Scientific Reports Biology Table of Contents e-alert: 26 May 2015

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26 May 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         New to NPG from Apr 2015 Co-published by Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Nature Publishing Group, Sister Journal to Cell Research. Cell Discovery is a new online open access, fully peer-reviewed journal publishes results of significance and originality in all areas of molecular & cell biology.  Discover more about Cell Discovery            Biological Sciences               Impact of hot events at different developmental stages of a moth: the closer to adult stage, the less reproductive output ▶     Wei Zhang, Xiang-Qian Chang, AryA. Hoffmann et al.     Hot days in summer (involving a few hours at particularly high temperatures) are expected to become more common under climate change. How such events at different life stages …             Increased gastrointestinal blood flow: An essential circulatory modification for euryhaline rainbow trout (Oncorhynchus mykiss) migrating to sea ▶     Jeroen Brijs, Michael Axelsson, Albin Gräns et al.     The large-scale migrations of anadromous fish species from freshwater to seawater have long been considered particularly enigmatic, as this life history necessitates potentially …             Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian Adaptation ▶     Jiasheng Song, Jing Xu, Jianzhong Shi et al.     The adaptation of H5N1 avian influenza viruses to human poses a great threat to public health. Previous studies indicate the adaptive mutations in viral polymerase of avian …             Representation of the Numerosity ‘zero’ in the Parietal Cortex of the Monkey ▶     Sumito Okuyama, Toshinobu Kuki, Hajime Mushiake     Zero is a fundamental concept in mathematics and modern science. Empty sets are considered a precursor of the concept of numerosity zero and a part of numerical continuum. How is …             Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila ▶     Ying Kuo, Huanwei Huang, Tao Cai et al.     Target of rapamycin (TOR) is an evolutionarily conserved serine/threonine protein kinase that functions as a central regulator of cellular growth and metabolism by forming two …             Flower evolution of alpine forbs in the open top chambers (OTCs) from the Qinghai-Tibet Plateau ▶     Chan Zhang, Lin-Lin Wang, Yong-Ping Yang et al.     Effects of global changes on biodiversity have been paid more and more attention world widely, and the open top chambers (OTCs) are the most common tools to study the effects of …             Enhanced segregation of concurrent sounds with similar spectral uncertainties in individuals with autism spectrum disorder ▶     I-Fan Lin, Takashi Yamada, Yoko Komine et al.     When acoustic signals from different sound sources are mixed upon arrival at the ears, the auditory system organizes these acoustic elements by their features. This study shows …             Common AZFc structure may possess the optimal spermatogenesis efficiency relative to the rearranged structures mediated by non-allele homologous recombination ▶     Bo Yang, Yong-yi Ma, Yun-qiang Liu et al.     The azoopsermia factor c (AZFc) region of human Y-chromosome is an essential genomic segment for spermatogenesis with frequent non-allele homologous recombination (NAHR). Recent …             Expedited CO2 respiration in people with Miltenberger erythrocyte phenotype GP.Mur ▶     Kate Hsu, Mei-Shin Kuo, Ching-Che Yao et al.     In Southeast Asia, Miltenberger antigen subtype III (Mi.III; GP.Mur) is considered one of the most important red blood cell antigens in the field of transfusion medicine. Mi.III …             Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects ▶     Osamu Hashizume, Sakiko Ohnishi, Takayuki Mito et al.     Age-associated accumulation of somatic mutations in mitochondrial DNA (mtDNA) has been proposed to be responsible for the age-associated mitochondrial respiration defects found …             Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues ▶     Surbhi Jain, Ting-Tsung Chang, Sitong Chen et al.     Hepatitis B virus (HBV) is a hepatotropic virus causing hepatitis, cirrhosis and hepatocellular carcinoma (HCC). The methylation status of the HBV DNA in its different forms can …             Hearing the light: neural and perceptual encoding of optogenetic stimulation in the central auditory pathway ▶     Wei Guo, Ariel E. Hight, Jenny X. Chen et al.     Optogenetics provides a means to dissect the organization and function of neural circuits. Optogenetics also offers the translational promise of restoring sensation, enabling …             Synapsin IIb as a functional marker of submissive behavior ▶     Elimelech Nesher, Igor Koman, Moshe Gross et al.     