Nature Reviews Genetics Contents May 2015 Volume 16 Number 5 pp 253-311

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TABLE OF CONTENTS
May 2015 Volume 16 Number 5
Impact Factor 39.794 *	In this issue Comment Research Highlights Reviews Also this month  Featured article: High-throughput functional genomics using CRISPR–Cas9 Ophir Shalem, Neville E. Sanjana & Feng Zhang
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Comment: The big medical data miss: challenges in establishing an open medical resource Eric J. Topol p253 | doi:10.1038/nrg3943 Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top RNA: Detailed probing of RNA structure in vivo p255 | doi:10.1038/nrg3939 PDF Population genetics: The peopling of Britain p256 | doi:10.1038/nrg3938 PDF Genetic testing: ACMG guides on the interpretation of sequence variants p256 | doi:10.1038/nrg3940 PDF Technology: Breaking Mendelian inheritance with CRISPR–Cas p258 | doi:10.1038/nrg3942 PDF DNA elements: Shaping up transcription factor binding p258 | doi:10.1038/nrg3944 PDF Clinical genetics: Sequencing for tailored melanoma immunotherapy p259 | doi:10.1038/nrg3945 PDF IN BRIEF Population genomics: Population-scale sequencing in Iceland | Complex traits: Genetic discovery, heritability and prediction | Model organisms: 100 S. cerevisiae genomes PDF Genetics JOBS of the week Postdoctoral Fellow in Quantitative Biology and Statistical Genomics UT Southwestern Medical Center at Dallas, TX Postdoctoral Fellowship in Functional Genomics Memorial Sloan Kettering Cancer Center (MSKCC) Postdoc Research Fellow in Cancer Genomics Mayo Clinic Florida Post-doctoral Researcher in Gene Expression & Epigenetics University Medical Center Utrecht (UMC Utrecht) PhD position in Molecular Biology - Epigenetic gene regulation acute myeloid leukaemia Institute of Molecular Biology (IMB) Mainz More Science jobs from Genetics EVENT Yeast Genetics & Genomics 21.07.15 Cold Spring Harbour, USA More science events from
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REVIEWS		Top
Rett syndrome: a complex disorder with simple roots Matthew J. Lyst & Adrian Bird p261 | doi:10.1038/nrg3897 Rett syndrome is a neurological disorder associated with mutations in the X-linked gene MECP2 (methyl-CpG-binding protein 2). This Review details emerging insights into the link between the functions of MeCP2 and the pathogenesis of Rett syndrome. Abstract | Full Text | PDF
Genetic linkage analysis in the age of whole-genome sequencing Jurg Ott, Jing Wang & Suzanne M. Leal p275 | doi:10.1038/nrg3908 Before genome-wide association studies, linkage analysis was the primary approach used for genetic mapping of complex traits in humans. Now, with the widespread application of whole-genome sequencing (WGS), linkage analysis based on WGS data is emerging as a useful tool for the identification of susceptibility genes for human disease. This Review reiterates the main principles of linkage analysis and provides guidelines for performing linkage analysis on WGS data. Abstract | Full Text | PDF
Beyond the thale: comparative genomics and genetics of Arabidopsis relatives Daniel Koenig & Detlef Weigel p285 | doi:10.1038/nrg3883 Arabidopsis thaliana, a member of the phenotypically diverse Brassicaceae family, has proved to be a key model organism for characterizing plant genome and morphological evolution. This Review outlines how recent comparative and functional genomic studies using Arabidopsis relatives have further advanced our understanding of plant diversity and evolution. Abstract | Full Text | PDF
High-throughput functional genomics using CRISPR-Cas9 Ophir Shalem, Neville E. Sanjana & Feng Zhang p299 | doi:10.1038/nrg3899 CRISPR-Cas9 has been adopted as a powerful genome-editing technology in various species. By generating libraries of thousands of guide RNAs — which direct the Cas9 nuclease to chosen genomic loci — high-throughput genetic perturbations are now possible. This Review discusses the latest applications of CRISPR-Cas9 in mammalian functional genomics screens. It covers related genome-scale applications of Cas9 for either gene knockout or transcriptional modulation, and provides comparisons with complementary RNA interference (RNAi)-based approaches. Abstract | Full Text | PDF
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Nature Genetics: Genomes of Icelanders The largest-ever set of human genomes from a single population and the consequent insights into mutation, evolution, gene function and disease predisposition are reported in four linked papers.  Access the Web Focus free online. Produced with support from Illumina
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