Nature Cell Biology contents: June 2015 Volume 17 Number 6, pp 707 - 827

If you are unable to see the message below, click here to view.

Advertisement Your First Choice: Cell Culture Products from Greiner Bio-One For small and large-scale experiments: From 1536 well microplates to 4,250 cm2 roller bottles Products for special applications: Microscopy, screening, 3D cell culture Surfaces for standard and sensitive cells: Cell lines, primary cells, stem cells Read more: www.gbo.com/tc TABLE OF CONTENTS June 2015 Volume 17, Issue 6 News and Views Articles Corrigenda Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement 1st Nature Immunology - Cellular & Molecular Immunology Joint Conference: Inflammation, Stress and Immune Homeostasis June 17-19, 2015 | The Swan Lake Hotel, Hefei, China  Register Now!   Advertisement New to NPG from Apr 2015 Co-published by Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Nature Publishing Group, Sister Journal to Cell Research. Cell Discovery is a new online open access, fully peer-reviewed journal publishes results of significance and originality in all areas of molecular & cell biology.  Discover more about Cell Discovery   News and Views Top Gut healing: haemocytes aid via Sax and Tkv jazzes it down   pp707 - 709 Lesley N. Weaver and Daniela Drummond-Barbosa doi:10.1038/ncb3178 Control of stem cell activity is essential for accurate regeneration. Pathogen- or chemical-induced intestinal damage is now shown to recruit haemocytes expressing bone morphogenetic protein signals that stimulate proliferation of intestinal stem cells and subsequently induce their quiescence, in conjunction with muscle-derived bone morphogenetic proteins. A temporal switch in expression of Type I receptors enables this two-phase response. See also: Article by Ayyaz et al. A niche role for cancer exosomes in metastasis   pp709 - 711 Yun Zhang and Xiao-Fan Wang doi:10.1038/ncb3181 Cancer cells are known to secrete exosomes with pro-metastatic effects. Pancreatic-cancer-derived exosomes are now shown to promote liver metastasis by eliciting pre-metastatic niche formation through a multi-step process. This involves uptake of exosome-derived factors by liver Kupffer cells and hepatic stellate cell activation to generate a fibrotic microenvironment with immune cell infiltrates that favours metastasis. See also: Article by Costa-Silva et al. Clarifying the role of condensin in shaping chromosomes   pp711 - 713 Kota Nagasaka and Toru Hirota doi:10.1038/ncb3183 A major controversy in the field of chromosome research has been whether condensin is required for achieving the highly compacted state of chromatin fibres in mitosis and meiosis. Through genetic experiments in mouse oocytes, condensin is now found to be indispensable for meiotic chromosome assembly by mediating chromosome compaction and disentanglement of sister chromatids and by conferring rigidity to chromosomes. See also: Article by Houlard et al. Cell Biology JOBS of the week Two Postdoctoral Positions in T Cell Biology National University of Singapore (NUS) Postdoctoral Fellow in Stem Cell Biology and Pharmacogenomics Northwestern University Postdoctoral Fellowships in Molecular / Cell / Cancer Biology MD Anderson Cancer Center Post-doctoral fellow in Hematopoietic Stem Cell Biology KU Leuven PhD position in Molecular Biology - Mathematical modelling of single-cell responses Institute of Molecular Biology (IMB) Mainz More Science jobs from Cell Biology EVENT 36th New Phytologist Symposium: Cell biology at the plant�microbe interface 29.12.15 Munich, Germany More science events from Articles Top Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming   pp715 - 725 Yasong Wu, Yuan Li, Hui Zhang, Yinghua Huang, Ping Zhao et al. doi:10.1038/ncb3172 Qin, Pei and colleagues report that autophagy is induced early during somatic cell reprogramming into induced pluripotent stem cells. mTORC1 and autophagy control reprogramming efficiency by modulating mitochondrial architecture and p62 levels. An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity   pp726 - 735 Diana Klompstra, Dorian C. Anderson, Justin Y. Yeh, Yuliya Zilberman and Jeremy Nance doi:10.1038/ncb3168 Nance and colleagues report that the E-cadherin HMR-1 recruits the RhoGAP PAC-1 to cell-cell contact and thereby drives symmetry breaking in