Dominance and submissiveness are important functional elements of the social hierarchy. By employing selective breeding based on a social interaction test, we developed mice with …             Antennae hold a key to Varroa-sensitive hygiene behaviour in honey bees ▶     Fanny Mondet, Cédric Alaux, Dany Severac et al.     In honey bees, Varroa sensitive hygiene (VSH) behaviour, which involves the detection and removal of brood parasitised by the mite Varroa destructor, can actively participate in …             Gene expression studies of a human monocyte cell line identify dissimilarities between differently manufactured glatiramoids ▶     Sarah Kolitz, Tal Hasson, Fadi Towfic et al.     Glatiramer Acetate (GA) has provided safe and effective treatment for multiple sclerosis (MS) patients for two decades. It acts as an antigen, yet the precise mechanism of action …             Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration ▶     Shanshan Cheng, Jinxing Hou, Chen Zhang et al.     Minocycline is a broad-spectrum tetracycline antibiotic. A number of preclinical studies have shown that minocycline exhibits neuroprotective effects in various animal models of …             Hydrodynamics of an Electrochemical Membrane Bioreactor ▶     Ya-Zhou Wang, Yun-Kun Wang, Chuan-Shu He et al.     An electrochemical membrane bioreactor (EMBR) has recently been developed for energy recovery and wastewater treatment. The hydrodynamics of the EMBR would significantly affect …             Increased production of BDNF in colonic epithelial cells induced by fecal supernatants from diarrheic IBS patients ▶     Peng Wang, Fei-Xue Chen, Chao Du et al.     Colonic brain-derived neurotrophic factor (BDNF) plays an essential role in pathogenesis of abdominal pain in diarrhea-predominant irritable bowel syndrome (IBS-D), but …             Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines ▶     Gregory Lee Szeto, Debra Van Egeren, Hermoon Worku et al.     B-cells are promising candidate autologous antigen-presenting cells (APCs) to prime antigen-specific T-cells both in vitro and in vivo. However to date, a significant barrier to …             Shear induced carboplatin binding within the cavity of a phospholipid mimic for increased anticancer efficacy ▶     Jingxin Mo, Paul K. Eggers, Xianjue Chen et al.     Vesicles 107 ± 19 nm in diameter, based on the self-assembly of tetra-para-phosphonomethyl calix[4]- arene bearing n-hexyl moieties attached to the phenolic oxygen centres, are …             Screening of aptamers specific to colorectal cancer cells and stem cells by utilizing On-chip Cell-SELEX ▶     Lien-Yu Hung, Chih-Hung Wang, Yu-Jui Che et al.     Colorectal cancer (CRC) is the most frequently diagnosed cancer around the world, causing about 700,000 deaths every year. It is clear now that a small fraction of CRC, named …             Intrinsically Disordered Energy Landscapes ▶     Yassmine Chebaro, Andrew J. Ballard, Debayan Chakraborty et al.     Analysis of an intrinsically disordered protein (IDP) reveals an underlying multifunnel structure for the energy landscape. We suggest that such ‘intrinsically disordered’ …             Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn’s disease patients ▶     Chuan-Xing Xiao, Jing-Jing Xiao, Hong-Zhi Xu et al.     Previous studies have highlighted the role of genetic predispositions in disease, and several genes had been identified as important in Crohn’s disease (CD). However, many of …             Bioinformatical Analysis of the Sequences, Structures and Functions of Fungal Polyketide Synthase Product Template Domains ▶     Lu Liu, Zheng Zhang, Chang-Lun Shao et al.     The product template (PT) domains, specifically in fungal non-reducing polyketide synthases (NR-PKSs), mediate the regioselective cyclization of polyketides dominating the final …             Sterilization of polydimethylsiloxane surface with Chinese herb extract: a new antibiotic mechanism of chlorogenic acid ▶     Song Ren, Ming Wu, Jiayu Guo et al.     Coating of polydimethylsiloxane (PDMS) surface with a traditional Chinese herb extract chlorogenic acid (CA) solves the contemporary problem of sterilization of PDMS surface. The …             Comparative Transcriptomic Analysis of Multiple Cardiovascular Fates from Embryonic Stem Cells Predicts Novel Regulators in Human Cardiogenesis ▶     Yang Li, Bo Lin, Lei Yang     Dissecting the gene expression programs which control the early stage cardiovascular development is essential for understanding the molecular mechanisms of human heart …             Physiologically motivated multiplex Kuramoto model describes phase diagram of cortical activity ▶     Maximilian Sadilek, Stefan Thurner     We derive a two-layer multiplex Kuramoto model from Wilson-Cowan type physiological equations that describe neural activity on a network of interconnected cortical regions. This …             Oligonucleotide Probes for ND-FISH Analysis to Identify Rye and Wheat Chromosomes ▶     Shulan Fu, Lei Chen, Yangyang Wang et al.     