Laboratory Investigation - Table of Contents alert Volume 95 Issue 10

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS Volume 95, Issue 10 (October 2015) In this issue Inside the USCAP Journals Research Articles Technical Reports Corrigendum Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Inside the USCAP Journals Top Inside the USCAP Journals 2015 95: 1090-1091; 10.1038/labinvest.2015.121 Full Text Research Articles Top GENITOURINARY AND REPRODUCTIVE SYSTEMS Enhancing eNOS activity with simultaneous inhibition of IKKβ restores vascular function in Ins2Akita+/− type-1 diabetic mice In diabetes, endothelial nitric oxide synthase (eNOS) produces superoxide rather than NO. This paper describes a treatment for enhancing NO availability in the type- 1 diabetic Ins2Akita+/− mouse model. Addition of salsalate, a negative regulator of inhibitor kappa B kinase, to a diet supplemented with L-arginine and sepiapterin, a precursor of the eNOS cofactor tetrahydrobiopterin, significantly improves vasorelaxation of thoracic/abdominal aorta in these mice. Manickam Krishnan, Preethi Janardhanan, Linda Roman, Robert L Reddick, Mohan Natarajan, Rien van Haperen, Samy L Habib, Rini de Crom and Sumathy Mohan 2015 95: 1092-1104; advance online publication, July 27, 2015; 10.1038/labinvest.2015.96 Abstract | Full Text HDAC is essential for epigenetic regulation of Thy-1 gene expression during LPS/TLR4-mediated proliferation of lung fibroblasts Lipopolysaccharide (LPS)-induced proliferation of lung fibroblasts correlates with loss of expression of thymocyte differentiation antigen-1 (Thy-1), accompanied by deacetylation of histones H3 and H4 at the Thy-1 gene promoter region. This paper shows that LPS down-regulates Thy-1 gene expression by activating histone deacetylases (HDACs) via toll-like receptor 4 (TLR4) signaling, which contributes to Thy-1 gene silencing and lung fibroblast proliferation, leading to pulmonary fibrosis. Shunpeng Xing, Fang Nie, Qiaoyi Xu, Yuxiao Deng, Wen Li, Zhongwei Yang, Xianyuan Zhao, Ping Zhu, Xiangrui Wang, Yuan Gao and Zhengyu He 2015 95: 1105-1116; advance online publication, July 27, 2015; 10.1038/labinvest.2015.97 Abstract | Full Text HEPATIC AND PANCREATIC SYSTEMS Tissue-type plasminogen activator suppresses activated stellate cells through low-density lipoprotein receptor-related protein 1 OPEN This study shows that in livers subjected to acute carbon tetrachloride poisoning, tissue-type plasminogen activator/lipoprotein receptor-related protein 1 (t-PA/LRP1) signaling through the Akt1 kinase is involved in the regression of activated stellate cells during repair. This finding is unique; previous studies in the kidney show that t-PA/LRP1 signaling through ERK, or extracellular-signal-regulated kinases, is pro-fibrotic. Liang-I Kang, Kumiko Isse, Kelly Koral, William C Bowen, Selen Muratoglu, Dudley K Strickland, George K Michalopoulos and Wendy M Mars 2015 95: 1117-1129; advance online publication, August 3, 2015; 10.1038/labinvest.2015.94 Abstract | Full Text Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression This study demonstrates that liver sinusoidal endothelial cell (LSEC) injury plays a “gatekeeper” role in the progression from simple steatosis to the early nonalcoholic steatohepatitis stage. The authors show that LSEC injury appears during the simple steatosis phase, and precedes the appearance of activated Kupffer cells and hepatic stellate cells. Masashi Miyao, Hirokazu Kotani, Tokiko Ishida, Chihiro Kawai, Sho Manabe, Hitoshi Abiru and Keiji Tamaki 2015 95: 1130-1144; advance online publication, July 27, 2015; 10.1038/labinvest.2015.95 Abstract | Full Text Galectin 3 regulates HCC cell invasion by RhoA and MLCK activation Galectin-3, a β-galactoside-binding lectin highly expressed in hepatocellular carcinoma (HCC) tissues, regulates HCC invasion and cell motility via mediation of the GTPase RhoA activation and myosin light chain 2 phosphorylation and the consequent reorganization of the actin cytoskeleton. These findings suggest that galectin-3 could be a diagnostic marker and therapeutic target for HCC. Nobuko Serizawa, Jijing Tian, Hiroo Fukada, Kornelia Baghy, Fiona Scott, Xiangling Chen, Zsofia Kiss, Kristin Olson, Dan Hsu, Fu-Tong Liu, Natalie J Török, Bin Zhao and Joy X