Nature Reviews Microbiology contents October 2015 Volume 13 Number 10 pp pp 599-657

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TABLE OF CONTENTS
October 2015 Volume 13 Number 10
Impact Factor 23.574 *	In this issue Research Highlights News and Analysis Reviews Perspectives Also this month  Featured article: Outermembrane vesicles from Gram-negative bacteria: biogenesis and functions Carmen Schwechheimer & Meta J. Kuehn
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RESEARCH HIGHLIGHTS Top Viral infection: Stemming influenza viruses p599 | doi:10.1038/nrmicro3553 These two studies report novel vaccination strategies to elicit antibodies that target the conserved stem region of haemagglutinin in order to generate protective immune responses against multiple influenza subtypes. PDF Viral evolution: The history of Lassa virus p600 | doi:10.1038/nrmicro3550 A new study delineates the origin and transmission pattern of Lassa virus, an important human pathogen. PDF Bacterial toxins: Pick 'n' mix toxins p600 | doi:10.1038/nrmicro3554 A new study shows that variability of contact-dependent growth inhibition toxins is linked to a large repertoire of cell-entry pathways. PDF Parasite biology: Malaria alters B cell lymphomagenesis p602 | doi:10.1038/nrmicro3555 Malaria infection modifies endemic Burkitt lymphomas by inducing a prolonged expansion of germinal centre B cell numbers. PDF Bacterial evolution: To divide and conquer p602 | doi:10.1038/nrmicro3556 A new study reports that the genetic diversification of Pseudomonas aeruginosa within the lungs of patients with cystic fibrosis (CF) is driven by regional isolation. PDF IN BRIEF Bacterial secretion: MIXing up T6SS effectors | Fungal ecology: A surprising find of far-flung fungi | Techniques & applications: Lighting up intestinal anaerobes | Microbiome: Interkingdom suppression of virulence | Viral infection: Growing our knowledge of HCV replication | Bacterial pathogenesis: Ironing out Legionella infection PDF Microbiology JOBS of the week Assistant Professor of Microbiology University of Tennessee Knoxville Assistant Professor in Microbiology The University of Iowa More Science jobs from Microbiology EVENT Genomics and Clinical Microbiology 17.01.16 Cambridge, UK More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH How apicomplexans became free-riders Christian K. Owusu & Hayley M. Bennett p603 | doi:10.1038/nrmicro3551 This month's Genome Watch explores apicomplexan adaptation to parasitism. PDF
REVIEWS		Top
Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions Carmen Schwechheimer & Meta J. Kuehn p605 | doi:10.1038/nrmicro3525 In this Review, Schwechheimer and Kuehn describe recent developments in elucidating the mechanisms of biogenesis and cargo selection of the outer-membrane vesicles (OMVs) produced by Gram-negative bacteria. They also discuss the functions of OMVs in bacterial physiology and during pathogenesis. Abstract | Full Text | PDF
Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi Lisa Brown, Julie M. Wolf, Rafael Prados-Rosales & Arturo Casadevall p620 | doi:10.1038/nrmicro3480 How extracellular vesicles traverse the thick cell walls of Gram-positive bacteria, mycobacteria and fungi has perplexed researchers. In this Review, Prados-Rosales and colleagues consider possible solutions to this conundrum and describe the diverse functions of the extracellular vesicles produced by these organisms. Abstract | Full Text | PDF
Structure and function of Fic proteins Craig R. Roy & Jacqueline Cherfils p631 | doi:10.1038/nrmicro3520 In this Review, Roy and Cherfils discuss the structures and functions of Fic proteins, focusing on how Fic proteins from bacterial pathogens mediate post-translational modifications of host cell proteins. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION A new perspective on lysogeny: prophages as active regulatory switches of bacteria Ron Feiner, Tal Argov, Lev Rabinovich, Nadejda Sigal, Ilya Borovok & Anat A. Herskovits p641 | doi:10.1038/nrmicro3527 In this Opinion article, Herskovits and colleagues introduce an emerging class of bacteria-phage symbiotic interaction — which they term 'active lysogeny' — in which phages regulate the expression of bacterial genes by precise insertion and excision events. Abstract | Full Text | PDF
SCIENCE AND SOCIETY Cooperative development of antimicrobials: looking back to look ahead Carl Nathan p651 | doi:10.1038/nrmicro3523 In this Science and Society article, Carl Nathan reviews historical collaborations between industry and academic instiutions that developed antimicrobials, and discusses similar strategies that have recently emerged to tackle the crisis of antimicrobial resistance. Abstract | Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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