Nature Communications - 09 December 2015

Weekly Content Alert Nature Communications is now fully open access. Read more. 09 December 2015  Featured image: Atherton et al. show how two proteins respond to the cell’s pulling force to promote the formation of focal adhesions. Latest content: Review Articles Corrigendum Journal homepage Recommend to library Web feed     Latest Review View all Reviews     The structural origin of anomalous properties of liquid water OPEN Anders Nilsson and Lars G. M. Pettersson Water is the most common liquid in nature, with unusual properties that could be linked to the peculiar hydrogen-bonding network holding the molecules together. Here, Nilsson and Pettersson review recent progress in searching the connections between local configurations and thermodynamic responses of water. 08 December 2015 | doi: 10.1038/ncomms9998 Physical Sciences  Fluids and plasma physics  Physical chemistry        Latest Articles View all Articles     A DNA-based system for selecting and displaying the combined result of two input variables OPEN Huajie Liu, Jianbang Wang, Shiping Song, Chunhai Fan and Kurt V. Gothelf DNA based sensors provide substantial amounts of information that requires integration and processing. Here the authors demonstrate a DNA-based calculator that takes two inputs, identifies the solution in a library of answers and displays the result. 08 December 2015 | doi: 10.1038/ncomms10089 Biological Sciences  Molecular biology  Declining resilience of ecosystem functions under biodiversity loss OPEN Tom H. Oliver, Nick J. B. Isaac, Tom A. August, Ben A. Woodcock, David B. Roy and James M. Bullock Global change may affect the resilience of ecosystem functions by altering community composition. Here, Oliver et al. show that in Great Britain since the 1970s there have been significant net declines among animal species that provide key ecosystem functions such as pollination and pest control. 08 December 2015 | doi: 10.1038/ncomms10122 Biological Sciences  Ecology  EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques OPEN Hye Yun Kim, Hyunjin Vincent Kim, Seonmi Jo, C. Justin Lee, Seon Young Choi, Dong Jin Kim and YoungSoo Kim Amyloid-beta deposits are a pathological hallmark of Alzheimer’s disease, and have previously been targeted in immunisation therapies. Here, the authors show that oral administration of the small molecule EPPS reduces Aß plaque and oligomer load in APP/PS1 mice and improves learning and memory performance. 08 December 2015 | doi: 10.1038/ncomms9997 Biological Sciences  Cell biology  Neuroscience  Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant OPEN Enrico Leipold, Andrea Hanson-Kahn, Miya Frick, Ping Gong, Jonathan A. Bernstein, Martin Voigt, Istvan Katona, R. Oliver Goral, Janine Altmüller, Peter Nürnberg, Joachim Weis, Christian A. Hübner, Stefan H. Heinemann and Ingo Kurth A mutation in the sodium channel Nav1.9 has been identified in a family and shown to associate with cold-aggravated pain. Here, the authors characterize the electrophysiological consequences of this mutation and propose a mechanism for the pain that the individuals experience. 08 December 2015 | doi: 10.1038/ncomms10049 Biological Sciences  Biochemistry  Genetics  Neuroscience  SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment OPEN Syed A. Mian, Kevin Rouault-Pierre, Alexander E. Smith, Thomas Seidl, Irene Pizzitola, Aytug Kizilors, Austin G. Kulasekararaj, Dominique Bonnet and Ghulam J. Mufti Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders with diverse phenotypes and can derive from hematopietic stem cells after the acquisition of specific somatic aberrations. In this study, the authors show that MDS initiating cells in some cases of sideroblastic anemia with SF3B1 mutations, can arise from hematopoietic stem cells. 08 December 2015 | doi: 10.1038/ncomms10004 Biological Sciences  Cancer  Genetics  Medical research  PAM multiplicity marks genomic target sites as inhibitory to CRISPR-Cas9 editing OPEN Abba Malina, Christopher J. F. Cameron, Francis Robert, Mathieu Blanchette, Josée Dostie and Jerry Pelletier A key step for the use of CRISPR-Cas9 in any study is the design of the guide RNA, however the underlying principles are still poorly understood. Here the authors show that multiple protospacer adjacent motif sequences are refractory to efficient targeting and repair. 08 December 2015 | doi: 10.1038/ncomms10124 Biological Sciences  Molecular biology  Asymmetric intramolecular α-cyclopropanation of aldehydes using a donor/acceptor carbene mimetic OPEN Chaosheng Luo, Zhen Wang and Yong Huang The formation of chiral centres adjacent to carbonyl groups is a highly challenging task in asymmetric catalysis. Here, the authors report the asymmetric diakylation of carbonyls via an intramolceular α-cyclopropanation procedure. 08 December 2015 | doi: 10.1038/ncomms10041 Chemical Sciences  Catalysis  Organic chemistry  Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila OPEN Honggang Wu, Manu, Renjie Jiao and Jun Ma How pattern formation is regulated relative to the size of an organism is unclear. Here, Wu et al. take data from gap gene expression in flies of different sizes together with simulations, identifying how scaling emerges dynamically and that local patterning influences global gene regulatory networks. 08 December 2015 | doi: 10.1038/ncomms10031 Biological Sciences  Cell biology  Developmental biology  PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis OPEN Christian F. Nielsen, Diana Huttner, Anna H. Bizard, Seiki Hirano, Tian-Neng Li, Timea Palmai-Pallag, Victoria A. Bjerregaard, Ying Liu, Erich A. Nigg, Lily Hui-Ching Wang and Ian D. Hickson During mitosis the translocase PICH binds to ultrafine bridges formed from DNA catenanes that are unresolved by topoisomerase II. In this study, the authors show that PICH stimulates toposiomerase II activity and that they cooperate to resolve these structures. 