Genomic in situ hybridization (GISH) has been widely used to detect rye (Secale cereale L.) chromosomes in wheat (Triticum aestivum L.) introgression lines. The routine procedure …             Comparison of nedaplatin-based versus cisplatin-based chemotherapy for advanced non-small cell lung cancer among East Asian populations: A meta-analysis ▶     Yun Liu, Shaorong Yu, Siwen Liu et al.     Whether nedaplatin and cisplatin are equally effective for advanced non-small cell lung cancer (NSCLC) remains uncertain. Therefore, we performed a meta-analysis of trials to …             Reliable Attention Network Scores and Mutually Inhibited Inter-network Relationships Revealed by Mixed Design and Non-orthogonal Method ▶     Yi-Feng Wang, Xiu-Juan Jing, Feng Liu et al.     The attention system can be divided into alerting, orienting, and executive control networks. The efficiency and independence of attention networks have been widely tested with …             New High Affinity Monoclonal Antibodies Recognize Non-Overlapping Epitopes On Mesothelin For Monitoring And Treating Mesothelioma ▶     Yi-Fan Zhang, Yen Phung, Wei Gao et al.     Mesothelin is an emerging cell surface target in mesothelioma and other solid tumors. Most antibody drug candidates recognize highly immunogenic Region I (296–390) on mesothelin. …             JBP485 promotes tear and mucin secretion in ocular surface epithelia ▶     Takahiro Nakamura, Yuiko Hata, Maho Nagata et al.     Dry eye syndrome (DES), a multifactorial disease of the tears and ocular surface, is one of the most common ocular disorders. Tear film contains ocular mucins and is essential …             Essential Genes in the Core Genome of the Human Pathogen Streptococcus pyogenes ▶     Yoann Le Breton, Ashton T. Belew, Kayla M. Valdes et al.     Streptococcus pyogenes (Group A Streptococcus, GAS) remains a major public health burden worldwide, infecting over 750 million people leading to over 500,000 deaths annually. GAS …             A method to determine the duration of the eclipse phase for in vitro infection with a highly pathogenic SHIV strain ▶     Yusuke Kakizoe, Shinji Nakaoka, Catherine A. A. Beauchemin et al.     The time elapsed between successful cell infection and the start of virus production is called the eclipse phase. Its duration is specific to each virus strain and, along with an …             Cloning and characterization of farnesyl pyrophosphate synthase from the highly branched isoprenoid producing diatom Rhizosolenia setigera ▶     Victor Marco Emmanuel N. Ferriols, Ryoko Yaginuma, Masao Adachi et al.     The diatom Rhizosolenia setigera Brightwell produces highly branched isoprenoid (HBI) hydrocarbons that are ubiquitously present in marine environments. The hydrocarbon …             fMRI measurements of amygdala activation are confounded by stimulus correlated signal fluctuation in nearby veins draining distant brain regions ▶     Roland N. Boubela, Klaudius Kalcher, Wolfgang Huf et al.     Imaging the amygdala with functional MRI is confounded by multiple averse factors, notably signal dropouts due to magnetic inhomogeneity and low signal-to-noise ratio, making it …             Cuticular protein with a low complexity sequence becomes cross-linked during insect cuticle sclerotization and is required for the adult molt ▶     Seulgi Mun, Mi Young Noh, Neal T. Dittmer et al.     In the insect cuticle, structural proteins (CPs) and the polysaccharide chitin are the major components. It has been hypothesized that CPs are cross-linked to other CPs and …             Hand Washing Induces a Clean Slate Effect in Moral Judgments: A Pupillometry and Eye-Tracking Study ▶     Kai Kaspar, Vanessa Krapp, Peter König     Physical cleansing is commonly understood to protect us against physical contamination. However, recent studies showed additional effects on moral judgments. Under the heading of …             Gene targeting by TALEN-induced homologous recombination in goats directs production of β-lactoglobulin-free, high-human lactoferrin milk ▶     Chenchen Cui, Yujie Song, Jun Liu et al.     β-Lactoglobulin (BLG) is a major goat’s milk allergen that is absent in human milk. Engineered endonucleases, including transcription activator-like effector nucleases (TALENs) …             Roles of small RNAs in the effects of nutrition on apoptosis and spermatogenesis in the adult testis ▶     Yongjuan Guan, Guanxiang Liang, Penelope A. R. Hawken et al.     We tested whether reductions in spermatozoal quality induced by under-nutrition are associated with increased germ cell apoptosis and disrupted spermatogenesis, and whether these …             Apterous A modulates wing size, bristle formation and patterning in Nilaparvata lugens ▶     Fangzhou Liu, Kaiyin Li, Jie Li et al.     