk has been reported, …             Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection ▶     Thomas Crellen, Fiona Allan, Sophia David et al.     Schistosoma mansoni is a parasitic fluke that infects millions of people in the developing world. This study presents the first application of population genomics to S. mansoni …             Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model ▶     Nicanor Obaldía III, Geoffrey S. Dow, Lucia Gerena et al.     Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies. …             Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues ▶     Tânia Lourenço, Joana Paes de Faria, Christian A. Bippes et al.     Extracellular matrix (ECM) proteins play a key role during oligodendrogenesis. While fibronectin (FN) is involved in the maintenance and proliferation of oligodendrocyte …             Late Arc/Arg3.1 expression in the basolateral amygdala is essential for persistence of newly-acquired and reactivated contextual fear memories ▶     Daisuke Nakayama, Yoshiko Hashikawa-Yamasaki, Yuji Ikegaya et al.     A feature of fear memory is its persistence, which could be a factor for affective disorders. Memory retrieval destabilizes consolidated memories, and then rapid molecular …             Iron mitigates DMT1-mediated manganese cytotoxicity via the ASK1-JNK signaling axis: Implications of iron supplementation for manganese toxicity ▶     Yee Kit Tai, Katherine C. M. Chew, Bryce W. Q. Tan et al.     Manganese (Mn2+) neurotoxicity from occupational exposure is well documented to result in a Parkinson-like syndrome. Although the understanding of Mn2+ cytotoxicity is still …             Niclosamide inhibits leaf blight caused by Xanthomonas oryzae in rice ▶     Sung-Il Kim, Jong Tae Song, Jin-Yong Jeong et al.     Rice leaf blight, which is caused by the bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo), results in huge losses in grain yield. Here, we show that Xoo-induced rice leaf …             Imperfection works: Survival, transmission and persistence in the system of Heliothis virescens ascovirus 3h (HvAV-3h), Microplitis similis and Spodoptera exigua ▶     Shun-Ji Li, Richard J. Hopkins, Yi-Pei Zhao et al.     Ascoviruses are insect-specific large DNA viruses that mainly infect noctuid larvae, and are transmitted by parasitoids in the fields. Heliothis virescens ascovirus 3h (HvAV-3h) …             Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel ▶     Takahiro Shibata, Katsuhiro Takahashi, Yui Matsubara et al.     Mast cells play important roles in allergic inflammation by secreting various mediators. In the present study, based on the finding that the medium conditioned by activated …             Appearance of β-lactam Resistance Genes in Agricultural Soils and Clinical Isolates over the 20th Century ▶     David W. Graham, Charles W. Knapp, Bent T. Christensen et al.     Debate exists about whether agricultural versus medical antibiotic use drives increasing antibiotic resistance (AR) across nature. Both sectors have been inconsistent at …             Differential regulation of taurine biosynthesis in rainbow trout and Japanese flounder ▶     Xuan Wang, Gen He, Kangsen Mai et al.     Animals have varied taurine biosynthesis capability, which was determined by activities of key enzymes including cysteine dioxygenase (CDO) and cysteine sulfinate decarboxylase …             Production, Characterization, and Epitope Mapping of Monoclonal Antibodies Against Different Subtypes of Rabbit Hemorrhagic Disease Virus (RHDV) ▶     Desheng Kong, Jiasen Liu, Qian Jiang et al.     In 2010, a new rabbit hemorrhagic disease virus (RHDV) variant, designated RHDV2, was identified for the first time in Italy. Studies have shown that RHDV2 differs from RHDV1 …             Phantom limb perception interferes with motor imagery after unilateral upper-limb amputation ▶     Yuanyuan Lyu, Xiaoli Guo, Robin Bekrater-Bodmann et al.     A potential contributor to impaired motor imagery in amputees is an alteration of the body schema as a result of the presence of a phantom limb. However, the nature of the …             A novel role for Crp in controlling magnetosome biosynthesis in Magnetospirillum gryphiswaldense MSR-1 ▶     Tong Wen, Fangfang Guo, Yunpeng Zhang et al.     