Nature Communications - 21 October 2015

Advertisement Sputtered Metal Deep-UV Interference Filters Manufactured using single substrates of UV-grade fused silica and backed by warranty, these filters are available in 11 different passbands in a wide range of sizes, from 2mm-200mm. Laser damage thresholds >0.15 J/cm2 using a 355nm laser (10 ns pulse, 10 Hz), and suffer no degradation after 2 hours @ 300ºC. www.chroma.com     Weekly Content Alert Nature Communications is now fully open access. Read more. 21 October 2015  Featured image: Burns et al. map the development of the mouse inner ear, identifying cell subtypes and development cues using single-cell RNA-Seq. Latest content: Review Articles Corrigenda Journal homepage Recommend to library Web feed   Advertisement Nature Energy: Call for Papers Launching in January 2016, Nature Energy is now open for submissions and inviting high-quality research from across the natural and social sciences. The journal will be dedicated to exploring all aspects of the on-going discussion of energy provision; from the generation and storage of energy, to its distribution and management, the needs and demands of the different actors, and the impacts that energy technologies and policies have on societies. Submit your next research paper to the journal.       Latest Review View all Reviews     Structural analysis of hierarchically organized zeolites OPEN Sharon Mitchell, Ana B. Pinar, Jeffrey Kenvin, Paolo Crivelli, Jörg Kärger and Javier Pérez-Ramírez Hierarchically organized zeolites are materials retaining the crystalline order and associated functionality of bulk zeolites while also integrating a multilevel pore network. Here, the authors review the raft of techniques applied to characterize their crystal, pore and active site structures. 20 October 2015 | doi: 10.1038/ncomms9633 Chemical Sciences  Catalysis  Materials science        Latest Articles View all Articles     Electric eels use high-voltage to track fast-moving prey OPEN Kenneth C. Catania Weakly electric fish species use low-voltage to sense their surroundings, whereas a few strongly electric species use high-voltage as a weapon. Here the author shows that electric eels cross this boundary, using high-voltage simultaneously as a stunning weapon and as an electrical radar system to track fast-moving prey. 20 October 2015 | doi: 10.1038/ncomms9638 Biological Sciences  Zoology  Landscape simplification filters species traits and drives biotic homogenization OPEN Sagrario Gámez-Virués, David J. Perović, Martin M. Gossner, Carmen Börschig, Nico Blüthgen, Heike de Jong, Nadja K. Simons, Alexandra-Maria Klein, Jochen Krauss, Gwen Maier, Christoph Scherber, Juliane Steckel, Christoph Rothenwöhrer, Ingolf Steffan-Dewenter, Christiane N. Weiner, Wolfgang Weisser, Michael Werner, Teja Tscharntke and Catrin Westphal Agricultural intensification may negatively impact biodiversity via a number of mechanisms. Here, Gámez-Virués et al. show that landscape simplification acts as an environmental filter to homogenise grassland arthropod communities into pools of species with less specialised functional traits. 20 October 2015 | doi: 10.1038/ncomms9568 Biological Sciences  Ecology  Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa OPEN Brandyce St. Laurent, Becky Miller, Timothy A. Burton, Chanaki Amaratunga, Sary Men, Siv Sovannaroth, Michael P. Fay, Olivo Miotto, Robert W. Gwadz, Jennifer M. Anderson and Rick M. Fairhurst It is unknown whether artemisinin-resistant malaria parasites from Southeast Asia can infect any African species of Anopheles mosquitoes and thus spread to Africa. Here, St. Laurent et al. show that artemisinin-resistant isolates from Cambodia can indeed infect the major African vector, Anopheles coluzzii. 20 October 2015 | doi: 10.1038/ncomms9614 Biological Sciences  Microbiology  Activation and lysis of human CD4 cells latently infected with HIV-1 OPEN Amarendra Pegu, Mangaiarkarasi Asokan, Lan Wu, Keyun Wang, Jason Hataye, Joseph P. Casazza, Xiaoti Guo, Wei Shi, Ivelin Georgiev, Tongqing Zhou, Xuejun Chen, Sijy O’Dell, John-Paul Todd, Peter D. Kwong, Srinivas S. Rao, Zhi-yong Yang, Richard A. Koup, John R. Mascola and Gary J. Nabel The elimination of latently infected cells is a sought after goal in the treatment of HIV-1 infections. Here the authors develop an approach to eliminate latently HIV-1 infected cells by using an immunomodulatory protein, which can activate viral gene expression in these cells and direct T lymphocytes to lyse them in vitro. 20 October 2015 | doi: 10.1038/ncomms9447 Biological Sciences  Immunology  Medical research  Virology  Extremely durable biofouling-resistant metallic surfaces based on electrodeposited nanoporous tungstite films on steel OPEN Alexander B. Tesler, Philseok Kim, Stefan Kolle, Caitlin Howell, Onye Ahanotu and Joanna Aizenberg Steel is employed ubiquitously throughout human society thanks to its outstanding mechanical properties, however over time degradation can lead to a loss in performance. Here, the authors show that creating liquid-infused surfaces via electrodeposition of a tungstite film endows steel with a durable coating which inhibits corrosion and fouling. 