Nature Biotechnology Contents: Volume 33 pp 1009 - 1112

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Advertisement NEW WHITE PAPER: The Latest Advances in Cell and Tissue Engrafted Mice  This white paper provides an in-depth overview mice engrafted with human cells and tissues e and how they can help to bridge the biological gap between mice and humans.  Learn More About:   How cell and tissue engrafted mice are generated The application of immune system engrafted models in basic and applied research And, read an evaluation of the available super immunodeficient models for cell and issue Download Your Copy Today TABLE OF CONTENTS October 2015 Volume 33, Issue 10 Editorials News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Nature Microbiology: Call for Papers Launching in January 2016, Nature Microbiology is now open for submissions and inviting high-quality submissions. The journal will cover all aspects of microorganisms be it their evolution, physiology and cell biology, their interactions with each other, with a host, with an environment, or their societal significance.  Submit your next research paper to the journal.     Editorials Top Standing up for science   p1009 doi:10.1038/nbt.3384 Smear campaigns against those speaking out against scaremongering on genetically modified (GM) crops highlight why support for scientists involved in public outreach is so important. No sample left behind   p1010 doi:10.1038/nbt.3381 Maximizing the clinical impact of immune profiling will require dedicated immune monitoring facilities and community standards for handling patient samples. News Top Ebola vaccine trial falls short of homerun   pp1011 - 1012 Laura DeFrancesco doi:10.1038/nbt1015-1011 Roche gobbles Smarticles   p1012 doi:10.1038/nbt1015-1012a Illumina opens Helix genomics store   p1012 doi:10.1038/nbt1015-1012b First US biosimilar launch   p1013 doi:10.1038/nbt1015-1013b GSK collaborates with Apple on ResearchKit   pp1013 - 1014 Michael Eisenstein doi:10.1038/nbt1015-1013a First 3D-printed pill   p1014 doi:10.1038/nbt1015-1014a Syngenta rebuffs Monsanto, again   p1014 doi:10.1038/nbt1015-1014b Cat poop coffee goes biotech   p1014 doi:10.1038/nbt1015-1014c Landmark green light for Mosquirix malaria vaccine   pp1015 - 1016 Chris Morrison doi:10.1038/nbt1015-1015 Around the world in a month   p1016 doi:10.1038/nbt1015-1016 Kirk, to boldly go into synthetic biology   pp1017 - 1018 Emily Waltz doi:10.1038/nbt1015-1017 News Feature Gene drive overdrive   pp1019 - 1021 doi:10.1038/nbt.3361 The recent publication of a simple procedure for creating a CRISPR-Cas9-mediated gene drive has some researchers sounding the alarm. What are the risks to populations in the wild and what precautions are necessary? Laura DeFrancesco investigates. Advertisement Enhanced MALDI-TOF MS Performance and Flexibility  From a linear-only system to a unique QIT-TOF configuration to a high-resolution, high-energy TOF-TOF, Shimadzu's suite of MALDI mass spectrometers easily meets the needs of researchers with varying applications and budgets. Mine your data using our comprehensive software solutions. Learn more. Bioentrepreneur Top Building a business Philanthropy's role in translating scientific innovation   pp1022 - 1025 Hemai Parthasarathy and Lindy Fishburne doi:10.1038/nbt.3369 Opinion and Comment Top Correspondence Lessons in simplicity that should shape the future of drug delivery   pp1026 - 1027 Koen Raemdonck and Stefaan C De Smedt doi:10.1038/nbt.3366 Professionalism and ethics in animal research   pp1027 - 1028 Nikola Biller-Andorno, Herwig Grimm and Rebecca L Walker doi:10.1038/nbt.3363 Chinese government reaffirms backing for GM products   p1029 Rongrong Li, Qiang Wang and Alan McHughen doi:10.1038/nbt.3362 Increased bioavailable vitamin B6 in field-grown transgenic cassava for dietary sufficiency   pp1029 - 1032 Kuan-Te Li, Michael Moulin, Nathalie Mangel, Monique Albersen, Nanda M Verhoeven-Duif et al. doi:10.1038/nbt.3318 Features Top Patents Gene patent practice across plant and human genomes   pp1033 - 1038 Osmat A Jefferson, Deniz Kollhofer, Thomas H Ehrich and Richard A Jefferson doi:10.1038/nbt.3364 The uses of genetic sequences to inform, enable or create products or services for human biomedicine are substantially different from their uses in crop-based agriculture. Recent patents in synthetic nucleic acids and proteins   p1039 doi:10.1038/nbt.3382 News and Views Top A BiTE from cancer's intracellular menu   pp1040 - 1041 Alexander I Salter and Stanley R Riddell doi:10.1038/nbt.3370 T cells are targeted to tumor cells expressing an intracellular antigen using a bispecific antibody. See also: Research by Dao et al. Strain recovery from metagenomes   pp1041 - 1043 C Titus Brown doi:10.1038/nbt.3375 Genome assembly of closely related strains present in very large metagenome data sets is enabled by a de novo pre-assembly algorithm. See also: Computational Biology by Cleary et al. Stabilizing prospects for a universal flu