Nature Communications - 10 February 2016

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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Transition to a Moist Greenhouse with CO2 and solar forcing OPEN Max Popp, Hauke Schmidt and Jochem Marotzke Greenhouse-gas forcing has previously been thought to be rather ineffective at destroying the habitability of Earth-like planets. Here, the authors show that CO2 is as effective as solar forcing at causing a climate transition to a Moist-Greenhouse regime and thus poses an equal threat to a planet's habitability. 09 February 2016 | doi: 10.1038/ncomms10627 Earth Sciences  Atmospheric science  Climate science  Planetary sciences  Topographical pathways guide chemical microswimmers OPEN Juliane Simmchen, Jaideep Katuri, William E. Uspal, Mihail N. Popescu, Mykola Tasinkevych and Samuel Sánchez Self-propelled colloids can be used as cargo carriers, but it is challenging to control their motion without external fields. Here, Simmchen et al. use submicron patterns on a solid substrate to effectively confine the motion of the chemically active Janus microswimmers along the edges of the patterns. 09 February 2016 | doi: 10.1038/ncomms10598 Physical Sciences  Applied physics  Condensed matter  Exciton diamagnetic shifts and valley Zeeman effects in monolayer WS2 and MoS2 to 65 Tesla OPEN Andreas V. Stier, Kathleen M. McCreary, Berend T. Jonker, Junichiro Kono and Scott A. Crooker The spin and valley degrees of freedom are coupled in two-dimensional transition-metal dichalcogenides. Here, the authors use high magnetic fields to optically measure the valley Zeeman effect and diamagnetic exciton shift in tungsten disulphide and molybdenum disulphide, and determine the exciton binding energies. 09 February 2016 | doi: 10.1038/ncomms10643 Physical Sciences  Condensed matter  Materials science  Genomic insights into the Ixodes scapularis tick vector of Lyme disease OPEN Monika Gulia-Nuss, Andrew B. Nuss, Jason M. Meyer, Daniel E. Sonenshine, R. Michael Roe, Robert M. Waterhouse, David B. Sattelle, José de la Fuente, Jose M. Ribeiro, Karine Megy, Jyothi Thimmapuram, Jason R. Miller, Brian P. Walenz, Sergey Koren, Jessica B. Hostetler, Mathangi Thiagarajan, Vinita S. Joardar, Linda I. Hannick, Shelby Bidwell, Martin P. Hammond et al. Ticks transmit a large number of pathogens that cause human diseases. Here, the authors sequence the genome of the tick Ixodes scapularis and uncover expansion of genes associated with parasitic processes unique to ticks and tick-host interactions. 09 February 2016 | doi: 10.1038/ncomms10507 Biological Sciences  Genetics  Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer OPEN Pasquale Sansone, Claudio Ceccarelli, Marjan Berishaj, Qing Chang, Vinagolu K. Rajasekhar, Fabiana Perna, Robert L. Bowman, Michele Vidone, Laura Daly, Jennifer Nnoli, Donatella Santini, Mario Taffurelli, Natalie N. C. Shih, Michael Feldman, Jun J. Mao, Christopher Colameco , Jinbo Chen, Angela DeMichele, Nicola Fabbri, John H. Healey et al. ER+ breast cancer patients treated with endocrine therapies often acquire resistance and develop metastasis. In this study, the authors demonstrate that endocrine therapies can promote the self-renewal of CD133hi/ERlo drug resistant cells with metastatic potential driven through the IL6-Notch3 axis activation. 09 February 2016 | doi: 10.1038/ncomms10442 Biological Sciences  Cancer  Medical research  Agriculture causes nitrate fertilization of remote alpine lakes OPEN E. J. Hundey, S. D. Russell, F. J. Longstaffe and K. A. Moser The long-range atmospheric transport and deposition of reactive nitrogen may be affected by human activities. Here, the authors use isotope data to constrain sources of reactive nitrogen to high elevation lakes in the Uinta Mountains, finding that the majority originates from distant agricultural activities. 08 February 2016 | doi: 10.1038/ncomms10571 Earth Sciences  Atmospheric science  Biogeochemistry  Genome-wide association study identifies multiple susceptibility loci for craniofacial microsomia OPEN Yong-Biao Zhang, Jintian Hu, Jiao Zhang, Xu Zhou, Xin Li, Chaohao Gu, Tun Liu, Yangchun Xie, Jiqiang Liu, Mingliang Gu, Panpan Wang, Tingting Wu, Jin Qian, Yue Wang, Xiaoqun Dong, Jun Yu and Qingguo Zhang Craniofacial microsomia is a congenital anomaly that affects the development of the skull. Here, the authors perform a genome-wide association study on patients in China and identify particular loci that provide insights into genetic mechanisms. 08 February 2016 | doi: 10.1038/ncomms10605 Biological Sciences  Genetics  Ionic polarization-induced current–voltage hysteresis in CH3NH3PbX3 perovskite solar cells OPEN Simone Meloni, Thomas Moehl, Wolfgang Tress, Marius Franckevičius, Michael Saliba, Yong Hui Lee, Peng Gao, Mohammad Khaja Nazeeruddin, Shaik Mohammed Zakeeruddin, Ursula Rothlisberger and Michael Graetzel The origin of hysteresis remains an open question in lead-halide perovskite solar cells. Here, Meloni et al. investigate the causes of hysteresis using an experimental and computational approach, finding that the observed hysteresis is due to halide ion-vacancy movement in the perovskite. 08 February 2016 | doi: 10.1038/ncomms10334 Physical Sciences  Nanotechnology  Physical chemistry  KRAS insertion mutations are oncogenic and exhibit distinct functional properties OPEN Yasmine White, Aditi Bagchi, Jessica Van Ziffle, Anagha Inguva, Gideon Bollag, Chao Zhang, Heidi Carias, David Dickens, Mignon Loh, Kevin Shannon and Ari J. Firestone Amino acid substitutions in K-Ras that constitutively activate the protein are common in cancer. Here, the authors describe mutations in the K-Ras Switch 2 domain and show that the mutant proteins accumulate in the active conformation, exhibit defective binding to PI3 kinase, and are hypersensitive to MEK inhibitors. 08 February 2016 | doi: 10.1038/ncomms10647 Biological Sciences  Cancer  Genetics  Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer OPEN Shigeru Hashimoto, Shuji Mikami, Hirokazu Sugino, Ayumu Yoshikawa, Ari Hashimoto, Yasuhito Onodera, Shotaro Furukawa, Haruka Handa, Tsukasa Oikawa, Yasunori Okada, Mototsugu Oya and Hisataka Sabe Acquisition of mesenchymal properties by cancer cells is a critical event for the development of malignancy. Here, the authors show that in renal cancer cells, lysosphosphatidic acid does not utilize the RhoA pathway but specifically activates the Arf6 mesenchymal pathway via its GPCRs and EFA6 to promote invasion, metastasis and drug resistance. 