20 October 2015 | doi: 10.1038/ncomms9649 Physical Sciences  Materials science  Nanotechnology  Structural isomserism in gold nanoparticles revealed by X-ray crystallography OPEN Shubo Tian, Yi-Zhi Li, Man-Bo Li, Jinyun Yuan, Jinlong Yang, Zhikun Wu and Rongchao Jin Revealing structural isomerism in nanoparticles remains a largely unresolved task. Here, the authors use several techniques, including single-crystal X-ray crystallography, to characterize two structural isomers of Au38, and report their different optical and catalytic properties and differences in stability. 20 October 2015 | doi: 10.1038/ncomms9667 Chemical Sciences  Catalysis  Inorganic chemistry  Nanotechnology  Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9 OPEN Lindsey K. Roper, Joseph S. Briguglio, Chantell S. Evans, Meyer B. Jackson and Edwin R. Chapman Pituitary gonadotropes secrete follicle-stimulating hormone (FSH) in both male and female mice. Roper et al. show that the synaptotagmin isoform syt-9 is specifically required for FSH secretion, but only in females, revealing a mechanism by which specificity can be encoded in complex secretory cells. 20 October 2015 | doi: 10.1038/ncomms9645 Biological Sciences  Cell biology  Neuroscience  Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases OPEN Lingyao Kong, Jinkui Cheng, Yujuan Zhu, Yanglin Ding, Jingjing Meng, Zhizhong Chen, Qi Xie, Yan Guo, Jigang Li, Shuhua Yang and Zhizhong Gong Signaling by the plant hormone abscisic acid (ABA) is regulated by the ABI1 protein phosphatase. Here Kong et al. propose that ABA signaling is fine-tuned by ubiquitination of ABI1 which promotes ABI degradation in response to ABA. 20 October 2015 | doi: 10.1038/ncomms9630 Biological Sciences  Plant sciences  High-temperature superconductivity in space-charge regions of lanthanum cuprate induced by two-dimensional doping OPEN F. Baiutti, G. Logvenov, G. Gregori, G. Cristiani, Y. Wang, W. Sigle, P. A. van Aken and J. Maier Introduction of higher-dimensional structure elements into solids is used to generate unusual materials properties. Here, the authors report how replacing LaO planes with SrO dopants yields space-charge induced superconductivity, showing the potential of two-dimensional doping in this field. 20 October 2015 | doi: 10.1038/ncomms9586 Physical Sciences  Condensed matter  Materials science  Quantifying randomness in real networks OPEN Chiara Orsini, Marija M. Dankulov, Pol Colomer-de-Simón, Almerima Jamakovic, Priya Mahadevan, Amin Vahdat, Kevin E. Bassler, Zoltán Toroczkai, Marián Boguñá, Guido Caldarelli, Santo Fortunato and Dmitri Krioukov Many complex properties of real networks appear as consequences of a small set of their basic properties. Here, the authors show that dk-random graphs that reproduce degree distributions, degree correlations, and clustering in real networks, reproduce a variety of their other properties as well. 20 October 2015 | doi: 10.1038/ncomms9627 Physical Sciences  Theoretical physics  Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection OPEN Brodie Miles, Shannon M. Miller, Joy M. Folkvord, Abigail Kimball, Mastooreh Chamanian, Amie L. Meditz, Tessa Arends, Martin D. McCarter, David N. Levy, Eva G. Rakasz, Pamela J. Skinner and Elizabeth Connick Antibody responses are impaired during HIV and SIV infection. Here the authors show that viral infection contributes to this process by multiple mechanisms acting on regulatory T follicular cells, including their expansion and increased suppression of the follicular T helper cells. 20 October 2015 | doi: 10.1038/ncomms9608 Biological Sciences  Immunology  Virology  Electromechanical oscillations in bilayer graphene OPEN Muhammed M. Benameur, Fernando Gargiulo, Sajedeh Manzeli, Gabriel Autès, Mahmut Tosun, Oleg V. Yazyev and Andras Kis Graphene nanoelectromechanical systems enable the study of the interplay between electrical conductivity and mechanical properties. Here, the authors observe oscillations in the electromechanical response of bilayer graphene due to wrinkling, rather than the linear response seen in single layers. 20 October 2015 | doi: 10.1038/ncomms9582 Physical Sciences  Materials science  Nanotechnology  Ultrafast electronic state conversion at room temperature utilizing hidden state in cuprate ladder system OPEN R. Fukaya, Y. Okimoto, M. Kunitomo, K. Onda, T. Ishikawa, S. Koshihara, H. Hashimoto, S. Ishihara, A. Isayama, H. Yui and T. Sasagawa Controlling material properties on sub-picosecond scales using photons could allow for ultrafast optoelectronic devices. Here, the authors propose an ultrafast photoinduced metal-to-insulator transition in a two-leg ladder cuprate superconductor based on time-resolved reflection spectroscopy. 20 October 2015 | doi: 10.1038/ncomms9519 Physical Sciences  Applied physics  Condensed matter  Cationic cluster formation versus disproportionation of low-valent indium and gallium complexes of 2,2’-bipyridine OPEN Martin R. Lichtenthaler, Florian Stahl, Daniel Kratzert, Lorenz Heidinger, Erik Schleicher, Julian Hamann, Daniel Himmel, Stefan Weber and Ingo Krossing Group 13 metals such as gallium and indium with oxidation states of +I tend to disproportionate into more stable 0 and +III states. Here, the authors report that with a 2,2'-bipyridine ligand Ga(+I) forms a paramagnetic mononuclear Ga(+III) complex, whereas the indium analogue aggregates forming cationic clusters retaining the +I state. 