Magnetotactic bacteria (MTB) are specialized microorganisms that synthesize intracellular magnetite particles called magnetosomes. Although many studies have focused on the …             Involvement of hormones in olfactory imprinting and homing in chum salmon ▶     Hiroshi Ueda, Shingo Nakamura, Taro Nakamura et al.     The olfactory hypothesis for salmon imprinting and homing to their natal stream is well known, but the endocrine hormonal control mechanisms of olfactory memory formation in …             The optimal sex pheromone release rate for trapping the codling moth Cydia pomonella (Lepidoptera: Tortricidae) in the field ▶     Wei Liu, Jing Xu, Runzhi Zhang     For successful pest management, codlemone (E, E-8,10-dodecadien-1-ol) is widely used to monitor codling moth. The pheromone release rate is essential for the lure’s …             Application of a novel phosphinothricin N-acetyltransferase (RePAT) gene in developing glufosinate-resistant rice ▶     Ying Cui, Ziduo Liu, Yue Li et al.     Currently, only few glufosinate-resistant genes are available for commercial application. Thus, developing novel glufosinate-resistant genes with commercial feasibility is …             The establishment of species-specific primers for the molecular identification of ten stored-product psocids based on ITS2 rDNA ▶     Zi-Hua Zhao, Bing-Yi Cui, Zhi-Hong Li et al.     Psocids are important stored product pests found worldwide that can be spread through grain trade. Most stored-product psocids, including eggs, nymphs, and adults, are very small …             The impact of orientation filtering on face-selective neurons in monkey inferior temporal cortex ▶     Jessica Taubert, Valerie Goffaux, Goedele Van Belle et al.     Faces convey complex social signals to primates. These signals are tolerant of some image transformations (e.g. changes in size) but not others (e.g. picture-plane rotation). By …             Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma ▶     Atsushi Takai, Valerie Fako, Hien Dang et al.     Three-dimensional cell culture methods are viable in vitro approaches that facilitate the examination of biological features cancer cells present in vivo. In this study, we …             Detecting signatures of positive selection associated with musical aptitude in the human genome ▶     Xuanyao Liu, Chakravarthi Kanduri, Jaana Oikkonen et al.     Abilities related to musical aptitude appear to have a long history in human evolution. To elucidate the molecular and evolutionary background of musical aptitude, we compared …             Comparative and phylogenetic analysis of the mitochondrial genomes in basal hymenopterans ▶     Sheng-Nan Song, Pu Tang, Shu-Jun Wei et al.     The Symphyta is traditionally accepted as a paraphyletic group located in a basal position of the order Hymenoptera. Herein, we conducted a comparative analysis of the …             Quantitative molecular phenotyping with topically applied SERS nanoparticles for intraoperative guidance of breast cancer lumpectomy ▶     Yu Wang, Soyoung Kang, Altaz Khan et al.     There is a need to image excised tissues during tumor-resection procedures in order to identify residual tumors at the margins and to guide their complete removal. The imaging of …             Nocturnally migrating songbirds drift when they can and compensate when they must ▶     Kyle G. Horton, Benjamin M. Van Doren, Phillip M. Stepanian et al.     The shortest possible migratory route for birds is not always the best route to travel. Substantial research effort has established that birds in captivity are capable of …             Deciphering the biological effects of acupuncture treatment modulating multiple metabolism pathways ▶     Aihua Zhang, Guangli Yan, Hui Sun et al.     Acupuncture is an alternative therapy that is widely used to treat various diseases. However, detailed biological interpretation of the acupuncture stimulations is limited. We …             Copying hierarchical leaders’ voices? Acoustic plasticity in female Japanese macaques ▶     Alban Lemasson, Ronan Jubin, Nobuo Masataka et al.     It has been historically claimed that call production in nonhuman primates has been shaped by genetic factors, although, recently socially-guided plasticity and cortical control …             Genetic analysis of arsenic accumulation in maize using QTL mapping ▶     Zhongjun Fu, Weihua Li, Xiaolong Xing et al.     