08 February 2016 | doi: 10.1038/ncomms10656 Biological Sciences  Cancer  Cell biology  Common electronic origin of superconductivity in (Li,Fe)OHFeSe bulk superconductor and single-layer FeSe/SrTiO3 films OPEN Lin Zhao, Aiji Liang, Dongna Yuan, Yong Hu, Defa Liu, Jianwei Huang, Shaolong He, Bing Shen, Yu Xu, Xu Liu, Li Yu, Guodong Liu, Huaxue Zhou, Yulong Huang, Xiaoli Dong, Fang Zhou, Kai Liu, Zhongyi Lu, Zhongxian Zhao, Chuangtian Chen et al. The mechanism of high-temperature superconductivity in the iron-based materials remains not fully understood. Here, the authors report on ARPES measurements on an FeSe-based bulk superconductor, whose electronic properties are found to be similar to those of single-layer FeSe/STO films. 08 February 2016 | doi: 10.1038/ncomms10608 Physical Sciences  Condensed matter  Optogenetic control of nuclear protein export OPEN Dominik Niopek, Pierre Wehler, Julia Roensch, Roland Eils and Barbara Di Ventura Light-inducible control of protein subcellular localization holds great promise for synthetic biology applications and insights into basic cell biology. Here the authors develop a genetically-encoded light-inducible nuclear export system and apply it to a synthetic repressor and p53 transcriptional activity. 08 February 2016 | doi: 10.1038/ncomms10624 Biological Sciences  Biotechnology  Single crystal functional oxides on silicon OPEN Saidur Rahman Bakaul, Claudy Rayan Serrao, Michelle Lee, Chun Wing Yeung, Asis Sarker, Shang-Lin Hsu, Ajay Kumar Yadav, Liv Dedon, Long You, Asif Islam Khan, James David Clarkson, Chenming Hu, Ramamoorthy Ramesh and Sayeef Salahuddin Synthesis of single-crystal complex-oxide films directly on silicon is difficult due to differing interfacial chemistry. Here, the authors demonstrate room-temperature integration of single-crystal lead zirconate titanate on to silicon to act as a gate insulator in a field-effect transistor. 08 February 2016 | doi: 10.1038/ncomms10547 Physical Sciences  Applied physics  Materials science  Rapid radiation in bacteria leads to a division of labour OPEN Wook Kim, Stuart B. Levy and Kevin R. Foster The division of labour—where individuals specialise on different tasks—is fundamental to many sophisticated and ancient biological systems. Here the authors show that bacteria can deploy a robust and functional division of labour in a matter of days via a single mutation. 08 February 2016 | doi: 10.1038/ncomms10508 Biological Sciences  Evolution  Microbiology  Mechanical evidence that Australopithecus sediba was limited in its ability to eat hard foods OPEN Justin A. Ledogar, Amanda L. Smith, Stefano Benazzi, Gerhard W. Weber, Mark A. Spencer, Keely B. Carlson, Kieran P. McNulty, Paul C. Dechow, Ian R. Grosse, Callum F. Ross, Brian G. Richmond, Barth W. Wright, Qian Wang, Craig Byron, Kristian J. Carlson, Darryl J. de Ruiter, Lee R. Berger, Kelli Tamvada, Leslie C. Pryor, Michael A. Berthaume et al. Dietary adaptations of extinct early humans are often inferred from dental microwear data. Here, the authors employ mechanical analyses to show that Australopithecus sediba had limited ability to consume hard foods. 08 February 2016 | doi: 10.1038/ncomms10596 Biological Sciences  Evolution  Palaeontology  Shaping metallic glasses by electromagnetic pulsing OPEN Georg Kaltenboeck, Marios D. Demetriou, Scott Roberts and William L. Johnson Metallic glasses can be softened to different shapes whilst maintaining mechanical properties, and the related thermoplastic processing requires a heating source and an applied force. Here, the authors show an effective thermoplastic approach by a coupling between electric pulses and a magnetic field. 08 February 2016 | doi: 10.1038/ncomms10576 Physical Sciences  Applied physics  Materials science  Experimental control of transport resonances in a coherent quantum rocking ratchet OPEN Christopher Grossert, Martin Leder, Sergey Denisov, Peter Hänggi and Martin Weitz The ratchet effect can be used as a tool to control coherent quantum transport of ultra-cold atoms. Here, the authors demonstrate a rocking quantum ratchet with a rubidium BEC, and reveal the existence of quantum transport resonances. 08 February 2016 | doi: 10.1038/ncomms10440 Physical Sciences  Atomic and molecular physics  Iron-catalysed cross-coupling of organolithium compounds with organic halides OPEN Zhenhua Jia, Qiang Liu, Xiao-Shui Peng and Henry N. C. Wong Cross coupling reactions of organolithiums are challenging due to their high reactivity, though palladium catalysed versions have been reported. Here, the authors report the cross coupling of organolithiums with aryl halides with inexpensive and widely available iron catalysts. 05 February 2016 | doi: 10.1038/ncomms10614 Chemical Sciences  Catalysis  Organic chemistry  Anthropogenic noise increases fish mortality by predation OPEN Stephen D. Simpson, Andrew N. Radford, Sophie L. Nedelec, Maud C. O. Ferrari, Douglas P. Chivers, Mark I. McCormick and Mark G. Meekan Little evidence exists on whether human-generated noise directly affects survival of wildlife. Here, Simpson et al. show that damselfish exposed to motorboat noise have elevated metabolic rates, reduced responses to predatory attacks, and suffer increased predation compared to fish in ambient conditions. 05 February 2016 | doi: 10.1038/ncomms10544 Biological Sciences  Ecology  Zoology  Macrospin dynamics in antiferromagnets triggered by sub-20 femtosecond injection of nanomagnons OPEN D. Bossini, S. Dal Conte, Y. Hashimoto, A. Secchi, R. V. Pisarev, Th. Rasing, G. Cerullo and A. V. Kimel Magnetic order in nature is defined by the exchange interaction, however its understanding on the ultrafast- and nanometer-scales is limited. Here, the authors follow the femtosecond sub-nanometer dynamics of the antiferromagnetic order parameter in KNiF3 triggered by photo-generated exchange magnons. 05 February 2016 | doi: 10.1038/ncomms10645 Physical Sciences  Condensed matter  Monolayer-to-bilayer transformation of silicenes and their structural analysis OPEN Ritsuko Yaokawa, Tetsu Ohsuna, Tetsuya Morishita, Yuichiro Hayasaka, Michelle J. S. Spencer and Hideyuki Nakano Two dimensional forms of silicon offer different conductive properties to that of the bulk material, promising applications in new electronic technologies. Here, the authors report the fabrication of bilayer silicenes which, unlike their monolayer form, are indirect bandgap semiconductors. 05 February 2016 | doi: 10.1038/ncomms10657 Chemical Sciences  Inorganic chemistry  Materials science  Nanotechnology  Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli OPEN Akira Nakagawa, Eitaro Matsumura, Takashi Koyanagi, Takane Katayama, Noriaki Kawano, Kayo Yoshimatsu, Kenji Yamamoto, Hidehiko Kumagai, Fumihiko Sato and Hiromichi Minami Opiates—the gold standard for pain relief—are currently produced by extraction from opium poppies. Here the authors show that bacteria can serve as an efficient and flexible platform for the production of opiates by demonstrating the total synthesis of Thebaine and hydrocodone from stepwise fermentation in E. coli. 05 February 2016 | doi: 10.1038/ncomms10390 Biological Sciences  Bioengineering  Biotechnology  Microbiology  PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness OPEN Xin Wang, Youn-Sang Jung, Sohee Jun, Sunhye Lee, Wenqi Wang, Andrea Schneider, Young Sun Oh, Steven H. Lin, Bum-Joon Park, Junjie Chen, Khandan Keyomarsi and Jae-Il Park Stem cells are found in many tumour types and are thought to be partially responsible for cell survival following therapy. Here, the authors show that PCNA-associated factor, PAF, contributes to stemness in breast cancer cells and pharmacological targeting of PAF reduces mammosphere formation. 