08 December 2015 | doi: 10.1038/ncomms9962 Biological Sciences  Cell biology  The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids OPEN Mirjana Kessler, Karen Hoffmann, Volker Brinkmann, Oliver Thieck, Susan Jackisch, Benjamin Toelle, Hilmar Berger, Hans-Joachim Mollenkopf, Mandy Mangler, Jalid Sehouli, Christina Fotopoulou and Thomas F. Meyer The mechanisms underlying fallopian tube epithelial renewal are unclear. Here, Kessler et al. isolate adult stem cells from the human fallopian tube epithelium and generate 3D organoids from these cells in vitro that have a similar architecture to that of the fallopian tube. 08 December 2015 | doi: 10.1038/ncomms9989 Biological Sciences  Cell biology  Developmental biology  Magneto-optical investigation of spin–orbit torques in metallic and insulating magnetic heterostructures OPEN Mohammad Montazeri, Pramey Upadhyaya, Mehmet C. Onbasli, Guoqiang Yu, Kin L. Wong, Murong Lang, Yabin Fan, Xiang Li, Pedram Khalili Amiri, Robert N. Schwartz, Caroline A. Ross and Kang L. Wang The study of spin orbit torques in insulating materials via conventional transport methods is restricted due to low electrical conductivity. Here, the authors use magneto-optical methods to measure spin orbit torques in ferromagnetic-insulator/heavy-metal heterostructures. 08 December 2015 | doi: 10.1038/ncomms9958 Physical Sciences  Condensed matter  Magnetic microscopy and topological stability of homochiral Néel domain walls in a Pt/Co/AlOx trilayer OPEN M. J. Benitez, A. Hrabec, A. P. Mihai, T. A. Moore, G. Burnell, D. McGrouther, C. H. Marrows and S. McVitie Broken symmetry at the interface with a heavy metal gives rise to a chiral exchange interaction in ferromagnetic thin films, which may be used to control magnetic domain walls. Here, the authors demonstrate how this effect enforces topologically stable homochiral domain walls in a Pt/Co/AlOx trilayer. 08 December 2015 | doi: 10.1038/ncomms9957 Physical Sciences  Condensed matter  Identification and characterization of latency-associated peptide-expressing γδ T cells OPEN Rafael M. Rezende, Andre P. da Cunha, Chantal Kuhn, Stephen Rubino, Hanane M’Hamdi, Galina Gabriely, Tyler Vandeventer, Shirong Liu, Ron Cialic, Natalia Pinheiro-Rosa, Rafael P. Oliveira, Jellert T. Gaublomme, Nikolaus Obholzer, James Kozubek, Nathalie Pochet, Ana M. C. Faria and Howard L. Weiner Latency-associated peptide (LAP) is a membrane-bound form of TGF-β1. Here the authors show that LAP marks a subset of regulatory γδ T cells with innate gut-homing properties, which present antigen and induce CD4+ Foxp3+ in Peyer's patches and lamina propria. 08 December 2015 | doi: 10.1038/ncomms9726 Biological Sciences  Immunology  An event-based architecture for solving constraint satisfaction problems OPEN Hesham Mostafa, Lorenz K. Müller and Giacomo Indiveri Constraint satisfaction problems are typically solved using conventional von Neumann computing architectures, which are however ill-suited to solving them. Here, the authors present a prototype for an event-based architecture that yield state of the art performance on random SAT problems. 08 December 2015 | doi: 10.1038/ncomms9941 Physical Sciences  Applied physics  Theoretical physics  Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution OPEN S. Kasar, J. Kim, R. Improgo, G. Tiao, P. Polak, N. Haradhvala, M. S. Lawrence, A. Kiezun, S. M. Fernandes, S. Bahl, C. Sougnez, S. Gabriel, E. S. Lander, H. T. Kim, G. Getz and J. R. Brown The oncogenic events driving indolent chronic lymphocytic leukaemia are relatively unknown. Here, the authors perform whole genome sequencing on 30 such tumours and identify recurrent mutations in IGLL5 and two activation induced cytidine deaminase signatures that are operative at different stages of CLL evolution. 07 December 2015 | doi: 10.1038/ncomms9866 Biological Sciences  Cancer  Genetics  Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions OPEN Bernadette Nera, Hui-Shun Huang, Thao Lai and Lifeng Xu TRF2 is a member of the shelterin complex, essential in protecting telomeres from end-to-end fusions; however, increased levels of TRF2 are associated with cancer. Here, the authors show overexpression of TRF2 results in genomic instability through replication fork stalling and chromosome fusions. 07 December 2015 | doi: 10.1038/ncomms10132 Biological Sciences  Cell biology  Molecular biology  Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin OPEN Pan F. Chan, Velupillai Srikannathasan, Jianzhong Huang, Haifeng Cui, Andrew P. Fosberry, Minghua Gu, Michael M. Hann, Martin Hibbs, Paul Homes, Karen Ingraham, Jason Pizzollo, Carol Shen, Anthony J. Shillings, Claus E. Spitzfaden, Robert Tanner, Andrew J. Theobald, Robert A. Stavenger, Benjamin D. Bax and Michael N. Gwynn Type IIA topoisomerases (topo2As) create transient double-strand DNA breaks. Here, the authors report structures showing how QPT-1 binds in the DNA/topo2A complex at the same site as the fluoroquinolone moxifloxacin, and discuss the potential for developing new classes of antibiotics. 07 December 2015 | doi: 10.1038/ncomms10048 Biological Sciences  Biochemistry  Microbiology  Identification of an allosteric binding site for RORγt inhibition OPEN Marcel Scheepstra, Seppe Leysen, Geert C. van Almen, J. Richard Miller, Jennifer Piesvaux, Victoria Kutilek, Hans van Eenennaam, Hongjun Zhang, Kenneth Barr, Sunil Nagpal, Stephen M. Soisson, Maria Kornienko, Kristen Wiley, Nathaniel Elsen, Sujata Sharma, Craig C. Correll, B. Wesley Trotter, Mario van der Stelt, Arthur Oubrie, Christian Ottmann et al. Upon the binding of small ligands, nuclear receptors regulate the transcription of genes that are associated with a number of disease mechanisms. Here, the authors report on a novel allosteric ligand binding site on the nuclear receptor RORγt. 