The EDGE

KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis

M Arock, K Sotlar, C Akin, S Broesby-Olsen, G Hoermann, L Escribano, T K Kristensen, H C Kluin-Nelemans, O Hermine, P Dubreuil, W R Sperr, K Hartmann, J Gotlib, N C P Cross, T Haferlach, A Garcia-Montero, A Orfao, J Schwaab, M Triggiani, H-P Horny, D D Metcalfe, A Reiter and P Valent

Leukemia 2015 29: 1223-1232; advance online publication, February 4, 2015; 10.1038/leu.2015.24

Imprinted genes in myeloid lineage commitment in normal and malignant hematopoiesis

L Benetatos and G Vartholomatos

Leukemia 2015 29: 1233-1242; advance online publication, February 23, 2015; 10.1038/leu.2015.47

Spotlight Review

Role of chromosomal aberrations in clonal diversity and progression of acute myeloid leukemia

T Bochtler, S Fröhling and A Krämer

Leukemia 2015 29: 1243-1252; advance online publication, February 12, 2015; 10.1038/leu.2015.32

Original Articles

ACUTE LEUKEMIAS

L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

C Rosilio, M Nebout, V Imbert, E Griessinger, Z Neffati, J Benadiba, T Hagenbeek, H Spits, J Reverso, D Ambrosetti, J-F Michiels, B Bailly-Maitre, H Endou, M F Wempe and J-F Peyron

Leukemia 2015 29: 1253-1266; advance online publication, December 8, 2014; 10.1038/leu.2014.338

Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells

W Fiskus, S Sharma, S Saha, B Shah, S G T Devaraj, B Sun, S Horrigan, C Leveque, Y Zu, S Iyer and K N Bhalla

Leukemia 2015 29: 1267-1278; advance online publication, December 8, 2014; 10.1038/leu.2014.340

Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells

D H Spencer, M A Young, T L Lamprecht, N M Helton, R Fulton, M O'Laughlin, C Fronick, V Magrini, R T Demeter, C A Miller, J M Klco, R K Wilson and T J Ley

Leukemia 2015 29: 1279-1289; advance online publication, January 20, 2015; 10.1038/leu.2015.6

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

L Chen, W Chen, M Mysliwski, J Serio, J Ropa, F A Abulwerdi, R J Chan, J P Patel, M S Tallman, E Paietta, A Melnick, R L Levine, O Abdel-Wahab, Z Nikolovska-Coleska and A G Muntean

Leukemia 2015 29: 1290-1300; advance online publication, February 4, 2015; 10.1038/leu.2015.18

Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia

M T Witkowski, L Cimmino, Y Hu, T Trimarchi, H Tagoh, M D McKenzie, S A Best, L Tuohey, T A Willson, S L Nutt, M Busslinger, I Aifantis, G K Smyth and R A Dickins

Leukemia 2015 29: 1301-1311; advance online publication, February 6, 2015; 10.1038/leu.2015.27

A randomised comparison of the novel nucleoside analogue sapacitabine with low-dose cytarabine in older patients with acute myeloid leukaemia

A K Burnett, N Russell, R K Hills, N Panoskaltsis, A Khwaja, C Hemmaway, P Cahalin, R E Clark and D Milligan

Leukemia 2015 29: 1312-1319; advance online publication, February 13, 2015; 10.1038/leu.2015.38

CHRONIC MYELOPROLIFERATIVE NEOPLASIAS

The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy

L D Wang, T N Rao, R G Rowe, P T Nguyen, J L Sullivan, D S Pearson, S Doulatov, L Wu, R C Lindsley, H Zhu, D J DeAngelo, G Q Daley and A J Wagers

Leukemia 2015 29: 1320-1330; advance online publication, February 6, 2015; 10.1038/leu.2015.19

Interferon alpha 2 maintenance therapy may enable high rates of treatment discontinuation in chronic myeloid leukemia

A Burchert, S Saussele, E Eigendorff, M C Müller, K Sohlbach, S Inselmann, C Schütz, S K Metzelder, J Ziermann, P Kostrewa, J Hoffmann, R Hehlmann, A Neubauer and A Hochhaus

Leukemia 2015 29: 1331-1335; advance online publication, February 25, 2015; 10.1038/leu.2015.45

The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European Countries

V S Hoffmann, M Baccarani, J Hasford, D Lindoerfer, S Burgstaller, D Sertic, P Costeas, J Mayer, K Indrak, H Everaus, P Koskenvesa, J Guilhot, G Schubert-Fritschle, F Castagnetti, F Di Raimondo, S Lejniece, L Griskevicius, N Thielen, T Sacha, A Hellmann, A G Turkina, A Zaritskey, A Bogdanovic, Z Sninska, I Zupan, J-L Steegmann, B Simonsson, R E Clark, A Covelli, G Guidi and R Hehlmann

Leukemia 2015 29: 1336-1343; advance online publication, March 18, 2015; 10.1038/leu.2015.73

Mutations and long-term outcome of 217 young patients with essential thrombocythemia or early primary myelofibrosis

F Palandri, R Latagliata, N Polverelli, A Tieghi, M Crugnola, B Martino, M Perricone, M Breccia, E Ottaviani, N Testoni, F Merli, F Aversa, G Alimena, M Cavo, G Martinelli, L Catani, M Baccarani and N Vianelli

Leukemia 2015 29: 1344-1349; advance online publication, March 24, 2015; 10.1038/leu.2015.87

CHRONIC LYMPHOCYTIC LEUKEMIA

PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model

T Motiwala, H Kutay, N Zanesi, F W Frissora, X Mo, N Muthusamy and S T Jacob

Leukemia 2015 29: 1350-1359; advance online publication, December 8, 2014; 10.1038/leu.2014.341