04 February 2016 | doi: 10.1038/ncomms10633 Biological Sciences  Cancer  Cell biology  Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics OPEN Emrah Eroglu, Benjamin Gottschalk, Suphachai Charoensin, Sandra Blass, Helmut Bischof, Rene Rost, Corina T. Madreiter-Sokolowski, Brigitte Pelzmann, Eva Bernhart, Wolfgang Sattler, Seth Hallström, Tadeusz Malinski, Markus Waldeck-Weiermair, Wolfgang F. Graier and Roland Malli Nitric oxide is a volatile free radical second messenger with a large number of biological effects. Here Eroglu et al. develop genetically encoded fluorescent biosensors for nitric oxide and use them to visualise subcellular nitric oxide dynamics in single cells. 04 February 2016 | doi: 10.1038/ncomms10623 Biological Sciences  Biotechnology  Cell biology  Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo OPEN Igor Pavlovic, Divyeshsinh T. Thakor, Jessica R. Vargas, Colin J. McKinlay, Sebastian Hauke, Philipp Anstaett, Rafael C. Camuña, Laurent Bigler, Gilles Gasser, Carsten Schultz, Paul A. Wender and Henning J. Jessen Photocaged inositol-pyrophosphates offer a tool to study cellular signalling, but their challenging synthesis has precluded any biological studies so far. Here, the authors report the synthesis and cellular delivery of a photocaged analogue, and show that it mediates protein translocation in cellulo. 04 February 2016 | doi: 10.1038/ncomms10622 Chemical Sciences  Biochemistry  Chemical biology  Organic chemistry  Sustained hole inversion layer in a wide-bandgap metal-oxide semiconductor with enhanced tunnel current OPEN Gem Shoute, Amir Afshar, Triratna Muneshwar, Kenneth Cadien and Douglas Barlage Wide-bandgap, metal-oxide thin-film transistors are limited in their application by the lack of available p-type material. Here, the authors demonstrate a wide-bandgap metal-oxide n-type semiconductor that sustains a strong p-type inversion layer using a barrier dielectric with a high-dielectric constant. 04 February 2016 | doi: 10.1038/ncomms10632 Physical Sciences  Materials science  Microbial metabolomics in open microscale platforms OPEN Layla J. Barkal, Ashleigh B. Theberge, Chun-Jun Guo, Joe Spraker, Lucas Rappert, Jean Berthier, Kenneth A. Brakke, Clay C. C. Wang, David J. Beebe, Nancy P. Keller and Erwin Berthier Traditional methods for microbial culture and subsequent metabolomics are time-consuming and labour-intensive. Here the authors present a microscale culture platform with integrated extraction for efficient, low-volume metabolomics of relevant microenvironments and microbial co-cultures. 04 February 2016 | doi: 10.1038/ncomms10610 Biological Sciences  Biochemistry  Chemical biology  Microbiology  Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage OPEN Samar Alsafadi, Alexandre Houy, Aude Battistella, Tatiana Popova, Michel Wassef, Emilie Henry, Franck Tirode, Angelos Constantinou, Sophie Piperno-Neumann, Sergio Roman-Roman, Martin Dutertre and Marc-Henri Stern Mutations in the splicing factor SF3B1 are found in uveal melanoma. Here, Alsafadi et al. use RNA-sequencing data from these cancers and experimental models, and show that mutant SF3B1 promotes alternative branchpoints in a specific gene subset and that the mutant protein gains a new function. 04 February 2016 | doi: 10.1038/ncomms10615 Biological Sciences  Cancer  Molecular biology  Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression OPEN André Franz, Paul A. Pirson, Domenic Pilger, Swagata Halder, Divya Achuthankutty, Hamid Kashkar, Kristijan Ramadan and Thorsten Hoppe Cdc48/p97 is a key component of the ubiquitin-proteasome system, acting as a ubiquitin-directed segregase to regulate multiple cellular functions. Here the authors identify UBXN-3/FAF1 as a crucial regulator of chromatin-associated protein degradation that recruits Cdc48/p97 to DNA replication forks. 04 February 2016 | doi: 10.1038/ncomms10612 Biological Sciences  Molecular biology  The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation OPEN Roberto Melero, Nele Hug, Andrés López-Perrote, Akio Yamashita, Javier F. Cáceres and Oscar Llorca UPF1 is a central Nonsense-mediated mRNA decay—(NMD), a mechanism to degrade mRNAs containing premature translation termination codons-factor—whose phosphorylation is key to triggering NMD. Here the authors show that the DHX34 helicase acts as a scaffold in promoting UPF1 phosphorylation by SMG1 to promotes NMD. 04 February 2016 | doi: 10.1038/ncomms10585 Biological Sciences  Biochemistry  Biophysics  Molecular biology  Elastic spheres can walk on water OPEN Jesse Belden, Randy C. Hurd, Michael A. Jandron, Allan F. Bower and Tadd T. Truscott Stone skipping on water is a very classical phenomenon, but the relevant fluid dynamics is more complicated than what is normally expected. Here, Belden et al. study the effect of elasticity on the skipping dynamics and show why soft spheres can skip much easier than solid spheres. 04 February 2016 | doi: 10.1038/ncomms10551 Physical Sciences  Fluids and plasma physics  Structural basis of complement membrane attack complex formation OPEN Marina Serna, Joanna L. Giles, B. Paul Morgan and Doryen Bubeck The membrane attack complex (MAC) is an immune effector that kills pathogens by forming pores in their membrane. Here the authors use cryo-electron microscopy to reveal that the full MAC is an asymmetric pore with a split-washer configuration and identify a network of interactions that provide a basis for sequential assembly. 04 February 2016 | doi: 10.1038/ncomms10587 Biological Sciences  Biochemistry  Biophysics  Immunology  Activating frataxin expression by repeat-targeted nucleic acids OPEN Liande Li, Masayuki Matsui and David R. Corey Expansion of the trinucleotide GAA within an intronic FXN RNA can cause Friedreich's Ataxia (FRDA), an incurable genetic disorder. Here, the authors show that anti-GAA duplex RNAs or single-stranded locked nucleic acids increases FXN protein expression in patient-derived cells to levels similar to wild-type cells. 04 February 2016 | doi: 10.1038/ncomms10606 Biological Sciences  Molecular biology  Structure of the poly-C9 component of the complement membrane attack complex OPEN Natalya V. Dudkina, Bradley A. Spicer, Cyril F. Reboul, Paul J. Conroy, Natalya Lukoyanova, Hans Elmlund, Ruby H. P. Law, Susan M. Ekkel, Stephanie C. Kondos, Robert J. A. Goode, Georg Ramm, James C. Whisstock, Helen R. Saibil and Michelle A. Dunstone The membrane attack complex is a heteromeric assembly of complement proteins where multiple copies of C9 are recruited by the C5b678 complex to form lytic pores in pathogen membranes. Here the authors present the structure of a soluble pore-like form of the C9 component that reveals details of the oligomerization interfaces. 