Nature Communications - 07 October 2015

Advertisement NEW WHITE PAPER: The Latest Advances in Cell and Tissue Engrafted Mice  This white paper provides an in-depth overview mice engrafted with human cells and tissues e and how they can help to bridge the biological gap between mice and humans. Learn More About: How cell and tissue engrafted mice are generated The application of immune system engrafted models in basic and applied research And, read an evaluation of the available super immunodeficient models for cell and issue  Download Your Copy Today     Weekly Content Alert Nature Communications is now fully open access. Read more. 07 October 2015  Featured image: Kivell et al. suggest the hand of extinct human species Homo naledi was used for tree climbing and tool manipulation. Latest content: Articles Corrigendum Journal homepage Recommend to library Web feed     Latest Articles View all Articles     The hand of Homo naledi OPEN Tracy L. Kivell, Andrew S. Deane, Matthew W. Tocheri, Caley M. Orr, Peter Schmid, John Hawks, Lee R. Berger and Steven E. Churchill It is unclear to what extent early hominins were adapted to arboreal climbing. Here, the authors show that the nearly complete hand of H. naledi from South Africa has markedly curved digits and otherwise human-like wrist and palm, which indicates the retention of a significant degree of climbing. 06 October 2015 | doi: 10.1038/ncomms9431 Biological Sciences  Evolution  Palaeontology  The foot of Homo naledi OPEN W. E. H. Harcourt-Smith, Z. Throckmorton, K. A. Congdon, B. Zipfel, A. S. Deane, M. S. M. Drapeau, S. E. Churchill, L. R. Berger and J. M. DeSilva Hominin fossils reveal high diversity in the types of terrestrial bipedalism. Here, the authors show that the foot of Homo naledi from South Africa is predominantly human-like in morphology and inferred function and is well adapted for striding bipedalism. 06 October 2015 | doi: 10.1038/ncomms9432 Biological Sciences  Evolution  Palaeontology  Surprising trunk rotational capabilities in chimpanzees and implications for bipedal walking proficiency in early hominins OPEN Nathan E. Thompson, Brigitte Demes, Matthew C. O’Neill, Nicholas B. Holowka and Susan G. Larson Greater trunk flexibility in humans is thought to be a major adaptation to bipedal walking compared to chimpanzees. Here Thompson et al. show that chimpanzees are capable of human-like trunk rotations during bipedalism, suggesting bipedal proficiency was present in early hominins. 06 October 2015 | doi: 10.1038/ncomms9416 Biological Sciences  Evolution  Zoology  Charge-transfer crystallites as molecular electrical dopants OPEN Henry Méndez, Georg Heimel, Stefanie Winkler, Johannes Frisch, Andreas Opitz, Katrein Sauer, Berthold Wegner, Martin Oehzelt, Christian Röthel, Steffen Duhm, Daniel Többens, Norbert Koch and Ingo Salzmann The fundamental mechanisms of doping organic semiconductors are poorly understood compared with their inorganic counterparts. Here, the authors demonstrate that small conjugated molecules and conjugated polymers exhibit fundamentally different phenomena upon doping despite similar compositions. 06 October 2015 | doi: 10.1038/ncomms9560 Physical Sciences  Condensed matter  Materials science  Physical chemistry  Effect of interfaces on the nearby Brownian motion OPEN Kai Huang and Izabela Szlufarska Brownian motion of biomolecules and colloidal particles near solid walls is expected to be rather different from that in bulk, but the details have been highly controversial. Here, Huang and Szlufarska show a general breakdown of traditional no-slip boundary conditions at short timescales that clarifies the controversy. 06 October 2015 | doi: 10.1038/ncomms9558 Physical Sciences  Fluids and plasma physics  Theoretical physics  Acidic phospholipids govern the enhanced activation of IgG-B cell receptor OPEN Xiangjun Chen, Weiling Pan, Yinqiang Sui, Hua Li, Xiaoshan Shi, Xingdong Guo, Hai Qi, Chenqi Xu and Wanli Liu Adaptive immunity is the memory of previously experienced pathogens, where B cells establish a rapid antibody response upon IgG-B cell receptor activation. Here, Chen et al. show that sequestration of the cytoplasmic domain of mIgG by plasma membrane phospholipids prevents inappropriate activation of IgG-BCR signalling. 06 October 2015 | doi: 10.1038/ncomms9552 Biological Sciences  Biochemistry  Immunology  Quantifying the stabilizing effects of protein–ligand interactions in the gas phase OPEN Timothy M. Allison, Eamonn Reading, Idlir Liko, Andrew J. Baldwin, Arthur Laganowsky and Carol V. Robinson Relatively few techniques can quantitatively measure the effect of ligands on membrane protein stability. Here the authors demonstrate the use of ion-mobility mass spectrometry to accurately measure and quantify ligand-induced protein stabilization in the gas phase. 06 October 2015 | doi: 10.1038/ncomms9551 Biological Sciences  Biochemistry  Spin-dependent recombination probed through the dielectric polarizability OPEN Sam L. Bayliss, Neil C. Greenham, Richard H. Friend, Hélène Bouchiat and Alexei D Chepelianskii Weak spin-orbit coupling in organic materials results in unique spin-dependent phenomena which may be exploited in spintronic or photovoltaic devices. Here, the authors use the dielectric properties of carbon-based semiconductors to study spin-selective carrier recombination during magnetic resonance. 