Apterous A (apA), a member of the LIM-homeobox gene family, plays a critical role in the development of wing. The achaete-scute Complex (AS-C) encodes basic helix-loop-helix …             The Epidemiological Study of Coxsackievirus A6 revealing Hand, Foot and Mouth Disease Epidemic patterns in Guangdong, China ▶     Hanri Zeng, Jing Lu, Huanying Zheng et al.     Enterovirus A71 (EVA71) and Coxsackievirus A16 (CVA16) are regarded as the two major causative pathogens in hand, foot and mouth disease (HFMD) epidemics. However, CVA6, …             Granger causal time-dependent source connectivity in the somatosensory network ▶     Lin Gao, Linda Sommerlade, Brian Coffman et al.     Exploration of transient Granger causal interactions in neural sources of electrophysiological activities provides deeper insights into brain information processing mechanisms. …             Δ10(E)-Sphingolipid Desaturase Involved in Fusaruside Mycosynthesis and Stress Adaptation in Fusarium graminearum ▶     Yuan Tian, Guo Y. Zhao, Wei Fang et al.     Sphingolipids are biologically important and structurally distinct cell membrane components. Fusaruside (1) is a 10,11-unsaturated immunosuppressive fungal sphingolipid with …             Tracing the dynamic life story of a Bronze Age Female ▶     Karin Margarita Frei, Ulla Mannering, Kristian Kristiansen et al.     Ancient human mobility at the individual level is conventionally studied by the diverse application of suitable techniques (e.g. aDNA, radiogenic strontium isotopes, as well as …             Structural and functional characterization of a novel scFv anti-HSP60 of Strongyloides sp. ▶     Marcelo Arantes Levenhagen, Fabiana de Almeida Araújo Santos, Patrícia Tiemi Fujimura et al.     Phage display is a powerful technology that selects specific proteins or peptides to a target. We have used Phage Display to select scFv (single-chain variable fragment) clones …             Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis ▶     Xun Yuan, Hua Wu, Hanxiao Xu et al.     Various studies have assessed the clinicopathological and prognostic value of Notch1 and Notch3 expression in Non-small cell lung cancer (NSCLC), but their results remain …             Effects of Tris(1,3-dichloro-2-propyl) Phosphate (TDCPP) in Tetrahymena Thermophila: Targeting the Ribosome ▶     Jing Li, John P. Giesy, Liqin Yu et al.     Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) has been frequently detected in the environment, and exposure to TDCPP appears widespread. It has been implicated to cause toxicity …             Synergetic antibacterial activity of reduced graphene oxide and boron doped diamond anode in three dimensional electrochemical oxidation system ▶     Xiujuan Qi, Ting Wang, Yujiao Long et al.     A 100% increment of antibacterial ability has been achieved due to significant synergic effects of boron-doped diamond (BDD) anode and reduced graphene oxide (rGO) coupled in a …             Characterization of a xylanase-producing Cellvibrio mixtus strain J3-8 and its genome analysis ▶     Yi-Rui Wu, Jianzhong He     Cellvibrio mixtus strain J3-8 is a gram-negative, xylanase-producing aerobic soil bacterium isolated from giant snails in Singapore. It is able to produce up to 10.1 U ml−1 of …             Analysis of large mutations in BARD1 in patients with breast and/or ovarian cancer: the Polish population as an example ▶     Katarzyna Klonowska, Magdalena Ratajska, Karol Czubak et al.     Only approximately 50% of all familial breast cancers can be explained by known genetic factors, including mutations in BRCA1 and BRCA2. One of the most extensively studied …             A new look at the essence of the imaging photoplethysmography ▶     Alexei A. Kamshilin, Ervin Nippolainen, Igor S. Sidorov et al.     Photoplethysmography (PPG) is a noninvasive optical method accepted in the clinical use for measurements of arterial oxygen saturation. It is widely believed that the light …             Swirl Flow Bioreactor coupled with Cu-alginate beads: A system for the eradication of Coliform and Escherichia coli from biological effluents ▶     Sov Atkinson, Simon F. Thomas, Paul Goddard et al.     It is estimated that approximately 1.1 billion people globally drink unsafe water. We previously reported both a novel copper-alginate bead, which quickly reduces pathogen loading …             Complex network models reveal correlations among network metrics, exercise intensity and role of body changes in the fatigue process ▶     Vanessa Helena Pereira, Maria Carolina Traina Gama, Filipe Antônio Barros Sousa et al.     The aims of the present study were analyze the fatigue process at distinct intensity efforts and to investigate its occurrence as interactions at distinct body changes during …             Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients ▶     Hiroaki Ito, Katsuyuki Hasegawa, Yuuki Hasegawa et al.     Blood tests, which are commonly used for cancer screening, generally have low sensitivity. Here, we developed a novel rapid and simple method to generate silver nanoscale …             Structural Insights into Substrate Specificity of Feruloyl-CoA 6’-Hydroxylase from Arabidopsis thaliana ▶     Xinxiao Sun, Dayong Zhou, Palani Kandavelu et al.     