04 February 2016 | doi: 10.1038/ncomms10588 Biological Sciences  Biochemistry  Biophysics  Immunology  GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex OPEN Paul G. Anastasiades, Andre Marques-Smith, Daniel Lyngholm, Tom Lickiss, Sayda Raffiq, Dennis Kätzel, Gero Miesenböck and Simon J. B. Butt GABAergic interneurons are key components of cortical circuits, yet their early connectivity is unknown. Here the authors show that during early postnatal development, Nkx2-1-derived interneurons engage in layer-specific and dynamic circuits, which are distinct from those in the mature neocortex. 04 February 2016 | doi: 10.1038/ncomms10584 Biological Sciences  Developmental biology  Neuroscience  Probabilistic modelling of chromatin code landscape reveals functional diversity of enhancer-like chromatin states OPEN Jian Zhou and Olga G. Troyanskaya The chromatin functional state can be derived from the binding patterns of chromatin factors. Here, Zhou and Troyanskaya report a data-driven probabilistic modelling of dependencies between chromatin factors that can divide enhancer-like chromatin states into three functionally distinct groups. 04 February 2016 | doi: 10.1038/ncomms10528 Biological Sciences  Bioinformatics  Molecular biology  Quantum electric-dipole liquid on a triangular lattice OPEN Shi-Peng Shen, Jia-Chuan Wu, Jun-Da Song, Xue-Feng Sun, Yi-Feng Yang, Yi-Sheng Chai, Da-Shan Shang, Shou-Guo Wang, James F. Scott and Young Sun In magnetic materials, geometry-defined competing interactions between spins combined with quantum fluctuations can present the possibility of quantum liquid states which do not order even as 0K is approached. Here, the authors present an analogue built from electric dipoles on a triangular lattice. 04 February 2016 | doi: 10.1038/ncomms10569 Physical Sciences  Condensed matter  Realization of mid-infrared graphene hyperbolic metamaterials OPEN You-Chia Chang, Che-Hung Liu, Chang-Hua Liu, Siyuan Zhang, Seth R. Marder, Evgenii E. Narimanov, Zhaohui Zhong and Theodore B. Norris The use of graphene can provide another useful building block for metamaterials. Here, Chang et al. have explored the experimental realization of a mid-infrared hyperbolic metamaterial, in which the role of the metal in providing a conducting layer is taken over by graphene. 04 February 2016 | doi: 10.1038/ncomms10568 Physical Sciences  Nanotechnology  Optical physics  Suppression of the antiferromagnetic pseudogap in the electron-doped high-temperature superconductor by protect annealing OPEN M. Horio, T. Adachi, Y. Mori, A. Takahashi, T. Yoshida, H. Suzuki, L. C. C. Ambolode, K. Okazaki, K. Ono, H. Kumigashira, H. Anzai, M. Arita, H. Namatame, M. Taniguchi, D. Ootsuki, K. Sawada, M. Takahashi, T. Mizokawa, Y. Koike and A. Fujimori et al. In cuprates, superconductivity exists in a narrow window at high electron doping concentration with strong antiferromagnetic correlations. Here, the authors demonstrate superconductivity with no effect of antiferromagnetic order in a cuprate for a wide electron doping range following a protect anneal process. 04 February 2016 | doi: 10.1038/ncomms10567 Physical Sciences  Condensed matter  Selective silicate-directed motility in diatoms OPEN Karen Grace V. Bondoc, Jan Heuschele, Jeroen Gillard, Wim Vyverman and Georg Pohnert Diatoms often dominate production in aquatic communities, but the amount of available dissolved silicic acid (dSi) limits their growth. Here, Bondoc et al., show that diatoms perceive gradients in dSi, and can increase the encounter with this resource by chemotaxis toward high concentrations under resource-limited conditions. 04 February 2016 | doi: 10.1038/ncomms10540 Biological Sciences  Ecology  Oceanography  MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome OPEN Derek J. C. Tai, Yen C. Liu, Wei L. Hsu, Yun L. Ma, Sin J. Cheng, Shau Y. Liu and Eminy H. Y. Lee Post-translational modifications of methyl-CpG-binding protein 2 (MeCP2) are important for its function and dysfunction in Rett syndrome. Here, Tai et al. show a functional interaction between MeCP2 SUMOylation and phosphorylation in rodent behavior and synaptic plasticity. 04 February 2016 | doi: 10.1038/ncomms10552 Biological Sciences  Neuroscience  Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability OPEN Afzal Husain, Nasim A. Begum, Takako Taniguchi, Hisaaki Taniguchi, Maki Kobayashi and Tasuku Honjo Topoisomerase 1 (TOP1) relieves superhelical tension when DNA strands are unwound during transcription. Here, Husain et al. report that SMARCA4, an ATP-dependent chromatin remodeller, is associated with TOP1 and suppresses transcription-associated genomic instability. 04 February 2016 | doi: 10.1038/ncomms10549 Biological Sciences  Cell biology  Molecular biology  A role for diatom-like silicon transporters in calcifying coccolithophores OPEN Grażyna M. Durak, Alison R. Taylor, Charlotte E. Walker, Ian Probert, Colomban de Vargas, Stephane Audic, Declan Schroeder, Colin Brownlee and Glen L. Wheeler Silicification by diatoms and calcification by coccolithophores are distinct biomineralisation processes that influence global carbon cycling and the abundance of marine plankton. Here, Durak et al. show that diatom-like silicon transporters are present in coccolithophores, and that silicon is required for formation of their calcium carbonate coccoliths. 04 February 2016 | doi: 10.1038/ncomms10543 Biological Sciences  Ecology  Oceanography  Open access resources for genome-wide association mapping in rice OPEN Susan R. McCouch, Mark H. Wright, Chih-Wei Tung, Lyza G. Maron, Kenneth L. McNally, Melissa Fitzgerald, Namrata Singh, Genevieve DeClerck, Francisco Agosto-Perez, Pavel Korniliev, Anthony J. Greenberg, Ma. Elizabeth B. Naredo, Sheila Mae Q. Mercado, Sandra E. Harrington, Yuxin Shi, Darcy A. Branchini, Paula R. Kuser-Falcão, Hei Leung, Kowaru Ebana, Masahiro Yano et al. Understanding the link between genotype and phenotype can facilitate efforts by breeders to utilize natural variation and develop new crop varieties. Here the authors present a diverse germplasm collection, a high-density genotyping array and a set of bioinformatic tools to enable association mapping in rice. 04 February 2016 | doi: 10.1038/ncomms10532 Biological Sciences  Genetics  Plant sciences  Genome-wide association and high-resolution phenotyping link Oryza sativa panicle traits to numerous trait-specific QTL clusters OPEN Samuel Crowell, Pavel Korniliev, Alexandre Falcão, Abdelbagi Ismail, Glenn Gregorio, Jason Mezey and Susan