06 October 2015 | doi: 10.1038/ncomms9534 Physical Sciences  Applied physics  Condensed matter  Two-photon fluorescence lifetime imaging of primed SNARE complexes in presynaptic terminals and β cells OPEN Noriko Takahashi, Wakako Sawada, Jun Noguchi, Satoshi Watanabe, Hasan Ucar, Akiko Hayashi-Takagi, Sho Yagishita, Mitsuyo Ohno, Hiroshi Tokumaru and Haruo Kasai Synaptic vesicles are held in a fusion-competent state prior to their rapid release, which is thought to depend upon formation of trans-SNARE complexes. Takahashi et al. directly image this primed state using FLIM/FRET, and demonstrate differences in basal SNARE organization between neurons and β cells. 06 October 2015 | doi: 10.1038/ncomms9531 Biological Sciences  Biophysics  Cell biology  Neuroscience  A higher order visual neuron tuned to the spatial amplitude spectra of natural scenes OPEN Olga Dyakova, Yu-Jen Lee, Kit D. Longden, Valerij G. Kiselev and Karin Nordström Natural scenes contain statistics that are constrained in both space and time. Here, the authors show that, in insects as in mammals, both higher order neural mechanisms and behavioural discrimination are tuned to natural spatial statistics. 06 October 2015 | doi: 10.1038/ncomms9522 Biological Sciences  Neuroscience  Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors OPEN Hélène O. B. Gautier, Kimberley A. Evans, Katrin Volbracht, Rachel James, Sergey Sitnikov, Iben Lundgaard, Fiona James, Cristina Lao-Peregrin, Richard Reynolds, Robin J. M. Franklin and Ragnhildur T Káradóttir Myelin regeneration can occur spontaneously in demyelinating diseases but the underlying mechanisms are incompletely understood. Here the authors show that neuronal activity and glutamatergic synapses instruct oligodendrocyte progenitor cells to differentiate into new myelinating oligodendrocytes. 06 October 2015 | doi: 10.1038/ncomms9518 Biological Sciences  Neuroscience  Hydrodynamic schooling of flapping swimmers OPEN Alexander D. Becker, Hassan Masoud, Joel W. Newbolt, Michael Shelley and Leif Ristroph Schooling or flocking of animals in nature is generally explained via an energy optimization approach. Here, Becker et al. mimic the conditions for an infinite array of swimmers in a water tank and show that fluid dynamic interactions alone are sufficient to lead to coherent and collective locomotion. 06 October 2015 | doi: 10.1038/ncomms9514 Physical Sciences  Fluids and plasma physics  Terahertz-driven linear electron acceleration OPEN Emilio A. Nanni, Wenqian R. Huang, Kyung-Han Hong, Koustuban Ravi, Arya Fallahi, Gustavo Moriena, R. J. Dwayne Miller and Franz X. Kärtner Pulses of light offer a way to create particle accelerators that are a fraction of the size of conventional approaches. Here, the authors demonstrate the linear acceleration of electrons with kiloelectronvolt energy gain and in extremely short bunches using optically-generated terahertz pulses. 06 October 2015 | doi: 10.1038/ncomms9486 Physical Sciences  Fluids and plasma physics  Optical physics  Mechanically activated switching of Si-based single-molecule junction as imaged with three-dimensional dynamic probe Miki Nakamura, Shoji Yoshida, Tomoki Katayama, Atsushi Taninaka, Yutaka Mera, Susumu Okada, Osamu Takeuchi and Hidemi Shigekawa Mechanically induced conformational modulation can be used to control the conductance of single molecules junctions, but it is hard to be realized due to broken junctions. Here, the authors probe three-dimensional dynamics of Si/single-molecule/Si junctions, whose conductance shows a binary change. 06 October 2015 | doi: 10.1038/ncomms9465 Physical Sciences  Applied physics  Atomic and molecular physics  Physical chemistry  Pronounced polarization-induced energy level shifts at boundaries of organic semiconductor nanostructures OPEN K. A. Cochrane, A. Schiffrin, T. S. Roussy, M. Capsoni and S. A. Burke Interfaces are essential in organic semiconductor devices, yet the detailed connection between interface geometry and energy level alignment are not fully understood. Here, Cochrane et al. quantify energy level shifts with sub-molecular resolution within a nanoscale model organic semiconductor system. 06 October 2015 | doi: 10.1038/ncomms9312 Physical Sciences  Condensed matter  Materials science  Shadows of anyons and the entanglement structure of topological phases OPEN J. Haegeman, V. Zauner, N. Schuch and F. Verstraete Tensor network states efficiently parametrize many-body quantum ground states and entanglement properties of strongly correlated systems. Here, the authors show how the presence of anyons and topological order can be related to symmetry breaking in the virtual boundary theory of the network. 