Scientific Reports Biology Table of Contents e-alert: 21 April 2015

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21 April 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         A new online, open access journal publishing high quality research into the neurobiology of learning in experimental conditions and in an educational environment. Published by Nature Publishing Group in partnership with The University of Queensland, Australia. Learn more at www.nature.com/npjscilearn           Biological Sciences               A decline of LAMP- 2 predicts ursodeoxycholic acid response in primary biliary cirrhosis ▶     Lu Wang, Guan-ya Guo, Jing-bo Wang et al.     Biochemical response to ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis (PBC) is variable. We have previously reported that augmented expression of …             Multiple myeloma acquires resistance to EGFR inhibitor via induction of pentose phosphate pathway ▶     Yan Chen, Ruibin Huang, Jianghua Ding et al.     Multiple myeloma (MM) was characterized by frequent mutations in KRAS/NRAS/BRAF within the EGFR pathway that could induce resistance to EGFR inhibitors. We here report that EGFR …             Metabolite localization in living drosophila using High Resolution Magic Angle Spinning NMR ▶     Vincent Sarou-Kanian, Nicolas Joudiou, Fanny Louat et al.     We have developed new methods enabling in vivo localization and identification of metabolites through their 1H NMR signatures, in a drosophila. Metabolic profiles in localized …             Maximum-likelihood method identifies meiotic restitution mechanism from heterozygosity transmission of centromeric loci: application in citrus ▶     José Cuenca, Pablo Aleza, José Juárez et al.     Polyploidisation is a key source of diversification and speciation in plants. Most researchers consider sexual polyploidisation leading to unreduced gamete as its main origin. Un…             Office Paper Platform for Bioelectrochromic Detection of Electrochemically Active Bacteria using Tungsten Trioxide Nanoprobes ▶     A. C. Marques, L. Santos, M. N. Costa et al.     Electrochemically active bacteria (EAB) have the capability to transfer electrons to cell exterior, a feature that is currently explored for important applications in …             Phage-mediated horizontal transfer of a Staphylococcus aureus virulence-associated genomic island ▶     Bo Youn Moon, Joo Youn Park, Sun Yung Hwang et al.     Staphylococcus aureus is a major pathogen of humans and animals. The capacity of S. aureus to adapt to different host species and tissue types is strongly influenced by the …             CRISPR/Cas9-mediated endogenous protein tagging for RESOLFT super-resolution microscopy of living human cells ▶     Michael Ratz, Ilaria Testa, Stefan W. Hell et al.     Overexpression is a notorious concern in conventional and especially in super-resolution fluorescence light microscopy studies because it may cause numerous artifacts including …             Mechanism of the Antigen-Independent Cytokinergic SPE-7 IgE Activation of Human Mast Cells in Vitro ▶     Heather J. Bax, Holly Bowen, Tihomir S. Dodev et al.     Release of pro-inflammatory mediators by mast cells is a key feature of allergic disease. The ‘dogma’ is that IgE molecules merely sensitise mast cells by binding FcεRI prior to …             Spatiotemporal distribution of different extracellular polymeric substances and filamentation mediate Xylella fastidiosa adhesion and biofilm formation ▶     Richard Janissen, Duber M. Murillo, Barbara Niza et al.     Microorganism pathogenicity strongly relies on the generation of multicellular assemblies, called biofilms. Understanding their organization can unveil vulnerabilities leading to …             Isolation and characterization of a native avirulent strain of Streptococcus suis serotype 2: a perspective for vaccine development ▶     Xinyue Yao, Ming Li, Jing Wang et al.     Streptococcus suis, an emerging infectious pathogen, is the cause of two large-scale outbreaks of human streptococcal toxic shock syndrome in China, and has attracted much …             N2O production, a widespread trait in fungi ▶     Koki Maeda, Aymé Spor, Véronique Edel-Hermann et al.     N2O is a powerful greenhouse gas contributing both to global warming and ozone depletion. While fungi have been identified as a putative source of N2O, little is known about their …             Sound Packing DNA: packing open circular DNA with low-intensity ultrasound ▶     DongHee Park, Bong-Kwang Jung, Hyunjin Park et al.     