McCouch Panicle architecture is an important determinant of crop yield and a target of selection by plant breeders. Here, Crowell et al. combine image-based phenotyping with high-density array-based genotyping to perform a genome-wide association study revealing a number of candidate genes linked to panicle variation in rice. 04 February 2016 | doi: 10.1038/ncomms10527 Biological Sciences  Genetics  Plant sciences  VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8 OPEN Debapriya Ghosh, Silvia Pinto, Lydia Danglot, Ine Vandewauw, Andrei Segal, Nele Van Ranst, Melissa Benoit, Annelies Janssens, Rudi Vennekens, Pieter Vanden Berghe, Thierry Galli, Joris Vriens and Thomas Voets The temperature-sensitive TRPM8 channel is essential for cold sensing and has been linked to pathological cold hypersensitivity. Here, the authors find TRPM8 insertion in the cell membrane is mediated by VAMP7 following atypical LAMP1-containing vesicle transport, and that loss of VAMP7 leads to reduced cold avoidance in vivo. 04 February 2016 | doi: 10.1038/ncomms10489 Biological Sciences  Cell biology  Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer OPEN Zina Dubeykovskaya, Yiling Si, Xiaowei Chen, Daniel L. Worthley, Bernhard W. Renz, Aleksandra M. Urbanska, Yoku Hayakawa, Ting Xu, C. Benedikt Westphalen, Alexander Dubeykovskiy, Duan Chen, Richard A. Friedman, Samuel Asfaha, Karan Nagar, Yagnesh Tailor, Sureshkumar Muthupalani, James G. Fox, Jan Kitajewski and Timothy C. Wang During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells release TFF2, which suppresses the expansion of myeloid cells and cancer progression. 04 February 2016 | doi: 10.1038/ncomms10517 Biological Sciences  Cancer  Cell biology  Neuroscience  Transplanted neurons integrate into adult retinas and respond to light OPEN Praseeda Venugopalan, Yan Wang, Tu Nguyen, Abigail Huang, Kenneth J. Muller and Jeffrey L. Goldberg Replacing lost retinal ganglion cells is a potential treatment for optic neuropathies such as glaucoma. Here, the authors show that transplanted donor RGCs can successfully integrate into a mature host retina in vivo, projecting axons along the intact visual pathway and responding to light stimuli. 04 February 2016 | doi: 10.1038/ncomms10472 Biological Sciences  Cell biology  Neuroscience  Suppression law of quantum states in a 3D photonic fast Fourier transform chip OPEN Andrea Crespi, Roberto Osellame, Roberta Ramponi, Marco Bentivegna, Fulvio Flamini, Nicolò Spagnolo, Niko Viggianiello, Luca Innocenti, Paolo Mataloni and Fabio Sciarrino Computational speedup in photonic quantum devices depends on multi-particle interference, which must be certified through known benchmark algorithms. Here, to this end, the authors develop a scalable approach for the implementation of the fast Fourier transform algorithm in 3D photonic integrated interferometers. 04 February 2016 | doi: 10.1038/ncomms10469 Physical Sciences  Optical physics  Theoretical physics  Design of crystal-like aperiodic solids with selective disorder–phonon coupling OPEN Alistair R. Overy, Andrew B. Cairns, Matthew J. Cliffe, Arkadiy Simonov, Matthew G. Tucker and Andrew L. Goodwin Conventional crystallography focuses on structurally-ordered systems, where interesting physics or novel material functions emerge. Here, Overy et al. propose an approach of designing functional materials with strongly correlated disorder, which can couple with phonons to affect lattice dynamics. 04 February 2016 | doi: 10.1038/ncomms10445 Physical Sciences  Condensed matter  Materials science  Physical chemistry  ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function OPEN Aarti Sharma, Alexander K. Lyashchenko, Lei Lu, Sara Ebrahimi Nasrabady, Margot Elmaleh, Monica Mendelsohn, Adriana Nemes, Juan Carlos Tapia, George Z. Mentis and Neil A. Shneider The mechanism by which FUS mutations cause familial ALS remains unclear. Here, the authors use mouse transgenic models to show that a toxic gain-of-function underlies motor neuron degeneration, and that the toxicity of mutant FUS does not depend on a loss or excess of FUS activity. 04 February 2016 | doi: 10.1038/ncomms10465 Biological Sciences  Neuroscience  Evidence for link between modelled trends in Antarctic sea ice and underestimated westerly wind changes OPEN Ariaan Purich, Wenju Cai, Matthew H. England and Tim Cowan Mechanisms responsible for the recent increase in Antarctic sea ice cover remain elusive. Here, the authors show that model underestimates of changes in wind-induced ocean circulation may contribute, in part, to the failure of CMIP5 models to accurately capture modern Antarctic sea ice trends. 04 February 2016 | doi: 10.1038/ncomms10409 Earth Sciences  Atmospheric science  Oceanography  Origin of the spin Seebeck effect in compensated ferrimagnets OPEN Stephan Geprägs, Andreas Kehlberger, Francesco Della Coletta, Zhiyong Qiu, Er-Jia Guo, Tomek Schulz, Christian Mix, Sibylle Meyer, Akashdeep Kamra, Matthias Althammer, Hans Huebl, Gerhard Jakob, Yuichi Ohnuma, Hiroto Adachi, Joseph Barker, Sadamichi Maekawa, Gerrit E. W. Bauer, Eiji Saitoh, Rudolf Gross, Sebastian T. B. Goennenwein et al. Ferrimagnets possess multiple spin sub-lattices resulting in a complex magnon band structure and subtle spin transport across interfaces. Here, the authors show how the spin Seebeck effect, the thermal generation of pure spin current, may be an effective tool to study these magnetic excitations. 04 February 2016 | doi: 10.1038/ncomms10452 Physical Sciences  Condensed matter  Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature OPEN Xingjun Zhu, Wei Feng, Jian Chang, Yan-Wen Tan, Jiachang Li, Min Chen, Yun Sun and Fuyou Li In photothermal therapy for cancer treatment, hyperthermic effects can damage healthy tissues and inhibit therapeutic efficacy. Here, the authors use core-shell lanthanide-based nanoparticles to monitor microscopic temperatures and to ablate cancer tissue at low temperatures. 04 February 2016 | doi: 10.1038/ncomms10437 Biological Sciences  Bioengineering  Cancer  Nanotechnology  A monoclonal antibody against KCNK9 K+ channel extracellular domain inhibits tumour growth and metastasis OPEN Han Sun, Liqun Luo, Bachchu Lal, Xinrong Ma, Lieping Chen, Christine L. Hann, Amy M. Fulton, Daniel J. Leahy, John Laterra and Min Li The potassium channel KCNK9 mediates important biological processes and is often overexpressed in breast and lung cancers. In this study, the authors developed a specific monoclonal antibody against the extracellular domain of KCNK9 and show that it inhibits cancer growth and metastasis in vivo through both cell autonomous and immune-dependent cellular cytotoxicity. 