Nature Reviews Cancer contents October 2015 Volume 15 Number 10 pp573-634

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TABLE OF CONTENTS
October 2015 Volume 15 Number 10		Advertisement
Impact Factor 37.912 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Cancer origins  Featured article: MYC: connecting selective transcriptional control to global RNA production Theresia R. Kress, Arianna Sabò & Bruno Amati	Real-Time Killing Assay for CAR T-Cells  xCELLigence Real-Time Cell Analysis (RTCA) Instruments from ACEA Biosciences enable label-free kinetic characterization of CAR T-cell mediated cytolysis of tumor cells with the push of a button. For more info & a FREE demo offer, visit www.aceabio.com/CART
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RESEARCH HIGHLIGHTS Top Tumour immunology: An exhausting metabolic competition p573 | doi:10.1038/nrc4014 Two studies published in Cell have shown that reduction of glucose levels in the tumour microenvironment by highly glycolytic tumour cells reduces the ability of tumour-infiltrating lymphocytes to trigger an antitumour immune response. PDF Therapy: Conscious uncoupling p574 | doi:10.1038/nrc4011 Herrero et al. have shown that inhibition of ERK dimerization with a small molecule prevents tumorigenesis. PDF MYC: Splicing up your survival p574 | doi:10.1038/nrc4013 Westbrook and colleagues show that knockdown of spliceosome components causes synthetic lethality in cells with hyperactive MYC, highlighting a possible therapeutic opportunity. PDF Genomics: The interloper p576 | doi:10.1038/nrc4012 Three studies have revealed a role for the retrotransposon long interspersed element 1 (LINE-1) in tumour progression. PDF IN BRIEF Lymphoma: A malaria mechanism | Oncogenes: Altered traffic flow | Cancer stem cells: Different in the details | Tumour heterogeneity: Growth rates and tumour evolution | Obesity: The supersized tumour microenvironment | Pancreatic cancer: PDAC subtypes | Tumour suppression: PTEN gains new powers PDF Cancer JOBS of the week Higher Scientific Officer (Cancer Proteomics) Institute of Cancer Research (ICR) Optogenetics in Cancer Research Institut Curie Faculty Positions in Basic and Translational Cancer Research UNC Lineberger Comprehensive Cancer Center Postdoctoral Positions - Cancer Biology University of Kentucky Post-doctoral fellow – breast cancer research University Health Network More Science jobs from Cancer EVENT Lung Cancer Centre of Excellence Conference 2015 13.12.15 Manchester, UK More science events from
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REVIEWS		Top
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road Christopher J. Caunt, Matthew J. Sale, Paul D. Smith & Simon J. Cook p577 | doi:10.1038/nrc4000 MEK1 and MEK2 have key roles in tumorigenesis and, therefore, represent promising targets for cancer therapy. This Review discusses the mechanisms of action of different inhibitors of MEK1 and MEK2, the mechanisms of resistance to these inhibitors and their current clinical progress. Abstract | Full Text | PDF | Supplementary information
MYC: connecting selective transcriptional control to global RNA production Theresia R. Kress, Arianna Sabo & Bruno Amati p593 | doi:10.1038/nrc3984 The transcription factor MYC upregulates and downregulates distinct sets of target genes, promoting cell growth and proliferation, increased metabolic rate and RNA biogenesis. This Review discusses MYC-mediated transcriptional regulation in normal growth control, as well as in tumour development and maintenance. Abstract | Full Text | PDF
The multifaceted functions of sirtuins in cancer Angeliki Chalkiadaki & Leonard Guarente p608 | doi:10.1038/nrc3985 This Review discusses the roles of members of the sirtuin (SIRT) family in cancer biology, which have dichotomous, context-dependent functions as tumour suppressors and oncogenes. Furthermore, the authors discuss the possibility of targeting the sirtuins for anticancer therapy. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: Cancer origins Constitutional epimutation as a mechanism for cancer causality and heritability? Megan P. Hitchins p625 | doi:10.1038/nrc4001 Aberrations in gene expression due to an altered epigenotype that is widely distributed in normal tissues are referred to as constitutional epimutations. This Opinion article discusses the potential contribution of constitutional epimutations to the 'missing' causality and heritability of cancer. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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