Arsenic (As) is a toxic heavy metal that can accumulate in crops and poses a threat to human health. The genetic mechanism of As accumulation is unclear. Herein, we used …             Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel ▶     Ren-Gong Zhuo, Peng Peng, Xiao-Yan Liu et al.     TREK-2, a member of two-pore-domain potassium channel family, regulates cellular excitability in response to diverse stimuli. However, how such stimuli control channel function …             IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity ▶     Yuval Avnir, Corey T. Watson, Jacob Glanville et al.     IGHV polymorphism provides a rich source of humoral immune system diversity. One important example is the IGHV1-69 germline gene where the biased use of alleles that encode the …             Identification of different mechanisms leading to PAX6 down-regulation as potential events contributing to the onset of Hirschsprung disease ▶     María Valle Enguix-Riego, Ana Torroglosa, Raquel María Fernández et al.     Hirschsprung disease (HSCR) is attributed to a failure of neural crest derived cells to migrate, proliferate, differentiate or survive in the bowel wall during embryonic Enteric …             Transcriptional activation of follistatin by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress ▶     Chen Lin, Xinyuan Zhao, Desen Sun et al.     Silica nanoparticles (SiO2 NPs) cause oxidative stress in respiratory system. Meanwhile, human cells launch adaptive responses to overcome SiO2 NP toxicity. However, besides a …             Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages ▶     Lei Shi, Zhe Zhang, Bing Su     There are many differences in brain structure and function between males and females. However, how these differences were manifested during development and maintained through …             Identification of a Vibrio cholerae chemoreceptor that senses taurine and amino acids as attractants ▶     So-ichiro Nishiyama, Yohei Takahashi, Kentaro Yamamoto et al.     Vibrio cholerae, the etiological agent of cholera, was found to be attracted by taurine (2-aminoethanesulfonic acid), a major constituent of human bile. Mlp37, the closest …             Treatment of beta amyloid 1–42 (Aβ1–42)-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo ▶     Andrea Kwakowsky, Kyoko Potapov, SooHyun Kim et al.     In Alzheimer’s disease (AD), there is a loss in cholinergic innervation targets of basal forebrain which has been implicated in substantial cognitive decline. Amyloid beta …             (−)-Epigallocatechin-3-Gallate Enhances Hepatitis C Virus Double-Stranded RNA Intermediates-Triggered Innate Immune Responses in Hepatocytes ▶     Yizhong Wang, Jieliang Li, Xu Wang et al.     (−)-Epigallocatechin-3-gallate (EGCG), a major polyphenol component of green tea, has recently been identified as an inhibitor of hepatitis C virus (HCV) entry. Here, we examined …             Theta synchronization between medial prefrontal cortex and cerebellum is associated with adaptive performance of associative learning behavior ▶     Hao Chen, Yi-jie Wang, Li Yang et al.     Associative learning is thought to require coordinated activities among distributed brain regions. For example, to direct behavior appropriately, the medial prefrontal cortex …             Genetic dissection of plant architecture and yield-related traits in Brassica napus ▶     Guangqin Cai, Qingyong Yang, Hao Chen et al.     An optimized plant architecture (PA) is fundamental for high-yield breeding but the genetic control of the important trait is largely unknown in rapeseed. Here plant architecture …             X-ray Irradiated Vaccine Confers protection against Pneumonia caused by Pseudomonas Aeruginosa ▶     Yanyan Li, Zhenling Wang, Xiaoxiao Liu et al.     Pseudomonas aeruginosa is a gram-negative bacterium and one of the leading causes of nosocomial infection worldwide, however, no effective vaccine is currently available in the …             Knockout of BRD7 results in impaired spermatogenesis and male infertility ▶     Heran Wang, Ran Zhao, Chi Guo et al.     