07 December 2015 | doi: 10.1038/ncomms9833 Biological Sciences  Biochemistry  Molecular biology  Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression OPEN Amy Tarangelo, Nathanael Lo, Rebecca Teng, Eunsun Kim, Linh Le, Deborah Watson, Emma E. Furth, Pichai Raman, Ursula Ehmer and Patrick Viatour E2F transcription factors are primarily known for the regulation of the cell cycle and are often dysregulated in cancer. Here, the authors show that during cancer progression E2F1 recruits a Pontin/Reptin complex to E2F target genes to open chromatin and increase E2F transcriptional response. 07 December 2015 | doi: 10.1038/ncomms10028 Biological Sciences  Cancer  Cell biology  Room-temperature in situ nuclear spin hyperpolarization from optically pumped nitrogen vacancy centres in diamond OPEN Jonathan P. King, Keunhong Jeong, Christophoros C. Vassiliou, Chang S. Shin, Ralph H. Page, Claudia E. Avalos, Hai-Jing Wang and Alexander Pines Methods to increase nuclear spin polarization can enhance the sensitivity of magnetic resonance techniques however they are often limited to unfavourable conditions. Here, the authors achieve room temperature hyperpolarization of bulk 13C nuclear spins by exploiting the optical response of nitrogen vacancy centers in diamond crystals. 07 December 2015 | doi: 10.1038/ncomms9965 Physical Sciences  Condensed matter  Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo OPEN Duy T. Tran, Andrius Masedunskas, Roberto Weigert and Kelly G. Ten Hagen The cytoskeleton plays a crucial role in secretion. Here Tran et al. demonstrate that cortical actin is rearranged at the site of vesicle fusion and recruited to fused secretory granules in Drosophila salivary glands, and show that branched actin nucleators are required for cargo expulsion. 07 December 2015 | doi: 10.1038/ncomms10098 Biological Sciences  Cell biology  Quadratic Fermi node in a 3D strongly correlated semimetal OPEN Takeshi Kondo, M. Nakayama, R. Chen, J. J. Ishikawa, E.-G. Moon, T. Yamamoto, Y. Ota, W. Malaeb, H. Kanai, Y. Nakashima, Y. Ishida, R. Yoshida, H. Yamamoto, M. Matsunami, S. Kimura, N. Inami, K. Ono, H. Kumigashira, S. Nakatsuji, L. Balents et al. 5d transition metal iridates provide a platform to study the combined effects of strong spin orbit coupling and strong electronic correlations. Here, the authors find a quadratic band touching in the band structure of Pr2Ir2O7, suggesting it may be tuned to form various strongly correlated topological phases. 07 December 2015 | doi: 10.1038/ncomms10042 Physical Sciences  Condensed matter  Hybrid integrated biological–solid-state system powered with adenosine triphosphate OPEN Jared M. Roseman, Jianxun Lin, Siddharth Ramakrishnan, Jacob K. Rosenstein and Kenneth L. Shepard There is enormous potential in combining the capabilities of the biological and the solid-state to create hybrid engineered systems. Here, the authors develop a technique to incorporate and activate ATPases in in vitro membranes to produce energy-harvestable currents to power an integrated circuit. 07 December 2015 | doi: 10.1038/ncomms10070 Biological Sciences  Bioengineering  Biophysics  Biotechnology  Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons OPEN Houbo Jiang, Zhimin Xu, Ping Zhong, Yong Ren, Gaoyang Liang, Haley A. Schilling, Zihua Hu, Yi Zhang, Xiaomin Wang, Shengdi Chen, Zhen Yan and Jian Feng The efficiency of reprogramming of fibroblasts into induced dopaminergic neurons is often low. Here, Jiang et al. demonstrate increased transdifferentiation rates by inducing cell cycle arrest, suppressing p53, Tet 1 and by adding neurotrophic factors to the media. 07 December 2015 | doi: 10.1038/ncomms10100 Biological Sciences  Cell biology  Neuroscience  DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons OPEN Olivia Engmann, Albert Giralt, Nicolas Gervasi, Lucile Marion-Poll, Laila Gasmi, Odile Filhol, Marina R. Picciotto, Diana Gilligan, Paul Greengard, Angus C. Nairn, Denis Hervé and Jean-Antoine Girault Changes in environment are known to alter reward system responses, although the underlying mechanisms are unclear. Here, Engmann et al. show that DARPP-32 interacts directly with β-adducin in the mouse striatum to regulate structural and behavioural plasticity in response to novel environment and drug exposure. 07 December 2015 | doi: 10.1038/ncomms10099 Biological Sciences  Cell biology  Neuroscience  Ontogeny of the maxilla in Neanderthals and their ancestors OPEN Rodrigo S. Lacruz, Timothy G. Bromage, Paul O’Higgins, Juan-Luis Arsuaga, Chris Stringer, Ricardo Miguel Godinho, Johanna Warshaw, Ignacio Martínez, Ana Gracia-Tellez, José María Bermúdez de Castro and Eudald Carbonell Unlike modern humans, Neanderthals had large and projecting faces. Here, the authors show that the maxilla of modern humans is distinct from those of the Neanderthal and Middle Pleistocene hominins from Sima de los Huesos because their growth processes differ markedly during the postnatal period. 07 December 2015 | doi: 10.1038/ncomms9996 Biological Sciences  Evolution  Palaeontology  Corticostriatal pathways contribute to the natural time course of positive mood OPEN Roee Admon and Diego A. Pizzagalli Positive mood can occur as a result of a stimulus or spontaneously. Admon and Pizzagalli measure variations in neural responses to a positive stimulus over time, and identify cortico-striatal interactions associated with sustained positive mood which are reduced in individuals with a history of depression. 07 December 2015 | doi: 10.1038/ncomms10065 Biological Sciences  Rapid RNA–ligand interaction analysis through high-information content conformational and stability landscapes OPEN Nathan J. Baird, James Inglese and Adrian R. Ferré-D’Amaré The structure and biological properties of RNAs are a function of changing cellular conditions. Here, Baird et al. report a high-throughput Förster resonance energy transfer (FRET) method to rapidly compare RNA structure modulation by cognate and non-cognate ligands across multiplexed solution conditions. 