Nature Immunology Contents: May 2015 Volume 16 pp 435 - 544

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS May 2015 Volume 16, Issue 5 Commentary News and Views Research Highlights Review Articles Corrigenda Errata Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement 1st Nature Immunology - Cellular & Molecular Immunology Joint Conference: Inflammation, Stress and Immune Homeostasis June 17-19, 2015 | The Swan Lake Hotel, Hefei, China  Register Now!    Commentary Top A vision and a prescription for big data-enabled medicine   pp435 - 439 Damien Chaussabel and Bali Pulendran doi:10.1038/ni.3151 Genetic, environmental and socioeconomic factors render humanity remarkably diverse. '-Omic' and sensor technologies permit the capture of this diversity with unprecedented precision. Leveraging these technologies in clinical decision making will help to bring about the long-heralded personalization of medicine. News and Views Top Brainless immunity no more   pp440 - 441 Sachin P Gadani and Jonathan Kipnis doi:10.1038/ni.3145 The mediobasal hypothalamus detects increased amounts of tumor necrosis factor during the early phases of inflammation and relays this information to cells of the adaptive immune system by mobilizing free fatty acids. See also: Article by Kim et al. Cytoplasmic methylation fuels leukocyte invasion   pp441 - 443 Bernhard Wehrle-Haller doi:10.1038/ni.3142 The methyltransferase Ezh2, an epigenetic regulator associated with tumor-cell metastasis, also methlyates the cytoplasmic integrin adaptor talin. This modification inhibits the binding of talin to F-actin, which enhances the migration and invasion of dendritic cells and neutrophils. See also: Article by Gunawan et al. GBPs take AIM at Francisella   pp443 - 444 Katherine A Fitzgerald and Vijay A K Rathinam doi:10.1038/ni.3144 Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis of Francisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death. See also: Article by Man et al. | Article by Meunier et al. TREML4 adds fuel to the TLR7 fire   pp445 - 446 Mihai G Netea and Frank L van de Veerdonk doi:10.1038/ni.3149 The cell-surface receptor TREML4 amplifies cellular responses to single-stranded RNA by regulating recruitment of the adaptor MyD88 to the receptor TLR7. Mice lacking TREML4 show impaired antiviral immunity but also reduced severity of lupus-like disease. See also: Article by Ramirez-Ortiz et al. Immunology JOBS of the week Assistant Professor in Transplant Tolerance Immunology University of Toronto Postdoctoral position in Immunology, Institut Curie Institut Curie Avian Immunology Post-Doctoral Research Opportunity ORAU/ORISE Faculty Position in Immunology Northwestern University Masters (M.Sc.) in Immunology Trinity College Dublin More Science jobs from Immunology EVENT 3rd International Conference on ImmunoMetabolism: Molecular and Cellular Immunology of Metabolism 24th Sept - 29th Sept 2015 Chania, Greece More science events from Research Highlights Top Mycobacterial sensing | IL-33 supports TH1 cells | Necroptosis regulator | Developmental stage matters | TREM2 function in microglia | Targeting Nur77 in sepsis Review Top IL-6 as a keystone cytokine in health and disease   pp448 - 457 Christopher A Hunter and Simon A Jones doi:10.1038/ni.3153 IL-6 has context-dependent pro- and anti-inflammatory properties and is now regarded as a prominent target for clinical intervention. Hunter and Jones discuss the effect of IL-6 on innate and adaptive immunity, and consider how the immunobiology of IL-6 may inform clinical decisions. Advertisement The ChemiDoc™ Touch Imaging System by Bio-Rad  Get the quantitation of digital imaging with the sensitivity of film. Introducing the ChemiDoc™ Touch Imaging System, the latest addition to the V3 Western Workflow™. By providing optimal exposure for all samples and detecting signals distributed over a much broader range than film, the ChemiDoc Touch Imager ensures the quality and reproducibility of your western blotting results. See performance data.    