C. elegans embryos. Haemocytes control stem cell activity in the Drosophila intestine   pp736 - 748 Arshad Ayyaz, Hongjie Li and Heinrich Jasper doi:10.1038/ncb3174 Jasper and colleagues report that following intestinal damage in Drosophila, haemocytes recruited to the intestine secrete Dpp, promoting intestinal stem cell proliferation and, at later stages of regeneration, the re-establishment of intestinal stem cell quiescence. See also: News and Views by Weaver & Drummond-Barbosa Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation   pp749 - 758 Kazuya Tsujita, Tadaomi Takenawa and Toshiki Itoh doi:10.1038/ncb3162 Itoh and colleagues find that the membrane-bending protein FBP17 is released from membranes at the leading edge of migrating cells following increased tension involving a feedback loop, in which FBP17 also promotes tension through actin protrusion formation. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis   pp759 - 770 Susmita Kaushik and Ana Maria Cuervo doi:10.1038/ncb3166 Cuervo and colleagues find that perilipin proteins associated with lipid droplets are degraded by chaperone-mediated autophagy to facilitate recruitment of the lipolytic machinery to lipid droplets. Condensin confers the longitudinal rigidity of chromosomes   pp771 - 781 Martin Houlard, Jonathan Godwin, Jean Metson, Jibak Lee, Tatsuya Hirano et al. doi:10.1038/ncb3167 By inactivating condensin I or II before the first meiotic division in mouse oocytes, Nasmyth and colleagues demonstrate that condensin is needed for chromatin thread formation and chromosome rigidity. See also: News and Views by Nagasaka & Hirota A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity   pp782 - 792 Richard M. Monaghan, Robert G. Barnes, Kate Fisher, Tereza Andreou, Nicholas Rooney et al. doi:10.1038/ncb3170 Whitmarsh and colleagues identify a nuclear form of the mitochondrial enzyme, CLK-1 in C. elegans and COQ7 in human cells, respectively, that senses reactive oxygen species and regulates gene expression. Inactivation of a Gαs-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis   pp793 - 803 Ramiro Iglesias-Bartolome, Daniela Torres, Romina Marone, Xiaodong Feng, Daniel Martin et al. doi:10.1038/ncb3164 Gutkind and colleagues delineate a tumour suppressive signalling pathway involving the Gαs G protein and the PKA kinase, which inhibits pro-tumorigenic Yap and Shh signalling in epidermal stem cells. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth   pp804 - 815 Philippe Depeille, Linda M. Henricks, Robert A. H. van de Ven, Ed Lemmens, Chih-Yang Wang et al. doi:10.1038/ncb3175 Roose and colleagues report that the RasGRP1 and SOS1 guanine nucleotide exchange factors have opposing roles downstream of the EGFR, with RasGRP1 restricting SOS1-induced KRAS-ERK activation and suppressing intestinal tumorigenesis. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver   pp816 - 826 Bruno Costa-Silva, Nicole M. Aiello, Allyson J. Ocean, Swarnima Singh, Haiying Zhang et al. doi:10.1038/ncb3169 Lyden and colleagues report that pancreatic cancer-derived exosomes induce a pre-metastatic niche in the liver by promoting TGFβ secretion from Kupffer cells, leading to fibronectin production in hepatic stellate cells and macrophage recruitment. See also: News and Views by Zhang & Wang Advertisement More Confidence in Your Western Blotting  The new V3 Western Workflow™ from Bio-Rad streamlines your western blot protocol and delivers reliable results faster. Visualize and verify results at each step of your experiment, and quantify your proteins with confidence.   Corrigenda Top Corrigendum: Nuclear actin and myosins: Life without filaments   p827 Primal de Lanerolle and Leonid Serebryannyy doi:10.1038/ncb3182 Corrigendum: Nuclear actin and myosins: Life without filaments   p827 Primal de Lanerolle and Leonid Serebryannyy doi:10.1038/ncb3186 Top Advertisement Celebrating the 25th Anniversary of SELEX: An Aptamer Symposium Supported by the American Society of Gene & Cell Therapy, the Aptamers Workshop will provide a unique opportunity to celebrate the 25th anniversary of aptamers and to meet researchers around the world developing nucleic acid aptamers as high affinity targeting reagents for both diagnosis and therapy. Find out more: www.asgct.org/am15/   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.