Coumarins belong to an important class of plant secondary metabolites. Feruloyl-CoA 6’-hydroxylase (F6’H), a 2-oxoglutarate dependent dioxygenase (2OGD), catalyzes a pivotal step …             A terpenoid phytoalexin plays a role in basal defense of Nicotiana benthamiana against Potato virus X ▶     Ran Li, Chuan-Sia Tee, Yu-Lin Jiang et al.     Terpenoid phytoalexins function as defense compound against a broad spectrum of pathogens and pests in the plant kingdom. However, the role of phytoalexin in antiviral defense is …             Short-Range Mobility and the Evolution of Cooperation: An Experimental Study ▶     Alberto Antonioni, Marco Tomassini, Angel Sánchez     A pressing issue in biology and social sciences is to explain how cooperation emerges in a population of self-interested individuals. Theoretical models suggest that one such …             Innate lymphotoxin receptor mediated signaling promotes HSV-1 associated neuroinflammation and viral replication ▶     Yong Liang, Kaiting Yang, Jingya Guo et al.     Host anti-viral innate immunity plays important roles in the defense against HSV-1 infection. In this study, we find an unexpected role for innate LT/LIGHT signaling in promoting …             Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice ▶     Shinya Yufune, Yasushi Satoh, Isao Takamatsu et al.     The critical period is a distinct time-window during the neonatal stage when animals display elevated sensitivity to certain environmental stimuli, and particular experiences can …             Method of preparing an equimolar DNA mixture for one-step DNA assembly of over 50 fragments ▶     Kenji Tsuge, Yukari Sato, Yuka Kobayashi et al.     In the era of synthetic biology, techniques for rapidly constructing a designer long DNA from short DNA fragments are desired. To realize this, we attempted to establish a method …             Atlas of tissue renin-angiotensin-aldosterone system in human: A transcriptomic meta-analysis ▶     Ali Nehme, Catherine Cerutti, Nedra Dhaouadi et al.     Tissue renin-angiotensin-aldosterone system (RAAS) has attracted much attention because of its physiological and pharmacological implications; however, a clear definition of …             The alternate role of direct and environmental transmission in fungal infectious disease in wildlife: threats for biodiversity conservation ▶     Farah N. Al-Shorbaji, Rodolphe E. Gozlan, Benjamin Roche et al.     Emerging fungal pathogens have substantial consequences for infected hosts, as revealed by the global decline of amphibian species from the chytrid fungus. According to the …             The up-scaling of ecosystem functions in a heterogeneous world ▶     Andrew M. Lohrer, Simon F. Thrush, Judi E. Hewitt et al.     Earth is in the midst of a biodiversity crisis that is impacting the functioning of ecosystems and the delivery of valued goods and services. However, the implications of large …             Differences in the strength of cortical and brainstem inputs to SSA and non-SSA neurons in the inferior colliculus ▶     Yaneri A. Ayala, Adanna Udeh, Kelsey Dutta et al.     In an ever changing auditory scene, change detection is an ongoing task performed by the auditory brain. Neurons in the midbrain and auditory cortex that exhibit …             Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells ▶     Marie Berg Nygaard, Kristian Almstrup, Louise Lindbæk et al.     Primary cilia are sensory organelles that coordinate numerous cellular signalling pathways during development and adulthood. Defects in ciliary assembly or function lead to a …             Sleep-independent offline consolidation of response inhibition during the daytime post-training period ▶     Motoyasu Honma, Takuya Yoshiike, Hiroki Ikeda et al.     Appropriate inhibitory response control is associated with goal-directed behavior. Sleep accelerates the offline consolidation of acquired motor skills that are explicitly …             Predicting disease progression from short biomarker series using expert advice algorithm ▶     Kai Morino, Yoshito Hirata, Ryota Tomioka et al.     Well-trained clinicians may be able to provide diagnosis and prognosis from very short biomarker series using information and experience gained from previous patients. Although …             C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth ▶     Song Lin Chua, Krishnakumar Sivakumar, Morten Rybtke et al.     Stress response plays an important role on microbial adaptation under hostile environmental conditions. It is generally unclear how the signaling transduction pathway mediates a …             Transcriptome sequencing of three Ranunculus species (Ranunculaceae) reveals candidate genes in adaptation from terrestrial to aquatic habitats ▶     Ling-Yun Chen, Shu-Ying Zhao, Qing-Feng Wang et al.     