07 December 2015 | doi: 10.1038/ncomms9898 Biological Sciences  Biophysics  Molecular biology  Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics OPEN Pierre-Yves Colin, Balint Kintses, Fabrice Gielen, Charlotte M. Miton, Gerhard Fischer, Mark F. Mohamed, Marko Hyvönen, Diego P. Morgavi, Dick B Janssen and Florian Hollfelder Environmental DNA from unculturable microorganisms contains genes with useful functions that remain difficult to identify and isolate. Here Colin, Kintses et al. demonstrate the screening of millions of samples in pL volumes to directly identify new enzymatic activities and complements sequence-based approaches. 07 December 2015 | doi: 10.1038/ncomms10008 Biological Sciences  Analytical chemistry  Biochemistry  Real-space collapse of a polariton condensate OPEN L. Dominici, M. Petrov, M. Matuszewski, D. Ballarini, M. De Giorgi, D. Colas, E. Cancellieri, B. Silva Fernández, A. Bramati, G. Gigli, A. Kavokin, F. Laussy and D. Sanvitto Microcavity polaritons are a fluid of coupled photonic and electronic excitations that share many of the properties of Bose–Einstein condensates. Here, the authors show that the sudden creation of these bosonic fluids at high density results in the concentration of the particles, unlike an atomic gas that would expand. 04 December 2015 | doi: 10.1038/ncomms9993 Physical Sciences  Condensed matter  Optical physics  Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection OPEN Teng Zuo, Jianfeng Sun, Guiqin Wang, Liwei Jiang, Yanan Zuo, Danyang Li, Xuanling Shi, Xi Liu, Shilong Fan, Huanhuan Ren, Hongxing Hu, Lina Sun, Boping Zhou, Mifang Liang, Paul Zhou, Xinquan Wang and Linqi Zhang Unravelling the mechanism of the recognition of the highly pathogenic influenza A viruses by antibodies is important for understanding their protective function. Zuo et al. characterise the mechanism of recognition of the H5N1 influenza virus by human monoclonal antibodies isolated from convalescent individuals. 04 December 2015 | doi: 10.1038/ncomms9855 Biological Sciences  Immunology  Virology  Dynamic labelling of neural connections in multiple colours by trans-synaptic fluorescence complementation OPEN Lindsey J. Macpherson, Emanuela E. Zaharieva, Patrick J. Kearney, Michael H. Alpert, Tzu-Yang Lin, Zeynep Turan, Chi-Hon Lee and Marco Gallio The ability to map the activity of synapses within a circuit will help in elucidating the neural basis of behaviour. Here, Macpherson et al. report new strategies to specifically label active synapses in Drosophila with multi-colour fluorescence tags. 04 December 2015 | doi: 10.1038/ncomms10024 Biological Sciences  Genetics  Neuroscience  Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells OPEN Sree Deepthi Muthukrishnan, Xuehui Yang, Robert Friesel and Leif Oxburgh The growth factors BMP and FGF both stimulate the self-renewal of nephron progenitor cells (NPCs), but how these signals overlap is unclear. Here in the mouse, Muthukrishnan et al. find BMP7 and FGF9 coordinately regulate AP-1 transcriptional activity, promoting G1-S cell cycle progression and NPC proliferation. 04 December 2015 | doi: 10.1038/ncomms10027 Biological Sciences  Cell biology  Developmental biology  A highly reversible room-temperature lithium metal battery based on crosslinked hairy nanoparticles OPEN Snehashis Choudhury, Rahul Mangal, Akanksha Agrawal and Lynden A. Archer There is intensive research effort in suppressing lithium dendrite growth in lithium batteries. Here, the authors report the use of a crosslinked nanoparticle-polymer composite membrane with high mechanical strength and ionic conductivity which enables stable cycling of lithium metal batteries. 04 December 2015 | doi: 10.1038/ncomms10101 Physical Sciences  Materials science  Nanotechnology  Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis OPEN Sayaka Ishihara, Akihiko Nishikimi, Eiji Umemoto, Masayuki Miyasaka, Makoto Saegusa and Koko Katagiri Rap1, a member of the Ras family of small guanine triphosphatases, mediates lymphocyte adhesion to high endothelial venules. Here the authors show that depending on its activation status Rap1 plays a dual role in T cell adhesion and by regulating T cell homeostasis is involved in the protection from colitis. 04 December 2015 | doi: 10.1038/ncomms9982 Biological Sciences  Cell biology  Immunology  Enhancing the magnetic anisotropy of maghemite nanoparticles via the surface coordination of molecular complexes OPEN Yoann Prado, Niéli Daffé, Aude Michel, Thomas Georgelin, Nader Yaacoub, Jean-Marc Grenèche, Fadi Choueikani, Edwige Otero, Philippe Ohresser, Marie-Anne Arrio, Christophe Cartier-dit-Moulin, Philippe Sainctavit, Benoit Fleury, Vincent Dupuis, Laurent Lisnard and Jérôme Fresnais The enhancement of the magnetic anisotropy of superparamagnetic nanoparticles may increase their functionality. Here, the authors report that the functionalization of maghemite nanoparticles with cobalt(II) complexes enhances their magnetic anisotropy, and subsequently blocking temperature and coercive field. 04 December 2015 | doi: 10.1038/ncomms10139 Chemical Sciences  Inorganic chemistry  Materials science  Nanotechnology  MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours OPEN Elizabeth J. Perlman, Samantha Gadd, Stefan T. Arold, Anand Radhakrishnan, Daniela S. Gerhard, Lawrence Jennings, Vicki Huff, Jaime M. Guidry Auvil, Tanja M. Davidsen, Jeffrey S. Dome, Daoud Meerzaman, Chih Hao Hsu, Cu Nguyen, James Anderson, Yussanne Ma, Andrew J. Mungall, Richard A. Moore, Marco A. Marra, Charles G. Mullighan, Jing Ma et al. Wilms tumour is a rare renal neoplasm that primarily affects children but the genomic changes responsible for its development are currently largely unknown. In this study, the authors identify somatic mutations of the MLLT1 gene that are potentially involved in the aetiology of a subset of Wilms tumours. 