19 October 2015 | doi: 10.1038/ncomms9288 Chemical Sciences  Inorganic chemistry  Spectromicroscopic insights for rational design of redox-based memristive devices OPEN Christoph Baeumer, Christoph Schmitz, Amr H. H. Ramadan, Hongchu Du, Katharina Skaja, Vitaliy Feyer, Philipp Müller, Benedikt Arndt, Chun-Lin Jia, Joachim Mayer, Roger A. De Souza, Claus Michael Schneider, Rainer Waser and Regina Dittmann Memristive devices offer a future low-power solution to data storage and logic operations, but there is still a lack of suitable material design rules. Here, the authors present a design rule for retention-failure-resistant devices based on spectromicroscopic studies of strontium titanate. 19 October 2015 | doi: 10.1038/ncomms9610 Physical Sciences  Applied physics  Medical research  Observing in space and time the ephemeral nucleation of liquid-to-crystal phase transitions OPEN Byung-Kuk Yoo, Oh-Hoon Kwon, Haihua Liu, Jau Tang and Ahmed H. Zewail The phenomenon of crystallization is common in nature, but surprisingly the nucleation pathways from liquid to solid are poorly understood due to the lack of effective experimental probes. Yoo et al. observe the existence of a nucleation precursor in titanium dioxide using single-pulse electron microscopy. 19 October 2015 | doi: 10.1038/ncomms9639 Physical Sciences  Materials science  Physical chemistry  Observation of a phononic Mollow triplet in a multimode hybrid spin-nanomechanical system OPEN B. Pigeau, S. Rohr, L. Mercier de Lépinay, A. Gloppe, V. Jacques and O. Arcizet The Mollow triplet, originally observed in the fluorescence spectrum of an optically excited two level system, is a signature of quantum electrodynamics. Here, the authors observe its phononic equivalent by magnetically coupling a single nitrogen-vacancy qubit to the vibrations of a silicon carbide nanowire. 19 October 2015 | doi: 10.1038/ncomms9603 Physical Sciences  Atomic and molecular physics  Nanotechnology  Optical physics  Genetic discovery for oil production and quality in sesame OPEN Xin Wei, Kunyan Liu, Yanxin Zhang, Qi Feng, Linhai Wang, Yan Zhao, Donghua Li, Qiang Zhao, Xiaodong Zhu, Xiaofeng Zhu, Wenjun Li, Danlin Fan, Yuan Gao, Yiqi Lu, Xianmei Zhang, Xiumei Tang, Congcong Zhou, Chuanrang Zhu, Lifeng Liu, Ruichun Zhong et al. Sesame is a valuable oilseed crop with a small diploid genome and high seed-oil content making it an attractive model for genetic studies. Here, Wei et al. sequence more than 705 sesame varieties and perform a genome-wide association study to identify genes associated with important agronomic traits. 19 October 2015 | doi: 10.1038/ncomms9609 Biological Sciences  Genetics  Plant sciences  Directly measuring mean and variance of infinite-spectrum observables such as the photon orbital angular momentum OPEN Bruno Piccirillo, Sergei Slussarenko, Lorenzo Marrucci and Enrico Santamato The more degrees of freedom a quantum observable has, the more complicated it is to measure its probability distribution. Here, the authors deduce the mean and variance of an infinite-dimensional variable, the orbital angular momentum of light, from a two-dimensional one: spin angular momentum. 19 October 2015 | doi: 10.1038/ncomms9606 Physical Sciences  Optical physics  Quantum-secure covert communication on bosonic channels OPEN Boulat A. Bash, Andrei H. Gheorghe, Monika Patel, Jonathan L. Habif, Dennis Goeckel, Don Towsley and Saikat Guha Communications encryption does prevent unauthorized decoding, but does not ensure stealth of the transmission. Here, the authors characterize the quantum limits of covert communication on lossy thermal-noise bosonic channels. 19 October 2015 | doi: 10.1038/ncomms9626 Physical Sciences  Theoretical physics  High-performance mussel-inspired adhesives of reduced complexity OPEN B. Kollbe Ahn, Saurabh Das, Roscoe Linstadt, Yair Kaufman, Nadine R. Martinez-Rodriguez, Razieh Mirshafian, Ellina Kesselman, Yeshayahu Talmon, Bruce H. Lipshutz, Jacob N. Israelachvili and J. Herbert Waite Mussels use strong filaments to adhere to rocks, preventing them from being swept away in strong currents. Here, the authors borrow and simplify chemistries from the mussel foot to create a one component adhesive system which holds potential for employment in nanofabrication protocols. 19 October 2015 | doi: 10.1038/ncomms9663 Physical Sciences  Biotechnology  Materials science  Cavity-less on-chip optomechanics using excitonic transitions in semiconductor heterostructures OPEN Hajime Okamoto, Takayuki Watanabe, Ryuichi Ohta, Koji Onomitsu, Hideki Gotoh, Tetsuomi Sogawa and Hiroshi Yamaguchi Integrated optomechanical systems can be created by combining semiconductor optoelectronic devices and nanoscale resonators. Here, the authors demonstrate a semiconductor modulation-doped heterostructure-cantilever that achieves efficient optomechanical transduction without the need for an optical cavity. 