04 February 2016 | doi: 10.1038/ncomms10339 Biological Sciences  Cancer  Intracellular mGluR5 plays a critical role in neuropathic pain OPEN Kathleen Vincent, Virginia M. Cornea, Yuh-Jiin I. Jong, André Laferrière, Naresh Kumar, Aiste Mickeviciute, Jollee S. T. Fung, Pouya Bandegi, Alfredo Ribeiro-da-Silva, Karen L. O’Malley and Terence J. Coderre mGluR5 has been shown to play a role in chronic pain regulation. Here, the authors use membrane permeable and non-transported, impermeable mGluR5 antagonists to show that spinal analgesic effects in vivo are mediated by intracellular rather than cell surface mGluR5. 03 February 2016 | doi: 10.1038/ncomms10604 Biological Sciences  Cell biology  Neuroscience  NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force OPEN Chenyu Li, Chenyi Xue, Qiaoyun Yang, Boon Chuan Low and Yih-Cherng Liou During metaphase, alignment of chromosomes is facilitated by oscillations driven by the chromokinesin Kid. Here Li et al. show that the microtubule-associated protein NuSAP is a novel regulator of Kid, regulating the amplitude and velocity of chromosome oscillation. 03 February 2016 | doi: 10.1038/ncomms10597 Biological Sciences  Cell biology  Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth OPEN Michael S. Nakazawa, T. S. Karin Eisinger-Mathason, Navid Sadri, Joshua D. Ochocki, Terence P. F. Gade, Ruchi K. Amin and M. Celeste Simon Hypoxia is a common feature of soft tissue sarcomas, resulting in the activation of HIF-1α, which promotes metastasis. Here, Nakazawa et al. show that paradoxically HIF-2α is epigenetically silenced during the progression of multiple sarcoma subtypes, and when reexpressed, blocks tumour growth in vivo. 03 February 2016 | doi: 10.1038/ncomms10539 Biological Sciences  Cancer  Medical research  Molecular biology  Highly robust crystalsome via directed polymer crystallization at curved liquid/liquid interface OPEN Wenda Wang, Hao Qi, Tian Zhou, Shan Mei, Lin Han, Takeshi Higuchi, Hiroshi Jinnai and Christopher Y. Li Self-assemblies of polymers to form polymersomes in solution can be used as carriers for drug delivery, but it is challenging to control polymer crystallization to improve their mechanical stability. Here, Wang et al. show the formation of nanosized crystalsomes composed of polymer lamellar single crystals. 03 February 2016 | doi: 10.1038/ncomms10599 Physical Sciences  Bioengineering  Materials science  Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions OPEN Maxwell W. Brown, Yoori Kim, Gregory M. Williams, John D. Huck, Jennifer A. Surtees and Ilya J. Finkelstein DNA-binding proteins need to scan the genome to find their targets though how this occurs in the crowded nuclear environment is poorly understood. Here the authors use single-molecular fluorescence to show the repair complex Msh2-Msh3 can hop over blocks that impede the sliding complex Msh2-Msh6. 03 February 2016 | doi: 10.1038/ncomms10607 Biological Sciences  Molecular biology  Absence of a spin-signature from a single Ho adatom as probed by spin-sensitive tunneling OPEN M. Steinbrecher, A. Sonntag, M. dos Santos Dias, M. Bouhassoune, S. Lounis, J. Wiebe, R. Wiesendanger and A. A. Khajetoorians Magnetic stability of holmium atoms on a platinum(111) surface has recently been reported, raising prospects for atomic-scale spintronics, however contradictory results have since emerged. Here, Steinbrecher et al. find evidence for an invisibility of the holmium spin to scanning tunnelling spectroscopy techniques which challenges recent results. 03 February 2016 | doi: 10.1038/ncomms10454 Physical Sciences  Condensed matter  Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages OPEN Beate M. Lichtenberger, Maria Mastrogiannaki and Fiona M. Watt The molecular mechanisms regulating skin dermal changes are unclear. Here, the authors show that deletion of Hedgehog (Hh) in the upper dermis alters the response to epidermal Wnt signalling, which, together with changes in extracellular matrix production, influences distinct fibroblast lineages differently. 03 February 2016 | doi: 10.1038/ncomms10537 Biological Sciences  Cell biology  Developmental biology  Marine mammals harbor unique microbiotas shaped by and yet distinct from the sea OPEN Elisabeth M. Bik, Elizabeth K. Costello, Alexandra D. Switzer, Benjamin J. Callahan, Susan P. Holmes, Randall S. Wells, Kevin P. Carlin, Eric D. Jensen, Stephanie Venn-Watson and David A. Relman Little is known about the microbiota of marine mammals, despite the crucial ecological roles played by these animals. Here, Bik et al. describe the bacterial communities associated with various body sites in dolphins and sea lions, as well as the microbiota of their dietary fish and adjacent seawater. 03 February 2016 | doi: 10.1038/ncomms10516 Biological Sciences  Ecology  Microbiology  Zoology  A role for Mfb1p in region-specific anchorage of high-functioning mitochondria and lifespan in Saccharomyces cerevisiae OPEN Wolfgang M. Pernice, Jason D. Vevea and Liza A. Pon Mitochondria are asymmetrically inherited during cell division, a process that can affect cell fate and lifespan. Here the authors describe a mechanism for mitochondrial quality control in yeast that maintains a reservoir of high-functioning mitochondria in mother cells and preserves maternal reproductive capacity. 03 February 2016 | doi: 10.1038/ncomms10595 Biological Sciences  Cell biology  Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis OPEN Xiaoting Wu, Angeleen Fleming, Thomas Ricketts, Mariana Pavel, Herbert Virgin, Fiona M. Menzies and David C. Rubinsztein The molecular mechanisms behind how autophagy may impact on developmental pathways and cell fate decisions are unclear. Here Wu et al. identify Notch receptors being taken up into ATG16L1-positive autophagosomes and, using a mouse mutant model, show that changes in autophagy can impact on stem cell fate. 03 February 2016 | doi: 10.1038/ncomms10533 Biological Sciences  Cell biology  Developmental biology  PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications OPEN G. I. Lancaster, H. L. Kammoun, M. J. Kraakman, G. M. Kowalski, C. R. Bruce and M. A. Febbraio Protein kinase R (PKR) has been suggested to act as a mediator of ER stress and inflammation in obesity. Here, Lancaster et al. find that genetic loss of PKR does not alter the development of obesity, and suggest that the use of littermate controls may explain differences in mouse knockout phenotypes. 03 February 2016 | doi: 10.1038/ncomms10626 Biological Sciences  Medical research  Major bacterial lineages are essentially devoid of CRISPR-Cas viral defence systems OPEN David Burstein, Christine L. Sun, Christopher T. Brown, Itai Sharon, Karthik Anantharaman, Alexander J. Probst, Brian C. Thomas and Jillian F. Banfield It is thought that CRISPR-Cas systems, which confer acquired immunity to phage and archaeal viruses, are widespread among bacteria and archaea. Here, Burstein et al. show that entire lineages of uncultivated microorganisms are essentially devoid of CRISPR-Cas systems. 