04 December 2015 | doi: 10.1038/ncomms10013 Biological Sciences  Cancer  Genetics  Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation OPEN María Soler Artigas, Louise V. Wain, Suzanne Miller, Abdul Kader Kheirallah, Jennifer E. Huffman, Ioanna Ntalla, Nick Shrine, Ma’en Obeidat, Holly Trochet, Wendy L. McArdle, Alexessander Couto Alves, Jennie Hui, Jing Hua Zhao, Peter K. Joshi, Alexander Teumer, Eva Albrecht, Medea Imboden, Rajesh Rawal, Lorna M. Lopez, Jonathan Marten et al. Genetic and environmental factors impact on lung function, important in the diagnosis of pulmonary diseases. Here the authors use imputation of genotypes to the 1000 Genomes Project reference panel to identify novel, low frequency variants associated with lung function. 04 December 2015 | doi: 10.1038/ncomms9658 Biological Sciences  Genetics  In situ X-ray diffraction and the evolution of polarization during the growth of ferroelectric superlattices OPEN Benjamin Bein, Hsiang-Chun Hsing, Sara J. Callori, John Sinsheimer, Priya V. Chinta, Randall L. Headrick and Matthew Dawber X-ray diffraction provides valuable information on the crystalline order of materials, such as the spacing of atomic layers. Here, the authors demonstrate rapid in situ X-ray diffraction measurements of strained ferroelectric oxide thin film superlattices during their layer-by-layer deposition. 04 December 2015 | doi: 10.1038/ncomms10136 Physical Sciences  Condensed matter  Vinculin controls talin engagement with the actomyosin machinery OPEN Paul Atherton, Ben Stutchbury, De-Yao Wang, Devina Jethwa, Ricky Tsang, Eugenia Meiler-Rodriguez, Pengbo Wang, Neil Bate, Roy Zent, Igor L. Barsukov, Benjamin T. Goult, David R. Critchley and Christoph Ballestrem The mechanosensitive proteins talin and vinculin mediate the linkage between integrin-bound extracellular matrix and the actin cytoskeleton. Here the authors dissect distinct roles for two actin-binding sites within talin on adhesion complex assembly and maturation, which are regulated by vinculin binding to talin. 04 December 2015 | doi: 10.1038/ncomms10038 Biological Sciences  Cell biology  Fibrocyte-like cells mediate acquired resistance to anti-angiogenic therapy with bevacizumab OPEN Atsushi Mitsuhashi, Hisatsugu Goto, Atsuro Saijo, Van The Trung, Yoshinori Aono, Hirokazu Ogino, Takuya Kuramoto, Sho Tabata, Hisanori Uehara, Keisuke Izumi, Mitsuteru Yoshida, Hiroaki Kobayashi, Hidefusa Takahashi, Masashi Gotoh, Soji Kakiuchi, Masaki Hanibuchi, Seiji Yano, Hiroyasu Yokomise, Shoji Sakiyama and Yasuhiko Nishioka et al. Acquired resistance to anti-angiogenic drugs, including bevacizumab, may occur in cancer patients. In this study the authors identify in the tumour microenvironment, fibrocyte-like cells derived from the bone marrow that mediate the resistance to bevacizumab through the production of FGF2. 04 December 2015 | doi: 10.1038/ncomms9792 Biological Sciences  Cancer  Cell biology  Medical research  Systematic pan-cancer analysis of tumour purity OPEN Dvir Aran, Marina Sirota and Atul J. Butte The importance of the tumour microenvironment has now been realised, however the presence of non-tumour cells in cancer samples can complicate genomic analyses. Here, the authors estimate tumour purity in 10,000 samples from the TCGA dataset and can detect a signature of T cell activation. 04 December 2015 | doi: 10.1038/ncomms9971 Biological Sciences  Cancer  Immunology  Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation OPEN Bhalchandra Jadhav, Michael McKenna, Nicholas Johnson, Stephen High, Irmgard Sinning and Martin R. Pool Sec62 is a membrane-bound protein that is involved in the translocation of proteins via the signal recognition particle-independent pathway. Here, the authors show that the receptor SRα displaces Sec62 from the translocon and isolate the domain on SRα that is responsible for this. 04 December 2015 | doi: 10.1038/ncomms10133 Biological Sciences  Cell biology  Molecular biology  Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7 OPEN Michael S. Minett, Vanessa Pereira, Shafaq Sikandar, Ayako Matsuyama, Stéphane Lolignier, Alexandros H. Kanellopoulos, Flavia Mancini, Gian D. Iannetti, Yury D. Bogdanov, Sonia Santana-Varela, Queensta Millet, Giorgios Baskozos, Raymond MacAllister, James J. Cox, Jing Zhao and John N. Wood Nav1.7 channels are known to regulate pain perception in humans and mice. Here, the authors provide evidence that Nav1.7 deletion leads to transcriptional upregulation of opioid peptides in sensory neurons, and that treatment with the opioid blocker naloxone helps reverse analgesia in mice and human Nav1.7 nulls. 04 December 2015 | doi: 10.1038/ncomms9967 Biological Sciences  Cell biology  Molecular biology  Neuroscience  Structural insights into the DNA-binding specificity of E2F family transcription factors OPEN Ekaterina Morgunova, Yimeng Yin, Arttu Jolma, Kashyap Dave, Bernhard Schmierer, Alexander Popov, Nadejda Eremina, Lennart Nilsson and Jussi Taipale The E2F family of transcription factors controls many important cellular processes. Here, the authors determine the structure of an atypical E2F that contains two DNA binding domains, and propose a mechanism of action for these atypical E2Fs. 03 December 2015 | doi: 10.1038/ncomms10050 Biological Sciences  Biochemistry  Molecular biology  Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8 OPEN Clinton Yu, Haibin Mao, Eric J. Novitsky, Xiaobo Tang, Scott D. Rychnovsky, Ning Zheng and Lan Huang Cullin-RING ubiquitin ligases (CRLs) require neddylation of their cullin scaffolds for full activity. Here the authors use a quantitative cross-linking mass spectrometry approach to characterize three different full-length human Cul1-Rbx1 complexes to shed light on how neddylation regulates the activity of CRLs. 03 December 2015 | doi: 10.1038/ncomms10053 Biological Sciences  Analytical chemistry  Biochemistry  The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs OPEN Benedikt M. Beckmann, Rastislav Horos, Bernd Fischer, Alfredo Castello, Katrin Eichelbaum, Anne-Marie Alleaume, Thomas Schwarzl, Tomaž Curk, Sophia Foehr, Wolfgang Huber, Jeroen Krijgsveld and Matthias W. Hentze RNA-binding proteins (RBPs) are implicated in many biological functions. Here the authors expand the human and yeast RNA interactome identifying new and conserved RBPs, several of which with no prior function assigned to RNA biology or structural motifs known to mediate RNA-binding, and suggesting new roles of RNA as modulators of protein function. 