Adaptation to aquatic habitats is a formidable challenge for terrestrial angiosperms that has long intrigued scientists. As part of a suite of work to explore the molecular …             The Role of Cyclooxygenase-2, Interleukin-1β and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage ▶     Pei-Pei Guan, Jing-Wen Guo, Xin Yu et al.     MMP-1 expression is detected in fluid shear stress (20 dyn/cm2)-activated and osteoarthritic human chondrocytes, however, the precise mechanisms underlying shear-induced MMP-1 …             The neural dynamic mechanisms of asymmetric switch costs in a combined Stroop-task-switching paradigm ▶     Shanshan Wu, Glenn Hitchman, Jinfeng Tan et al.     Switch costs have been constantly found asymmetrical when switching between two tasks of unequal dominance. We used a combined Stroop-task-switching paradigm and recorded …             Quantitative High-Throughput Identification of Drugs as Modulators of Human Constitutive Androstane Receptor ▶     Caitlin Lynch, Jinghua Zhao, Ruili Huang et al.     The constitutive androstane receptor (CAR, NR1I3) plays a key role in governing the transcription of numerous hepatic genes that involve xenobiotic metabolism/clearance, energy …             A novel DNA sequence motif in human and mouse genomes ▶     Shilu Zhang, Fang Du, Hongkai Ji     We report a novel DNA sequence motif in human and mouse genomes. This motif has several interesting features indicating that it is highly likely to be an unknown functional …             SIRT1 protects rat lung tissue against severe burn-induced remote ALI by attenuating the apoptosis of PMVECs via p38 MAPK signaling ▶     Xiaozhi Bai, Lei Fan, Ting He et al.     Silent information regulator type-1 (SIRT1) has been reported to be involved in the cardiopulmonary protection. However, its role in the pathogenesis of burn-induced remote acute …             Cyclin-dependent kinase 11p110 (CDK11p110) is crucial for human breast cancer cell proliferation and growth ▶     Yubing Zhou, Chao Han, Duolu Li et al.     Cyclin-dependent kinases (CDKs) play important roles in the development of many types of cancers by binding with their paired cyclins. However, the function of CDK11 larger …             Fluorescence lifetime imaging of endogenous biomarker of oxidative stress ▶     Rupsa Datta, Alba Alfonso-García, Rachel Cinco et al.     Presence of reactive oxygen species (ROS) in excess of normal physiological level results in oxidative stress. This can lead to a range of pathological conditions including …             Is impaired response inhibition independent of symptom dimensions in obsessive-compulsive disorder? Evidence from ERPs ▶     Hui Lei, Xiongzhao Zhu, Jie Fan et al.     Impaired response inhibition has been consistently reported in patients diagnosed with obsessive-compulsive disorder (OCD). This clinically heterogeneous disorder is …             Interactions between tick and transmitted pathogens evolved to minimise competition through nested and coherent networks ▶     Agustín Estrada-Peña, José de la Fuente, Richard S. Ostfeld et al.     Natural foci of ticks, pathogens, and vertebrate reservoirs display complex relationships that are key to the circulation of pathogens and infection dynamics through the …             G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch ▶     Ai-Jiao Guan, Meng-Jie Shen, Jun-Feng Xiang et al.     Nucleic acid based molecular device is a developing research field which attracts great interests in material for building machinelike nanodevices. G-quadruplex, as a new type of …             High accuracy thermal conductivity measurement of aqueous cryoprotective agents and semi-rigid biological tissues using a microfabricated thermal sensor ▶     Xin M. Liang, Praveen K. Sekar, Gang Zhao et al.     An improved thermal-needle approach for accurate and fast measurement of thermal conductivity of aqueous and soft biomaterials was developed using microfabricated thermal …             Mitochondrial DNA haplogroups and short-term neurological outcomes of ischemic stroke ▶     Biyang Cai, Zhizhong Zhang, Keting Liu et al.     Stroke is one of the leading causes of death and long-term disability worldwide. Mitochondrial DNA (mtDNA) is a potential contributor for the sex differences of ischemic stroke …             Continuous de novo biosynthesis of haem and its rapid turnover to bilirubin are necessary for cytoprotection against cell damage ▶     Taka-aki Takeda, Anfeng Mu, Tran Tien Tai et al.     It is well known that haem serves as the prosthetic group of various haemoproteins that function in oxygen transport, respiratory chain, and drug metabolism. However, much less …             Phosphorylation of Nonmuscle myosin II-A regulatory light chain resists Sendai virus fusion with host cells ▶     Provas Das, Shekhar Saha, Sunandini Chandra et al.     