BRD7 was originally identified as a novel bromodomain gene and a potential transcriptional factor. BRD7 was found to be extensively expressed in multiple mouse tissues but was …             Proteome quantification of cotton xylem sap suggests the mechanisms of potassium-deficiency-induced changes in plant resistance to environmental stresses ▶     Zhiyong Zhang, Maoni Chao, Sufang Wang et al.     Proteomics was employed to investigate the molecular mechanisms of apoplastic response to potassium(K)-deficiency in cotton. Low K (LK) treatment significantly decreased the K …             Are we failing to protect threatened mangroves in the Sundarbans world heritage ecosystem? ▶     Swapan K. Sarker, Richard Reeve, Jill Thompson et al.     The Sundarbans, the largest mangrove ecosystem in the world, is under threat from historical and future human exploitation and sea level rise. Limited scientific knowledge on the …             Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity ▶     Ke Liu, Run Lei, Qiong Li et al.     Transferrin receptor (TFR) is an important iron transporter regulating iron homeostasis and has long been used as a marker for clathrin mediated endocytosis. However, little is …             Development of non-defective recombinant densovirus vectors for microRNA delivery in the invasive vector mosquito, Aedes albopictus ▶     Peiwen Liu, Xiaocong Li, Jinbao Gu et al.     We previously reported that mosquito densoviruses (MDVs) are potential vectors for delivering foreign nucleic acids into mosquito cells. However, considering existing expression …             Intranasal Insulin Prevents Anesthesia-Induced Spatial Learning and Memory Deficit in Mice ▶     Yongli Zhang, Chun-ling Dai, Yanxing Chen et al.     Elderly individuals are at increased risk of cognitive decline after anesthesia. General anesthesia is believed to be a risk factor for Alzheimer’s disease (AD). At present, …             Improving brightness and photostability of green and red fluorescent proteins for live cell imaging and FRET reporting ▶     Bryce T. Bajar, Emily S. Wang, Amy J. Lam et al.     Many genetically encoded biosensors use Förster resonance energy transfer (FRET) to dynamically report biomolecular activities. While pairs of cyan and yellow fluorescent …             HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation ▶     Kaifan Dai, Salar N Khan, Yimeng Wang et al.     The elicitation of HIV-1 broadly neutralizing antibodies following envelope glycoprotein (Env) vaccination is exceedingly difficult. Suboptimal engagement of naïve B cells is …             Phenotypic and functional alterations of pDCs in lupus-prone mice ▶     Zhenyuan Zhou, Jianyang Ma, Chunyuan Xiao et al.     Plasmacytoid dendritic cells (pDCs) were considered to be the major IFNα source in systemic lupus erythematosus (SLE) but their phenotype and function in different disease status …             Amyloidβ Peptides in interaction with raft-mime model membranes: a neutron reflectivity insight ▶     Valeria Rondelli, Paola Brocca, Simona Motta et al.     The role of first-stage β–amyloid aggregation in the development of the Alzheimer disease, is widely accepted but still unclear. Intimate interaction with the cell membrane is …             Serum microRNA microarray analysis identifies miR-4429 and miR-4689 are potential diagnostic biomarkers for biliary atresia ▶     Rui Dong, Zhen Shen, Chao Zheng et al.     This study aimed to investigate pathogenesis and novel diagnostic biomarkers of biliary atresia (BA). Serum samples from infants with BA and non-BA neonatal cholestasis (NC) were …             Resting-state functional connectivity between the dorsal anterior cingulate cortex and thalamus is associated with risky decision-making in nicotine addicts ▶     Zhengde Wei, Nannan Yang, Ying Liu et al.     Nicotine addiction is associated with risky behaviors and abnormalities in local brain areas related to risky decision-making such as the dorsal anterior cingulate cortex (dACC), …             Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium ▶     Qin Wang, Shengwei Yang, Cuihua Jiang et al.     Assessment of myocardial viability is deemed necessary to aid in clinical decision making whether to recommend revascularization therapy for patients with myocardial infarction …             An ultrasensitive label-free electrochemical immunosensor based on signal amplification strategy of multifunctional magnetic graphene loaded with cadmium ions ▶     Faying Li, Yueyun Li, Yunhui Dong et al.     