06 October 2015 | doi: 10.1038/ncomms9284 Physical Sciences  Theoretical physics  Loss of KLF14 triggers centrosome amplification and tumorigenesis OPEN Guangjian Fan, Lianhui Sun, Peipei Shan, Xianying Zhang, Jinliang Huan, Xiaohong Zhang, Dali Li, Tingting Wang, Tingting Wei, Xiaohong Zhang, Xiaoyang Gu, Liangfang Yao, Yang Xuan, Zhaoyuan Hou, Yongping Cui, Liu Cao, Xiaotao Li, Shengping Zhang and Chuangui Wang Centrosome amplification is common in cancer, but the mechanism is not clear. Here the authors uncover a role for Kruppel-like factor 14 (KLF14) as a transcriptional repressor of polo-like kinase 4 (PLK4); KLF14 depletion correlates with increased PLK4 in human samples and leads to centrosome amplification and tumorigenesis in mice. 06 October 2015 | doi: 10.1038/ncomms9450 Biological Sciences  Cancer  Cell biology  Topologically robust sound propagation in an angular-momentum-biased graphene-like resonator lattice OPEN Alexander B. Khanikaev, Romain Fleury, S. Hossein Mousavi and Andrea Alù Topological order for sound remains largely unexplored. Here, Khanikaev et al. introduce the concept of topological order in classical acoustics, realizing robust topological protection and one-way edge propagation of sound in a suitably designed resonator lattice, thus expanding the ability to tailor acoustic waves. 06 October 2015 | doi: 10.1038/ncomms9260 Physical Sciences  Condensed matter  Materials science  Kinesin-5 is a microtubule polymerase OPEN Yalei Chen and William O Hancock Kinesin-5 is a tetrameric motor that slides antiparallel microtubules during mitotic spindle assembly. Chen and Hancock show that this motor also promotes microtubule assembly by stabilising protofilaments at growing plus ends, which results in the formation of banana peel-like structures. 06 October 2015 | doi: 10.1038/ncomms9160 Biological Sciences  Cell biology  Measuring fast stochastic displacements of bio-membranes with dynamic optical displacement spectroscopy OPEN C. Monzel, D. Schmidt, C. Kleusch, D. Kirchenbüchler, U. Seifert, A-S Smith, K. Sengupta and R. Merkel Precise quantification of stochastic motions of biological membranes is limited by a lack of suitable detection methods. Here Monzel et al. develop dynamic optical displacement spectroscopy to measure stochastic membrane displacements at 20 nm/10 μs spatiotemporal resolution. 06 October 2015 | doi: 10.1038/ncomms9162 Biological Sciences  Biophysics  Cell biology  Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells OPEN Tsunekazu Oikawa, Eliane Wauthier, Timothy A. Dinh, Sara R. Selitsky, Andrea Reyna-Neyra, Guido Carpino, Ronald Levine, Vincenzo Cardinale, David Klimstra, Eugenio Gaudio, Domenico Alvaro, Nancy Carrasco, Praveen Sethupathy and Lola M. Reid With no cell lines available, investigating the aetiology of human fibrolamellar hepatocellular carcinomas (hFL-HCCs) has proved problematic. Here, Oikawa et al. establish a model of hFL-HCCs as a transplantable tumour line maintained in immune-compromised mice, which proves rich in cancer stem cells. 06 October 2015 | doi: 10.1038/ncomms9070 Biological Sciences  Cancer  Observing the overall rocking motion of a protein in a crystal OPEN Peixiang Ma, Yi Xue, Nicolas Coquelle, Jens D. Haller, Tairan Yuwen, Isabel Ayala, Oleg Mikhailovskii, Dieter Willbold, Jacques-Philippe Colletier, Nikolai R. Skrynnikov and Paul Schanda Small-amplitude overall motion of molecules in crystals limits the achievable resolution in X-ray diffraction, yet little is known about its exact nature. Here, the authors obtain NMR, XRD and MD data from three different crystal forms of a protein (ubiquitin) to gain insight into amplitude and timescale of such motions. 05 October 2015 | doi: 10.1038/ncomms9361 Biological Sciences  Biochemistry  Biophysics  Physical chemistry  Exploring three-dimensional orbital imaging with energy-dependent photoemission tomography OPEN S. Weiß, D. Lüftner, T. Ules, E. M. Reinisch, H. Kaser, A. Gottwald, M. Richter, S. Soubatch, G. Koller, M. G. Ramsey, F. S. Tautz and P. Puschnig Experimental data from angle-resolved photoemission spectroscopy can be utilized on molecular films to retrieve real-space images of molecular orbitals in two dimensions. Here, by scanning initial states as a function of photon energy, the authors can reconstruct three-dimensional orbital images. 05 October 2015 | doi: 10.1038/ncomms9287 Physical Sciences  Atomic and molecular physics  Physical chemistry  miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program OPEN Shicheng Su, Qiyi Zhao, Chonghua He, Di Huang, Jiang Liu, Fei Chen, Jianing Chen, Jian-You Liao, Xiuying Cui, Yunjie Zeng, Herui Yao, Fengxi Su, Qiang Liu, Shanping Jiang and Erwei Song Fibroblast activity is regulated by tissue macrophages. Here the authors show that two miRNAs regulated by IL-4 and IL-13 in macrophages target SOCS1 and PPARγ and modulate profibrogenic macrophage program in vitro and in vivo, and that alterations of these miRNAs are found in fibrosis. 05 October 2015 | doi: 10.1038/ncomms9523 Biological Sciences  Immunology  Molecular biology  Brightness-equalized quantum dots OPEN Sung Jun Lim, Mohammad U. Zahid, Phuong Le, Liang Ma, David Entenberg, Allison S. Harney, John Condeelis and Andrew M. Smith Quantum dots with different size emit light at different wavelengths but also different brightness, which complicates analysis of fluorescence images. Here, the authors synthesize multicolour brightness-equalized quantum dots by controlling the composition and structure of core-shell HgCdSeS-CdZnS nanocrystals. 