19 October 2015 | doi: 10.1038/ncomms9478 Physical Sciences  Applied physics  Materials science  Optical physics  Enhancer repertoires are reshaped independently of early priming and heterochromatin dynamics during B cell differentiation OPEN Mohamed-Amin Choukrallah, Shuang Song, Antonius G. Rolink, Lukas Burger and Patrick Matthias Enhancers in differentiated haematopoietic cells are generally believed to be primed prior to lineage commitment. Here, the authors show that early priming and Polycomb group mediated silencing have minor roles in shaping the enhancer repertoire in differentiated B cells and that most active enhancers are generated de novo. 19 October 2015 | doi: 10.1038/ncomms9324 Biological Sciences  Cell biology  Molecular biology  Purely organic electroluminescent material realizing 100% conversion from electricity to light OPEN Hironori Kaji, Hajime Suzuki, Tatsuya Fukushima, Katsuyuki Shizu, Katsuaki Suzuki, Shosei Kubo, Takeshi Komino, Hajime Oiwa, Furitsu Suzuki, Atsushi Wakamiya, Yasujiro Murata and Chihaya Adachi Organic light-emitting diodes promise a more environment-friendly future for light sources, but many use rare metals. Here, the authors present an approach that achieves external quantum efficiency over 40% by realising 100% up-conversion from triplet to singlet excitons and thus 100% radiative emission. 19 October 2015 | doi: 10.1038/ncomms9476 Physical Sciences  Materials science  Optical physics  An Xist-activating antisense RNA required for X-chromosome inactivation OPEN Mrinal K. Sarkar, Srimonta Gayen, Surinder Kumar, Emily Maclary, Emily Buttigieg, Michael Hinten, Archana Kumari, Clair Harris, Takashi Sado and Sundeep Kalantry The X-chromosome linked long non-coding RNA, Xist, is a master regulator of the X inactivation. Here, the authors report that XistAR, an Xist anti-sense long non-coding RNA encoded within the mouse Xist gene and transcribed only from the inactive X chromosome, regulates Xist expression. 19 October 2015 | doi: 10.1038/ncomms9564 Biological Sciences  Genetics  Molecular biology  Cooperation is related to dispersal patterns in Sino-Tibetan populations OPEN Jia-Jia Wu, Ting Ji, Qiao-Qiao He, Juan Du and Ruth Mace Dispersal is key to establishing patterns of cooperation. Here, the authors show that social organization is associated with levels of cooperation in Sino-Tibetan populations with strikingly different dispersal patterns. 19 October 2015 | doi: 10.1038/ncomms9693 Biological Sciences  Evolution  Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function OPEN Karzan Muhammad, Suneel Reddy-Alla, Jan H Driller, Dietmar Schreiner, Ulises Rey, Mathias A. Böhme, Christina Hollmann, Niraja Ramesh, Harald Depner, Janine Lützkendorf, Tanja Matkovic, Torsten Götz, Dominique D. Bergeron, Jan Schmoranzer, Fabian Goettfert, Mathew Holt, Markus C. Wahl, Stefan W. Hell, Peter Scheiffele, Alexander M. Walter et al. Synaptic assembly depends on trans-synaptic Neurexin/Neuroligin signalling. Here, Muhammad et al. show that Spinophilin, a pre-synaptic scaffolding protein, interacts with Neurexin, in competition with Syd-1, to regulate the formation and function of synaptic active zones at Drosophila neuromuscular junctions. 16 October 2015 | doi: 10.1038/ncomms9362 Biological Sciences  Cell biology  Neuroscience  A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C OPEN Florencia Cano, Radu Rapiteanu, G. Sebastiaan Winkler and Paul J. Lehner mRNA deadenylation, the first step in regulated degradation, is mediated by the action of the CCR4-NOT and PAN2-PAN3 complexes. Here the authors show that the RNA-binding E3 ubiquitin-ligase MEX-3C associates with the CCR4-NOT complex and ubiquitinates the catalytic subunit CNOT7 to regulate its deadenylation activity. 16 October 2015 | doi: 10.1038/ncomms9670 Biological Sciences  Biochemistry  Molecular biology  Perpendicular reading of single confined magnetic skyrmions OPEN Dax M. Crum, Mohammed Bouhassoune, Juba Bouaziz, Benedikt Schweflinghaus, Stefan Blügel and Samir Lounis Magnetic skyrmions are particle-like configurations which can emerge in the magnetization of materials possessing a chiral exchange interaction. Here, the authors demonstrate how spin-mixing magnetoresistance can allow for the reliable perpendicular detection of single nanoscale skyrmions in Pd/Fe/Ir(111) thin films. 16 October 2015 | doi: 10.1038/ncomms9541 Physical Sciences  Condensed matter  Theoretical physics  Anisotropic in-plane thermal conductivity observed in few-layer black phosphorus OPEN Zhe Luo, Jesse Maassen, Yexin Deng, Yuchen Du, Richard P. Garrelts, Mark S Lundstrom, Peide D. Ye and Xianfan Xu The two-dimensional material black phosphorus could find uses in energy applications. Here, the authors study the difference in in-plane thermal conductivity along the armchair and zigzag directions in suspended few-layer black phosphorus, and show the dependence of this anisotropy on sample thickness. 16 October 2015 | doi: 10.1038/ncomms9572 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Encapsulation of sulfur with thin-layered nickel-based hydroxides for long-cyclic lithium–sulfur cells OPEN Jian Jiang, Jianhui Zhu, Wei Ai, Xiuli Wang, Yanlong Wang, Chenji Zou, Wei Huang and Ting Yu Development of lithium-sulfur cells is hindered by many problems such as the dissolution of polysulfides. Here, the authors use thin nickel-based hydroxide layers to entrap both sulfur and intermediate polysulfides in the cathode, which mitigates the problems leading to high battery performance. 