Scientific Reports Biology Table of Contents e-alert: 14 April 2015

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14 April 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         A new online, open access, multi- and cross- disciplinary journal dedicated to publishing the finest research on systems biology and all its approaches. Published by Nature Publishing Group in partnership with the Systems Biology Institute (SBI). Learn more at http://bit.ly/1xK0IRG           Biological Sciences               A Dynamic View of ATP-coupled Functioning Cycle of Hsp90 N-terminal Domain ▶     Huaqun Zhang, Chen Zhou, Wuyan Chen et al.     Heat-shock protein 90 (Hsp90) is one of the most important chaperones involved in multiple cellular processes. The chaperoning function of Hsp90 is intimately coupled to the …             The role of TORC1 in muscle development in Drosophila ▶     Isabelle Hatfield, Innocence Harvey, Erika R. Yates et al.     Myogenesis is an important process during both development and muscle repair. Previous studies suggest that mTORC1 plays a role in the formation of mature muscle from immature …             MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction ▶     Ying Lin, Vusumuzi Leroy Sibanda, Hong-Mei Zhang et al.     Myocardial infarction (MI) is a leading cause of death in the world and many genes are involved in it. Transcription factor (TFs) and microRNAs (miRNAs) are key regulators of gene …             HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGFβ-signaling in hypoxic microenvironment. ▶     Neha Nagpal, Hafiz M. Ahmad, Shibu Chameettachal et al.     The molecular mechanisms of hypoxia induced breast cell migration remain incompletely understood. Our results show that hypoxia through hypoxia-inducible factor (HIF) brings about …             Defining Minimum Essential Factors to Derive Highly Pure Human Endothelial Cells from iPS/ES Cells in an Animal Substance-Free System ▶     Yu-Ting Wu, I.-Shing Yu, Kuen-Jer Tsai et al.     It is desirable to obtain unlimited supplies of endothelial cells for research and therapeutics. However, current methods of deriving endothelial cells from humans suffer from …             A Novel 96well-formatted Micro-gap Plate Enabling Drug Response Profiling on Primary Tumour Samples ▶     Wei-Yuan Ma, Lo-Chang Hsiung, Chen-Ho Wang et al.     Drug-based treatments are the most widely used interventions for cancer management. Personalized drug response profiling remains inherently challenging with low cell count …             Classification of foodborne pathogens using near infrared (NIR) laser scatter imaging system with multivariate calibration ▶     Wenxiu Pan, Jiewen Zhao, Quansheng Chen     An optical sensor system, namely NIR laser scatter imaging system, was developed for rapid and noninvasive classification of foodborne pathogens. This developed system was used …             Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation ▶     Xinwei Wang, Liang Wei, Julie M. Cramer et al.     Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we …             The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions ▶     Kai Lu, Sujit Basu     Vascular endothelial growth factor A (VEGFA) plays an important role in tumour angiogenesis and its angiogenic action is mainly mediated through its VEGF receptor 2 (VEGFR-2). …             Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury ▶     Jiayin Wang, Jinchao Xia, Feng Zhang et al.     Galectin-1 (gal-1), a special lectin with high affinity to β-galactosides, is implicated in protection against ischemic brain injury. The present study investigated …             Assessment of radiocesium contamination in frogs 18 months after the Fukushima Daiichi nuclear disaster ▶     Noe Matsushima, Sadao Ihara, Minoru Takase et al.     We investigated the accumulation of radionuclides in frogs inhabiting radioactively contaminated areas around Fukushima Daiichi Nuclear Power Plant (FDNPP) to search for possible …             A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism ▶     Jana Indra Führing, Johannes Thomas Cramer, Julia Schneider et al.     In mammals, UDP-glucose pyrophosphorylase (UGP) is the only enzyme capable of activating glucose-1-phosphate (Glc-1-P) to UDP-glucose (UDP-Glc), a metabolite located at the …             Complete rat spinal cord transection as a faithful model of spinal cord injury for translational cell transplantation ▶     Dunja Lukovic, Victoria Moreno-Manzano, Eric Lopez-Mocholi et al.     Spinal cord injury (SCI) results in neural loss and consequently motor and sensory impairment below the injury. There are currently no effective therapies for the treatment of …             Enhancer of rudimentary homolog regulates DNA damage response in hepatocellular carcinoma ▶     Meng-Tzu Weng, Tzu-Hsun Tung, Jih-Hsiang Lee et al.     We previously demonstrated that the enhancer of rudimentary homolog (ERH) gene is required for the expression of multiple cell cycle and DNA damage response (DDR) genes. The …             Difference in microRNA expression and editing profile of lung tissues from different pig breeds related to immune responses to HP-PRRSV ▶     Jia Li, Zhisheng Chen, Junlong Zhao et al.     Porcine reproductive and respiratory syndrome (PRRS) is one of the most devastating diseases for the pig industry. Our goal was to identify microRNAs involved in the host immune …             Autophagy Stimulation Abrogates Herpes simplex Virus-1 Infection ▶     Abraam M. Yakoub, Deepak Shukla     Herpes simplex virus-1 (HSV-1) is a double-stranded DNA virus that causes life-long infections. HSV-1 infections may lead to herpetic stromal keratitis that may advance to corneal …             Biochar from commercially cultivated seaweed for soil amelioration ▶     David A. Roberts, Nicholas A. Paul, Symon A. Dworjanyn et al.     