05 October 2015 | doi: 10.1038/ncomms9210 Physical Sciences  Materials science  Nanotechnology  Optical physics  A quantum dot single-photon source with on-the-fly all-optical polarization control and timed emission OPEN Dirk Heinze, Dominik Breddermann, Artur Zrenner and Stefan Schumacher Single photon sources are important for applications in quantum information. Here, the authors exploit higher-order transitions from a biexciton state to the ground state of a semiconductor quantum dot to emit single photons with all-optical control of their frequency, polarization and emission time. 05 October 2015 | doi: 10.1038/ncomms9473 Physical Sciences  Condensed matter  Optical physics  Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility OPEN Fabian Feutlinske, Marietta Browarski, Min-Chi Ku, Philipp Trnka, Sonia Waiczies, Thoralf Niendorf, William B. Stallcup, Rainer Glass, Eberhard Krause and Tanja Maritzen Signalling is often fine-tuned by the exo-endocytic cycling of cell surface receptors. Here, the authors show that the endocytic adaptor protein Stonin1 is important for the endocytosis of NG2, a co-receptor for extracellular matrix and growth factors, and that loss of Stonin1 alters cell motility. 05 October 2015 | doi: 10.1038/ncomms9535 Biological Sciences  Cell biology  Electrical behaviour of dendritic spines as revealed by voltage imaging OPEN Marko A. Popovic, Nicholas Carnevale, Balazs Rozsa and Dejan Zecevic Dendritic spines located on individual neurons process information, but our understanding of the electrical behaviour of spines is still limited. Here, the authors use voltage-sensitive dye imaging techniques to monitor electrical signals from thin basal spines and show that synapses are not electrically isolated by the spine neck. 05 October 2015 | doi: 10.1038/ncomms9436 Biological Sciences  Neuroscience  Discovery of stable skyrmionic state in ferroelectric nanocomposites OPEN Y. Nahas, S. Prokhorenko, L. Louis, Z. Gui, I. Kornev and L. Bellaiche Whilst chiral magnets can support topologically protected particle-like magnetization textures called skyrmions, ferroelectric skyrmions have yet to be observed. Here, the authors use first-principles-based calculations to demonstrate the possibility of ferroelectric skyrmions in oxide nanocomposites. 05 October 2015 | doi: 10.1038/ncomms9542 Physical Sciences  Condensed matter  Theoretical physics  Self-assembled hybrid metal oxide base catalysts prepared by simply mixing with organic modifiers OPEN Masazumi Tamura, Ryota Kishi, Yoshinao Nakagawa and Keiichi Tomishige Self-assembled heterogeneous/homogeneous hybrid materials may offer ease of preparation and tunable catalytic performance. Here, the authors report the accelerated selective hydromethoxylation of acrylonitrile in the presence of CeO2 and 2-cyanopyridine, resulting from the proposed supramolecular complex. 05 October 2015 | doi: 10.1038/ncomms9580 Chemical Sciences  Catalysis  Materials science  Organic chemistry  MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway OPEN Zhipeng Meng, Toshiro Moroishi, Violaine Mottier-Pavie, Steven W. Plouffe, Carsten G. Hansen, Audrey W. Hong, Hyun Woo Park, Jung-Soon Mo, Wenqi Lu, Shicong Lu, Fabian Flores, Fa-Xing Yu, Georg Halder and Kun-Liang Guan A variety of signals have been reported to either activate or inhibit the Hippo kinase cascade. Here, Meng et al. show that mitogen activated protein kinase kinase kinase kinase (MAP4K) family members function in parallel to and are partially redundant with MST1/2 in regulating LATS in response to upstream signals. 05 October 2015 | doi: 10.1038/ncomms9357 Biological Sciences  Biochemistry  Cell biology  Developmental biology  Systematic analysis of somatic mutations impacting gene expression in 12 tumour types OPEN Jiarui Ding, Melissa K. McConechy, Hugo M. Horlings, Gavin Ha, Fong Chun Chan, Tyler Funnell, Sarah C. Mullaly, Jüri Reimand, Ali Bashashati, Gary D. Bader, David Huntsman, Samuel Aparicio, Anne Condon and Sohrab P. Shah Assessing functional impact of mutations in cancer on gene expression can improve our understanding of cancer biology and may identify potential therapeutic targets. Here, Ding et al. describe a novel statistical model named xseq for a systematic survey of how mutations impact transcriptome landscapes across 12 different tumour types. 05 October 2015 | doi: 10.1038/ncomms9554 Biological Sciences  Bioinformatics  Genetics  Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation OPEN Ben J. E. Raveney, Shinji Oki, Hirohiko Hohjoh, Masakazu Nakamura, Wakiro Sato, Miho Murata and Takashi Yamamura Eomesodermin is a master regulator of effector CD8+ T cells. Here the authors show that it also plays a critical role in pathogenic CD4+ cells in a mouse model of multiple sclerosis, and its inactivation ameliorates the chronic stage of the disease. 