vaccine   pp1043 - 1044 doi:10.1038/nbt.3378 Research Highlights   p1044 doi:10.1038/nbt.3368 Biotechnology JOBS of the week Assistant Professor, Stem Cell Genomics University of California, Santa Cruz Postdoctoral Position Genetic Interaction Mapping Helmholtz Association Postdoctoral Scientist John Innes Centre (JIC) Post-Doc positions in Bioinformatics / Biostatistics University of Florida Two Postdoctoral Positions within Drug Discovery and Protein Biochemistry University of Copenhagen More Science jobs from Biotechnology EVENT Plant Genomes & Biotechnology: from Genes to Networks December 2, 2015 Cold Spring Harbor, USA More science events from Computational Biology Top Analysis ConStrains identifies microbial strains in metagenomic datasets   pp1045 - 1052 Chengwei Luo, Rob Knight, Heli Siljander, Mikael Knip, Ramnik J Xavier et al. doi:10.1038/nbt.3319 Different bacterial strains in a metagenome are distinguished using a method that detects SNPs in conserved genes. Detection of low-abundance bacterial strains in metagenomic datasets by eigengenome partitioning   pp1053 - 1060 Brian Cleary, Ilana Lauren Brito, Katherine Huang, Dirk Gevers, Terrance Shea et al. doi:10.1038/nbt.3329 Bacterial strains that make up as little as 0.00001% of a microbial community are detected in metagenomic sequencing data. See also: News and Views by Brown Research Top Perspective Systems strategies for developing industrial microbial strains   pp1061 - 1072 Sang Yup Lee and Hyun Uk Kim doi:10.1038/nbt.3365 Brief Communications Subangstrom single-molecule measurements of motor proteins using a nanopore   pp1073 - 1075 Ian M Derrington, Jonathan M Craig, Eric Stava, Andrew H Laszlo, Brian C Ross et al. doi:10.1038/nbt.3357 The movement of single motor proteins on DNA is measured at subangstrom resolution using a nanopore. Improving folate (vitamin B9) stability in biofortified rice through metabolic engineering   pp1076 - 1078 Dieter Blancquaert, Jeroen Van Daele, Simon Strobbe, Filip Kiekens, Sergei Storozhenko et al. doi:10.1038/nbt.3358 Folate stability in stored biofortified rice is improved by complexing to folate-binding proteins. Article Therapeutic bispecific T-cell engager antibody targeting the intracellular oncoprotein WT1   pp1079 - 1086 Tao Dao, Dmitry Pankov, Andrew Scott, Tatyana Korontsvit, Victoriya Zakhaleva et al. doi:10.1038/nbt.3349 A bi-specific antibody that binds both T cells and a tumor-specific intracellular antigen shows therapeutic promise in mouse models of cancer. See also: News and Views by Salter & Riddell Letters De novo sequencing and variant calling with nanopores using PoreSeq   pp1087 - 1091 Tamas Szalay and Jene A Golovchenko doi:10.1038/nbt.3360 Nanopore sequencing of microbial genomes is achieved at low coverage without a reference genome using PoreSeq. Optogenetic control of endogenous Ca2+ channels in vivo    pp1092 - 1096 Taeyoon Kyung, Sangkyu Lee, Jung Eun Kim, Taesup Cho, Hyerim Park et al. doi:10.1038/nbt.3350 A single-component optogenetic tool controls calcium fluxes with high dynamic range. Engineering pulmonary vasculature in decellularized rat and human lungs   pp1097 - 1102 Xi Ren, Philipp T Moser, Sarah E Gilpin, Tatsuya Okamoto, Tong Wu et al. doi:10.1038/nbt.3354 In a step toward bioengineered lungs, the vasculature is regenerated in decellularized rat and human lung scaffolds. Resources A catalog of the mouse gut metagenome   pp1103 - 1108 Liang Xiao, Qiang Feng, Suisha Liang, Si Brask Sonne, Zhongkui Xia et al. doi:10.1038/nbt.3353 The mouse gut microbiome is catalogued and compared to the human microbiome. Errata Erratum: Prediction of human population responses to toxic compounds by a collaborative competition   p1109 Federica Eduati, Lara M Mangravite, Tao Wang, Hao Tang, J Christopher Bare et al. doi:10.1038/nbt1015-1109a Erratum: Drug pipeline: 2Q15   p1109 Laura DeFrancesco doi:10.1038/nbt1015-1109b Corrigendum Corrigendum: Assembling large genomes with single-molecule sequencing and locality-sensitive hashing   p1109 Konstantin Berlin, Sergey Koren, Chen-Shan Chin, James P Drake, Jane M Landolin et al. doi:10.1038/nbt1015-1109c Careers and Recruitment Top The right track for you in biotech and biomedical sciences   pp1110 - 1111 Laxmi Ravi Iyer and Sandhya Sriram doi:10.1038/nbt.3376 In Singapore, a recent panel showcased the many career paths and options available for those in the biotech sector. People People   p1112 doi:10.1038/nbt.3379 Advertisement Nature Plants: Call for Papers Nature Plants launched in January and covers all aspects of plants be it their evolution, genetics, development or metabolism, their interactions with the environment, or their societal significance. The journal welcomes high quality submissions and encourages you and your colleagues to consider submitting your next research paper to the journal.  Submit your next research paper to the journal.     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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