03 December 2015 | doi: 10.1038/ncomms10127 Biological Sciences  Biochemistry  Molecular biology  DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression OPEN Aliza P. Wingo, Lynn M. Almli, Jennifer J. Stevens, Torsten Klengel, Monica Uddin, Yujing Li, Angela C. Bustamante, Adriana Lori, Nastassja Koen, Dan J. Stein, Alicia K. Smith, Allison E. Aiello, Karestan C. Koenen, Derek E. Wildman, Sandro Galea, Bekh Bradley, Elisabeth B. Binder, Peng Jin, Greg Gibson and Kerry J. Ressler et al. DICER1 is required for the maturation of miRNAs which regulate expression of thousands of genes. Here the authors show significantly reduced levels of DICER1 in individuals having post-traumatic stress disorder and comorbid depression suggestive of a role in the molecular mechanism of the condition. 03 December 2015 | doi: 10.1038/ncomms10106 Biological Sciences  Genetics  Neuroscience  The effect of soil-borne pathogens depends on the abundance of host tree species OPEN Yu Liu, Suqin Fang, Peter Chesson and Fangliang He Fitness advantages conferred on species living at low density is thought to be one mechanism by which stable biodiversity is maintained. Here, Liu et al. show that recruitment of seedlings in high-density populations of a subtropical tree is suppressed by soil pathogens, with little effect at low-density. 03 December 2015 | doi: 10.1038/ncomms10017 Biological Sciences  Ecology  Optogenetic mutagenesis in Caenorhabditis elegans OPEN Kentaro Noma and Yishi Jin Inducing random mutation of C. elegans DNA is a widely used technique to investigate gene and protein function. Here the authors introduce a method of optogenetic mutagenesis, driving the generation of reactive oxygen species, which avoids the use of toxic chemicals. 03 December 2015 | doi: 10.1038/ncomms9868 Biological Sciences  Molecular biology  CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production OPEN Ludovic Arnold, Hélène Perrin, Camille Baudesson de Chanville, Marielle Saclier, Patricia Hermand, Lucie Poupel, Elodie Guyon, Fabrice Licata, Wassila Carpentier, José Vilar, Rémi Mounier, Bénédicte Chazaud, Nora Benhabiles, Alexandre Boissonnas, Béhazine Combadiere and Christophe Combadiere Chemokine-driven infiltration of inflammatory macrophages is central to the muscle regenerative response to injury. Here the authors show that the function of infiltrating macrophages is also important as notexin-induced muscle injury in mice is rescued by CX3CR1 knockout owing to enhanced ApoE production. 03 December 2015 | doi: 10.1038/ncomms9972 Biological Sciences  Medical research  Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency OPEN Michal Kovac, Claudia Blattmann, Sebastian Ribi, Jan Smida, Nikola S. Mueller, Florian Engert, Francesc Castro-Giner, Joachim Weischenfeldt, Monika Kovacova, Andreas Krieg, Dimosthenis Andreou, Per-Ulf Tunn, Hans Roland Dürr, Hans Rechl, Klaus-Dieter Schaser, Ingo Melcher, Stefan Burdach, Andreas Kulozik, Katja Specht, Karl Heinimann et al. Osteosarcomas are a heterogenous group of tumours and little is known about how these tumours evolve. Here, Kovac et al. use exome sequencing and discover that although no driver gene explains the majority of these tumours, they are characterized by specific mutation signatures and genomic instability typical of BRCA1/2-deficient tumours. 03 December 2015 | doi: 10.1038/ncomms9940 Biological Sciences  Cancer  Genetics  Asymmetric ring structure of Vps4 required for ESCRT-III disassembly OPEN Christophe Caillat, Pauline Macheboeuf, Yuanfei Wu, Andrew A. McCarthy, Elisabetta Boeri-Erba, Gregory Effantin, Heinrich G. Göttlinger, Winfried Weissenhorn and Patricia Renesto Vps4 is a AAA+ family protein involved in the disassembly of ESCRT-III polymers during membrane fission events such as occur during HIV budding. Here the authors propose a structure-based model of how the conformational flexibility of Vps4 can be translated into mechanical forces to disassemble ESCRT-III during membrane fission. 03 December 2015 | doi: 10.1038/ncomms9781 Biological Sciences  Biochemistry  Biophysics  Cell biology  Ultralight shape-recovering plate mechanical metamaterials OPEN Keivan Davami, Lin Zhao, Eric Lu, John Cortes, Chen Lin, Drew E. Lilley, Prashant K. Purohit and Igor Bargatin Unusual mechanical properties can be obtained with careful design of metamaterials. Here, Davami et al. use a microscale periodic cellular design to create plate mechanical metamaterials which exhibit ultralow mass per unit area, enhanced bending stiffness and ability to recover after extreme deformations. 03 December 2015 | doi: 10.1038/ncomms10019 Physical Sciences  Materials science  Nanotechnology  Nanoscale assembly processes revealed in the nacroprismatic transition zone of Pinna nobilis mollusc shells OPEN Robert Hovden, Stephan E. Wolf, Megan E. Holtz, Frédéric Marin, David A. Muller and Lara A. Estroff The study of biomineralization processes in molluscs can help to understand the properties of the final composites. Here, Hovden et al. have studied the early stages of nacre formation using high resolution scanning transmission electron microscopy, giving new insight into nacre formation. 