05 October 2015 | doi: 10.1038/ncomms9437 Biological Sciences  Immunology  Wave-driven butterfly distribution of Van Allen belt relativistic electrons OPEN Fuliang Xiao, Chang Yang, Zhenpeng Su, Qinghua Zhou, Zhaoguo He, Yihua He, D. N. Baker, H. E. Spence, H. O. Funsten and J. B. Blake Relativistic electrons trapped in the Van Allen radiation belts sometimes exhibit a minimum of their pitch angle distribution at 90°. Here, the authors explain the origin of this phenomenon in terms of chorus and magnetosonic waves through simulations and observations of a geomagnetic storm data. 05 October 2015 | doi: 10.1038/ncomms9590 Physical Sciences  Astronomy  Islands contribute disproportionately high amounts of evolutionary diversity in passerine birds OPEN Knud A. Jønsson and Ben G. Holt Islands generally have fewer species than continental areas and are not thought to contribute significantly to continental diversity. Here, the authors show islands can be more dynamic and export many more evolutionary lineages than expected based on contemporary diversity patterns. 05 October 2015 | doi: 10.1038/ncomms9538 Biological Sciences  Ecology  Evolution  Deterministic processes vary during community assembly for ecologically dissimilar taxa OPEN Jeff R. Powell, Senani Karunaratne, Colin D. Campbell, Huaiying Yao, Lucinda Robinson and Brajesh K. Singh Both deterministic and stochastic processes likely contribute to the assembly of ecological communities. Here, Powell et al. measure soil microbial community and habitat turnover across Scotland and show that stochastic processes usually dominate the assembly of fungal but not bacterial communities. 05 October 2015 | doi: 10.1038/ncomms9444 Biological Sciences  Ecology  Microbiology  Dynamic acousto-optic control of a strongly coupled photonic molecule OPEN Stephan Kapfinger, Thorsten Reichert, Stefan Lichtmannecker, Kai Müller, Jonathan J. Finley, Achim Wixforth, Michael Kaniber and Hubert J. Krenner Dynamic control of components is required for large-scale quantum photonic networks. Here, Kapfinger et al. show dynamic control of the interaction between two coupled photonic crystal nanocavities forming a photonic molecule. Tuning is achieved by using an electrically generated radio frequency surface acoustic wave. 05 October 2015 | doi: 10.1038/ncomms9540 Physical Sciences  Materials science  Nanotechnology  Optical physics  A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles OPEN Chensu Wang, Yiguang Wang, Yang Li, Brian Bodemann, Tian Zhao, Xinpeng Ma, Gang Huang, Zeping Hu, Ralph J. DeBerardinis, Michael A. White and Jinming Gao Endocytic organelles are a dynamic continuum of vacuolar structures that impact various cell physiological processes. Here, the authors report a library of ultra-pH sensitive fluorescent nanoparticles for the controlled perturbation and quantification of catabolic organelle maturation at organelle resolution. 05 October 2015 | doi: 10.1038/ncomms9524 Biological Sciences  Cell biology  Chemical biology  ‘Emergency exit’ of bone-marrow-resident CD34+DNAM-1brightCXCR4+-committed lymphoid precursors during chronic infection and inflammation OPEN Federica Bozzano, Francesco Marras, Maria Libera Ascierto, Claudia Cantoni, Giovanni Cenderello, Chiara Dentone, Antonio Di Biagio, Giancarlo Orofino, Eugenio Mantia, Silvia Boni, Pasqualina De Leo, Antonino Picciotto, Fulvio Braido, Francesca Antonini, Ena Wang, Francesco Marincola, Lorenzo Moretta and Andrea De Maria Lymphocytes are on high demand during chronic infections. Here, the authors show that human lymphoid precursors, normally found in the bone marrow, circulate in the blood of chronic inflammation patients and give rise to natural killer cells and other lymphocytes. 05 October 2015 | doi: 10.1038/ncomms9109 Biological Sciences  Immunology  Genome-wide association study identifies multiple susceptibility loci for glioma OPEN Ben Kinnersley, Marianne Labussière, Amy Holroyd, Anna-Luisa Di Stefano, Peter Broderick, Jayaram Vijayakrishnan, Karima Mokhtari, Jean-Yves Delattre, Konstantinos Gousias, Johannes Schramm, Minouk J. Schoemaker, Sarah J. Fleming, Stefan Herms, Stefanie Heilmann, Stefan Schreiber, Heinz-Erich Wichmann, Markus M. Nöthen, Anthony Swerdlow, Mark Lathrop, Matthias Simon et al. Using meta-analysis of previous genome-wide association studies against the latest reference variant databases, this work identifies five new risk loci for glioblastoma and non-glioblastoma type of glioma. 01 October 2015 | doi: 10.1038/ncomms9559 Biological Sciences  Genetics  Asymmetric synthesis of syn-propargylamines and unsaturated β-amino acids under Brønsted base catalysis OPEN Yingcheng Wang, Mingjie Mo, Kongxi Zhu, Chao Zheng, Hongbin Zhang, Wei Wang and Zhihui Shao Propargylamines are of interest both as biologically active compounds and versatile synthetic intermediates. Here, the authors report a method for the organocatalytic asymmetric synthesis of propargylamines through addition of carbon nucleophiles to alkynyl imines. 01 October 2015 | doi: 10.1038/ncomms9544 Chemical Sciences  Catalysis  Organic chemistry  SiR–Hoechst is a far-red DNA stain for live-cell nanoscopy OPEN Gražvydas Lukinavičius, Claudia Blaukopf, Elias Pershagen, Alberto Schena, Luc Reymond, Emmanuel Derivery, Marcos Gonzalez-Gaitan, Elisa D’Este, Stefan W. Hell, Daniel Wolfram Gerlich and Kai Johnsson Existing DNA stains for live cell microscopy are either toxic, require illumination with blue light, or are not compatible with super-resolution microscopy. Here the authors develop SiRHoechst, a non-toxic far-red DNA stain that is compatible with super-resolution microscopy. 