Nature Reviews Molecular Cell Biology contents May 2015 Volume 16 Number 5 pp 265-324

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TABLE OF CONTENTS
May 2015 Volume 16 Number 5
Impact Factor 36.458 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Technologies and techniques  Featured article: Regulation of RAF protein kinases in ERK signalling Hugo Lavoie & Marc Therrien
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RESEARCH HIGHLIGHTS Top Post-translational modifications: Crotonylation versus acetylation p265 | doi:10.1038/nrm3992 p300 catalyses histone crotonylation, which activates transcription more efficiently than histone acetylation. PDF Stem cells: SIRT7, the UPR and HSC ageing p266 | doi:10.1038/nrm3981 This paper shows that sirtuin 7 (SIRT7) promotes the regenerative capacity of aged haematopoietic stem cells by driving a regulatory branch of the mitochondrial unfolded protein response. PDF Epigenetics: Characterizing enhancers with dCas9 p266 | doi:10.1038/nrm3983 Two studies show that protein fusions of deactivated Cas9 (dCas9) with histone remodellers can be used to characterize enhancers, and alter epigenetic marks and gene expression. PDF Mechanotransduction: VE-cadherin lets it flow p268 | doi:10.1038/nrm3985 This study shows that the transmembrane domain of VE-cadherin binds to VEGFR2 and VEGFR3, a new component of the junction mechanosensory complex. PDF JOURNAL CLUB The ribosome prophecy p268 | doi:10.1038/nrm3993 A prophetic theoretical article, which hypothesized that ribosomes have regulatory roles in controlling gene expression, inspired Maria Barna to rethink the value of purely theoretical scientific publications. PDF IN BRIEF Plant development: A fruit-bearing microRNA | Membrane trafficking: Recycling through a new complex | Post-translational modifications: When ubiqutin piggybacks | Cell senescence: Communicating with senescence | Cell migration: Speed and persistence | Cell division: Sorting ageing mitochondria PDF JOBS of the week ERC-funded Postdoctoral Researcher in Molecular Cell Biology Max Planck Institute of Molecular Physiology PhD position in Molecular Biology - Mathematical modelling of single-cell responses Institute of Molecular Biology (IMB) Mainz Research Associate, primary T cell biology CELLECTIS Inc. Post-doctoral Researcher in Gene Expression & Epigenetics University Medical Center Utrecht (UMC Utrecht) Post-doctoral position in Biomedical Research Case Western Reserve University More Science jobs from EVENT ToProB: Towards Programmable Biology 30.07.15 York, UK More science events from
REVIEWS		Top
Article series: Technologies and techniques Multidimensional proteomics for cell biology Mark Larance & Angus I. Lamond p269 | doi:10.1038/nrm3970 Advances in mass spectrometry-based proteomics are enabling the multidimensional analysis of protein properties such as abundance, localization, post-translational modifications and interactions for thousands of proteins. Complemented by new tools for data analysis and integration, these advances are transforming our understanding of various biological processes. Abstract | Full Text | PDF | Supplementary information
Regulation of RAF protein kinases in ERK signalling Hugo Lavoie & Marc Therrien p281 | doi:10.1038/nrm3979 RAF family kinases, which were first described over 30 years ago, primarily act as signalling relays downstream of RAS. Key mechanistic and structural studies are shaping our view of how RAF proteins and RAF-related pseudokinases are regulated; they also highlight the mechanisms underlying pathological RAF signalling and the unforeseen limitations of RAF inhibitors. Abstract | Full Text | PDF | Supplementary information
Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments Margaret A. Goodell, Hoang Nguyen & Noah Shroyer p299 | doi:10.1038/nrm3980 Somatic stem cells are responsible for tissue maintenance and repair throughout life. Studies on blood, skin and intestinal epithelium have revealed that multiple types of stem cells with distinct roles perform such regenerative functions. Moreover, stem cells have greater developmental flexibility than had previously been appreciated under stress conditions such as acute injury. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Building endocytic pits without clathrin Ludger Johannes, Robert G. Parton, Patricia Bassereau & Satyajit Mayor p311 | doi:10.1038/nrm3968 How endocytic pits are formed in clathrin- and caveolin-independent endocytosis remains poorly understood. However, recent insight suggests that different forms of clathrin-independent endocytosis might involve the actin-driven focusing of membrane constituents, the lectin-glycosphingolipid-dependent construction of endocytic nanoenvironments and the use of Bin-Amphiphysin-Rvs (BAR) domain proteins as scaffolding modules. Abstract | Full Text | PDF | Supplementary information
ESSAY The unravelling of the ubiquitin system Aaron Ciechanover p322 | doi:10.1038/nrm3982 Aaron Ciechanover describes the discovery of the ubiquitin system and the analysis of its components using a 'classical' biochemical approach. These findings, which were published in a relatively modest journal, would prove to be ground-breaking. Abstract | Full Text | PDF
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