03 December 2015 | doi: 10.1038/ncomms10097 Physical Sciences  Inorganic chemistry  Materials science  Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche OPEN Michelle A. Lawson, Michelle M. McDonald, Natasa Kovacic, Weng Hua Khoo, Rachael L. Terry, Jenny Down, Warren Kaplan, Julia Paton-Hough, Clair Fellows, Jessica A. Pettitt, T. Neil Dear, Els Van Valckenborgh, Paul A. Baldock, Michael J. Rogers, Colby L. Eaton, Karin Vanderkerken, Allison R. Pettit, Julian M. W. Quinn, Andrew C. W. Zannettino, Tri Giang Phan et al. Therapy resistant dormant myeloma cells contribute to disease relapse. Here, the authors use intravital microscopy to track the location of these cells and demonstrate that they hone to the endosteal niche within the bone. 03 December 2015 | doi: 10.1038/ncomms9983 Biological Sciences  Cancer  Medical research  PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype OPEN Shunlei Duan, Guohong Yuan, Xiaomeng Liu, Ruotong Ren, Jingyi Li, Weizhou Zhang, Jun Wu, Xiuling Xu, Lina Fu, Ying Li, Jiping Yang, Weiqi Zhang, Ruijun Bai, Fei Yi, Keiichiro Suzuki, Hua Gao, Concepcion Rodriguez Esteban, Chuanbao Zhang, Juan Carlos Izpisua Belmonte, Zhiguo Chen et al. The tumor suppressor PTEN is often mutated or lost in glioblastoma. Here, the authors demonstrate that in neuronal stem cells PTEN trans-represses PAX7 gene expression and PTEN deficiency promotes PAX7-dependent neoplastic transformation. 03 December 2015 | doi: 10.1038/ncomms10068 Biological Sciences  Cancer  Cell biology  Target engagement and drug residence time can be observed in living cells with BRET OPEN Matthew B. Robers, Melanie L. Dart, Carolyn C. Woodroofe, Chad A. Zimprich, Thomas A. Kirkland, Thomas Machleidt, Kevin R. Kupcho, Sergiy Levin, James R. Hartnett, Kristopher Zimmerman, Andrew L. Niles, Rachel Friedman Ohana, Danette L. Daniels, Michael Slater, Monika G. Wood, Mei Cong, Yi-Qiang Cheng and Keith V. Wood Drug molecules operate through physical interaction with specific cellular targets, and understanding this interaction is important for mechanisms and the potential therapeutic effect of drug candidates. Here, the authors show that bioluminescence resonance energy transfer can be used to monitor the intracellular engagement of a drug with its target. 03 December 2015 | doi: 10.1038/ncomms10091 Chemical Sciences  Chemical biology  Medicinal chemistry  Structured line illumination Raman microscopy OPEN Kozue Watanabe, Almar F. Palonpon, Nicholas I. Smith, Liang-da Chiu, Atsushi Kasai, Hitoshi Hashimoto, Satoshi Kawata and Katsumasa Fujita Raman imaging provides visualization of molecular content in a sample, but has been practically limited in resolution. Here, the authors implement structured line illumination in slit-scanning Raman microscopy, expanding its resolvable spatial frequencies without spoiling the advantage of the Raman approach. 02 December 2015 | doi: 10.1038/ncomms10095 Physical Sciences  Optical physics  Transformable liquid-metal nanomedicine OPEN Yue Lu, Quanyin Hu, Yiliang Lin, Dennis B. Pacardo, Chao Wang, Wujin Sun, Frances S. Ligler, Michael D. Dickey and Zhen Gu The use of inorganic carriers for drug delivery is often limited by toxicity and persistence of inorganic species in the body. Here, the authors report the use of nanocarriers with a liquid-phase eutectic gallium-indium core capable of delivering doxorubicin and subsequently fusing and degrading under mildly acidic conditions. 02 December 2015 | doi: 10.1038/ncomms10066 Chemical Sciences  Cancer  Chemical biology  Nanotechnology  Transformation and patterning of supermicelles using dynamic holographic assembly OPEN Oliver E.C. Gould, Huibin Qiu, David J. Lunn, John Rowden, Robert L. Harniman, Zachary M. Hudson, Mitchell A. Winnik, Mervyn J. Miles and Ian Manners Block copolymers can form micelles and assemblies of micelles (supermicelles) when placed in suitable solvents. Here, the authors use optical tweezers to control the arrangement and deposition of supermicelles into higher-order patterned nanostructures. 02 December 2015 | doi: 10.1038/ncomms10009 Physical Sciences  Condensed matter  Materials science  Physical chemistry  LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice OPEN Jeesun Kim, Anup Kumar Singh, Yoko Takata, Kevin Lin, Jianjun Shen, Yue Lu, Marc A. Kerenyi, Stuart H. Orkin and Taiping Chen At puberty, hormones stimulate mammalian oocytes to resume meiosis, which is linked to dynamic epigenetic changes, but what controls such changes are unknown. Here, Kim et al. identify LSD1, a lysine demethylase, as regulating histone methylation at meiotic progression and also female fertility. 02 December 2015 | doi: 10.1038/ncomms10116 Biological Sciences  Cell biology  Developmental biology  Boundaries can steer active Janus spheres OPEN Sambeeta Das, Astha Garg, Andrew I. Campbell, Jonathan Howse, Ayusman Sen, Darrell Velegol, Ramin Golestanian and Stephen J. Ebbens Self-propelled colloidal particles can be potentially used to transport cargoes at the microscale, but it is challenging to prevent randomization of their motion by Brownian rotations. Here, Das et al. quench these rotations by solid walls, which guide in-plane swimming without the need for external fields. 02 December 2015 | doi: 10.1038/ncomms9999 Physical Sciences  Fluids and plasma physics  Materials science  Physical chemistry  Phase diagram for the transition from photonic crystals to dielectric metamaterials OPEN Mikhail V. Rybin, Dmitry S. Filonov, Kirill B. Samusev, Pavel A. Belov, Yuri S. Kivshar and Mikhail F. Limonov Distinguishing between photonic crystals and metamaterials can provide a path for designing low-loss artificial materials with a range of novel applications. Here, Rybin et al. introduce a concept of phase transitions between all-dielectric metamaterials and photonic crystals based on the physics of Mie and Bragg resonances. 02 December 2015 | doi: 10.1038/ncomms10102 Physical Sciences  Materials science  Optical physics  Broadband chirality-coded meta-aperture for photon-spin resolving OPEN Luping Du, Shan Shan Kou, Eugeniu Balaur, Jasper J. Cadusch, Ann Roberts, Brian Abbey, Xiao-Cong Yuan, Dingyuan Tang and Jiao Lin Nano-apertures cannot distinguish between distinct spin-states of photons because of information loss upon light-aperture interaction. Here, Du et al. report a subwavelength aperture integrated with metasurfaces which breaks spin degeneracy and produces opposite transmission spectra over a broad spectral range. 