Nature Reviews Molecular Cell Biology contents June 2015 Volume 16 Number 6 pp 325-388

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TABLE OF CONTENTS
June 2015 Volume 16 Number 6
Impact Factor 36.458 *	In this issue Research Highlights Reviews Also this month Article series: Cell death and autophagy  Featured article: DNA replication origin activation in space and time Michalis Fragkos, Olivier Ganier, Philippe Coulombe & Marcel Méchali
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RESEARCH HIGHLIGHTS Top Non-coding RNA: X-chromosome inactivation unravelled p325 | doi:10.1038/nrm3998 Guttman and colleagues discovered proteins that bind the lncRNA Xist and mediate gene silencing during X-chromosome inactivation. PDF Cell signalling: Double duty for Dishevelled p326 | doi:10.1038/nrm3995 Dishevelled recruits E3 ligases to WNT co-receptors to facilitate their degradation and the downregulation of WNT signalling. PDF Post-translational modifications: A chromosome's guide to the spindle equator p326 | doi:10.1038/nrm4000 Microtubule detyrosination guides CENP-E-dependent transport of pole-proximal chromosomes to the spindle equator during mitosis. PDF RNA: 3′ UTR alternatives to protein localization p327 | doi:10.1038/nrm3996 Berkovits and Mayr show that 3′ UTRs generated by alternative polyadenylation can recruit the RNA-binding protein HUR and its effector SET, which regulate the cellular localization of the translated proteins. PDF Nuclear envelope: Curving out a nuclear pore p328 | doi:10.1038/nrm4006 The basket nucleoproteins Nup1 and Nup60 contribute to nuclear pore complex formation by inducing membrane curvature. PDF IN BRIEF Autophagy: Chaperone-mediated autophagy degrades CHK1 | Protein folding: Drugs for protein misfolding diseases | DNA damage response: Taking the DDR down a Notch PDF Molecular Cell Biology JOBS of the week Postdoctoral Fellowships in Molecular / Cell / Cancer Biology MD Anderson Cancer Center PhD position in Molecular Biology - Mathematical modelling of single-cell responses Institute of Molecular Biology (IMB) Mainz Postdoctoral Fellow Weill Cornell College of Medicine Research Fellow Mayo Medical School - Mayo Clinic Postdoc Bioinformatics and Medical Epigenomics CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences More Science jobs from Molecular Cell Biology EVENT ToProB: Towards Programmable Biology 30.07.15 York, UK More science events from
REVIEWS		Top
Article series: Cell death and autophagy Live to die another way: modes of programmed cell death and the signals emanating from dying cells Yaron Fuchs & Hermann Steller p329 | doi:10.1038/nrm3999 Apoptosis, autophagy and necroptosis are discussed in the context of molecular mechanisms of programmed cell death during development and tissue homeostasis. The signals that dying cells produce can in turn induce the apoptosis or proliferation of neighbouring cells. Abstract | Full Text | PDF
New roles for mitochondrial proteases in health, ageing and disease Pedro M. Quirós, Thomas Langer & Carlos López-ótin p345 | doi:10.1038/nrm3984 Mitochondrial proteases can be classified into subgroups depending on their function and location. They are highly specific and modulate biochemical activities that are essential for mitochondrial function and integrity. Impaired or dysregulated function of mitoproteases is associated with ageing and longevity, as well as with pathological conditions and human hereditary diseases. Abstract | Full Text | PDF
DNA replication origin activation in space and time Michalis Fragkos, Olivier Ganier, Philippe Coulombe & Marcel Méchali p360 | doi:10.1038/nrm4002 During the G1-S phase transition of the cell cycle, a variable subset of previously 'licensed' origins of replication is activated to initiate DNA synthesis. Insight is being gained into the mechanisms underlying which origins are activated and when; these mechanisms are associated with nuclear organization, cell differentiation and replication stress. Abstract | Full Text | PDF
A giant molecular proton pump: structure and mechanism of respiratory complex I Leonid A. Sazanov p375 | doi:10.1038/nrm3997 The mitochondrial respiratory chain comprises large multi-subunit protein complexes that generate ATP. The crystal structure of the entire bacterial complex I was recently solved, providing novel insights into its core architecture, as well as the electron transfer and proton translocation pathways and the coupling between them. Abstract | Full Text | PDF | Supplementary information
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*2013 Journal Citation Report (Thomson Reuters, 2013)

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