16 October 2015 | doi: 10.1038/ncomms9622 Chemical Sciences  Materials science  Nanotechnology  Towards a general diastereoselective route to oxabicyclo[3.2.1]octanes via a gold-catalysed cascade reaction OPEN Junkai Fu, Yueqing Gu, Hao Yuan, Tuoping Luo, Song Liu, Yu Lan, Jianxian Gong and Zhen Yang Oxygenated bicyclic cores are common to many natural and bioactive compounds, but their efficient synthesis can be difficult. Here, the authors report a gold-catalysed diastereoselective process for the synthesis of oxabicyclo[3.2.1]octanes via a domino process. 16 October 2015 | doi: 10.1038/ncomms9617 Chemical Sciences  Catalysis  Organic chemistry  Anisotropic in-plane thermal conductivity of black phosphorus nanoribbons at temperatures higher than 100 K OPEN Sangwook Lee, Fan Yang, Joonki Suh, Sijie Yang, Yeonbae Lee, Guo Li, Hwan Sung Choe, Aslihan Suslu, Yabin Chen, Changhyun Ko, Joonsuk Park, Kai Liu, Jingbo Li, Kedar Hippalgaonkar, Jeffrey J. Urban, Sefaattin Tongay and Junqiao Wu Understanding the flow of heat in materials just one or a few atoms thick is vital for harnessing them in compact electronic devices. Here, the authors present the temperature-dependent thermal conductivity of black phosphorus ribbons and demonstrate an intrinsic orientation dependence. 16 October 2015 | doi: 10.1038/ncomms9573 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Structural basis for phosphatidylinositol-phosphate biosynthesis OPEN Oliver B. Clarke, David Tomasek, Carla D. Jorge, Meagan Belcher Dufrisne, Minah Kim, Surajit Banerjee, Kanagalaghatta R. Rajashankar, Lawrence Shapiro, Wayne A. Hendrickson, Helena Santos and Filippo Mancia CDP-alcohol phosphotransferases (CDP-APs) are critical for the biosynthesis of glycerophospholipids. Here, Clarke et al. present the first structure of an enzymatically active CDP-AP in the presence of a bound lipid substrate and propose a mechanism for substrate binding and catalysis. 16 October 2015 | doi: 10.1038/ncomms9505 Biological Sciences  Biochemistry  Biophysics  High catalytic activity of oriented 2.0.0 copper(I) oxide grown on graphene film OPEN Ana Primo, Ivan Esteve-Adell, Juan F. Blandez, Amarajothi Dhakshinamoorthy, Mercedes Álvaro, Natalia Candu, Simona M. Coman, Vasile I. Parvulescu and Hermenegildo García Supported metal nanoparticles have been widely used as heterogeneous catalysts. Here, the authors report the synthesis of (1.1.1) copper on few layer graphene which oxidize to orientated (2.0.0) copper(I) oxide nanoplatelets which display high catalytic activity for a number of organic coupling reactions. 16 October 2015 | doi: 10.1038/ncomms9561 Chemical Sciences  Catalysis  Materials science  Organic chemistry  Slab rollback orogeny in the Alps and evolution of the Swiss Molasse basin OPEN Fritz Schlunegger and Edi Kissling The stratigraphy of the Molasse basin has been related to the convergent regime, but aspects do not fit with observations or isostatic models. Here, the authors show that rollback of the European plate may have caused the thick sedimentary successions in the foreland basin, independent of plate convergence mechanisms. 16 October 2015 | doi: 10.1038/ncomms9605 Earth Sciences  Geology and geophysics  Aqueous multiphoton lithography with multifunctional silk-centred bio-resists OPEN Yun-Lu Sun, Qi Li, Si-Ming Sun, Jing-Chun Huang, Bo-Yuan Zheng, Qi-Dai Chen, Zheng-Zhong Shao and Hong-Bo Sun Scientists are increasingly realising the potential for natural materials in micro- and nanofabrication. Here, the authors employ silk-based resists for aqueous multiphoton lithography towards generating intricate structures by femtosecond direct writing. 16 October 2015 | doi: 10.1038/ncomms9612 Chemical Sciences  Bioengineering  Materials science  Nanotechnology  Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53 Qi Fei, Ke Shang, Jianhua Zhang, Shannon Chuai, Desheng Kong, Tianlun Zhou, Shijun Fu, Ying Liang, Chong Li, Zhi Chen, Yuan Zhao, Zhengtian Yu, Zheng Huang, Min Hu, Haiyan Ying, Zhui Chen, Yun Zhang, Feng Xing, Jidong Zhu, Haiyan Xu et al. SETDB1 is a histone methyltransferase and a role for the protein has been proposed in cancer. Here, the authors show that SETDB1 contributes to hepatocellular cancer by preferably forming a complex with mutant p53, resulting in di-methylation of a critical lysine residue and stabilization of the protein. 16 October 2015 | doi: 10.1038/ncomms9651 Biological Sciences  Cancer  Cell biology  Optimized measurements of separations and angles between intra-molecular fluorescent markers OPEN Kim I. Mortensen, Jongmin Sung, Henrik Flyvbjerg and James A. Spudich Single molecule super-resolution microscopy can reliably localize objects with high precision, but the accuracy can be called into question. Here the authors present a methodology to accurately and precisely measure nanometre separation and orientation of two fixed fluorophores from colour-separated images. 16 October 2015 | doi: 10.1038/ncomms9621 Biological Sciences  Applied physics  Biotechnology  The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis OPEN Manando Nakasaki, Yongsung Hwang, Yun Xie, Sunny Kataria, Rupali Gund, Edries Y. Hajam, Rekha Samuel, Renu George, Debashish Danda, Paul M.J., Tomoyuki Nakamura, Zhouxin Shen, Steve Briggs, Shyni Varghese and Colin Jamora Stiffness in the extracellular matrix is thought to contribute to pathological cutaneous fibrosis. Here, the authors identify the elastic fibre protein Fibulin-5 as a link and potential therapeutic target mediating the transition of cutaneous stiffening to fibrosis. 