03 February 2016 | doi: 10.1038/ncomms10613 Biological Sciences  Genetics  Microbiology  Virology  Diapause is associated with a change in the polarity of secretion of insulin-like peptides OPEN Yohei Matsunaga, Yoko Honda, Shuji Honda, Takashi Iwasaki, Hiroshi Qadota, Guy M. Benian and Tsuyoshi Kawano Insulin-like peptides INS-7 and INS-35 suppress larval diapause in Caenorhabditis elegans via unknown mechanism. Here, Matsunaga et al. show that the secretory polarity of both peptides changes in diapause, when these peptides are secreted into the intestinal lumen instead of the body cavity like in other larval stages. 03 February 2016 | doi: 10.1038/ncomms10573 Biological Sciences  Developmental biology  Seamless growth of a supramolecular carpet OPEN Ju-Hyung Kim, Jean-Charles Ribierre, Yu Seok Yang, Chihaya Adachi, Maki Kawai, Jaehoon Jung, Takanori Fukushima and Yousoo Kim The potential of organic molecular devices are limited by our inability to uniformly arrange them as thin films on metals, especially over imperfect surfaces. Here, the authors demonstrate the growth of a self-organized molecular carpet, which can extend over steps and terraces while retaining regularity. 03 February 2016 | doi: 10.1038/ncomms10653 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease OPEN Tuulia Hyötyläinen, Livnat Jerby, Elina M. Petäjä, Ismo Mattila, Sirkku Jäntti, Petri Auvinen, Amalia Gastaldelli, Hannele Yki-Järvinen, Eytan Ruppin and Matej Orešič Non-alcoholic fatty liver disease (NAFLD) is a risk factor for other types of liver diseases. Here, the authors integrate transcriptomic and metabolomic data from patients with NAFLD with a genome-scale metabolic model to paint a comprehensive picture of liver function in NAFLD. 03 February 2016 | doi: 10.1038/ncomms9994 Biological Sciences  Medical research  High-efficiency electrochemical thermal energy harvester using carbon nanotube aerogel sheet electrodes OPEN Hyeongwook Im, Taewoo Kim, Hyelynn Song, Jongho Choi, Jae Sung Park, Raquel Ovalle-Robles, Hee Doo Yang, Kenneth D. Kihm, Ray H. Baughman, Hong H. Lee, Tae June Kang and Yong Hyup Kim Conversion of low-grade waste heat into electricity is an important energy harvesting strategy. Here, the authors fabricate carbon nanotube aerogel-based thermo-electrochemical cells, which are potentially low-cost and relatively high-efficiency materials for this application. 03 February 2016 | doi: 10.1038/ncomms10600 Chemical Sciences  Materials science  Nanotechnology  Physical chemistry  Homochiral D4-symmetric metal–organic cages from stereogenic Ru(II) metalloligands for effective enantioseparation of atropisomeric molecules OPEN Kai Wu, Kang Li, Ya-Jun Hou, Mei Pan, Lu-Yin Zhang, Ling Chen and Cheng-Yong Su Homochiral molecular capsules offer potential applications in chiral separation and stereospecific catalysis. Here, by pre-resolution of Δ/Λ-metalloligand precursors, the authors are able to assemble enantiopure supramolecular cages capable of stereoselective host-guest behaviour. 03 February 2016 | doi: 10.1038/ncomms10487 Chemical Sciences  Inorganic chemistry  Organic chemistry  Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4 OPEN Petra Hartmann, Zhe Zhou, Lucia Natarelli, Yuanyuan Wei, Maliheh Nazari-Jahantigh, Mengyu Zhu, Jochen Grommes, Sabine Steffens, Christian Weber and Andreas Schober The RNAse III endonuclease Dicer is crucial for processing of pre-miRNAs in health and disease. Here the authors show that endothelial Dicer promotes atherosclerosis by increasing miR-103 levels leading to suppression of the anti-inflammatory transcription factor KLF4, thus suggesting a novel approach to treat this disease. 03 February 2016 | doi: 10.1038/ncomms10521 Biological Sciences  Cell biology  Medical research  Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders OPEN Takanobu Nakazawa, Ryota Hashimoto, Kazuto Sakoori, Yuki Sugaya, Asami Tanimura, Yuki Hashimotodani, Kazutaka Ohi, Hidenaga Yamamori, Yuka Yasuda, Satomi Umeda-Yano, Yuji Kiyama, Kohtarou Konno, Takeshi Inoue, Kazumasa Yokoyama, Takafumi Inoue, Shusuke Numata, Tohru Ohnuma, Nakao Iwata, Norio Ozaki, Hitoshi Hashimoto et al. The molecular mechanisms of neurotrophin receptor trafficking are only partially understood. Here the authors show that ARHGAP33 interacts with SORT1 to regulate TrkB trafficking, the dysfunction of which impairs synapse development and leads to schizophrenia-related behavioural abnormalities in mice. 03 February 2016 | doi: 10.1038/ncomms10594 Biological Sciences  Neuroscience  Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin OPEN K. Long, L. Moss, L. Laursen, L. Boulter and C. ffrench-Constant The extracellular matrix is suggested to play a role in neurogenesis, but it is unclear what role integrin signalling may play in the developing neuroepithelium. Here, in chick, Long et al. show that expression of constitutively active integrin beta-1 enhances neurogenesis via a novel Wnt7 and decorin pathway. 03 February 2016 | doi: 10.1038/ncomms10354 Biological Sciences  Cell biology  Developmental biology  Stabilization of active matter by flow-vortex lattices and defect ordering OPEN Amin Doostmohammadi, Michael F. Adamer, Sumesh P. Thampi and Julia M. Yeomans Active matter can be described as either wet or dry, depending on whether hydrodynamics or frictional damping dominates the interactions. Here, the authors show that an increase in friction can stabilise the chaotic flow observed in wet active systems to give an ordered lattice of topological defects. 03 February 2016 | doi: 10.1038/ncomms10557 Physical Sciences  Fluids and plasma physics  Materials science  Theoretical physics  Evidence for the stability of the West Antarctic Ice Sheet divide for 1.4 million years OPEN Andrew S. Hein, John Woodward, Shasta M. Marrero, Stuart A. Dunning, Eric J. Steig, Stewart P. H. T. Freeman, Finlay M. Stuart, Kate Winter, Matthew J. Westoby and David E. Sugden Predicting the West Antarctic Ice Sheet's response to future warming is hindered by a lack of historical evidence. Here, based on geomorphological evidence from and cosmogenic dating of Ellsworth Mountains' deposits, the authors show that at least a regional ice sheet survived Pleistocene interglacial cycles. 03 February 2016 | doi: 10.1038/ncomms10325 Earth Sciences  Climate science  Geology and geophysics  Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation OPEN Kien Nguyen and Paul C. Whitford During protein elongation, the translocation of mRNA and tRNA molecules across the 30S ribosomal subunit is associated with large-scale motions of the 30S head domain. Here the authors carry out MD simulations to probe the associated steric interactions and identify novel tilting motions during the late stages of translocation. 