Nature Reviews Molecular Cell Biology contents November 2015 Volume 16 Number 11 pp 639-698

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TABLE OF CONTENTS
November 2015 Volume 16 Number 11
Impact Factor 37.806 *	In this issue Research Highlights Addendum Progress Reviews Perspectives Also this month Article series: Technologies and techniques  Featured article: Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes Søren Lykke-Andersen & Torben Heick Jensen
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RESEARCH HIGHLIGHTS Top Molecular networks: Protein droplets in the spotlight p639 | doi:10.1038/nrm4070 Current research illustrates that various proteins, implicated in both physiological and pathological processes, can undergo phase separation to form liquid droplets. PDF Development: Ubiquitylation determines cell fate p640 | doi:10.1038/nrm4071 The ubiquitylation enzyme cullin 3 and its adaptor KBTBD8 mediate stem cell specification into neural crest by modulating the translation of a specific set of mRNAs. PDF DNA damage response: ATR prevents premature apoptosis p640 | doi:10.1038/nrm4072 The DNA damage response kinase ATR has an anti-apoptotic role in mitochondria. PDF In the news: The Nobel Prize 2015: The year of DNA repair p640 | doi:10.1038/nrm4078 DNA damage repair is in the spotlight this year — the Nobel Prize in Chemistry 2015 was awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar “for mechanistic studies of DNA repair”. PDF JOURNAL CLUB Reconciling randomness and precision p642 | doi:10.1038/nrm4077 Leonie Ringrose highlights how mathematical modelling can provide insights into fundamental mechanisms underlying epigenetic regulation. PDF Plant cell biology: CRISPR-Cas protection from plant viruses p642 | doi:10.1038/nrm4079 Transgenic plants expressing viral DNA-targeting components of the CRISPR-Cas genome editing system are immune to geminiviruses. PDF IN BRIEF Epigenetics: Methylation in paternal inheritance | Cell adhesion: SUMO controls a tug of war at junctions PDF Molecular Cell Biology JOBS of the week Postdoctoral researcher IBM, Zurich Research Laboratory Bioinformatics Postdoctoral Associate Baylor College of Medicine (BCM) Postdoctoral Research Associate UNC Lineberger Comprehensive Cancer Center Postdoctoral Fellow (210316) The Henry M.Jackson Foundation Research Scientist (#79025) California Institute for Biomedical Research More Science jobs from Molecular Cell Biology EVENT LS2 Annual Meeting 2016 15.02.16 Lausanne, Switzerland More science events from
ADDENDUM		Top
Ciliary phosphoinositides regulate Hedgehog signalling Katharine H. Wrighton p641 | doi:10.1038/nrm4075 Full Text | PDF
PROGRESS		Top
Targeting Polycomb systems to regulate gene expression: modifications to a complex story Neil P. Blackledge, Nathan R. Rose & Robert J. Klose p643 | doi:10.1038/nrm4067 Recent findings have demonstrated that Polycomb repressive complexes (PRCs) control gene expression through their co-recruitment to specific CpG island elements with transcription factors and non-coding RNAs. Moreover, they revealed that the interplay between PRC1 and PRC2 to achieve transcriptional repression is more intricate than was previously thought. Abstract | Full Text | PDF
REVIEWS		Top
Article series: Technologies and techniques Ribosome profiling reveals the what, when, where and how of protein synthesis Gloria A. Brar & Jonathan S. Weissman p651 | doi:10.1038/nrm4069 Ribosome profiling has the power to interrogate — in vivo and on a global scale — what is being translated, how this translation is regulated and where in the cell the translation of specific sets of proteins occurs. Abstract | Full Text | PDF | Supplementary information
Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes Søren Lykke-Andersen & Torben Heick Jensen p665 | doi:10.1038/nrm4063 Nonsense-mediated mRNA decay (NMD) degrades mRNAs with abnormally positioned translation termination codons. It is now becoming apparent that NMD targets mRNAs to enable mammalian cells to adjust their transcriptomes and their proteomes to changing physiological conditions and during diverse cellular processes. Abstract | Full Text | PDF | Supplementary information
Transcriptional regulation of hepatic lipogenesis Yuhui Wang, Jose Viscarra, Sun-Joong Kim & Hei Sook Sul p678 | doi:10.1038/nrm4074 Glucose from excess dietary carbohydrate is converted to fatty acids in the liver through de novo lipogenesis. Lipogenic genes have common features in their promoters and are coordinately regulated at the transcriptional level. Recent insights have been gained into the signalling pathways that regulate key transcription factors such as USFs, SREBP1C, LXRs and ChREBP. Abstract | Full Text | PDF
PERSPECTIVES		Top
TIMELINE The discovery of modular binding domains: building blocks of cell signalling Bruce J. Mayer p691 | doi:10.1038/nrm4068 The discovery of modular protein- and lipid-binding domains was a crucial turning point in our understanding of the logic and evolution of cell signalling mechanisms. The late, great Tony Pawson was instrumental in their discovery. Abstract | Full Text | PDF
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