Molecular Systems Biology - New articles published - 1 Jun 2015

May 2015 | Volume 11, Number 5 Submit Table of Contents Articles News & Views Articles Corrigendum Editorials Volume 11, Number 5 Articles Orthogonal control of expression mean and variance by epigenetic features at different genomic loci Analyses of the molecular basis of gene expression noise by smFISH and flow cytometry show that in mammalian cells, mean expression and noise are uncorrelated across genomic locations and are affected by the local chromatin environment. Siddharth S Dey, Jonathan E Foley, Prajit Limsirichai, David V Schaffer, and Adam P Arkin Published online 05.05.2015 News & Views Tuning noise in gene expression The relative contribution of promoter architecture and the associated chromatin environment in regulating gene expression noise has remained elusive. Arkin, Schaffer and colleagues (Dey et al, 2015) show that mean expression and noise are uncorrelated and influenced by the chromatin environment. Sanjay Tyagi Published online 05.05.2015 Articles Fractional killing arises from cell‐to‐cell variability in overcoming a caspase activity threshold Non‐genetic cell‐to‐cell variability results in fractional killing by TRAIL and therapeutic antibody agonists, limiting their effectiveness as anti‐cancer drugs. A simple model of initiator caspase dynamics reveals a threshold in caspase activity that separates dying and surviving cells. Jérémie Roux, Marc Hafner, Samuel Bandara, Joshua J Sims, Hannah Hudson, Diana Chai, and Peter K Sorger Published online 07.05.2015 Corrigendum Genome‐wide study of mRNA degradation and transcript elongation in Escherichia coli Huiyi Chen, Katsuyuki Shiroguchi, Hao Ge, and Xiaoliang Sunney Xie Published online 11.05.2015 Editorials The making of Tara Oceans: funding blue skies research for our Blue Planet Transforming a romantic idea into the large‐scale Tara Oceans project was made possible by risk‐taking funders that provided seed support to a self‐organized community of highly committed researchers. Eric Karsenti Published online 21.05.2015 Computational eco‐systems biology in Tara Oceans: translating data into knowledge The computational analysis of the data collected by Tara Oceans represents a formidable challenge that will push the boundaries of our understanding of ecosystems at a planetary scale. Shinichi Sunagawa, Eric Karsenti, Chris Bowler, and Peer Bork Published online 21.05.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.