15 October 2015 | doi: 10.1038/ncomms9574 Biological Sciences  Medical research  Liquid exfoliation of solvent-stabilized few-layer black phosphorus for applications beyond electronics OPEN Damien Hanlon, Claudia Backes, Evie Doherty, Clotilde S. Cucinotta, Nina C. Berner, Conor Boland, Kangho Lee, Andrew Harvey, Peter Lynch, Zahra Gholamvand, Saifeng Zhang, Kangpeng Wang, Glenn Moynihan, Anuj Pokle, Quentin M. Ramasse, Niall McEvoy, Werner J. Blau, Jun Wang, Gonzalo Abellan, Frank Hauke et al. While phosphorene is an exciting new 2D material, techniques to produce it in large quantities in a stable, processable form are lacking. Here, the authors achieve this using liquid phase exfoliation and demonstrate the resultant nanosheets to be useful in a number of applications. 15 October 2015 | doi: 10.1038/ncomms9563 Physical Sciences  Materials science  Nanotechnology  Discovery of protein acetylation patterns by deconvolution of peptide isomer mass spectra OPEN Nebiyu Abshiru, Olivier Caron-Lizotte, Roshan Elizabeth Rajan, Adil Jamai, Christelle Pomies, Alain Verreault and Pierre Thibault Deciphering patterns of histone modifications that modulate chromatin structure and function is important, but remains challenging. Here the authors describe a method to uncover patterns of site-specific histone acetylation by deconvolution of overlapping peptide isomer mass spectra. 15 October 2015 | doi: 10.1038/ncomms9648 Biological Sciences  Analytical chemistry  Biochemistry  Observation of correlated electronic decay in expanding clusters triggered by near-infrared fields OPEN B. Schütte, M. Arbeiter, T. Fennel, G. Jabbari, A.I. Kuleff, M.J.J. Vrakking and A. Rouzée In clusters, relaxation of excited atoms can lead to ionization of nearby atoms, a process known as interatomic Coulomb decay. Here, the authors report on a so far unobserved correlated electronic decay process following Rydberg atom generation in clusters ionized by intense near-infrared fields. 15 October 2015 | doi: 10.1038/ncomms9596 Physical Sciences  Atomic and molecular physics  Storage of multiple single-photon pulses emitted from a quantum dot in a solid-state quantum memory OPEN Jian-Shun Tang, Zong-Quan Zhou, Yi-Tao Wang, Yu-Long Li, Xiao Liu, Yi-Lin Hua, Yang Zou, Shuang Wang, De-Yong He, Geng Chen, Yong-Nan Sun, Ying Yu, Mi-Feng Li, Guo-Wei Zha, Hai-Qiao Ni, Zhi-Chuan Niu, Chuan-Feng Li and Guang-Can Guo Quantum repeaters are critical components for distributing entanglement over long distances, and they can be improved by the elimination of multi-photon-pair events. Here, the authors demonstrate the storage of single photons emitted by a quantum dot in a polarization maintaining solid-state memory. 15 October 2015 | doi: 10.1038/ncomms9652 Physical Sciences  Applied physics  Optical physics  RFX transcription factors are essential for hearing in mice OPEN Ran Elkon, Beatrice Milon, Laura Morrison, Manan Shah, Sarath Vijayakumar, Manoj Racherla, Carmen C. Leitch, Lorna Silipino, Shadan Hadi, Michèle Weiss-Gayet, Emmanuèle Barras, Christoph D. Schmid, Aouatef Ait-Lounis, Ashley Barnes, Yang Song, David J. Eisenman, Efrat Eliyahu, Gregory I. Frolenkov, Scott E. Strome, Bénédicte Durand et al. Inner ear hair cells are non-regenerative mechanosensory cells essential for hearing. Here, with cell-type-specific expression analyses, the authors identify RFX transcription factors as central mediators of their survival during terminal differentiation and thus essential for hearing in mice. 15 October 2015 | doi: 10.1038/ncomms9549 Biological Sciences  Developmental biology  IRSp53 senses negative membrane curvature and phase separates along membrane tubules OPEN Coline Prévost, Hongxia Zhao, John Manzi, Emmanuel Lemichez, Pekka Lappalainen, Andrew Callan-Jones and Patricia Bassereau The inverted-BAR domain protein IRSp53 associates with the inner leaflet of tubular membranes such as filopodia. Here, Prévost et al. demonstrate that the I-BAR domain of IRSp53 senses negative membrane curvature, and undergoes phase separation which may aid its clustering upon filopodia generation. 15 October 2015 | doi: 10.1038/ncomms9529 Biological Sciences  Cell biology  Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling OPEN Lishan Fang, Junchao Cai, Baixue Chen, Shanshan Wu, Rong Li, Xiaonan Xu, Yi Yang, Hongyu Guan, Xun Zhu, Le Zhang, Jie Yuan, Jueheng Wu and Mengfeng Li Despite the absence of frequent mutations of key components of Wnt/β-catenin signalling, this pathway is often constitutively activated in non-small cell lung carcinoma. In this study, the authors demonstrate the inhibitory effect of miR-582-3p on negative regulators of the Wnt/β-catenin pathway which is consequently triggered to sustain lung tumour growth. 