01 October 2015 | doi: 10.1038/ncomms9497 Biological Sciences  Biotechnology  Cell biology  A deuterostome origin of the Spemann organiser suggested by Nodal and ADMPs functions in Echinoderms OPEN François Lapraz, Emmanuel Haillot and Thierry Lepage Establishment of the body plan in chordates is determined by an organizing centre located on the dorsal side of the embryo. Here, the authors show that the ventral ectoderm of the sea urchin embryo is an organizing centre that shares several fundamental properties with the amphibian Spemann organizer. 01 October 2015 | doi: 10.1038/ncomms9434 Biological Sciences  Developmental biology  Evolution  Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography OPEN Michael J. Page, André L. Lourenço, Tovo David, Aaron M. LeBeau, Fiore Cattaruzza, Helena C. Castro, Henry F. VanBrocklin, Shaun R. Coughlin and Charles S. Craik Functional imaging of proteolytic activity is an emerging strategy to guide patient diagnosis and monitor clinical outcome. Here the authors present a peptide-based probe to detect and localize thrombin activity ex vivo and non-invasively in mouse models of wounding and pulmonary thrombosis. 01 October 2015 | doi: 10.1038/ncomms9448 Biological Sciences  Biotechnology  Enantiomeric switching of chiral metamaterial for terahertz polarization modulation employing vertically deformable MEMS spirals OPEN Tetsuo Kan, Akihiro Isozaki, Natsuki Kanda, Natsuki Nemoto, Kuniaki Konishi, Hidetoshi Takahashi, Makoto Kuwata-Gonokami, Kiyoshi Matsumoto and Isao Shimoyama Spectroscopy in the terahertz range requires polarization modulation. Here, Kan et al. demonstrate a chirality switchable metamaterial for polarization modulation employing deformable spirals. A polarization rotation as high as 28° is achieved, providing a practical and compact polarization modulator for the terahertz range. 01 October 2015 | doi: 10.1038/ncomms9422 Physical Sciences  Applied physics  Materials science  Optical physics  Controllability of structural brain networks OPEN Shi Gu, Fabio Pasqualetti, Matthew Cieslak, Qawi K. Telesford, Alfred B. Yu, Ari E. Kahn, John D. Medaglia, Jean M. Vettel, Michael B. Miller, Scott T. Grafton and Danielle S. Bassett Cognitive control is fundamental to human intelligence, yet the principles constraining the neural dynamics of cognitive control remain elusive. Here, the authors use network control theory to demonstrate that the structure of brain networks dictates their functional role in controlling dynamics. 01 October 2015 | doi: 10.1038/ncomms9414 Biological Sciences  Applied physics  Neuroscience  Systems biology  Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function OPEN Job de Lange, Atiq Faramarz, Anneke B. Oostra, Renee X. de Menezes, Ida H. van der Meulen, Martin A. Rooimans, Davy A. Rockx, Ruud H. Brakenhoff, Victor W. van Beusechem, Randall W. King, Johan P. de Winter and Rob M. F. Wolthuis Cohesion is associated with many forms of cancer. De Lange et al. show that such cohesion defects can sensitise cells to apoptosis in response to a new APC/C ubiquitin ligase inhibitor, by prolonging mitotic arrest and checkpoint activation due to cohesion fatigue. 01 October 2015 | doi: 10.1038/ncomms9399 Biological Sciences  Cancer  Cell biology  The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division OPEN Min Jia, Zelin Shan, Ying Yang, Chunhua Liu, Jianchao Li, Zhen-Ge Luo, Mingjie Zhang, Yu Cai, Wenyu Wen and Wenning Wang The scaffold protein Miranda is required for the asymmetric segregation of the RNA binding protein Staufen to ganglion mother cells during Drosophila neuroblast division. Jia et al. map the interaction between these proteins and present a crystal structure of the interacting domains. 01 October 2015 | doi: 10.1038/ncomms9381 Biological Sciences  Biochemistry  Neuroscience  Dynamical preparation of Floquet Chern insulators Luca D’Alessio and Marcos Rigol It is predicted that topologically trivial insulators may become topologically non-trivial when periodically driven. Here, the authors consider the dynamics of a graphene-like system under a circularly polarized electric field and follow the time evolution of topological parameters. 01 October 2015 | doi: 10.1038/ncomms9336 Physical Sciences  Condensed matter  Theoretical physics  Ultralow-threshold multiphoton-pumped lasing from colloidal nanoplatelets in solution OPEN Mingjie Li, Min Zhi, Hai Zhu, Wen-Ya Wu, Qing-Hua Xu, Mark Hyunpong Jhon and Yinthai Chan Multiphoton-pumped lasing from semiconductor nanocrystals in solution is difficult due to Auger recombination, low volume fraction and high threshold. Here, Li et al. demonstrate photostable, ultralow threshold multi-photon pumped lasing from colloidal CdSe/CdS nanoplatelets in a Fabry-Pérot optical resonator. 