Jiang 2015 95: 1145-1156; advance online publication, July 6, 2015; 10.1038/labinvest.2015.77 Abstract | Full Text Endoplasmic reticulum stress as a novel target to ameliorate epithelial-to-mesenchymal transition and apoptosis of human peritoneal mesothelial cells Endoplasmic reticulum (ER) stress induces epithelial-to-mesenchymal transition (EMT) and apoptosis in peritoneal mesothelial cells in a time- and dose-dependent manner. Blocking ER stress ameliorates transforming growth factor-β1-induced EMT and apoptosis, demonstrating the role of ER stress as an adaptive response to peritoneal damage. Therefore, the modulation of ER stress is a novel approach to ameliorate peritoneal fibrosis. Hyun-Soo Shin, Eun-Sun Ryu, Eok-Soo Oh and Duk-Hee Kang 2015 95: 1157-1173; advance online publication, July 20, 2015; 10.1038/labinvest.2015.91 Abstract | Full Text Inhibition of dipeptidyl peptidase IV protects tacrolimus-induced kidney injury Tacrolimus is a maintenance immunosuppressant that is widely used in renal transplant recipients. Current results reveal that inhibition of dipeptidyl peptidase IV (DPP IV) is effective in improving tacrolimus-induced renal damage. Therefore, a targeted therapy aimed at inhibiting DPP IV may be a useful new approach in the management of both nephropathy and diabetes in renal-transplant patients receiving tacrolimus. Sun W Lim, Long Jin, Shang G Piao, Byung H Chung and Chul W Yang 2015 95: 1174-1185; advance online publication, August 3, 2015; 10.1038/labinvest.2015.93 Abstract | Full Text Technical Reports Top MODELS AND TECHNIQUES Investigation of the potential of Raman spectroscopy for oral cancer detection in surgical margins This study shows how well Raman spectroscopy enables discrimination between oral cavity squamous cell carcinoma and surrounding healthy tissue structures. This knowledge supports the development of robust and reliable classification algorithms for future implementation of Raman spectroscopy in clinical practice. Froukje LJ Cals, Tom C Bakker Schut, José A Hardillo, Robert J Baatenburg de Jong, Senada Koljenović and Gerwin J Puppels 2015 95: 1186-1196; advance online publication, August 3, 2015; 10.1038/labinvest.2015.85 Abstract | Full Text Differential miRNA expressions in peripheral blood mononuclear cells for diagnosis of lung cancer Because peripheral blood mononucleated cells (PBMCs) act as the first line of defense against malignancy in immune system, their dysfunction may occur as an early event in cancer immunogenicity or immune evasion. This paper shows that differential miRNA expression of PBMCs may provide a new diagnostic approach for the early detection non-small cell lung cancer. Jie Ma, Yanli Lin, Min Zhan, Dean L Mann, Sanford A Stass and Feng Jiang 2015 95: 1197-1206; advance online publication, July 6, 2015; 10.1038/labinvest.2015.88 Abstract | Full Text Heterogeneity of subordination of the IL-18/IFN-γ axis to caspase-1 among patients with Crohn’s disease To determine whether subordination of the Th1 response to the inflammasome pathway is maintained in intestinal inflammation, the authors employed inflamed mucosa explant cultures from patients with Crohn's disease (CD). Th1 cytokine production was assessed in relation with inflammation intensity. Subordination of the Th1 response to caspase-1, effector of the inflammasome, was determined in explant cultures subjected to pharmacological inhibition of caspase-1. This model demonstrated heterogeneity of subordination of the Th1 response to caspase-1 among CD patients, and may be a screening tool for personalized medicine. Anne Jarry, Céline Bossard, Laure Droy-Dupré, Christelle Volteau, Arnaud Bourreille, Guillaume Meurette, Jean-François Mosnier and Christian L Laboisse 2015 95: 1207-1217; advance online publication, July 13, 2015; 10.1038/labinvest.2015.89 Abstract | Full Text Corrigendum Top Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes Thiago M De Assuncao, Yan Sun, Nidhi Jalan-Sakrikar, Mary C Drinane, Bing Q Huang, Ying Li, Jaime I Davila, Ruisi Wang, Steven P O'Hara, Gwen A Lomberk, Raul A Urrutia, Yasuhiro Ikeda and Robert C Huebert 2015 95: 1218; 10.1038/labinvest.2015.99 Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group |One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.