15 October 2015 | doi: 10.1038/ncomms9640 Biological Sciences  Cancer  Cell biology  Crystalline CO2-based polycarbonates prepared from racemic catalyst through intramolecularly interlocked assembly OPEN Ye Liu, Wei-Min Ren, Wei-Ping Zhang, Rong-Rong Zhao and Xiao-Bing Lu Crystalline polycarbonates can be formed by mixing enantiopure polymers with opposite configurations. Here, the authors produce crystalline intramolecular stereocomplexed polycarbonates using a racemic catalyst, and show that these display similar properties to those formed by mixing the two enantiomers. 15 October 2015 | doi: 10.1038/ncomms9594 Chemical Sciences  Catalysis  Organic chemistry  Formation of functional super-helical assemblies by constrained single heptad repeat OPEN Sudipta Mondal, Lihi Adler-Abramovich, Ayala Lampel, Yaron Bram, Sophia Lipstman and Ehud Gazit Advances in bionanotechnology demand an increased portfolio of assemblies beyond those currently available. Here, the authors design a crystallographically characterized super-helical sequence composed of single heptad repeats which, through derivatisation, offers vast potential applications. 15 October 2015 | doi: 10.1038/ncomms9615 Chemical Sciences  Biochemistry  Biotechnology  Nanotechnology  Single-molecule spectroscopy exposes hidden states in an enzymatic electron relay OPEN Iris Grossman, Haim Yuval Aviram, Gad Armony, Amnon Horovitz, Hagen Hofmann, Gilad Haran and Deborah Fass A major challenge in following electron transfer through dithiol/disulfide exchange is the dearth of accompanying spectroscopic effects. Here, the authors use single-molecule Förster resonance energy transfer experiments to illuminate disulfide bond rearrangements within the enzyme quiescin sulfhydryl oxidase. 15 October 2015 | doi: 10.1038/ncomms9624 Chemical Sciences  Biophysics  Catalysis  Mesoporous MnCeOx solid solutions for low temperature and selective oxidation of hydrocarbons OPEN Pengfei Zhang, Hanfeng Lu, Ying Zhou, Li Zhang, Zili Wu, Shize Yang, Hongliang Shi, Qiulian Zhu, Yinfei Chen and Sheng Dai Precious metal free catalysts for aerobic oxidation of hydrocarbons are industrially useful materials. Here, the authors report a mesoporous maganese-cerium oxide solid solution that is highly active for the selective oxidation of C-H bonds in hydrocarbons under mild conditions. 15 October 2015 | doi: 10.1038/ncomms9446 Chemical Sciences  Catalysis  Inorganic chemistry  Materials science  Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear OPEN Joseph C. Burns, Michael C. Kelly, Michael Hoa, Robert J. Morell and Matthew W. Kelley Heterogeneous sensory epithelia of the inner ear are difficult to study owing to the few cells that can be isolated. Here the authors provide insight into the developmental processes underlying the formation of these cells by single-cell RNA-Seq. 15 October 2015 | doi: 10.1038/ncomms9557 Biological Sciences  Developmental biology  Stability of single skyrmionic bits OPEN J. Hagemeister, N. Romming, K. von Bergmann, E. Y. Vedmedenko and R. Wiesendanger Magnetic skyrmions are swirling magnetization textures which are topologically stabilized in helical magnets under an applied magnetic field. Here, the authors use Monte Carlo simulations to explore the stability of skyrmions against a ferromagnetic phase and their potential as single bits. 14 October 2015 | doi: 10.1038/ncomms9455 Physical Sciences  Condensed matter  Theoretical physics  STAT3-mediated IGF-2 secretion in the tumour microenvironment elicits innate resistance to anti-IGF-1R antibody OPEN Ji-Sun Lee, Ju-Hee Kang, Hye-Jin Boo, Su-Jung Hwang, Sungyoul Hong, Su-Chan Lee, Young-Jun Park, Tae-Moon Chung, Hyewon Youn, Seung Mi Lee, Byoung Jae Kim, June-Key Chung, Yeonseok Chung, William N. William, Young Kee Shin, Hyo-Jong Lee, Seung-Hyun Oh and Ho-Young Lee Cixutumumab is an anti-IGF-1R monoclonal antibody and is used to treat cancer; however, tumours can develop resistance to the therapy. Here, the authors show that the resistance is mediated by activation of STAT3 that results in an IGF2/IGF-2R signalling loop and recruitment of macrophages. 14 October 2015 | doi: 10.1038/ncomms9499 Biological Sciences  Cancer  Immunology  Medical research  Notch signal strength controls cell fate in the haemogenic endothelium OPEN Leonor Gama-Norton, Eva Ferrando, Cristina Ruiz-Herguido, Zenhy Liu, Jordi Guiu, Abul B. M. M. K. Islam, Sung-Uk Lee, Minhong Yan, Cynthia J. Guidos, Nuria López-Bigas, Takahiro Maeda, Lluis Espinosa, Raphael Kopan and Anna Bigas It is unclear how Notch1 signals regulate both the maintenance of the endothelial fate and the endothelial-to-hematopoietic transition in the embryonic aorta. Here the authors show that those cells in which Notch1 ligand Jag1 is out-competed by Dll4 remain endothelial, while higher Jag1 activity leads to generation of hematopoietic stem cells. 14 October 2015 | doi: 10.1038/ncomms9510 Biological Sciences  Cell biology  Developmental biology  Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins OPEN Daniel Schlam, Richard D. Bagshaw, Spencer A. Freeman, Richard F. Collins, Tony Pawson, Gregory D. Fairn and Sergio Grinstein Phagocytosis of large (but not small) particles requires PI 3-kinase activity. Here, Schlam et al. show that Rho GTPase-activating proteins are recruited to the phagocytic cup by products of PI 3-kinase, resulting in the local inactivation of Rac and Cdc42 and allowing for the completion of internalization of large particles. 