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| 9 June 2015 Application Notes bring you the latest information about innovative tools and technologies and their applications in the lab. We hope that you will find this service useful and informative and encourage you to sign up for future Updates to ensure that you never miss one! | ||||||||||
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 | | Screening and quantification of the tumor microenvironment with micro-ultrasound and photoacoustic imaging www.visualsonics.com > The family of Vevo® Imaging Systems from FUJIFILM VisualSonics, Inc. is leading to translational breakthroughs in the understanding of cancer progression and therapy. More specifically, high-frequency ultrasound and photoacoustic imaging of orthotopic and patient-derived xenograft (PDX) models of human cancer have empowered researchers in the past decade, with key translational findings on tumor growth and microenvironment and in response to new and existing cancer therapies. This Application Note focuses on the deep-tissue-imaging capabilities of micro-ultrasound and photoacoustic imaging that contributed to these translational findings..
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 | | Microreactor technology - Controlled temperature, controlled flowrate www.fluigent.com > FutureChemistry's FlowStart B-200 microreactor platform in combination with Fluigent's Flow Control Solution (MFCSTM, Fluiwell, Flowell) enables increased process control due to the combination of excellent heat dissipation and a pulseless flow that shows beneficial effect when batchwise syntheses or droplet generation turn out to be low yielded or difficult to control.
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 | | High-throughput microRNA Target Screening: miR-122 Case Study www.switchgeargenomics.com > MicroRNAs (miRNAs) are important regulators of gene expression and have been shown to play a role in numerous biological processes such as cellular signaling (1), cell differentiation, growth, development, and apoptosis (2). Mutations and improper regulation of miRNAs have been linked to a variety of physiological disorders such as cancer and heart disease (3,4). In animals, miRNAs are usually complementary to one or more a sites in the 3'UTRs of specific genes. Although current computational predictions of miRNA-UTR interactions provide important guidance for experimental analysis of miRNAs, little functional data exists on which to train prediction algorithms. Genome-wide transcript analysis can identify candidate target transcripts but cannot measure both the changes in a transcript's stability or translational efficiency attributable to miRNAs. We have created a genome-wide library of human 3'UTR-luciferase reporter constructs to enable researchers to screen thousands of potential miRNA targets in a high throughput fashion. Using this strategy, we sought to identify new targets of miR-122, an important regulator of cholesterol and fatty-acid metabolism in liver that has been suggested as a therapeutic target for metabolic disease (5).
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 | | SafeSeqr - Fast and Robust Food Authenticity Testing using Next-Generation Sequencing (NGS) www.sciencevision.com.my/ > SAFESeqr provides a complete solution for food authenticity test with the development of SAFESeqr Kit for NGS library preparation and SAFESeqr Suite analysis software. SAFESeqr delivers robust, specific, and fast identification of up to 1842 eukaryotic species and 1161 eukaryotic genus. Combining SAFESeqr one-step PCR library preparation workflow and the Illumina MiSeq NGS platform, it is capable of detecting resolving complex and low level sample mixtures requiring only 2ng of input DNA. SAFESeqr complete solution with the highest-quality data generated can be easily visualized and reported using the SAFESeqr Suite analysis software.
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 | | Comparison of real-time signals using white or clear microplates www.analytik-jena.com > Analytik Jena's product family includes the standard real-time thermal cyclers qTOWER 2.0 and 2.2. Featuring a striking, modern design, these systems allow quantitative PCR in an established 96 well format.
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 | | GelApp: Mobile gel electrophoresis analyser www.a-star.edu.sg > GelApp is a free mobile application that automatically detects and quantifies gel electrophoresis bands for "on-the-go" gel documenta-tion. It facilitates quantitative biological research by providing more accurate band sizes.Through the novel implementation of Gabor filters, faint bands can be better detected from noisy backgrounds than conventional image analysis methods. Plotting the marker standard as a logarithmic (log) graph, the sample band sizes are calculated more accurately. Combined, these features help increase the productivity and accu-racy of gel electrophoresis analysis that every scientist can carry in their pockets.
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