30 September 2015 | doi: 10.1038/ncomms9513 Physical Sciences  Materials science  Nanotechnology  Optical physics  Bio-inspired electron-delivering system for reductive activation of dioxygen at metal centres towards artificial flavoenzymes OPEN Yoann Roux, Rémy Ricoux, Frédéric Avenier and Jean-Pierre Mahy Activated atmospheric dioxygen is potentially an environmentally friendly oxidant. Here, the authors incorporate a flavin mononucleotide into a water soluble polymer, demonstrating single electron reduction of a metalloporphyrin centre, and subsequent activation of dioxygen for the oxidation of organic substrates. 30 September 2015 | doi: 10.1038/ncomms9509 Chemical Sciences  Catalysis  Inorganic chemistry  A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration OPEN Frederic Lagarrigue, Praju Vikas Anekal, Ho-Sup Lee, Alexia I. Bachir, Jailal N. Ablack, Alan F. Horwitz and Mark H. Ginsberg The leading edge of migrating cells contains activated integrins associated with growing actin filaments that form ‘sticky fingers’ to guide cell migration. Here, the authors detect a complex of MRL proteins, talin and activated integrins in lamellipodia and filopodia in living cells, comprising the tips of the ‘sticky fingers’. 30 September 2015 | doi: 10.1038/ncomms9492 Biological Sciences  Cell biology  A tunable azine covalent organic framework platform for visible light-induced hydrogen generation OPEN Vijay S. Vyas, Frederik Haase, Linus Stegbauer, Gökcen Savasci, Filip Podjaski, Christian Ochsenfeld and Bettina V. Lotsch Production of hydrogen via the photocatalytic reduction of water is an attractive source of energy, but the catalysts are often expensive and possess little room for modification. Here, the authors show that covalent organic frameworks can be tuned for optimal photocatalytic performance. 30 September 2015 | doi: 10.1038/ncomms9508 Chemical Sciences  Catalysis  Materials science  BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5 OPEN Junying Qin, Zhongmei Zhou, Wenlin Chen, Chunyan Wang, Hailin Zhang, Guangzhe Ge, Ming Shao, Dingyun You, Zhixiang Fan, Houjun Xia, Rong Liu and Ceshi Chen The zinc finger-containing transcription factor KLF5 drives cell proliferation and migration. Here, the authors show that the debuquitinase BAP1 directly stabilizes KLF5, thus promoting basal-like breast cancer cell-cycle progression and metastasis. 30 September 2015 | doi: 10.1038/ncomms9471 Biological Sciences  Cancer  Cell biology  Medical research  Towards a table-top microscope for nanoscale magnetic imaging using picosecond thermal gradients OPEN J. M. Bartell, D. H. Ngai, Z. Leng and G. D. Fuchs Table-top measurements of magnetic structures and dynamics in thin films are typically limited by temporal or spatial resolution. Here, the authors present a heat-based spatiotemporal magnetic microscopy method based on the anomalous Nernst effect, which may potentially overcome such limits. 30 September 2015 | doi: 10.1038/ncomms9460 Physical Sciences  Applied physics  Condensed matter  Cognitive tutoring induces widespread neuroplasticity and remediates brain function in children with mathematical learning disabilities OPEN Teresa Iuculano, Miriam Rosenberg-Lee, Jennifer Richardson, Caitlin Tenison, Lynn Fuchs, Kaustubh Supekar and Vinod Menon Mathematical learning disabilities (MLD) affect up to 20% of children and are linked to poorer socioeconomic and health outcomes in adulthood. Here, Iuculano et al. show that tutoring induced functional changes in multiple brain systems underlie remediation of poor maths skills in children with MLD. 30 September 2015 | doi: 10.1038/ncomms9453 Biological Sciences  Neuroscience  Limited dissemination of the wastewater treatment plant core resistome OPEN Christian Munck, Mads Albertsen, Amar Telke, Mostafa Ellabaan, Per Halkjær Nielsen and Morten O. A. Sommer Wastewater treatment plants (WWTPs) are thought to play a central role in the dissemination of antibiotic resistance genes. Here, the authors identify novel antibiotic resistance genes in WWTPs and show that only a few of the most abundant resistance genes are found outside the WWTP environment. 30 September 2015 | doi: 10.1038/ncomms9452 Biological Sciences  Ecology  Microbiology  Enhanced light absorption by mixed source black and brown carbon particles in UK winter OPEN Shang Liu, Allison C. Aiken, Kyle Gorkowski, Manvendra K. Dubey, Christopher D. Cappa, Leah R. Williams, Scott C. Herndon, Paola Massoli, Edward C. Fortner, Puneet S. Chhabra, William A. Brooks, Timothy B. Onasch, John T. Jayne, Douglas R. Worsnop, Swarup China, Noopur Sharma, Claudio Mazzoleni, Lu Xu, Nga L. Ng, Dantong Liu et al. Uncertainties in the absorptive properties of black and brown carbon particles limit our understanding of their warming potential. Following an extensive field campaign, Liu et al. report that the magnitude of warming is dependent on particle coatings, which vary due to source and photochemical aging. 30 September 2015 | doi: 10.1038/ncomms9435 Earth Sciences  Atmospheric science  Climate science  Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis OPEN Dong Hu, Mert Gur, Zhuan Zhou, Armin Gamper, Mien-Chie Hung, Naoya Fujita, Li Lan, Ivet Bahar and Yong Wan Krüppel-like factor 4 plays an important role in regulating responses to DNA damage, cell-fate decision and apoptosis. Here the authors show that aberrant regulation by methyltransferase PRMT5 results in failure to arrest the cell cycle and genome instability, pointing to a role in carcinogenesis. 