03 February 2016 | doi: 10.1038/ncomms10586 Biological Sciences  Biophysics  Ferroelastic switching in a layered-perovskite thin film OPEN Chuanshou Wang, Xiaoxing Ke, Jianjun Wang, Renrong Liang, Zhenlin Luo, Yu Tian, Di Yi, Qintong Zhang, Jing Wang, Xiu-Feng Han, Gustaaf Van Tendeloo, Long-Qing Chen, Ce-Wen Nan, Ramamoorthy Ramesh and Jinxing Zhang Ferroelastic switching in thin films is typically restricted by constraints from the substrate or occurs around twin-like domains. Here, the authors show reversible and non-volatile ferroelastic switching avoiding substrate constraints in layered-perovskite Bi_2WO_6 epitaxial films. 03 February 2016 | doi: 10.1038/ncomms10636 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Liver-derived ketone bodies are necessary for food anticipation OPEN Rohit Chavan, Céline Feillet, Sara S. Fonseca Costa, James E. Delorme, Takashi Okabe, Jürgen A. Ripperger and Urs Albrecht Food anticipation is thought to be initiated by the central clock in the brain. Here the authors show that the peripheral organs initiate this process by showing that liver-specific deletion of Per2 can inhibit food anticipation by interfering with ß-hydroxybutyrate production and its subsequent processing in the brain. 03 February 2016 | doi: 10.1038/ncomms10580 Biological Sciences  Biochemistry  Neuroscience  Common and rare variants associating with serum levels of creatine kinase and lactate dehydrogenase OPEN Ragnar P. Kristjansson, Asmundur Oddsson, Hannes Helgason, Gardar Sveinbjornsson, Gudny A. Arnadottir, Brynjar O. Jensson, Aslaug Jonasdottir, Adalbjorg Jonasdottir, G. Bragi Walters, Gerald Sulem, Arna Oskarsdottir, Stefania Benonisdottir, Olafur B. Davidsson, Gisli Masson, Olafur Th Magnusson, Hilma Holm, Olof Sigurdardottir, Ingileif Jonsdottir, Gudmundur I. Eyjolfsson, Isleifur Olafsson et al. Creatine kinase (CK) and lactate dehydrogenase (LDH) are biomarkers of tissue damages including myopathy and myocardial infarction. Here, Patrick Sulem and colleagues perform a genome-wide association study to identify common and rare genetic variants that associates with serum CK or LDH levels. 03 February 2016 | doi: 10.1038/ncomms10572 Biological Sciences  Genetics  Humans and seasonal climate variability threaten large-bodied coral reef fish with small ranges OPEN C. Mellin, D. Mouillot, M. Kulbicki, T. R. McClanahan, L. Vigliola, C. J. A. Bradshaw, R. E. Brainard, P. Chabanet, G. J. Edgar, D. A. Fordham, A. M. Friedlander, V. Parravicini, A. M. M. Sequeira, R. D. Stuart-Smith, L. Wantiez and M. J. Caley Knowing which species traits may confer resilience to human-mediated stressors will help predict future impacts on biodiversity. Here, Mellin et al. show that large bodied fish with small geographic ranges are disproportionately affected by the negative impacts of human disturbance and climate variability. 03 February 2016 | doi: 10.1038/ncomms10491 Biological Sciences  Ecology  Oceanography  Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo OPEN Takeshi Yoshimatsu, Florence D. D’Orazi, Clare R. Gamlin, Sachihiro C. Suzuki, Arminda Suli, David Kimelman, David W. Raible and Rachel O. Wong Neurons in the zebrafish retina regenerate. Here, Yoshimatsu and colleagues show that retinal horizontal cells maintain their synaptic preferences for a limited period before circuit remodeling is triggered after photoreceptor loss. 03 February 2016 | doi: 10.1038/ncomms10590 Biological Sciences  Cell biology  Developmental biology  Neuroscience  Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis OPEN Qi Cui, Su Yang, Peng Ye, E. Tian, Guoqiang Sun, Jiehua Zhou, Guihua Sun, Xiaoxuan Liu, Chao Chen, Kiyohito Murai, Chunnian Zhao, Krist T. Azizian, Lu Yang, Charles Warden, Xiwei Wu, Massimo D'Apuzzo, Christine Brown, Behnam Badie, Ling Peng, Arthur D. Riggs et al. TLX is a nuclear receptor essential for neural stem cell self-renewal and recently involved in glioblastoma development. In this study, the authors show that inhibition of TLX expression, achieved using a dendrimer nanovector-delivered siRNAs or viral vector-delivered shRNAs, reduces glioblastoma stem cells self renewal and in vivo tumour growth through activation of TET3. 03 February 2016 | doi: 10.1038/ncomms10637 Biological Sciences  Cancer  Cell biology  Rapid intensification and the bimodal distribution of tropical cyclone intensity OPEN Chia-Ying Lee, Michael K. Tippett, Adam H. Sobel and Suzana J. Camargo Tropical cyclones rarely achieve high intensities gradually. Here, the authors show that rapid intensification is relevant not only to short-term weather forecasting, but also to the relationship between tropical cyclones and climate. 03 February 2016 | doi: 10.1038/ncomms10625 Earth Sciences  Atmospheric science  Climate science    Nature Communications JOBS of the week Postdoctoral Fellowships in Health Sciences - 45 positions University of Oslo Senior Staff Research Associate University of California - San Francisco Research Assistant University of Bristol Research Associate The University of Manchester Research Fellow TU Dresden Research Scientist Coriell Institute for Medical Research Postdoctoral Research Assistant - Bioinformatics University of Dundee MRC Postdoctoral Scientist Medical Research Council 1-year bridging Post Doc fellowship Danish Diabetes Academy INDP2016 - 8 Fully Funded PhD Fellowships Champalimaud Neuroscience Programme More Science jobs from Nature Communications EVENT Techniques &Applications of Molecular Biology 11.07.16 Coventry, UK More science events from       Latest Corrigenda     Corrigendum: Glycan complexity dictates microbial resource allocation in the large intestine OPEN Artur Rogowski, Jonathon A. Briggs, Jennifer C. Mortimer, Theodora Tryfona, Nicolas Terrapon, Elisabeth C. Lowe, Arnaud Baslé, Carl Morland, Alison M. Day, Hongjun Zheng, Theresa E. Rogers, Paul Thompson, Alastair R. Hawkins, Madhav P. Yadav, Bernard Henrissat, Eric C. Martens, Paul Dupree, Harry J. Gilbert and David N. Bolam 05 February 2016 | doi: 10.1038/ncomms10705 Biological Sciences  Biochemistry  Microbiology      Corrigendum: An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer OPEN D. M. Janzen, E. Tiourin, J. A. Salehi, D. Y. Paik, J. Lu, M. Pellegrini and S. Memarzadeh 05 February 2016 | doi: 10.1038/ncomms10703 Biological Sciences  Cancer  Cell biology  Medical research      Corrigendum: Systematic pan-cancer analysis of tumour purity OPEN Dvir Aran, Marina Sirota and Atul J. Butte 05 February 2016 | doi: 10.1038/ncomms10707 Biological Sciences  Cancer  Immunology        Latest Erratum     Erratum: Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy Hilary A. Kenny, Madhu Lal-Nag, Erin A. White, Min Shen, Chun-Yi Chiang, Anirban K. Mitra, Yilin Zhang, Marion Curtis, Elizabeth M. Schryver, Sam Bettis, Ajit Jadhav, Matthew B. Boxer, Zhuyin Li, Marc Ferrer and Ernst Lengyel 03 February 2016 | doi: 10.1038/ncomms10649 Biological Sciences  Cancer        Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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