Nature Biotechnology Contents: Volume 33 pp 319 - 428

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Advertisement QUINTILES COMPREHENSIVE CANCER PANEL. A targeted sequencing assay for simultaneous analysis of genomic variation, which may be predictive of response to multiple therapies in clinical development. Identifies pathways, markers of disease and unique variant types to select for patient populations likely to benefit from targeted therapies. Learn More. TABLE OF CONTENTS April 2015 Volume 33, Issue 4 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Advertisement   Protein expression & purification—learn practical production tips from experts A centralized place to expand your knowledge on every step of protein expression and purification. Get free access NOW Japanese table of contents Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Editorial Top Rebooting review   p319 doi:10.1038/nbt.3202 Nature Biotechnology is reevaluating editorial oversight of papers centered on computational analyses in anticipation of the 'big data' world. News Top IDO inhibitors move center stage in immuno-oncology   pp321 - 322 Cormac Sheridan doi:10.1038/nbt0415-321 Apple's ResearchKit frees medical research   p322 doi:10.1038/nbt0415-322 Pfizer's CDK4/6 inhibitor approved for advanced breast cancer   pp323 - 324 Chris Morrison doi:10.1038/nbt0415-323 NIH innovation investment pays   p324 doi:10.1038/nbt0415-324 Obama catapults patient-empowered Precision Medicine   p325 Jeffrey L Fox doi:10.1038/nbt0415-325 Bavarian Nordic's prostate vaccine hits pay dirt   p326 doi:10.1038/nbt0415-326a 20-year-old EMA's birthday bash   p326 doi:10.1038/nbt0415-326b Nonbrowning GM apple cleared for market   pp326 - 327 Emily Waltz doi:10.1038/nbt0415-326c Around the world in a month   p327 doi:10.1038/nbt0415-327 Monsanto adds dicamba to its cache to counter weed threat   p328 Emily Waltz doi:10.1038/nbt0415-328 News Feature Engineers of scent   pp329 - 332 Emily Waltz doi:10.1038/nbt.3191 Companies exploring biotech approaches to flavor and fragrance production must navigate challenges in regulations, market dynamics and public perception. Emily Waltz investigates. Bioentrepreneur Top Datapage Academic partnerships 2014   p333 Brady Huggett doi:10.1038/nbt.3189 Podcast First Rounders Podcast: Kari Stefansson   p333 doi:10.1038/nbt.3186 Opinion and Comment Top Correspondence The quintessence of immunogenicity reporting for biotherapeutics   pp334 - 336 Gopi Shankar, Steven Arkin, Viswanath Devanarayan, Arno Kromminga, Valerie Quarmby et al. doi:10.1038/nbt.3181 Silence on the relevant literature and errors in implementation   pp336 - 339 Philippe Bastiaens, Marc R Birtwistle, Nils Bluthgen, Frank J Bruggeman, Kwang-Hyun Cho et al. doi:10.1038/nbt.3185 Response to Letter of Correspondence - Bastiaens et al.   pp339 - 342 Baruch Barzel and Albert-Laszlo Barabasi doi:10.1038/nbt.3184 Opportunities for drug repositioning from phenome-wide association studies   pp342 - 345 Majid Rastegar-Mojarad, Zhan Ye, Jill M Kolesar, Scott J Hebbring and Simon M Lin doi:10.1038/nbt.3183 Epigenomic annotation of genetic variants using the Roadmap Epigenome Browser   pp345 - 346 Xin Zhou, Daofeng Li, Bo Zhang, Rebecca F Lowdon, Nicole B Rockweiler et al. doi:10.1038/nbt.3158 Features Top Patents Are the gene-patent storm clouds dissipating? A global snapshot   pp347 - 352 Johnathon Liddicoat, Tess Whitton and Dianne Nicol doi:10.1038/nbt.3182 In genetic diagnostics testing, what are the boundaries of the global patent problem, and is there a real risk that patents and licensing practices could impede access to tests? Recent patent applications in epigenetics   p353 doi:10.1038/nbt.3205 News and Views Top Improving reference epigenome catalogs by computational prediction   pp354 - 355 Peter Ebert and Christoph Bock doi:10.1038/nbt.3194 Bioinformatic imputation of epigenomic marks promises to supplement catalogs of experimental data. See also: Computational Biology by Ernst & Kellis A dynamic picture of protein behavior in cells   pp356 - 357 Mary N Teruel, Bo Gu and Michael L Zhao doi:10.1038/nbt.3196 Protein dynamics in livings cells can now be studied by fully automated, high-throughput fluorescence correlation spectroscopy. See also: Research by Wachsmuth et al. Genetic variation and alternative splicing   pp357 - 359 Xavier Estivill doi:10.1038/nbt.3195 