The EMBO Journal Table of Contents for 14 October 2015; Vol. 34, No. 20

14 October 2015 | Volume 34, Number 20 Submit Table of Contents Editorial News & Views Articles Corrigenda Retractions Volume 34, Number 20 Editorial When things go wrong: correcting the scientific record Peer review is a successful quality assurance mechanism for a reliable scientific literature, but it does not always prevent the publication of flawed data. Journals need to be in a position to assess data and image aberrations and correct the literature. The scientific community should encourage author‐initiated corrections. Bernd Pulverer Published online 14.10.2015 News & Views pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit Several new structural studies provide insight into how autoinhibition of the mitophagy ubiquitin ligase Parkin is progressively relieved by PINK1‐dependent phosphorylation of ubiquitin and Parkin. Katja K Dove, Rachel E Klevit, and Katrin Rittinger Published online 07.09.2015 Stomaching Notch A new study shows that Notch signaling regulates the proliferation and differentiation of Lgr5 gastric stem cells and that uncontrolled Notch activity in stem cells leads to polyp formation. Xiaolei Yin and Jeffrey M Karp Published online 10.09.2015 Articles A Ubl/ubiquitin switch in the activation of Parkin A conformational switch between phospho‐ubiquitin binding and release of its ubiquitin‐like (Ubl) domain is a key step in the cascade of phosphorylation events that lead to activation of the ubiquitin ligase Parkin. Véronique Sauvé, Asparouh Lilov, Marjan Seirafi, Marta Vranas, Shafqat Rasool, Guennadi Kozlov, Tara Sprules, Jimin Wang, Jean‐François Trempe, and Kalle Gehring Published online 07.08.2015 Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis Three‐dimensional structures of parkin in various states reveal key control by its ubiquitin‐like domain (Ubl), which is allosterically displaced through phospho‐ubiquitin recruitment. Atul Kumar, Jacob D Aguirre, Tara EC Condos, R Julio Martinez‐Torres, Viduth K Chaugule, Rachel Toth, Ramasubramanian Sundaramoorthy, Pascal Mercier, Axel Knebel, Donald E Spratt, Kathryn R Barber, Gary S Shaw, and Helen Walden Published online 07.08.2015 Notch signaling regulates gastric antral LGR5 stem cell function The Notch signaling pathway is required to maintain LGR5+ antral stem cells and epithelial cell homeostasis. Elise S Demitrack, Gail B Gifford, Theresa M Keeley, Alexis J Carulli, Kelli L VanDussen, Dafydd Thomas, Thomas J Giordano, Zhenyi Liu, Raphael Kopan, and Linda C Samuelson Published online 12.08.2015 Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance Caenorhabditis elegans MKS‐5 (mammalian RPGRIP1L) is required for formation of the ciliary transition zone. MKS‐5 acts to exclude membrane‐associated signalling proteins from the TZ and limits PIP2 ciliary abundance. Victor L Jensen, Chunmei Li, Rachel V Bowie, Lara Clarke, Swetha Mohan, Oliver E Blacque, and Michel R Leroux Published online 21.09.2015 Alternative Hfq‐sRNA interaction modes dictate alternative mRNA recognition The RNA chaperone Hfq is required for most sRNA‐mediated regulation in bacteria. This study finds that sRNAs and mRNAs utilize distinct binding surfaces on Hfq, resulting in a combinatorial interaction that determines both sRNA stability and regulatory strength. Daniel J Schu, Aixia Zhang, Susan Gottesman, and Gisela Storz Published online 15.09.2015 Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG‐box transcription factor SOX‐2 The SOX‐2 transcription factor specifies terminal identities of distinct olfactory neurons by cooperating with cell type‐specific transcription factors in C. elegans. Amel Alqadah, Yi‐Wen Hsieh, Berta Vidal, Chieh Chang, Oliver Hobert, and Chiou‐Fen Chuang Published online 04.09.2015 Corrigenda Two classes of short interfering RNA in RNA silencing Andrew Hamilton, Olivier Voinnet, Louise Chappell, and David Baulcombe Published online 19.08.2015 Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4 Gabrielle Haas, Jacinthe Azevedo, Guillaume Moissiard, Angèle Geldreich, Christophe Himber, Marina Bureau, Toshiyuki Fukuhara, Mario Keller, and Olivier Voinnet Published online 19.08.2015 Differential effects of viral silencing suppressors on siRNA and miRNA loading support the existence of two distinct cellular pools of ARGONAUTE1 Gregory Schott, Arturo Mari‐Ordonez, Christophe Himber, Abdelmalek Alioua, Olivier Voinnet, and Patrice Dunoyer Published online 20.08.2015 Retractions Retraction: ‘Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana’ Gianinna Brigneti, Olivier Voinnet, Wan‐Xiang Li, Liang‐Hui Ji, Shou‐Wei Ding, and David C Baulcombe Published online 18.08.2015 Retraction: ‘An endogenous, systemic RNAi pathway in plants’ Patrice Dunoyer, Christopher A Brosnan, Gregory Schott, Yu Wang, Florence Jay, Abdelmalek Alioua, Christophe Himber, and Olivier Voinnet Published online 19.08.2015   Unsubscribe from or edit your subscription for this service. 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