Supercoiling DNA (folding DNA into a more compact molecule) from open circular forms requires significant bending energy. The double helix is coiled into a higher order helix …             Fructose decreases physical activity and increases body fat without affecting hippocampal neurogenesis and learning relative to an isocaloric glucose diet ▶     Catarina Rendeiro, Ashley M. Masnik, Jonathan G. Mun et al.     Recent evidence suggests that fructose consumption is associated with weight gain, fat deposition and impaired cognitive function. However it is unclear whether the detrimental …             Fast imaging of live organisms with sculpted light sheets ▶     Aleksander K. Chmielewski, Anders Kyrsting, Pierre Mahou et al.     Light-sheet microscopy is an increasingly popular technique in the life sciences due to its fast 3D imaging capability of fluorescent samples with low photo toxicity compared to …             Alterations in Ovarian Cancer Cell Adhesion Drive Taxol Resistance by Increasing Microtubule Dynamics in a FAK-dependent Manner ▶     Daniel J. McGrail, Niti N. Khambhati, Mark X. Qi et al.     Chemorefractory ovarian cancer patients show extremely poor prognosis. Microtubule-stabilizing Taxol (paclitaxel) is a first-line treatment against ovarian cancer. Despite the …             Massively parallel multiplex DNA sequencing for specimen identification using an Illumina MiSeq platform ▶     Shadi Shokralla, Teresita M. Porter, Joel F. Gibson et al.     Genetic information is a valuable component of biosystematics, especially specimen identification through the use of species-specific DNA barcodes. Although many genomics …             Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4 ▶     Li Jiang, Si-Cheng Liang, Chao Wang et al.     Glucuronidation mediated by uridine 5′-diphospho (UDP)-glucuronosyltransferase is an important detoxification pathway. However, identifying a selective probe of UDP- …             Enhanced functional connectivity and increased gray matter volume of insula related to action video game playing ▶     Diankun Gong, Hui He, Dongbo Liu et al.     Research has shown that distinct insular subregions are associated with particular neural networks (e.g., attentional and sensorimotor networks). Based on the evidence that …             A Conserved Signalling Pathway for Amoebozoan Encystation that was Co-Opted for Multicellular Development ▶     Yoshinori Kawabe, Christina Schilde, Qingyou Du et al.     The evolution of multicellularity required novel mechanisms for intercellular communication, but their origin is unclear. Dictyostelium cells exchange signals to position …             Gut-spilling in chordates: Evisceration in the tropical ascidian Polycarpa mytiligera ▶     Noa Shenkar, Tal Gordon     The ejection of internal organs, i.e., evisceration, is a well-known phenomenon in sea-cucumbers. We report the ability of a member of the Chordate phyla, the tropical ascidian …             Opposite effects of male and female helpers on social tolerance and proactive prosociality in callitrichid family groups ▶     Judith M. Burkart     Across a broad variety of primate species (including lemurs, New World monkeys, Old World monkeys, and apes), proactive prosociality and social tolerance are linked to …             Rab27A Regulates Transport of Cell Surface Receptors Modulating Multinucleation and Lysosome-Related Organelles in Osteoclasts ▶     Megumi Shimada-Sugawara, Eiko Sakai, Kuniaki Okamoto et al.     Rab27A regulates transport of lysosome-related organelles (LROs) and release of secretory granules in various types of cells. Here, we identified up-regulation of Rab27A during …             Hm-MyD88 and Hm-SARM: Two key regulators of the neuroimmune system and neural repair in the medicinal leech ▶     F. Rodet, A. Tasiemski, C. Boidin-Wichlacz et al.     Unlike mammals, the CNS of the medicinal leech can regenerate damaged neurites, thus restoring neural functions after lesion. We previously demonstrated that the injured leech …             Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies ▶     Gabriela A. N. Crespi, Stefan J. Hermans, Michael W. Parker et al.     Solanezumab (Eli Lilly) and crenezumab (Genentech) are the leading clinical antibodies targeting Amyloid-β (Aβ) to be tested in multiple Phase III clinical trials for the …             Nelfinavir and Nelfinavir Analogs Block Site-2 Protease Cleavage to Inhibit Castration-Resistant Prostate Cancer ▶     Min Guan, Leila Su, Yate-Ching Yuan et al.     Nelfinavir and its analogs inhibit proliferation and induce apoptosis of castration-resistant prostate cancer through inhibition of site-2 protease (S2P) activity, which leads to …             Arabidopsis FHY3/CPD45 regulates far-red light signaling and chloroplast division in parallel ▶     Ning Chang, Yuefang Gao, Lin Zhao et al.     