Seaweed cultivation is a high growth industry that is primarily targeted at human food and hydrocolloid markets. However, seaweed biomass also offers a feedstock for the …             Frequency Dependant Topological Alterations of Intrinsic Functional Connectome in Major Depressive Disorder ▶     Qinghua Luo, Zhou Deng, Jingxue Qin et al.     Major depressive disorder is associated with aberrant topological organizations of brain networks. However, whether this aberrance is shown in broader frequency bands or in a …             Near-shore Antarctic pH variability has implications for the design of ocean acidification experiments ▶     Gretchen Hofmann, Amanda L. Kelley, Emily C. Shaw et al.     Understanding how declining seawater pH caused by anthropogenic carbon emissions, or ocean acidification, impacts Southern Ocean biota is limited by a paucity of pH time-series. …             Practice explains abolished behavioural adaptation after human dorsal anterior cingulate cortex lesions ▶     H. van Steenbergen, E. Haasnoot, B. R. Bocanegra et al.     The role of mid-cingulate cortex (MCC), also referred to as dorsal anterior cingulate cortex, in regulating cognitive control is a topic of primary importance in cognitive …             Macroscopic and Macromolecular Specificity of Alkylphenol Anesthetics for Neuronal Substrates ▶     Brian P. Weiser, Michael A. Hall, Nathan L. Weinbren et al.     We used a photoactive general anesthetic called meta-azi-propofol (AziPm) to test the selectivity and specificity of alkylphenol anesthetic binding in mammalian brain. …             A pyrosequencing insight into sprawling bacterial diversity and community dynamics in decaying deadwood logs of Fagussylvatica and Piceaabies ▶     Björn Hoppe, Krüger Krger, Tiemo Kahl et al.     Deadwood is an important biodiversity hotspot in forest ecosystems. While saproxylic insects and wood-inhabiting fungi have been studied extensively, little is known about …             Plasticity of Lysteriolysin O Pores and its Regulation by pH and Unique Histidine ▶     Marjetka Podobnik, Marta Marchioretto, Manuela Zanetti et al.     Pore formation of cellular membranes is an ancient mechanism of bacterial pathogenesis that allows efficient damaging of target cells. Several mechanisms have been described, …             Potent effects of dioscin against liver fibrosis ▶     Xiaoling Zhang, Xu Han, Lianhong Yin et al.     We previously reported the promising effects of dioscin against liver injury, but its effect on liver fibrosis remains unknown. The present work investigated the activities of …             KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines ▶     João Lavrado, Hugo Brito, Pedro M. Borralho et al.     KRAS is one of the most frequently mutated oncogenes in human cancer, yet remaining undruggable. To explore a new therapeutic strategy, a library of …             Small Molecule Ice Recrystallization Inhibitors Enable Freezing of Human Red Blood Cells with Reduced Glycerol Concentrations ▶     Chantelle J. Capicciotti, Jayme D. R. Kurach, Tracey R. Turner et al.     In North America, red blood cells (RBCs) are cryopreserved in a clinical setting using high glycerol concentrations (40% w/v) with slow cooling rates (~1°C/min) prior to storage …             mTORC1 Maintains the Tumorigenicity of SSEA-4+ High-Grade Osteosarcoma ▶     Wu Zhang, Meng-Lei Ding, Jia-Nian Zhang et al.     Inactivation of p53 and/or Rb pathways restrains osteoblasts from cell-cycle exit and terminal differentiation, which underpins osteosarcoma formation coupled with …             Magnetization Transfer Imaging of Suicidal Patients with Major Depressive Disorder ▶     Ziqi Chen, Huawei Zhang, Zhiyun Jia et al.     Magnetization transfer imaging (MTI) provides a quantitative measure of the macromolecular structural integrity of brain tissue, as represented by magnetization transfer ratio …             A rapid and reliable strategy for chromosomal integration of gene(s) with multiple copies ▶     Pengfei Gu, Fan Yang, Tianyuan Su et al.     Direct optimization of the metabolic pathways on the chromosome requires tools that can fine tune the overexpression of a desired gene or optimize the combination of multiple …             PI3Kβ Inhibitor TGX221 Selectively Inhibits Renal Cell Carcinoma Cells with Both VHL and SETD2 mutations and Links Multiple Pathways ▶     Chenchen Feng, Yang Sun, Guanxiong Ding et al.     We aimed to exploit novel compounds with high selectivity to clear cell renal cell carcinoma (ccRCC) with common mutations. Using the GDSC databases, we searched for compounds …             Network Modularity is essential for evolution of cooperation under uncertainty ▶     David A. Gianetto, Babak Heydari     Cooperative behavior, which pervades nature, can be significantly enhanced when agents interact in a structured rather than random way; however, the key structural factors that …                 Epigenome Roadmap Nature Publishing Group presents an online portal - the Epigenome Roadmap - which collects key research papers from The NIH Roadmap Epigenomics Program, complemented by thematical 'threads' to help the readers mine the wealth of available information. 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