Diagnostic and prognostic role of PET/CT in patients with chronic lymphocytic leukemia and progressive disease

F R Mauro, S Chauvie, F Paoloni, A Biggi, G Cimino, A Rago, M Gentile, F Morabito, M Coscia, M Bellò, G M Sacchetti, D Rossi, L Laurenti, F Autore, M Campanelli, F Trastulli, E Nicolai, M Riminucci, G Gaidano, A Guarini, A Gallamini and R Foà

Leukemia 2015 29: 1360-1365; advance online publication, February 4, 2015; 10.1038/leu.2015.21

STEM CELLS

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α OPEN

C E Forristal, B Nowlan, R N Jacobsen, V Barbier, G Walkinshaw, C R Walkley, I G Winkler and J P Levesque

Leukemia 2015 29: 1366-1378; advance online publication, January 12, 2015; 10.1038/leu.2015.8

TRANSCRIPTIONAL CONTROL AND SIGNAL TRANSDUCTION

Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA

H-D Chae, B Mitton, N J Lacayo and K M Sakamoto

Leukemia 2015 29: 1379-1389; advance online publication, December 26, 2014; 10.1038/leu.2014.350

LYMPHOMA

A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation

F Abate, M Todaro, J-A van der Krogt, M Boi, I Landra, R Machiorlatti, F Tabbò, K Messana, C Abele, A Barreca, D Novero, M Gaudiano, S Aliberti, F Di Giacomo, T Tousseyn, E Lasorsa, R Crescenzo, L Bessone, E Ficarra, A Acquaviva, A Rinaldi, M Ponzoni, D L Longo, S Aime, M Cheng, B Ruggeri, P P Piccaluga, S Pileri, E Tiacci, B Falini, B Pera-Gresely, L Cerchietti, J Iqbal, W C Chan, L D Shultz, I Kwee, R Piva, I Wlodarska, R Rabadan, F Bertoni, G Inghirami and The European T-cell Lymphoma Study Group

Leukemia 2015 29: 1390-1401; advance online publication, December 23, 2014; 10.1038/leu.2014.347

BIN1 tumor suppressor regulates Fas/Fas ligand–mediated apoptosis through c-FLIP in cutaneous T-cell lymphoma

S Esmailzadeh, Y Huang, M-W Su, Y Zhou and X Jiang

Leukemia 2015 29: 1402-1413; advance online publication, January 12, 2015; 10.1038/leu.2015.9

Early B-cell-specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas in mice

K Yamamoto, B J Lee, C Li, R L Dubois, E Hobeika, G Bhagat and S Zha

Leukemia 2015 29: 1414-1424; advance online publication, February 13, 2015; 10.1038/leu.2015.41

Letters to the Editor

Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFκB activation in adult T-cell leukemia/lymphoma cells

S Kinpara, S Ito, T Takahata, Y Saitoh, A Hasegawa, M Kijiyama, A Utsunomiya, M Masuda, Y Miyazaki, M Matsuoka, M Nakamura, S Yamaoka, T Masuda and M Kannagi

Leukemia 2015 29: 1425-1429; advance online publication, January 8, 2014; 10.1038/leu.2015.1

Elevated serum sCD23 and sCD30 up to two decades prior to diagnosis associated with increased risk of non-Hodgkin lymphoma

M P Purdue, Q Lan, T J Kemp, A Hildesheim, S J Weinstein, J N Hofmann, J Virtamo, D Albanes, L A Pinto and N Rothman

Leukemia 2015 29: 1429-1431; advance online publication, January 8, 2014; 10.1038/leu.2015.2

Allelic imbalance in CALR somatic mutagenesis OPEN

A S Harutyunyan, R Jäger, D Chen, T Berg, E Rumi, B Gisslinger, D Pietra, H Gisslinger, M Cazzola and R Kralovics

Leukemia 2015 29: 1431-1435; advance online publication, January 8, 2015; 10.1038/leu.2015.3

The predominant myeloma clone at diagnosis, CDR3 defined, is constantly detectable across all stages of disease evolution

N Puig, I Conde, C Jiménez, M E Sarasquete, A Balanzategui, M Alcoceba, J Quintero, M C Chillón, E Sebastián, R Corral, L Marín, N C Gutiérrez, M-V Mateos, M González-Díaz, J F San-Miguel and R García-Sanz

Leukemia 2015 29: 1435-1437; advance online publication, January 8, 2015; 10.1038/leu.2015.7

CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo OPEN

G P Gregory, S J Hogg, L M Kats, E Vidacs, A J Baker, O Gilan, M Lefebure, B P Martin, M A Dawson, R W Johnstone and J Shortt

Leukemia 2015 29: 1437-1441; advance online publication, January 12, 2014; 10.1038/leu.2015.10

Targeting PD1–PDL1 immune checkpoint in plasmacytoid dendritic cell interactions with T cells, natural killer cells and multiple myeloma cells

A Ray, D S Das, Y Song, P Richardson, N C Munshi, D Chauhan and K C Anderson

Leukemia 2015 29: 1441-1444; advance online publication, January 30, 2015; 10.1038/leu.2015.11

Correspondence

Colony-stimulating factor-3 receptor, watch out for polymorphisms

C Bilbao-Sieyro, G Santana, L Torres-Miñana, C Rodriguez-Medina, M N Saez, M Perera, Angelina Lemes, S de la Iglesia, T Molero and M T Gomez-Casares

Leukemia 2015 29: 1445-1446; advance online publication, February 25, 2015; 10.1038/leu.2015.25