Herein, a novel and ultrasensitive label-free electrochemical immunosensor was proposed for quantitative detection of human Immunoglobulin G (IgG). The amino functionalized …             Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling ▶     Feng Liu, Wen Zhang, Fusheng Yang et al.     This study aimed to determine the expression of progranulin (PGRN) in hepatocellular carcinoma (HCC) cells in response to interleukin 6 (IL-6), a non-cellular component of the …             Low c-Met expression levels are prognostic for and predict the benefits of temozolomide chemotherapy in malignant gliomas ▶     Ming-Yang Li, Pei Yang, Yan-Wei Liu et al.     Aberrant c-Met has been implicated in the development of many cancers. The objective of this study was to identify an unfavorable prognostic marker that might guide decisions …             Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms ▶     Masaya Misaki, Hideo Suzuki, Jonathan Savitz et al.     Abnormal reward-related responses in the nucleus accumbens (NAcc) have been reported for major depressive disorder (MDD) patients. However, variability exists in the reported …             Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population ▶     Ruo-Han Hao, Yan Guo, Shan-Shan Dong et al.     Obesity is highly heritable, but the specific genes influencing obesity related traits are largely unknown. Fibroblast growth factor 2 (FGF2) could influence adipocyte …             Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions ▶     Shu-Hai Lin, Tengfei Liu, Xiaoyan Ming et al.     Cancer was hypothesized to be driven by cancer stem cells (CSCs), but the metabolic determinants of CSC-like phenotype still remain elusive. Here, we present that hexosamine …             Mechanical stretching stimulates collagen synthesis via down-regulating SO2/AAT1 pathway ▶     Jia Liu, Wen Yu, Yan Liu et al.     The aim of the study was to investigate the role of endogenous sulfur dioxide (SO2)/ aspartate aminotransferase 1 (AAT1) pathway in stretch-induced excessive collagen expression …             Effect of TGF-β1 on the Migration and Recruitment of Mesenchymal Stem Cells after Vascular Balloon Injury: Involvement of Matrix Metalloproteinase-14 ▶     Wei Zhao, Chengyan Wang, Ruixue Liu et al.     Restenosis or occlusion after vascular procedures is ascribed to intimal hyperplasia. Transforming growth factor (TGF)-β1 is involved in recruitment of mesenchymal stem cells …             Automaticity of Conceptual Magnitude ▶     Yarden Gliksman, Shai Itamar, Tali Leibovich et al.     What is bigger, an elephant or a mouse? This question can be answered without seeing the two animals, since these objects elicit conceptual magnitude. How is an object’s …             “Optical communication with brain cells by means of an implanted duplex micro-device with optogenetics and Ca2+ fluoroimaging” ▶     Takuma Kobayashi, Makito Haruta, Kiyotaka Sasagawa et al.     To better understand the brain function based on neural activity, a minimally invasive analysis technology in a freely moving animal is necessary. Such technology would provide …             Multi-functionalized carbon dots as theranostic nanoagent for gene delivery in lung cancer therapy ▶     Yu-Fen Wu, Hsi-Chin Wu, Chen-Hsiang Kuan et al.     Theranostics, an integrated therapeutic and diagnostic system, can simultaneously monitor the real-time response of therapy. Different imaging modalities can combine with a …             Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening ▶     Nicholas E. Calcaterra, Daniel J. Hoeppner, Huijun Wei et al.     The primate-specific brain voltage-gated potassium channel isoform Kv11.1-3.1 has been identified as a novel therapeutic target for the treatment of schizophrenia. While this …             Morpholino-mediated SOD1 reduction ameliorates an amyotrophic lateral sclerosis disease phenotype ▶     M. Nizzardo, C. Simone, F. Rizzo et al.     Neurotoxicity due to the accumulation of mutant proteins is thought to drive pathogenesis in neurodegenerative diseases. 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