Molecular Systems Biology - New articles published - 11 Jan 2016

November 2015 | Volume 11, Number 11 Submit Table of Contents Articles News & Views Volume 11, Number 11 Articles Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases The disordered part of the human proteome contains a large number of short linear motif occurrences that can bind to MAP kinases. These simple protein‐protein recruitment sites represent a major resource for ancient signaling enzymes to acquire new regulatory roles. András Zeke, Tomas Bastys, Anita Alexa, Ágnes Garai, Bálint Mészáros, Klára Kirsch, Zsuzsanna Dosztányi, Olga V Kalinina, and Attila Reményi Published online 03.11.2015 An experimentally supported model of the Bacillus subtilis global transcriptional regulatory network A new computational framework integrating network component analysis and model selection is combined with transcriptomic datasets and generates an expanded and more accurate transcriptional regulatory network (TRN) for Bacillus subtilis. Mario L Arrieta‐Ortiz, Christoph Hafemeister, Ashley Rose Bate, Timothy Chu, Alex Greenfield, Bentley Shuster, Samantha N Barry, Matthew Gallitto, Brian Liu, Thadeous Kacmarczyk, Francis Santoriello, Jie Chen, Christopher DA Rodrigues, Tsutomu Sato, David Z Rudner, Adam Driks, Richard Bonneau, and Patrick Eichenberger Published online 17.11.2015 A synthetic growth switch based on controlled expression of RNA polymerase Bacterial growth can be switched on/off by expressing the RNA polymerase large subunits under the control of an inducible promoter. When growth is switched off, cells reorient nutrient fluxes to increase the production of a metabolite of interest. Jérôme Izard, Cindy DC Gomez Balderas, Delphine Ropers, Stephan Lacour, Xiaohu Song, Yifan Yang, Ariel B Lindner, Johannes Geiselmann, and Hidde de Jong Published online 23.11.2015 Frequency modulation of ERK activation dynamics rewires cell fate Dynamic manipulation of ERK signaling at the single cell level reveals new features of the MAPK network topology and induces robust signaling responses that rewire cell fate decision independently of growth factor identity. Hyunryul Ryu, Minhwan Chung, Maciej Dobrzyński, Dirk Fey, Yannick Blum, Sung Sik Lee, Matthias Peter, Boris N Kholodenko, Noo Li Jeon, and Olivier Pertz Published online 27.11.2015 News & Views Signaling output: it's all about timing and feedbacks Different signals are transmitted by the same signaling pathway. Pertz and colleagues (Ryu et al, 2015) show by stimulation experiments with different ligands how the differential engagement of feedback and feed‐forward regulation leads to different pathway activity dynamics and alters cell fate. Nils Blüthgen Published online 27.11.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.