Nature Reviews Immunology Contents August 2015 Volume 15 Number 10 pp 595-663

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TABLE OF CONTENTS
October 2015 Volume 15 Number 10
Impact Factor 34.985 *	In this issue Research Highlights Reviews Also this month  Featured article: Emerging cytokine networks in colorectal cancer Nathan R. West, Sarah McCuaig, Fanny Franchini & Fiona Powrie
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RESEARCH HIGHLIGHTS Top Autoimmunity: The bug eye bandits p595 | doi:10.1038/nri3911 The intestinal microbiota activates pathogenic T cells in a model of autoimmune uveitis. PDF Macrophages: Controlling innate immune memory p596 | doi:10.1038/nri3914 The transcription factor ATF7 mediates epigenetic changes that lead to innate immune memory. PDF Regulatory T Cells: Distinct role in tissue repair p596 | doi:10.1038/nri3915 Regulatory T cells have a non-redundant role in tissue repair that is distinct from their suppressive functions. PDF Chemokines: Neutrophils leave a trail for T cells p597 | doi:10.1038/nri3917 Neutrophils guide CD8+ T cells into virus-infected tissue by leaving a trail of membrane particles enriched for CXCL12. PDF Inflammation: TET2: the terminator p598 | doi:10.1038/nri3912 The epigenetic modifier TET2 is required to repress interleukin-6 gene transcription and resolve inflammation. PDF JOURNAL CLUB Bringing Warburg to lymphocytes p598 | doi:10.1038/nri3918 Ruslan Medzhitov describes a 2002 paper by Craig Thompson and colleagues that brought the concept of Warburg metabolism to lymphocytes. PDF Immunology JOBS of the week postdoctoral positions in Immunology University of Pittsburgh Medical Center (UPMC) Post-Doctoral Research Fellow - Tumor Immunology Fred Hutchinson Cancer Research Center PostDoctoral Position in Immunology and Virology Herman B Wells Center for Pediatric Research More Science jobs from Immunology EVENT Plant Genetics and Breeding Technologies II 01.02.16 Vienna, Austria More science events from
REVIEWS		Top
Regulation of innate immune cell function by mTOR Thomas Weichhart, Markus Hengstschlager & Monika Linke p599 | doi:10.1038/nri3901 The rapid response of innate immune cells requires metabolic reprogramming to support their specific effector functions. As discussed here, mTOR is a key regulator of this process: it senses the environmental and intracellular nutritional status of innate immune cells to dictate and optimize the inflammatory response. Abstract | Full Text | PDF
Emerging cytokine networks in colorectal cancer Nathan R. West, Sarah McCuaig, Fanny Franchini & Fiona Powrie p615 | doi:10.1038/nri3896 Here, the authors review new insights into the diverse and pleiotropic roles of cytokines at different stages of colorectal cancer development and progression, emphasizing mutations and epigenetic adaptations that influence the oncogenic potential of cytokines and summarizing the challenges posed by complex cytokine networks for cancer immunomodulatory therapy. Abstract | Full Text | PDF
Immune defence against Candida fungal infections Mihai G. Netea et al. p630 | doi:10.1038/nri3897 This Review describes the host immune response to Candida fungal infections. The authors detail the innate and adaptive immune mechanisms, as well as the non-immune mechanisms, that are involved in the antifungal response. They also discuss emerging evidence suggesting that both innate and adaptive immune cells contribute to immune memory against Candida species. Abstract | Full Text | PDF
Lipid and small-molecule display by CD1 and MR1 Ildiko Van Rhijn, Dale I. Godfrey, Jamie Rossjohn & D. Branch Moody p643 | doi:10.1038/nri3889 This Review focuses on the lesser studied antigen-presenting molecules group 1 CD1 proteins and MHC class I-related protein (MR1). The authors explain how their mode of presentation of lipids and small molecules to T cells differs from that of peptide-MHC presentation, and how new technologies are revealing unique T cell subsets that are specific for CD1 and MR1 proteins. Abstract | Full Text | PDF
The nature of immune responses to urinary tract infections Soman N. Abraham & Yuxuan Miao p655 | doi:10.1038/nri3887 This Review describes our current understanding of innate and adaptive immune responses in the urinary tract and how immunomodulatory therapies could provide benefit in an era of increasing antibiotic resistance among uropathogens. Abstract | Full Text | PDF
Erratum: Genetic susceptibility to invasive Salmonella disease James J. Gilchrist, Calman A. MacLennan & Adrian V. S. Hill p663 | doi:10.1038/nri3909 Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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