Articles Top The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation   pp458 - 466 Qiao Zhang, Hong Kuang, Cong Chen, Jie Yan, Hanh Chi Do-Umehara et al. doi:10.1038/ni.3130 Cells closely monitor mitochondrial status. Liu and colleagues show that the kinase Jnk2 regulates mitophagy by inhibiting smARF. Loss of Jnk2 results in defective mitophagy and enhanced ROS generation during hypoxia, which leads to enhanced inflammasome activation. The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection   pp467 - 475 Si Ming Man, Rajendra Karki, R K Subbarao Malireddi, Geoffrey Neale, Peter Vogel et al. doi:10.1038/ni.3118 The mechanisms that control activation of the AIM2 inflammasome by cytosolic bacteria are unclear. Kanneganti and colleagues demonstrate that a pathway involving the transcription factor IRF1 is required for the activation of AIM2. See also: News and Views by Fitzgerald & Rathinam Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida   pp476 - 484 Etienne Meunier, Pierre Wallet, Roland F Dreier, Stéphanie Costanzo, Leonie Anton et al. doi:10.1038/ni.3119 How host cells induce the release of DNA from cytosolic bacteria is unclear. Broz and colleagues show that the guanylate-binding proteins GBP2 and GBP5 trigger bacteriolysis in infected host cells and thereby allow recognition by the sensor AIM2. See also: News and Views by Fitzgerald & Rathinam Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis   pp485 - 494 Matthew S Miller, Alexander Rialdi, Jessica Sook Yuin Ho, Micah Tilove, Luis Martinez-Gil et al. doi:10.1038/ni.3132 Mutations in the gene encoding the helicase senataxin have well established associations with the neurodegenerative disease ALS. Marazzi et al. show that senataxin can also attenuate virus-triggered responses by controlling RNA polymerase activity at genes encoding antiviral molecules. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity   pp495 - 504 Zaida G Ramirez-Ortiz, Amit Prasad, Jason W Griffith, William F Pendergraft III, Glenn S Cowley et al. doi:10.1038/ni.3143 Fine-tuning of TLR7 signaling modulates innate inflammatory responses. Means and colleagues identify the receptor TREML4 as an essential positive regulator of TLR7 signaling during antiviral responses and autoimmunity. See also: News and Views by Netea & van de Veerdonk The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin   pp505 - 516 Merry Gunawan, Nandini Venkatesan, Jia Tong Loh, Jong Fu Wong, Heidi Berger et al. doi:10.1038/ni.3125 Ezh2 is a protein methylase that epigenetically modifies chromatin. Su and colleagues identify a cytoplasmic role for Ezh2 whereby it controls the extravasation of innate leukocytes through methylation of talin and thereby influences inflammatory responses in vivo. See also: News and Views by Wehrle-Haller Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function   pp517 - 524 Leonid A Pobezinsky, Ruth Etzensperger, Susanna Jeurling, Amala Alag, Tejas Kadakia et al. doi:10.1038/ni.3146 Singer and colleagues show that let-7 microRNAs target Zbtb16 mRNA, which encodes the transcription factor PLZF, to modulate PLZF expression during the terminal differentiation of NKT cells into effector subsets. Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis   pp525 - 533 Min Soo Kim, Jingqi Yan, Wenhe Wu, Guo Zhang, Yalin Zhang et al. doi:10.1038/ni.3133 Peripheral innate immunological signals can amplify adaptive immune responses. Cai and colleagues show that hypothalamicexposure to the cytokine TNF triggers a neural response that amplifies peripheral lymphocyte activation in the spleen and adipose tissues. See also: News and Views by Gadani & Kipnis Responsiveness of B cells is regulated by the hinge region of IgD   pp534 - 543 Rudolf Übelhart, Eva Hug, Martina P Bach, Thomas Wossning, Marcus Dühren-von Minden et al. doi:10.1038/ni.3141 Mature naive B cells express membrane IgM and IgD B cell receptors. Jumaa and colleagues show that the hinge region of these regions confers differential responses to monovalent versus multivalent antigens and thereby influences B cell reactivity. Corrigenda Top Corrigendum: Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia   p544 Peter Rosenberger, Jan M Schwab, Valbona Mirakaj, Eva Masekowsky, Alice Mager et al. doi:10.1038/ni0515-544a Corrigendum: A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus   p544 Wanwisa Dejnirattisai, Wiyada Wongwiwat, Sunpetchuda Supasa, Xiaokang Zhang, Xinghong Dai et al. doi:10.1038/ni0515-544b Errata Top Erratum: The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes   p544 Pia Rantakari, Kaisa Auvinen, Norma Jäppinen, Maria Kapraali, Joona Valtonen et al. doi:10.1038/ni0515-544c Erratum: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells   p544 Ajithkumar Vasanthakumar, Kazuyo Moro, Annie Xin, Yang Liao, Renee Gloury et al. doi:10.1038/ni0515-544d Top Advertisement Epigenome Roadmap Nature Publishing Group presents an online portal - the Epigenome Roadmap - which collects key research papers from The NIH Roadmap Epigenomics Program, complemented by thematical 'threads' to help the readers mine the wealth of available information. Access the Epigenome Roadmap for FREE at: nature.com/epigenomeroadmap Produced with exclusive support from  Illumina    Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.