30 September 2015 | doi: 10.1038/ncomms9419 Biological Sciences  Cancer  Molecular biology  Localization of Hippo signalling complexes and Warts activation in vivo OPEN Shuguo Sun, B. V. V. G. Reddy and Kenneth D. Irvine Components of the Hippo signalling pathway localize to apical junctions in epithelial cells, where they regulate growth in response to mechanical and biochemical cues. Sun et al. show that these proteins are organized into distinct junctional complexes, which reorganize up on Hippo pathway activation. 30 September 2015 | doi: 10.1038/ncomms9402 Biological Sciences  Cell biology  Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus OPEN Liya Hu, Sasirekha Ramani, Rita Czako, Banumathi Sankaran, Ying Yu, David F. Smith, Richard D. Cummings, Mary K. Estes and B. V. Venkataram Prasad Rotaviruses cause life-threatening gastroenteritis in children and have been shown to have variations in glycan recognition from genetic alterations. Here, the authors use X-ray crystallography to indicate that these alterations can change the specificity of the virus from cows to infant humans. 30 September 2015 | doi: 10.1038/ncomms9346 Biological Sciences  Biochemistry  Virology  The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events OPEN Deanna N. Edwards, Amrita Machwe, Li Chen, Vilhelm A. Bohr and David K. Orren The loss of WRN helicase leads to abnormalities at chromosome ends and is associated with premature ageing phenotypes characteristic of Werner syndrome. Here the authors show that WRN acts in a structure- and sequence-specific manner on recombination intermediates relevant to telomere maintenance. 30 September 2015 | doi: 10.1038/ncomms9331 Biological Sciences  Biochemistry  Genetics  Molecular biology  A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1 OPEN Shilong Yang, Fan Yang, Ningning Wei, Jing Hong, Bowen Li, Lei Luo, Mingqiang Rong, Vladimir Yarov-Yarovoy, Jie Zheng, KeWei Wang and Ren Lai The venom of the Chinese red-headed centipede causes excruciating pain. Here, Yang et al. identify a novel toxin protein from the centipede venom and find that it can activate the nociceptive TRPV1 ion channel by binding to the channel’s outer pore to potentiate the heat activation machinery. 30 September 2015 | doi: 10.1038/ncomms9297 Biological Sciences  Biophysics  Neuroscience  PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells Haibo Han, Yantao Du, Wei Zhao, Sheng Li, Dongji Chen, Jing Zhang, Jiang Liu, Zhenhe Suo, Xiuwu Bian, Baocai Xing and Zhiqian Zhang α2δ1 is a marker of liver tumour-initiating cells. Here the authors show that PBX3 is necessary and sufficient for tumour initiation by α2δ1+ cells by regulating transcription of stemness genes, and that PBX3 is targeted by four miRNAs downregulated in α2δ1+ cells. 30 September 2015 | doi: 10.1038/ncomms9271 Biological Sciences  Cancer  Molecular biology  Subducting seamounts control interplate coupling and seismic rupture in the 2014 Iquique earthquake area OPEN Jacob Geersen, César R. Ranero, Udo Barckhausen and Christian Reichert On 1 April 2014 the Mw 8.1 Iquique earthquake seemed to close the well-recognized northern Chile seismic gap, producing only a small rupture. Here, the authors present seismic reflection and multibeam bathymetry data from the area suggesting that seamount subduction played a role in halting the rupture. 30 September 2015 | doi: 10.1038/ncomms9267 Earth Sciences  Geology and geophysics    Naturecommunications JOBS of the week Junior Research Chairs at Postdoctoral Level International Centre for Fundamental Physics - Ecole Normale Superieure (ENS-ICFP) Post Doctoral Research Associate Texas Tech University Health Sciences Center El Paso Senior Research Scientist California Institute of Technology PhD-scholarships Aarhus University Research Assistant University of Bristol Assistant Professor California Lutheran University Postdoctoral Position University of Geneva Medical School Postdoctoral Fellow Brigham & Women's Hospital - Harvard Medical School Research Associate – Pancreatic Cancer Modelling University College London (UCL) Lecturer (Assistant Professor) University of Bath More Science jobs from Naturecommunications EVENT Nano Israel 2016 02.22.16 Tel Aviv, Israel More science events from       Latest Corrigendum     Corrigendum: Enhanced role of eddies in the Arctic marine biological pump Eiji Watanabe, Jonaotaro Onodera, Naomi Harada, Makio C Honda, Katsunori Kimoto, Takashi Kikuchi, Shigeto Nishino, Kohei Matsuno, Atsushi Yamaguchi, Akio Ishida and Michio J. Kishi 30 September 2015 | doi: 10.1038/ncomms9441 Earth Sciences  Biogeochemistry  Climate science  Oceanography      Advertisement Open for Submissions  A new open access, multi-and interdisciplinary journal dedicated to publishing the finest research on both microbial biofilms and microbiomes, the journal is now open for submissions. Explore the benefits of submitting your next research article.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events You have been sent this Table of Contents Alert because you have opted in to receive it. 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