14 October 2015 | doi: 10.1038/ncomms9623 Biological Sciences  Cell biology  Water desalination with a single-layer MoS2 nanopore OPEN Mohammad Heiranian, Amir Barati Farimani and Narayana R. Aluru Nanopores in two-dimensional materials are arousing considerable interest as filtration membranes to solve the problem of providing fresh water to a growing population. Here, the authors evaluate the potential of single-layer MoS2 to effectively reject salt ions whilst maintaining high flow rates. 14 October 2015 | doi: 10.1038/ncomms9616 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury OPEN Jessica L. Nielson, Jesse Paquette, Aiwen W. Liu, Cristian F. Guandique, C. Amy Tovar, Tomoo Inoue, Karen-Amanda Irvine, John C. Gensel, Jennifer Kloke, Tanya C. Petrossian, Pek Y. Lum, Gunnar E. Carlsson, Geoffrey T. Manley, Wise Young, Michael S. Beattie, Jacqueline C. Bresnahan and Adam R. Ferguson Data-driven discovery in complex neurological disorders has potential to extract meaningful knowledge from large, heterogeneous datasets. Here the authors apply topological data analysis to assess therapeutic effects in preclinical traumatic brain injury and spinal cord injury research studies. 14 October 2015 | doi: 10.1038/ncomms9581 Biological Sciences  Neuroscience  Systems biology  ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function OPEN Young-Chan Kim, Aaron Snoberger, Jane Schupp and David M. Smith The 26S proteasome contains a hexamer of ATPase subunits, which binds, unfolds and translocates substrates in an ATP-dependent manner. Kim et al. use FRET to show that ATP binding preferentially occurs at neighbouring subunits of the hexamer, and identify two allosteric systems that coordinate translocation. 14 October 2015 | doi: 10.1038/ncomms9520 Biological Sciences  Biochemistry  Sleep disruption impairs haematopoietic stem cell transplantation in mice Asya Rolls, Wendy W. Pang, Ingrid Ibarra, Damien Colas, Patricia Bonnavion, Ben Korin, H. Craig Heller, Irving L. Weissman and Luis de Lecea How can you increase the success of hematopoietic stem cell (HSC) transplantation? In mice, Rolls et al. identify sleep in the donor as an important factor, finding that less sleep leads to 50% lower HSC engraftment, via miR-19b and suppressor of cytokine signaling genes, which prevent HSC homing. 14 October 2015 | doi: 10.1038/ncomms9516 Biological Sciences  Cell biology  Developmental biology  Accurate lineshape spectroscopy and the Boltzmann constant OPEN G.-W. Truong, J. D. Anstie, E. F. May, T. M. Stace and A. N. Luiten Reaching fundamental noise limits permits optimal extraction of spectroscopic information from an absorption measurement. Here, the authors demonstrate a quantum-limited spectrometer with which they can obtain an extremely accurate measurement of the excited-state hyperfine splitting in Cs. 14 October 2015 | doi: 10.1038/ncomms9345 Physical Sciences  Atomic and molecular physics  The Lin28/let-7 axis is critical for myelination in the peripheral nervous system OPEN Deniz Gökbuget, Jorge A. Pereira, Sven Bachofner, Antonin Marchais, Constance Ciaudo, Markus Stoffel, Johannes H. Schulte and Ueli Suter MicroRNAs are known to regulate myelination in the peripheral nervous system, but the underlying mechanisms remain unclear. Here the authors show that the Lin28B/let-7 axis drives the onset of myelination by promoting Krox20 expression through suppression of Notch signalling. 14 October 2015 | doi: 10.1038/ncomms9584 Biological Sciences  Developmental biology  Neuroscience    Nature Communications JOBS of the week Marie Curie 15 PhD Fellowships University of Cambridge Postdoctoral Research Associate University of Edinburgh Post-Doctoral Associate University of Miami PhD Studentship MRC-University of Glasgow Centre for Virus Research Post-doctoral Fellow Thomas Jefferson Univesrity 12 PhD student positions Universitatsklinikum Hamburg-Eppendorf Staff Clinician National Institute of Allergy and Infectious Diseases (NIAID) Research Associate University College London (UCL) Beamline Scientist Paul Scherrer Institut (PSI) Postdoctoral Position The University of Sheffield More Science jobs from Nature Communications EVENT Applied Bioinformatics in Life Sciences 17.03.16 Leuven, Belgium More science events from       Latest Corrigenda     Corrigendum: Transcription errors induce proteotoxic stress and shorten cellular lifespan Marc Vermulst, Ashley S. Denney, Michael J. Lang, Chao-Wei Hung, Stephanie Moore, M. Arthur Moseley, J. Will Thompson, Victoria Madden, Jacob Gauer, Katie J. Wolfe, Daniel W. Summers, Jennifer Schleit, George L. Sutphin, Suraiya Haroon, Agnes Holczbauer, Joanne Caine, James Jorgenson, Douglas Cyr, Matt Kaeberlein, Jeffrey N. Strathern et al. 14 October 2015 | doi: 10.1038/ncomms9738 Biological Sciences  Cell biology  Molecular biology      Corrigendum: MicroRNA-302b augments host defense to bacteria by regulating inflammatory responses via feedback to TLR/IRAK4 circuits Xikun Zhou, Xuefeng Li, Yan Ye, Kelei Zhao, Yan Zhuang, Yi Li, Yuquan Wei and Min Wu 14 October 2015 | doi: 10.1038/ncomms9679 Biological Sciences  Immunology  Microbiology      Advertisement Open for Submissions An interdisciplinary journal dedicated to publishing high-quality open research relevant to all aspects of schizophrenia and psychosis. 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