Enveloped viruses enter host cells through membrane fusion and the cells in turn alter their shape to accommodate components of the virus. However, the role of nonmuscle myosin …             Physical Sensing of Surface Properties by Microswimmers – Directing Bacterial Motion via Wall Slip ▶     Jinglei Hu, Adam Wysocki, Roland G. Winkler et al.     Bacteria such as Escherichia coli swim along circular trajectories adjacent to surfaces. Thereby, the orientation (clockwise, counterclockwise) and the curvature depend on the …             A Network Flow-based Analysis of Cognitive Reserve in Normal Ageing and Alzheimer’s Disease ▶     Sang Wook Yoo, Cheol E. Han, Joseph S. Shin et al.     Cognitive reserve is the ability to sustain cognitive function even with a certain amount of brain damages. Here we investigate the neural compensation mechanism of cognitive …             The Galvanotactic Migration of Keratinocytes is Enhanced by Hypoxic Preconditioning ▶     Xiaowei Guo, Xupin Jiang, Xi Ren et al.     The endogenous electric field (EF)-directed migration of keratinocytes (galvanotaxis) into wounds is an essential step in wound re-epithelialization. Hypoxia, which occurs …             Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR) ▶     Sandra Gomez, Laura Adalid-Peralta, Hector Palafox-Fonseca et al.     Excretory/Secretory (ES) proteins play an important role in the host-parasite interactions. Experimental identification of ES proteins is time-consuming and expensive. Alternative …             Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers ▶     Corinne Berclaz, Christophe Pache, Arno Bouwens et al.     The identification of a beta-cell tracer is a major quest in diabetes research. However, since MRI, PET and SPECT cannot resolve individual islets, optical techniques are …             Genomic analysis of a ginger pathogen Bacillus pumilus providing the understanding to the pathogenesis and the novel control strategy ▶     Yihui Yuan, Meiying Gao     Bacillus pumilus has been widely identified as a pathogen of plant and human, while the genetic information is rarely available for pathogenic B. pumilus strains. B. pumilus GR8 …             Action observation: mirroring across our spontaneous movement tempo ▶     Laura Avanzino, Giovanna Lagravinese, Ambra Bisio et al.     During action observation (AO), the activity of the “mirror system” is influenced by the viewer’s expertise in the observed action. A question that remains open is whether the …             MICCA: a complete and accurate software for taxonomic profiling of metagenomic data ▶     Davide Albanese, Paolo Fontana, Carlotta De Filippo et al.     The introduction of high throughput sequencing technologies has triggered an increase of the number of studies in which the microbiota of environmental and human samples is …             Chromodomain protein Tcd1 is required for macronuclear genome rearrangement and repair in Tetrahymena ▶     Jing Xu, Yajing Yuan, Aihua Liang et al.     The survival of an organism’s progeny depends on the maintenance of its genome. Programmed DNA rearrangement and repair in Tetrahymena occur during the differentiation of the …             Structure of Slitrk2–PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion ▶     Atsushi Yamagata, Yusuke Sato, Sakurako Goto-Ito et al.     Selective binding between pre- and postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic …             PALM-IST: Pathway Assembly from Literature Mining - an Information Search Tool ▶     Sapan Mandloi, Saikat Chakrabarti     Manual curation of biomedical literature has become extremely tedious process due to its exponential growth in recent years. To extract meaningful information from such large and …             Expression and purification of a single-chain Type IV restriction enzyme Eco94GmrSD and determination of its substrate preference ▶     Xinyi He, Victoria Hull, Julie A. Thomas et al.     The first reported Type IV restriction endonuclease (REase) GmrSD consists of GmrS and GmrD subunits. In most bacteria, however, the gmrS and gmrD genes are fused together to …             Heparin affinity purification of extracellular vesicles ▶     Leonora Balaj, Nadia A. Atai, Weilin Chen et al.     Extracellular vesicles (EVs) are lipid membrane vesicles released by cells. They carry active biomolecules including DNA, RNA, and protein which can be transferred to recipient …             Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis ▶     Jun-Jie Chen, Lin Dai, Lin-Xia Zhao et al.     Curcumin is a major component of turmeric and reportedly has anti-inflammatory and anti-oxidant effects. Neuroinflammation has been recognized to play an important role in the …             The pluripotency factor NANOG promotes the formation of squamous cell carcinomas ▶     Adelaida R. Palla, Daniela Piazzolla, Noelia Alcazar et al.     