CPD45 (chloroplast division45),which is also known as FHY3 (far-red elongated hypocotyl3), is a key factor in the far-red light signaling pathway in Arabidopsis. We previously …             E. coli OxyS non-coding RNA does not trigger RNAi in C. elegans ▶     Alper Akay, Peter Sarkies, Eric A. Miska     The discovery of RNA interference (RNAi) in C. elegans has had a major impact on scientific research, led to the rapid development of RNAi tools and has inspired RNA-based …             Intronic deletions of tva receptor gene decrease the susceptibility to infection by avian sarcoma and leukosis virus subgroup A ▶     Weiguo Chen, Yang Liu, Hongxing Li et al.     The group of avian sarcoma and leukosis virus (ASLV) in chickens contains six highly related subgroups, A to E and J. Four genetic loci, tva, tvb, tvc and tvj, encode for …             Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domain ▶     Tim Vervliet, Irma Lemmens, Elien Vandermarliere et al.     Anti-apoptotic B-cell lymphoma 2 (Bcl-2) family members target several intracellular Ca2-transport systems. Bcl-2, via its N-terminal Bcl-2 homology (BH) 4 domain, inhibits both …             Involvement of a C-terminal motif in the interference of primate lentiviral Vpu proteins with CD1d-mediated antigen presentation ▶     Susanna M. Bächle, Daniel Sauter, Sabrina Sibitz et al.     The HIV-1 accessory protein Vpu is emerging as a critical factor for viral evasion from innate immunity. We have previously shown that the Vpu proteins of two HIV-1 group M …             Crowding-induced Cooperativity in DNA Surface Hybridization ▶     Qun-li Lei, Chun-lai Ren, Xiao-hang Su et al.     High density DNA brush is not only used to model cellular crowding, but also has a wide application in DNA-functionalized materials. Experiments have shown complicated cooperative …             Phenotypic and Functional Characterization of Long-Term Cryopreserved Human Adipose-derived Stem Cells ▶     Kar Wey Yong, Belinda Pingguan-Murphy, Feng Xu et al.     Cryopreservation represents an effective technique to maintain the functional properties of human adipose-derived stem cells (ASCs) and allows pooling of cells via long-term …             Non-invasive Differentiation of Kidney Stone Types using X-ray Dark-Field Radiography ▶     Kai Scherer, Eva Braig, Konstantin Willer et al.     Treatment of renal calculi is highly dependent on the chemical composition of the stone in question, which is difficult to determine using standard imaging techniques. The …             Protective effects of low-intensity pulsed ultrasound on aluminum-induced cerebral damage in Alzheimer's disease rat model ▶     Wei-Ting Lin, Ran-Chou Chen, Wen-Wei Lu et al.     The protein expressions of neurotrophic factors can be enhanced by low-intensity pulsed ultrasound (LIPUS) stimulation in the brain. The purpose of this study was to demonstrate …             Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial ▶     Miao Jiang, Qinglin Zha, Chi Zhang et al.     Tripterygium wilfordii Hook F. (TwHF) based therapy has been proved as effective in treating rheumatoid arthritis (RA), yet the predictors to its response remains unclear. A …             The effects of interfacial potential on antimicrobial propensity of ZnO nanoparticle ▶     Manoranjan Arakha, Mohammed Saleem, Bairagi C. Mallick et al.     The work investigates the role of interfacial potential in defining antimicrobial propensity of ZnO nanoparticle (ZnONP) against different Gram positive and Gram negative …                 A new open access, multi-and interdisciplinary journal dedicated to publishing the highest quality papers on aging and age-related diseases, the journal is now open for submissions.  Explore the benefits of submitting your next research article.         • Careers & Jobs           naturejobs.com Science jobs of the week       Senior Fellow - Parkinson's Disease Research     University of Washington            Research Assistant     California Institute of Technology            Independent Research Fellowships     The University of York            Graduate Studentship     University of Oxford            Postdoctoral Fellowship     Linkopings University            Senior Statistician     Medical Research Council            Research Associate     University College London (UCL)            Research Associates x2     University of Bath            Laboratory Technician     University of Copenhagen            Clinician Scientists     Wellcome Trust - Medical Research Council Cambridge           No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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