The influence of genetic variation on alternative splicing and human disease is modeled in an algorithm that integrates gene expression data. Biotechnology JOBS of the week Assistant / Associate Professor, Biomedical Engineering University of South Dakota Postdoctoral Researcher in Single Cell Genomics VIB Center for the Biology of Disease, K.U.Leuven Exciting PhD Positions in Modern Biology VBC PhD Programme More Science jobs from Biotechnology EVENT 36th Semi-annual Biotechnology Vendor Showcase™ Event at University of California, Los Angeles October 22, 2015 CA, USA More science events from News Top Research Highlights   p359 doi:10.1038/nbt.3197 Computational Biology Top Commentary Federalist principles for healthcare data networks   pp360 - 363 Kenneth D Mandl and Isaac S Kohane doi:10.1038/nbt.3180 Applying federalist principles to networked health record data could facilitate realization of the potential of shared health data. Analysis Large-scale imputation of epigenomic datasets for systematic annotation of diverse human tissues OPEN   pp364 - 376 Jason Ernst and Manolis Kellis doi:10.1038/nbt.3157 Large-scale epigenomic profiles are predicted from experimental data using multiple regression tree models. See also: News and Views by Ebert & Bock Research Top Article Distributing a metabolic pathway among a microbial consortium enhances production of natural products   pp377 - 383 Kang Zhou, Kangjian Qiao, Steven Edgar and Gregory Stephanopoulos doi:10.1038/nbt.3095 Dividing a metabolic pathway between yeast and Escherichia coli enables synthesis of a small molecule. Letters High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells   pp384 - 389 Malte Wachsmuth, Christian Conrad, Jutta Bulkescher, Birgit Koch, Robert Mahen et al. doi:10.1038/nbt.3146 Automated fluorescence correlation spectroscopy data acquisition and analysis allows high throughput analysis of protein dynamics in cells. See also: News and Views by Teruel et al. Inducible in vivo genome editing with CRISPR-Cas9   pp390 - 394 Lukas E Dow, Jonathan Fisher, Kevin P O'Rourke, Ashlesha Muley, Edward R Kastenhuber et al. doi:10.1038/nbt.3155 Mouse lines with an inducible Cas9 gene enable in vivo disease modeling. ChIP-nexus enables improved detection of in vivo transcription factor binding footprints   pp395 - 401 Qiye He, Jeff Johnston and Julia Zeitlinger doi:10.1038/nbt.3121 Nucleotide-resolution mapping of transcription factor binding sites with an optimized ChIP-exo method reveals effects of local DNA sequence. Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice   pp402 - 407 Matthias Obenaus, Catarina Leitao, Matthias Leisegang, Xiaojing Chen, Ioannis Gavvovidis et al. doi:10.1038/nbt.3147 A humanized mouse model facilitates the identification of T cell receptors for unmutated cancer antigens. Resources Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean OPEN   pp408 - 414 Zhengkui Zhou, Yu Jiang, Zheng Wang, Zhiheng Gou, Jun Lyu et al. doi:10.1038/nbt.3096 Resequencing of 302 soybean accessions and GWAS provide a comprehensive resource for soybean geneticists and breeders. Acetylation site specificities of lysine deacetylase inhibitors in human cells   pp415 - 423 Christian Scholz, Brian T Weinert, Sebastian A Wagner, Petra Beli, Yasuyuki Miyake et al. doi:10.1038/nbt.3130 Comprehensive analysis of changes in protein acetylation in response to lysine deacetylase inhibitors uncovers inhibitor specificities. Corrigendum Corrigendum: Network deconvolution as a general method to distinguish direct dependencies in networks   p424 Soheil Feizi, Daniel Marbach, Muriel Medard and Manolis Kellis doi:10.1038/nbt0415-424 Careers and Recruitment Top Expanding ELSI to all areas of innovative science and technology   pp425 - 426 Dov Greenbaum doi:10.1038/nbt.3193 New curricula in the study of the ethical, legal and social implications of scientific research aims to further the conversation among all stakeholders in the interactions between science, technology and society. People People   p428 doi:10.1038/nbt.3203 Advertisement Complimentary print subscriptions to Nature Reviews Drug Discovery are available in the US, Canada and Europe and are provided to individuals involved in drug discovery and development.  Find out if you qualify now!      Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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