NANOG is a key pluripotency factor in embryonic stem cells that is frequently expressed in squamous cell carcinomas (SCCs). However, a direct link between NANOG and SCCs remains …             ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory ▶     Po-Han Chiang, Ta-Chun Chien, Chih-Cheng Chen et al.     Genetic variants in the human ortholog of acid-sensing ion channel-1a subunit (ASIC1a) gene are associated with panic disorder and amygdala dysfunction. Both fear learning and …             Longitudinal in vivo evaluation of bone regeneration by combined measurement of multi-pinhole SPECT and micro-CT for tissue engineering ▶     Philipp S. Lienemann, Stéphanie Metzger, Anna-Sofia Kiveliö et al.     Over the last decades, great strides were made in the development of novel implants for the treatment of bone defects. The increasing versatility and complexity of these implant …             New ambuic acid derivatives from the solid culture of Pestalotiopsis neglecta and their nitric oxide inhibitory activity ▶     Qiu-Yue Qi, Er-Wei Li, Jun-Jie Han et al.     Four new ambuic acid derivatives (1–4), and four known derivatives (5–8), were isolated from the solid culture of a plant pathogenic fungus Pestalotiopsis neglecta. Their …             ImmuSort, a database on gene plasticity and electronic sorting for immune cells ▶     Pingzhang Wang, Yehong Yang, Wenling Han et al.     Gene expression is highly dynamic and plastic. We present a new immunological database, ImmuSort. Unlike other gene expression databases, ImmuSort provides a convenient way to …             Genetic association study of circadian genes with seasonal pattern in bipolar disorders ▶     Pierre Alexis Geoffroy, Mohamed Lajnef, Frank Bellivier et al.     About one fourth of patients with bipolar disorders (BD) have depressive episodes with a seasonal pattern (SP) coupled to a more severe disease. However, the underlying genetic …             In Vivo Two-Photon Imaging of Axonal Dieback, Blood Flow, and Calcium Influx with Methylprednisolone Therapy after Spinal Cord Injury ▶     Peifu Tang, Yiling Zhang, Chao Chen et al.     Severe spinal cord injury (SCI) can cause neurological dysfunction and paralysis. However, the early dynamic changes of neurons and their surrounding environment after SCI are …             Punitive preferences, monetary incentives and tacit coordination in the punishment of defectors promote cooperation in humans ▶     Andreas Diekmann, Wojtek Przepiorka     Peer-punishment is effective in promoting cooperation, but the costs associated with punishing defectors often exceed the benefits for the group. It has been argued that …             Low-dose add-on memantine treatment may improve cognitive performance and self-reported health conditions in opioid-dependent patients undergoing methadone-maintenance-therapy ▶     Yun-Hsuan Chang, Shiou-Lan Chen, Sheng-Yu Lee et al.     An important interaction between opioid and dopamine systems has been indicated, and using opioids may negatively affect cognitive functioning. Memantine, a medication for …             Land use change influences soil C, N, and P stoichiometry under ‘Grain-to-Green Program’ in China ▶     Zhao Fazhu, Sun Jiao, Ren Chengjie et al.     Changes in land use might affect the combined C, N and P stoichiometry in soil. The Grain-to-Green Program (GTGP), which converts low-yield croplands or abandoned lands into …             Triplex real-time PCR–an improved method to detect a wide spectrum of mitochondrial DNA deletions in single cells ▶     Karolina A. Rygiel, John P. Grady, Robert W. Taylor et al.     Mitochondrial DNA (mtDNA) mutations are commonly found in the skeletal muscle of patients with mitochondrial disease, inflammatory myopathies and sarcopenia. The majority of …             Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice ▶     Jiangchao Li, Yuxiang Ye, Renli Zhang et al.     Secreted Slit proteins and their Roundabout (Robo) receptors act as a repulsive cue to preventaxons from migrating to inappropriate locations during the development of the nervous …             Regulation of Immunoproteasome Function in the Lung ▶     Ilona E. Keller, Oliver Vosyka, Shinji Takenaka et al.     Impaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to …             An embryo of protocells: The capsule of graphene with selective ion channels ▶     Zhan Li, Chunmei Wang, Longlong Tian et al.     The synthesis of artificial cell is a route for searching the origin of protocell. Here, we create a novel cell model of graphene capsules with selective ion channels, indicating …             Application of high-dimensional feature selection: evaluation for genomic prediction in man ▶     M. L. Bermingham, R. Pong-Wong, A. Spiliopoulou et al.     In this study, we investigated the effect of five feature selection approaches on the performance of a mixed model (G-BLUP) and a Bayesian (Bayes C) prediction method. 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