02 December 2015 | doi: 10.1038/ncomms10051 Physical Sciences  Nanotechnology  Optical physics  Rapid emergence and predominance of a broadly recognizing and fast-evolving norovirus GII.17 variant in late 2014 OPEN Martin C. W. Chan, Nelson Lee, Tin-Nok Hung, Kirsty Kwok, Kelton Cheung, Edith K. Y. Tin, Raymond W. M. Lai, E. Anthony S. Nelson, Ting F. Leung and Paul K. S. Chan Norovirus GII.4 has been predominating in viral gastroenteritis for 20 years. Here the authors report the emergence and predominance of a novel fast-evolving GII.17 lineage norovirus causing viral gastroenteritis in Hong Kong, with a shift in age distribution of affected individuals towards an older age as compared to GII.4. 02 December 2015 | doi: 10.1038/ncomms10061 Biological Sciences  Evolution  Microbiology  Virology  Structural insight into the mechanism of synergistic autoinhibition of SAD kinases OPEN Jing-Xiang Wu, Yun-Sheng Cheng, Jue Wang, Lei Chen, Mei Ding and Jia-Wei Wu The SAD kinases contain a UBA domain that binds to the kinase domain and has a role in autoinhibition and allosteric activation of the AMPK homoenzyme. Here, the authors identify an autoinhibitory sequence in SAD and show that the UBA domain synergistically functions as an autoinhibitory domain. 02 December 2015 | doi: 10.1038/ncomms9953 Biological Sciences  Biochemistry  Structural diversity in binary superlattices self-assembled from polymer-grafted nanocrystals OPEN Xingchen Ye, Chenhui Zhu, Peter Ercius, Shilpa N. Raja, Bo He, Matthew R. Jones, Matthew R. Hauwiller, Yi Liu, Ting Xu and A. Paul Alivisatos Binary nanocrystal superlattice metamaterials are arousing significant interest due to their potential for use in functional devices. Here, the authors endow the nanoparticles with polymer brushes which enable control over their spacings and thus mesoscale structure and properties. 02 December 2015 | doi: 10.1038/ncomms10052 Physical Sciences  Condensed matter  Materials science  Nanotechnology  A tyrosine–tryptophan dyad and radical-based charge transfer in a ribonucleotide reductase-inspired maquette OPEN Cynthia V. Pagba, Tyler G. McCaslin, Gianluigi Veglia, Fernando Porcelli, Jiby Yohannan, Zhanjun Guo, Miranda McDaniel and Bridgette A. Barry Tyrosine-tryptophan dyads are known to mediate electron transfer reactions in a range of different proteins. Here, the authors study a beta hairpin peptide, probing the tyrosine-tryptophan interaction and showing no hydrogen bonding but rather charge transfer between the tyrosyl radical and tryptophan'. 02 December 2015 | doi: 10.1038/ncomms10010 Chemical Sciences  Biochemistry  Biophysics  Suppressing molecular motions for enhanced room-temperature phosphorescence of metal-free organic materials OPEN Min Sang Kwon, Youngchang Yu, Caleb Coburn, Andrew W. Phillips, Kyeongwoon Chung, Apoorv Shanker, Jaehun Jung, Gunho Kim, Kevin Pipe, Stephen R. Forrest, Ji Ho Youk, Johannes Gierschner and Jinsang Kim Phosphorescent materials made of purely organic components are typically less efficient than their organometallic counterparts. Here, the authors report a strategy to improve the phosphorescence efficiency of metal-free materials by reducing radiationless transitions by covalently linking into a polymer matrix. 02 December 2015 | doi: 10.1038/ncomms9947 Chemical Sciences  Materials science  Organic chemistry  Physical chemistry  Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus OPEN Carey Lambert, Ian T. Cadby, Rob Till, Nhat Khai Bui, Thomas R. Lerner, William S. Hughes, David J. Lee, Luke J. Alderwick, Waldemar Vollmer, Elizabeth R. Sockett and Andrew L. Lovering The bacterium Bdellovibrio bacteriovorus invades and kills other bacteria, but it is unclear how it avoids degradation of its own cell wall. Here the authors identify the B. bacteriovorus protein Bd3460 as an endopeptidase inhibitor that prevents hydrolysis of the predator’s peptidoglycan during invasion of prey. 02 December 2015 | doi: 10.1038/ncomms9884 Biological Sciences  Biochemistry  Microbiology  Molecular biology  High-efficiency polymer solar cells with small photon energy loss OPEN Kazuaki Kawashima, Yasunari Tamai, Hideo Ohkita, Itaru Osaka and Kazuo Takimiya Maximising short-circuit current density and open circuit voltage in polymer-fullerene solar cells is a critical issue. Here, the authors use an aphthobisoxadiazole-based polymer and observe a low photon energy loss of 0.5 eV, with an open-circuit voltage of 1 V and power conversion efficiency of 9%. 02 December 2015 | doi: 10.1038/ncomms10085 Chemical Sciences  Applied physics  Materials science  Physical chemistry    Nature Communications JOBS of the week Clinical Research Fellow Imperial College London 3 PhD positions - Research Assistant Technische Universität Berlin Research Fellow Queen's University Belfast Staff Associate Herbert Irving Comprehensive Cancer Center Senior Bioinformatician Band 6 Guys and St Thomas NHS Foundation Postdoctoral Fellow Rutgers New Jersey Medical School Young Researchers Wallenberg Academy Fellows - Swedish university Postdoc Positions University of Texas Research Fellow Job Mayo Clinic Tenure-Track Faculty Position Ohio State University More Science jobs from Nature Communications EVENT Translational Immunology in Kidney Disease - ISN Nexus Symposium 2016 14.04.16 Berlin, Germany More science events from       Latest Corrigendum     Corrigendum: Resistive switching and its suppression in Pt/Nb:SrTiO3 junctions OPEN Evgeny Mikheev, Brian D. Hoskins, Dmitri B. Strukov and Susanne Stemmer 07 December 2015 | doi: 10.1038/ncomms10128 Physical Sciences  Materials science  Nanotechnology      Advertisement An open access journal dedicated to highlighting the most important scientific advances in Parkinson's disease research, spanning the motor and non-motor disorders of Parkinson's disease. Part of the Nature Partner Journals series, npj Parkinson's Disease is published in partnership with the Parkinson's Disease Foundation.  Open for submissions   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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